Article
Environmental Sciences
Fatemeh Fallah, Abasalt Hosseinzadeh Colagar, Hayder Abdulhadi Saleh, Mojtaba Ranjbar
Summary: This study investigated the association between enzymatic factors in semen, polymorphisms (SOD2 rs4880, GPX1 rs1050450, and CAT rs1001179), and male infertility. The results showed that the rs1050450 polymorphism was associated with a reduced risk of male infertility, asthenozoospermia, and teratozoospermia, while the rs4880 polymorphism was associated with an increased risk of male infertility and teratozoospermia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Urology & Nephrology
Xianling Zhou, Heng Shi, Shiping Zhu, Haixia Wang, Shengyun Sun
Summary: This study found through a meta-analysis that vitamin E and vitamin C can improve spousal pregnancy rates and semen parameters in infertile men.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Endocrinology & Metabolism
Tarique Hussain, Mahmoud Kandeel, Elsayed Metwally, Ghulam Murtaza, Dildar Hussain Kalhoro, Yulong Yin, Bie Tan, Muhammad Ismail Chughtai, Anjaleena Yaseen, Ali Afzal, Muhammad Saleem Kalhoro
Summary: Male infertility is a global issue with oxidative stress being the main contributing factor, affecting sperm quality and quantity. Dysfunction of mitochondria and inflammation also play important roles in compromised fertility. The interaction between oxidative stress and seminal plasma proteomes further influences male infertility. Understanding these factors can help improve strategies to prevent male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ahmed Ali, Derar R. Derar, Tamim M. Alhassun, Tariq I. Almundarij
Summary: This study investigated the effects of zinc, selenium, and vitamin E administration on semen quality and fertility in male dromedary camels with impotentia generandi. The results showed significant improvements in sperm cell concentration, motility, and viability after treatment. Initial sperm count can be used as a predictor of camel response to treatment.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Immunology
Emilia Morawiec, Michal Czerwinski, Anna Bednarska-Czerwinska, Andrzej Wiczkowski
Summary: Seminal microflora plays a crucial role in male fertility, and dysbiosis can lead to infertility and other reproductive problems. Inflammation negatively affects sperm quality and may cause partner infection. A comprehensive examination of seminal microflora can clarify the causes of infertility or prevent pathological conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Andrology
Xu-Chao Dai, Meng-Qi Zhang, Gang Chen, Kun Mei, Yan-Long Liu, Hong Huang, Zhi-Gang Wu
Summary: Wenzhou has improved its environmental quality through comprehensive environmental remediation, but the semen quality of infertile males remains unclear. This study examined whether better environmental quality improved semen quality in this region.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Review
Andrology
Kristian Leisegang, Pallav Sengupta, Ashok Agarwal, Ralf Henkel
Summary: Obesity is a global health problem that affects over a third of the population and can lead to complications such as cardiovascular diseases, type 2 diabetes, malignancy, neurodegeneration, and accelerated aging. In males, obesity can also impact reproductive health through various mechanisms, including disruption of hormonal axes and metabolic dysregulation. Moreover, obesity can negatively affect semen parameters and lead to chromatin condensation, DNA fragmentation, and epigenetic changes that may be passed on to offspring.
Article
Immunology
Claudia Omes, Veronica Tomasoni, Mara De Amici, Giorgia Testa, Cristina Torre, Rossella E. Nappi
Summary: Calprotectin concentration in seminal fluid may serve as a biological marker for preliminary screening in males at risk of infertility due to abnormalities in semen quality, such as morphology. Higher calprotectin concentration appears to be associated with better semen quality, and using calprotectin as a preliminary test can help differentiate individuals with abnormal semen parameters, particularly morphology.
Article
Environmental Sciences
Kajsa Ugelvig Petersen, Katia Keglberg Haervig, Esben Meulengracht Flachs, Jens Peter Bonde, Christian Lindh, Karin Sorig Hougaard, Gunnar Toft, Cecilia Host Ramlau-Hansen, Sandra Sogaard Tottenborg
Summary: This study examined the impact of PFAS exposure on reproductive function in young adult males. The results showed a slight association between higher levels of PFAS and follicle-stimulating hormone (FSH) levels, but no consistent associations with semen quality and testicular volume were found.
ENVIRONMENTAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Trimble L. Spitzer, J. C. Trussell, R. Matthew Coward, Karl R. Hansen, Kurt T. Barnhart, Marcelle Cedars, Michael P. Diamond, Stephen A. Krawetz, Fangbai Sun, Heping Zhang, Nanette Santoro, Anne Z. Steiner
Summary: This study aimed to investigate whether stress, as measured by salivary alpha-amylase and cortisol levels, has a negative impact on male fertility, as measured by semen parameters, pregnancy, and live birth rates. The results showed that high levels of stress markers were not associated with DNA fragmentation or abnormal semen parameters. In fact, an increase in salivary cortisol was associated with an increase in total sperm count and total motile sperm count. Moreover, there was no difference in pregnancy and live birth rates between men with high levels of stress markers and those with lower levels.
REPRODUCTIVE SCIENCES
(2022)
Review
Nutrition & Dietetics
Gloria Calagna, Valeria Catinella, Salvatore Polito, Antonio Schiattarella, Pasquale De Franciscis, Francesco D'Antonio, Giuseppe Cali, Antonino Perino, Gaspare Cucinella
Summary: The purpose of this study was to clarify the effect of vitamin D on male infertility. The results showed a relevant interrelation between vitamin D levels and semen parameters, particularly sperm motility. However, the evidence on the effect of vitamin D on male sex steroid hormone levels was inconclusive.
Article
Obstetrics & Gynecology
Nicole Banks, Fangbai Sun, Stephen A. Krawetz, R. Matthew Coward, Puneet Masson, James F. Smith, J. C. Trussell, Nanette Santoro, Heping Zhang, Anne Z. Steiner
Summary: This study found no significant association between vitamin D levels in the male partner and treatment outcomes, but a lower 25(OH)D level (<20 ng/mL) was associated with a higher rate of pregnancy loss. Further research is needed to better understand the impact of male vitamin D deficiency on miscarriage rates in couples.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Eliana Pintus, Jose Luis Ros-Santaella
Summary: Oxidative stress in the male reproductive system can impair sperm fertility, compromise offspring health, and induce oxidative damage to lipids, proteins, and nucleic acids. While a clear link has been shown in humans and laboratory rodents, limited information is available on the impact of impaired redox homeostasis in male fertility of domestic and wild animals. Strategies to mitigate the detrimental effects of oxidative stress on male fertility are reviewed, along with their potential economic and ecological implications in the livestock industry and biodiversity conservation.
Article
Cell Biology
Shubhadeep Roychoudhury, Anandan Das, Manesh Kumar Panner Selvam, Saptaparna Chakraborty, Petr Slama, Suresh C. Sikka, Kavindra Kumar Kesari
Summary: This study analyzed the research trend in radiotherapy associated with male infertility over the past 20 years. The results showed a positive growth in research on the impact of radiotherapy on male infertility, primarily focusing on its effects on semen parameters and fertility preservation techniques. However, there is limited research on the influence of radiotherapy on male reproductive hormones and omics-related research in male reproductive organs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Naveed Rauf, Ayesha Nawaz, Hizb Ullah, Rahim Ullah, Ghulam Nabi, Asad Ullah, Fazal Wahab, Sarwat Jahan, Junfen Fu
Summary: Vitamin C, E, and their nanoparticles have been found to effectively mitigate cisplatin-induced reproductive toxicity, restoring testicular function and improving tissue structure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
