Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 15, Issue 7, Pages 708-716Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2013.795553
Keywords
Amaranthaceae; Aerva javanica; flowers; flavonoid glycosides; characterization; biological activities
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Chromatographic purification of ethyl acetate soluble fraction of the methanolic extract of the flowers of Aerva javanica yielded three new acylated flavone glycosides: kaempferol-3-O--d-[4'-E-p-coumaroyl--l-rhamnosyl(16)]-galactoside (1), kaempferol-3-O--d-[4'-E-p-coumaroyl--l-rhamnosyl(16)]-(3-E-p-coumaroyl)galactoside (2), and kaempferol-3-O--d-[4'-E-p-coumaroyl--l-rhamnosyl(16)]-(4-E-p-coumaroyl)galactoside (3), along with p-coumaric acid (4), caffeic acid (5), gallic acid (6), eicosanyl-trans-p-coumarate (7), hexadecyl ferulate (8), and hexacosyl ferulate (9). The compounds 1-9 were characterized using 1D (H-1, C-13) and 2D NMR (HMQC, HMBC, and COSY) spectroscopy and mass spectrometry (EI-MS, HR-EI-MS, FAB-MS, and HR-FAB-MS) and in comparison with the reported data in the literature. Compound 1 showed weak inhibitory activity against enzymes, such as acetylcholinesterase, butyrylcholinesterase, and lipoxygenase with IC50 values 205.1, 304.1, and 212.3M, respectively, whereas compounds 2 and 3 were only weakly active against the enzyme acetylcholinesterase.
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