Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 12, Issue 11, Pages 1005-1009Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2010.522180
Keywords
Huperzia serrata; Lycopodium alkaloids; 6-hydroxy-5; 15-oxide-lycopodane; 12-deoxyhuperzine O; [3H]MK-801 binding; NMDA receptor
Funding
- Ministry of Science and Technology of China [2008ZXJ09002-011, 2009ZX09301-001]
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A new lycopodane-type Lycopodium alkaloid, 6-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkaloid for the first time, and showed an antagonist effect on the N-methyl-d-aspartate receptor with an IC50 value of 0.92M.
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