Article
Biochemistry & Molecular Biology
Zilin Liu, Xuezhong Wang, Jianping Li, Xiaoming Yang, Jun Huang, Chuang Ji, Xuyang Li, Lan Li, Jianlin Zhou, Yong Hu
Summary: This study found that GNA can trigger multiple cell death modalities, including ferroptosis and apoptosis, in human osteosarcoma cells, and inhibit cell growth and invasiveness. It was also found that GNA induces oxidative stress and affects the expression of certain genes involved in cell death regulation. In vivo experiments demonstrated that GNA can significantly delay tumor growth in a mouse model of osteosarcoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Payel Dey, Soumyajit Biswas, Rima Das, Sandipan Chatterjee, Utpal Ghosh
Summary: This study explores the synergistic anticancer activities of olaparib combined with a p38 MAPK inhibitor, SB203580, on non-small cell lung carcinoma A549 cells. The results demonstrate that while olaparib and SB203580 individually reduce cell viability in a dose-dependent manner, their combination synergistically reduces cell viability. The combination treatment enhances the anticancer potential of olaparib by increasing DNA damage-induced apoptosis and inhibiting telomerase activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Plant Sciences
Zhu Zhang, Wen-qing Chen, Shi-qing Zhang, Jing-xuan Bai, Bin Liu, Ken Kin-Lam Yung, Joshua Ka-Shun Ko
Summary: The study revealed that isoliquiritigenin (ISL) inhibited the progression of pancreatic cancer by blocking autophagy through the p38 MAPK signaling pathway.
Article
Biochemistry & Molecular Biology
Yuan Hu, Ling Lin, Kehong Liu, Enshuo Liu, Shumin Han, Zhihua Gong, Wenjun Xiao
Summary: With the current trend of global warming, the impairment of heat stress on human health is a serious concern. L-Theanine, a non-protein amino acid found in tea, has various biological activities, including immunoregulatory, anti-anxiety, and anti-oxidation effects. This study investigated the effect of l-theanine on heat stress-induced changes in immune function and its underlying mechanism using male BALB/c mice. The results indicated that l-theanine treatment attenuated heat stress-induced damage, inhibited inflammatory factors, and improved immune function. It is suggested that l-theanine may act through the P38 signaling pathway and regulate HSP27, PPAR-gamma, and Foxp3 proteins.
Article
Cell Biology
Pinaki Chaudhuri, Priya Putta, Michael A. Rosenbaum, Linda M. Graham
Summary: Endothelial cell migration is crucial for repairing monolayer disruption after angioplasties, but it is inhibited by lipid oxidation products like lysophosphatidylcholine (lysoPC). LysoPC activates phospholipase A2 to release arachidonic acid (ArA), which then activates arachidonic acid-regulated calcium (ARC) channels formed by STIM1, Orai1, and Orai3 proteins.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Multidisciplinary Sciences
El-Shaimaa A. Arafa, Mohamed S. Refaey, Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed
Summary: Research has shown that certain ginsenosides have therapeutic potential in downregulating p38 MAPK signaling, leading to their pharmacological benefits in various ailments. Studies on individual ginsenosides have focused on their specific molecular mechanisms of action, rather than the effects of whole-plant extracts.
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shohei Fukada, Kouji Ohta, Miyuki Sakuma, Misaki Akagi, Hiroki Kato, Takako Naruse, Takayuki Nakagawa, Hideo Shigeishi, Hiromi Nishi, Masaaki Takechi, Tomonao Aikawa
Summary: This study found that Sunitinib treatment can cause cell injury and apoptosis in oral keratinocytes, which is promoted by p38 activation and STAT3 downregulation. These findings suggest that oral mucosal complications may be associated with the cytotoxic effects of Sunitinib on oral keratinocytes.
Article
Fisheries
Dongdong Li, Ming Guo, Weikang Liang, Chunhua Jin, Chenghua Li
Summary: This study revealed the functional role of CHOP in sea cucumbers and the mechanism by which it regulates apoptosis. It was found that in sea cucumbers, CHOP mediates apoptosis induced by V. splendidus through the activation of the p38-MAPK pathway rather than the JNK/ERK-MAPK pathway.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biology
Xiang-Bo Jia, Quan Zhang, Lei Xu, Wen-Jian Yao, Li Wei
Summary: Lotus leaf flavonoids (LLF) have been shown to induce apoptosis in human lung cancer A549 cells in vitro through the ROS/p38 MAPK pathway, providing potential for further research and development.
BIOLOGICAL RESEARCH
(2021)
Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Cell Biology
Gang Wang, Li Ma, Bowen Wang, Fentang Gao, Jianfeng Li, Hongyi Cai, Juan Wang, Tiancheng Zhang, Hao Guo, Ping Xie, Yi Li
Summary: Tanshinone IIA can counteract radiation-induced myocardial injury by regulating the p38/p53 pathway, restoring cardiomyocyte proliferation and reducing cell apoptosis.
MEDIATORS OF INFLAMMATION
(2022)
Article
Environmental Sciences
Won-Young Lee, Hyun-Jung Park
Summary: T-2 toxin induces reproductive toxicity and germ cell damage. It reduces testicular germ cell number and downregulates their corresponding markers, but increases Sertoli cell markers and steroidogenic enzyme expression. T-2 toxin also decreases cell viability, increases apoptosis, and triggers ROS-mediated JNK/p38-MAPK signaling pathway, leading to mitochondrial dysfunction and apoptotic cell death in germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Wenfeng Li, Gen Zhang, Si Tan, Changqiu Gong, Yunjiao Yang, Mengyuan Gu, Zhenzhen Mi, Hongyan Y. Yang
Summary: The study found that anthocyanins from red radish have a protective effect on PA-treated rat aortic endothelial cells, preventing endothelial dysfunction caused by PA. Analysis of the anthocyanin composition in red radish identified pelargonidin as the main component, which can be effectively absorbed by the body. Further experiments confirmed that anthocyanins can increase cellular activity, reduce apoptosis, and exert their effects through the p38 mitogen-activated protein kinase signaling pathway.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Ting Li, Vincent Kam Wai Wong, Zhi Hong Jiang, Shui Ping Jiang, Yan Liu, Ting Yu Wang, Xiao Jun Yao, Xiao Hui Su, Feng Gen Yan, Juan Liu, Elaine Lai-Han Leung, Xiao Qin Yi, Yuen Fan Wong, Hua Zhou, Liang Liu
Article
Oncology
Fenggen Yan, Fen Yang, Rui Wang, Xiao Jun Yao, Liping Bai, Xing Zeng, JiaJun Huang, Vincent Kam Wai Wong, Christopher Wai Kei Lam, Hua Zhou, Xiaohui Su, Juan Liu, Ting Li, Liang Liu
Review
Oncology
Fenggen Yan, Xiumei Mo, Junfeng Liu, Siqi Ye, Xing Zeng, Dacan Chen
MOLECULAR MEDICINE REPORTS
(2017)
Article
Environmental Sciences
Fenggen Yan, Mei Wang, Jiaming Li, Hui Cheng, Jingjing Su, Xiaoshan Wang, Haiyun Wu, Lunzhu Xia, Xiaoxiang Li, Hebron C. Chang, Qinglin Li
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2012)
Article
Pharmacology & Pharmacy
Fenggen Yan, Mei Wang, Hui Chen, Jingjing Su, Xiaoshan Wang, Fei Wang, Lunzhu Xia, Qinglin Li
EUROPEAN JOURNAL OF PHARMACOLOGY
(2011)
Article
Integrative & Complementary Medicine
Ting Li, Fenggen Yan, Rui Wang, Hua Zhou, Liang Liu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2013)
Article
Multidisciplinary Sciences
Wang Mei, Chen Dong, Cheng Hui, Li Bin, Yan Fenggen, Su Jingjing, Peng Cheng, Sun Meiling, Hu Yawen, Wang Xiaoshan, Wang Guanghui, Chen Zhiwu, Li Qinglin