Article
Biochemistry & Molecular Biology
Qing-Xia Xu, Zhao-Jing Wang, Zi-Chao He, Jing Xu, Wei Xu, Xiu-Wei Yang
Summary: Nine new flavonoid dimers, named psocorylins R-Z (1-9), were isolated from the fruits of Psoralea corylifolia L. These compounds exhibited diverse structures, including rare cyclobutane-containing chalcone dimers and flavonoid monomer-linked dimers. Cytotoxicity assays showed that some of the compounds demonstrated cytotoxic activities against MCF-7 cells, and further experiments revealed their potential mechanism of action involving the Bcl-2/Bax/Cleaved caspase-3 pathway.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Neha Mahajan, Bhupendra Koul, Pankaj Gupta, Bhahwal Ali Shah, Joginder Singh
Summary: Psoralea corylifolia is a medicinal plant used in traditional herbal medicine for treating various skin disorders. It contains numerous bioactive compounds with anti-vitiligo, anti-microbial, anti-tumor, and anti-depression properties. Further research is needed to explore the extraction methods and dosage optimization of its bioactive constituents.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Hu-Tong-Yue Gao, Guang-Zhen Lang, Ying-Da Zang, Jie Ma, Jing-Zhi Yang, Fei Ye, Jin-Ying Tian, Pan-Pan Gao, Chuang-Jun Li, Dong-Ming Zhang
Summary: Nine new compounds were isolated from Psoralea corylifolia fruits, showing varying degrees of PTP1B inhibitory activity. Compounds 5 and 9 exhibited significant inhibition, with molecular docking simulations indicating low binding affinities to PTP1B.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Nan Li, Tao Liu, Shan Zhu, Yi Yang, Zijing Wang, Zhiyue Zhao, Xiang Wang, Wenxiao Qin, Yiqi Yan, Yang Liu, Qingmei Xia, Han Zhang
Summary: This study found that corylin can prevent skin aging by inhibiting oxidative stress through the Keap1-Nrf2 signaling pathway. These findings provide evidence for the discovery of novel therapies targeting skin aging.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Applied
Alice Cariola, Madeleine El Chami, Jonathan Granatieri, Luca Valgimigli
Summary: Bakuchiol is a potent tyrosinase inhibitor for treating skin photoaging. It exhibits competitive inhibition against mushroom tyrosinase with average K-i constants of 6.71 +/- 1.23 jiM and 1.15 +/- 0.34 jiM for monophenolase and diphenolase reactions respectively. It also shows good antioxidant activity, making it a potential natural food preservative against oxidation and food-browning.
Article
Chemistry, Multidisciplinary
Xiao-Wei Chen, Zi-Chao Hou, Chi Chen, Ling-Hui Zhang, Meng-En Chen, Fu-Min Zhang
Summary: The first enantioselective total syntheses of six natural and two proposed meroterpenoids from Psoralea corylifolia have been achieved in 7-9 steps from 2-methylcyclohexanone. These synthetic approaches offer a high level of flexibility, stereodivergent fashion, and short route, providing a potential platform for the preparation of various this-type meroterpenoids and their pseudo-natural products.
Article
Chemistry, Medicinal
Zi-Chao He, Qing-Xia Xu, Xiu-Wei Yang, Zhao-Jing Wang, Wei Xu
Summary: The study isolated various compounds from Psoralia corylifolia fruits and found that non-glycoside compounds showed stronger inhibition of NO production compared to glycoside compounds. The structure-activity relationships of non-glycoside compounds were also discussed.
Article
Biochemistry & Molecular Biology
Hye-Ock Jang, Tea-Young Ahn, Ji-Min Ju, Soo-Kyung Bae, Hyung-Ryong Kim, Da-Sol Kim
Summary: This study found that Psoralea corylifolia extracts and bakuchiol can promote odontogenic differentiation in human dental pulp stem cells. These findings may contribute to future research on dentin regeneration.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Agricultural Engineering
Yuanyue Wang, Yanjiao Luo, Yixin Zhang, Chaoqun Xu, Yu Yao, Jiajun Gu, Yude Peng, Yongzhen Pang, Gang Ding, Fengmei Suo, Guoan Shen, Shangang Jia, Baolin Guo
Summary: In this study, researchers identified PcPT11 as a prenyltransferase in Psoralea corylifolia capable of utilizing 23 substrates for the biosynthesis of prenylated polyphenols. PcPT11 exhibited highly regio-specific prenyltransferase activity at the C-6 position of flavonoids, leading to the production of compounds with important pharmacological effects. The study also demonstrated the strong expression of PcPT11 in fruits and leaves, as well as its localization in chloroplasts when expressed in Nicotiana benthamiana.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Oncology
Bhawna Chopra, Ashwani Kumar Dhingra, Ajmer Singh Grewal, Akash Jain, Jasmine Chaudhary, Parul Grover
Summary: The present study aims to explore the anticancer potential of bakuchiol and provide insights for the design and development of novel molecular entities for various disorders. Relevant literature and patents emphasizing the anticancer potential of bakuchiol were identified and reviewed. The findings suggest that bakuchiol has promising anticancer potential against various types of cancer, and it also shows synergistic or potentiating effects when used in combination with other anticancer drugs or natural compounds. Therefore, bakuchiol holds great potential as a therapeutic option for tumors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Ami Lee, Hyun Yang, Taesoo Kim, Hyunil Ha, Youn-Hwan Hwang
Summary: This study utilized a pharmacokinetic approach to identify bioavailable components in Psoralea corylifolia extracts and found that certain constituents of PC could benefit bone health.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biophysics
Yusheng Feng, Zhifen Han, Chong Chen, Xuchen Wang, Jing Liu, Yousef Khan, Maobin Xie, Yufeng Chen, Yue Zhang, Gang Li
Summary: A study has developed an intestinal stent loaded with a combination of traditional Chinese medicines for the treatment of intestinal tumors. The stent, made using emulsion electrospinning technology, has a core-shell structure and sustained drug release properties. In vitro tests have shown that the drug-loaded membrane effectively inhibits tumor cell growth.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biochemistry & Molecular Biology
Qingxia Xu, Youbo Zhang, Zichao He, Zhenyu Liu, Yingtao Zhang, Wei Xu, XiuWei Yang
Summary: This study systematically investigated the chemical constituents of Psoralea corylifolia and identified coumarins, isoflavones, flavonones, and meroterpenoids as the active compounds for treating osteoporosis. The study also corrected the structures of four known coumarins and reported 37 undescribed compounds.
Article
Toxicology
Linqi Ouyang, Zhiqiang Fan, Yang He, Long Tan, Guoyan Deng, Qin He, Yiran He, Ting Ouyang, Congjie Li, Qin Zhang, Hongyu Liu, Yajie Zuo
Summary: This study used network analysis to predict the components and mechanism of P. corylifolia-induced hepatotoxicity. Experimental verification showed that 4-hydroxylonchocarpin and corylifol A caused injury and apoptosis in hepatocytes.
TOXICOLOGY LETTERS
(2023)
