Article
Immunology
Yun Liu, Peigen Chen, Hui Fei, Mengxiong Li, Xian Li, Tian Li
Summary: In this study, analysis of endometrial tissue data from patients with recurrent miscarriage revealed a key module positively related to the numbers of miscarriages, with natural killer cells mediated cytotoxicity related genes playing a role. Specifically, CASP3 was identified as a key gene that down-regulates PARP1, with regulation by SP1. It was proposed that natural killer cells contribute to recurrent miscarriage through the SP1-CASP3-PARP1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Reproductive Biology
Donghai Zhang, Yongsheng Yu, Chuanfeng Ding, Ruonan Zhang, Tao Duan, Qian Zhou
Summary: Decreased B7-H3 inhibits trophoblast migration and invasion in unexplained recurrent miscarriage, as well as regulates IL-8 and IP-10 secretion from decidual natural killer cells. The study reveals a possible mechanism for the role of B7-H3 in unexplained recurrent miscarriage and suggests it as a potential therapeutic target.
BIOLOGY OF REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Isabel Cuadrado-Torroglosa, Alberto Pacheco, Ana Barrio, Nicolas Garrido, Pilar Aparicio, Nuria Pellicer, Juan Antonio Garcia-Velasco, Diana Alecsandru
Summary: This study aims to investigate the distribution and gene expression of endometrial immune cell populations, especially natural killer (NK) subsets, in assisted reproductive technology patients and healthy donors. The results showed a higher percentage of CD56dimCD16 thorn NK cells in patients compared to healthy donors. However, there was no statistically significant difference in endometrial gene expression or immune cell populations when categorizing patients by KIR genotype. Furthermore, there were no differences in binding between KIR and HLA-C molecules among these patient groups.
FERTILITY AND STERILITY
(2023)
Article
Immunology
William H. Palmer, Laura Ann Leaton, Ana Campos Codo, Bergren Crute, James Roest, Shiying Zhu, Jan Petersen, Richard P. Tobin, Patrick S. Hume, Matthew Stone, Adrie van Bokhoven, Mark E. Gerich, Martin D. McCarter, Yuwen Zhu, William J. Janssen, Julian P. Vivian, John Trowsdale, Andrew Getahun, Jamie Rossjohn, John Cambier, Liyen Loh, Paul J. Norman
Summary: Most human killer cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK) cells and recognize HLA class I molecules as ligands. However, KIR3DL3 is expressed in γδ and CD8(+) T cells and recognizes the B7 family ligand HHLA2, playing a role in immune checkpoint targeting. KIR3DL3(+) T cells in peripheral blood have an activated transitional memory phenotype and are hypofunctional, with biased T cell receptor (TCR) usage. Additionally, KIR3DL3 expression can be influenced by polymorphisms and variants in the proximal promoter and residue 86. These findings have implications for personalized targeting of KIR3DL3/HHLA2 checkpoint inhibition.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Gokcen Orgul, Klara Dalva, Sevim Dalva-Aydemir, Ridvan Goksel Alniacik, Hanife Guler Donmez, Ayse Nur Cakar, Meral Beksac, Mehmet Sinan Beksac
Summary: Maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, with fetal HLA-C and HLA-Bw4 genotypes being frequently detected in the miscarriage and complicated pregnancy groups. Inhibitory KIR/KIR ligand genotype combinations are also more common in these groups, suggesting enhanced NK cell inhibition may play a role in placenta-related obstetric complications.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Immunology
Victoria Male, Ashley Moffett
Summary: The presence of granulated lymphocytes known as uNK cells in the human uterine mucosa was first noted in the nineteenth century, but they were identified as a type of NK cell in 1990. Uterine NK cells have been found to be less cytotoxic than their peripheral counterparts. Recent research has identified three subpopulations of uNK cells that cluster separately from peripheral NK cells. This review examines the history of uNK cell research, their interactions with placental cells, their role in placental implantation, and their potential for defending against infection and mediating memory effects.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Immunology
Yonghong Zhang, Huiyan Wang, Panpan Qiu, Jingwen Jiang, Xuhong Wu, Jie Mei, Haixiang Sun
Summary: Placental trophoblasts play a role in the regulation of regulatory T cells through the PD-1/PD-L1 pathway, and decreased expression of PD-L1 in trophoblasts is associated with Treg deficiency in pregnancy failure. YY1 modulates the expression of PD-L1 in trophoblasts, and elevated levels of NO from M1 macrophages may lead to reduced YY1 expression in recurrent miscarriage.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yan Zhang, Ada W. C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G. E. Marsh, Robert Busch, Derek C. Macallan, Becca Asquith
Summary: Inhibitory killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses and affect T cell lifespan. The iKIR-ligand genotype is significantly associated with CD8+ T cell lifespan, with individuals having 4 iKIR-ligand gene pairs having double the lifespan compared to individuals with 2 gene pairs. The iKIR-ligand genotype also alters the immune aging phenotype of CD8+ and CD4+ T cells.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Immunology
Marcelo Borges Cavalcante, Pedro Henrique Alcantara da Silva, Thiago Ribeiro Carvalho, Olga Goiana Martins Sampaio, Fernanda Eunice Araujo Camara, Candice Torres de Melo Bezerra Cavalcante, Ricardo Barini, Joanne Kwak-Kim
Summary: This systematic review and meta-analysis aimed to investigate the difference in peripheral blood natural killer cell cytotoxicities (pNKCs) between nonpregnant and pregnant women with recurrent miscarriages (RM) and controls, and to determine if immunotherapy can reduce pNKCs. Results showed that both nonpregnant and pregnant women with RM had higher pNKCs compared to controls, and pNKCs were significantly reduced after immunotherapy. However, there were heterogeneities among the included studies regarding patient inclusion criteria, techniques used to measure pNKC, and types of immunotherapies.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Allergy
Nicholas R. Pollock, Genelle F. Harrison, Paul J. Norman
Summary: Interactions between killer cell immunoglobin-like receptors (KIR) and human leukocyte antigens (HLA) class I play crucial roles in regulating the effector functions of key cytotoxic cells in innate and adaptive immunity. The extreme diversity of this interaction is genetically determined and has evolved in response to the ever-changing environment of pathogen exposure. The independent segregation of KIR and HLA genes on separate chromosomes further contributes to the diversity. Specific combinations of inherited receptors and ligands may predispose individuals to certain immune-mediated diseases, including autoimmunity. The combinatorial diversity of KIR and HLA class I also affects the success rates of immunotherapy for these diseases. Detailed characterization of the extent and consequences of the combinatorial diversity is helping in understanding the etiopathology and predicting response to therapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Jiayu Wang, Jinli Ding, Sainan Zhang, Xin Chen, Sisi Yan, Yan Zhang, Tailang Yin
Summary: USP2a plays a crucial role in regulating trophoblast invasion and abnormal expression of USP2a may contribute to recurrent miscarriage by affecting trophoblast invasion. Interestingly, TGF-beta secreted by M2 macrophages can induce trophoblast migration and invasion, highlighting the complex interplay of various factors in the pathogenesis of RM.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Jones Lamptey, Fangfang Li, Enoch Appiah Adu-Gyamfi, Xue-Mei Chen, Armin Czika, Antonia Otoo, Tai-Hang Liu, Ying-Xiong Wang, Yu-Bin Ding
Summary: Research indicates that the downregulation of fascin is associated with the pathogenesis of early recurrent miscarriage, making it a potential therapeutic target against the disease.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Takeji Umemura, Satoru Joshita, Hiromi Saito, Shun-ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Masao Ota
Summary: Natural killer cells, mediated through KIR-HLA interactions, play a role in hepatocellular carcinoma (HCC) development. In patients with hepatitis C virus-associated cirrhosis, the presence of HLA-Bw4 and the KIR3DL1 + HLA-Bw4 pair was significantly associated with HCC onset, suggesting a potential risk factor for HCC development in HCV cirrhosis.
Meeting Abstract
Rheumatology
E. Erken, O. Goruroglu Ozturk, O. Kudas, F. Yildiz, D. Arslan Tas, F. Kibar, S. Dinkci, I. Turk
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Meeting Abstract
Transplantation
Ertugrul Erken, Ozlem Goruroglu Ozturk, Ozlem Kudas, Didem Arslan Tas, Ahmet Demirtas, Filiz Kibar, Suzan Dinkci, Eren Erken
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2015)
Article
Medicine, Research & Experimental
Ertugrul Erken, Ozlem Goruroglu Ozturk, Ozlem Kudas, Didem Arslan Tas, Ahmet Demirtas, Filiz Kibar, Suzan Dinkci, Eren Erken
MEDICAL SCIENCE MONITOR
(2015)
Article
Cardiac & Cardiovascular Systems
Oguz Akkus, Abdi Bozkurt, Didem Arslantas, Onur Kaypakli, Durmus Yildiray Sahin, Halil Aktas, Ozlem Goruroglu Ozturk, Fatih Yildiz, Akgun Yaman, Eren Erken
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2016)
Article
Medical Laboratory Technology
Selcuk Matyar, Ozlem Goruroglu Ozturk, Esin Ziyanoglu Karacor, Sedefgul Yuzbasioglu Ariyurek, Gulhan Sahin, Filiz Kibar, Akgun Yaman, Tamer Inal
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2016)
Article
Medical Laboratory Technology
Tamer C. Inal, Ozlem Goruroglu Ozturk, Filiz Kibar, Salih Cetiner, Selcuk Matyar, Gulcin Daglioglu, Akgun Yaman
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2018)
Article
Pharmacology & Pharmacy
Peyman U. Ertug, Fatma Aydinoglu, Ozlem Goruroglu Ozturk, Ergin Singirik, Nuran Ogulener
EUROPEAN JOURNAL OF PHARMACOLOGY
(2013)
Article
Medical Laboratory Technology
Ozlem Goruroglu Ozturk, Saime Paydas, Mustafa Balal, Gulhan Sahin, Esin Damla Ziyanoglu Karacor, Sedefgul Yuzbasioglu Ariyurek, Akgun Yaman
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2013)
Article
Engineering, Biomedical
Zafer Ufuk Cinkara, Saime Paydas, Mustafa Balal, Ertan Kara, Ozlem G. Ozturk, Tamer Inal
BIOMEDICAL RESEARCH-INDIA
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
G. Sezgin, E. Erken, N. Yilmaz, A. Ozkan, S. Matyar, I. Bayram, O. Goruroglu Ozturk
Article
Respiratory System
Ezgi Ozyilmaz, Ozlem Goruroglu Ozturk, Dilek Yunsel, Ali Deniz, Ismail Hanta, Sedat Kuleci, Gulsah Seydaoglu, Eren Erken, Ali Kocabas
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
(2014)
Article
Medicine, Research & Experimental
Filiz Kibar, Ozlem Goruroglu Ozturk, Aslihan Ulu, Eren Erken, Seza Inal, Suzan Dinkci, Behice Kurtaran, Yesim Tasova, Hasan Salih Zeki Aksu, Akgun Yaman
MEDICAL SCIENCE MONITOR
(2014)
Meeting Abstract
Rheumatology
Y. Bulut, D. Arslan Tas, O. Goruroglu Ozturk, U. Karaogullarindan
ANNALS OF THE RHEUMATIC DISEASES
(2017)
Meeting Abstract
Critical Care Medicine
A. Kocabas, E. Ozyilmaz, O. Goruroglu Ozturk, D. Yunsel, I. Hanta, S. Kuleci
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2014)
