Article
Orthopedics
Elizabeth B. Gausden, Mark W. Pagnano, Kevin Perry, Gina A. Suh, Daniel J. Berry, Matthew P. Abdel
Summary: Synchronous periprosthetic joint infections (PJIs) are a serious complication with high mortality rates. Patients with synchronous PJIs have a high 30-day mortality rate of 18% and a quarter of them require unplanned reoperation within the first year. Rheumatoid arthritis and liver disease are associated with increased risk of mortality.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Christoph Theil, Rouven F. Riegel, Georg Gosheger, Jan Schwarze, Tom Schmidt-Braekling, Burkhard Moellenbeck
Summary: The prevalence of AKIN in patients undergoing two-stage exchange is 33%, with older age, higher baseline creatinine level, and fungal infections identified as potential risk factors. Particularly in patients with chronic renal dysfunction, attention and optimized treatment should be provided to prevent AKIN.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Christoph Theil, Burkhard Moellenbeck, Jan Puetzler, Sebastian Klingebiel, Jan Schwarze, Georg Gosheger
Summary: In patients with chronic periprosthetic joint infection and massive femoral bone loss, the placement of a total femoral spacer can effectively control the infection. However, the reinfection rate and subsequent amputation rate after second-stage megaprosthetic total femoral arthroplasty is around 50%.
JOURNAL OF ARTHROPLASTY
(2023)
Review
Orthopedics
Shiyu Liao, Zhize Yang, Xiao Li, Jintian Chen, Jian-guo Liu
Summary: This study aimed to analyze the impact of different doses of vancomycin powder on periprosthetic joint infection (PJI) following total joint arthroplasty (TJA). The results showed that in primary total knee arthroplasty (TKA), both 1 g and 2 g of vancomycin powder were effective in preventing PJI, while in primary total hip arthroplasty (THA), 1 g of vancomycin powder had a better effect and the effect of 2 g was unclear. Vancomycin powder was also effective in reducing the incidence of PJI in revision TKA and revision THA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, General & Internal
Salvador A. Forte, Joseph A. D'Alonzo, Zachary Wells, Brett Levine, Stephen Sizer, Carl Deirmengian
Summary: The study evaluated the existing variations in laboratory-reported normal thresholds for common tests used to diagnose PJI, such as ESR, CRP, D-dimer, SF-WBC, and SF-PMN%. It was found that the laboratory-reported normal thresholds for these tests are significantly lower than the 2018 ICM recommended PJI-optimized thresholds.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Salvador A. Forte, Joseph A. D'Alonzo, Zachary Wells, Brett Levine, Stephen Sizer, Carl Deirmengian
Summary: Clinical laboratories may use different units of measure and normal thresholds for multipurpose laboratory tests, such as ESR, CRP, D-dimer, SF-WBC, and SF-PMN%, which may result in false-positive interpretation of these tests for diagnosing PJI.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Robin Patel
Summary: Arthroplasty-associated infection, or periprosthetic joint infection, is a rare disease that is different from native bone or joint infection. The infection involves interactions between microorganisms, the implant, and the host immune system. Even a small amount of microorganisms can cause infection, as bacteria (and sometimes fungi) adhere to and form biofilms on the arthroplasty surfaces that are resistant to antimicrobial agents and the immune system.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Michael Fuchs, Andrej Trampuz, Stephanie Kirschbaum, Tobias Winkler, F. Andrea Sass
Summary: The study revealed that local sPecam-1 levels are correlated to the infection status of the implant, showing potential as a biomarker for PJI with high predictive power. Further research is needed to uncover the underlying mechanism of sPecam-1's natural function in infection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Raffaele Iorio, Edoardo Viglietta, Daniele Mazza, Andrea Petrucca, Marina Borro, Santino Iolanda, Maurizio Simmaco, Andrea Ferretti
Summary: This study assessed the accuracy of MALDI-TOF MS for detecting alpha defensins in synovial fluids of patients with total knee or hip arthroplasty failures, demonstrating high sensitivity and specificity. The advantages of MALDI-TOF MS technology, including small sample requirement, rapid results, and cost-effectiveness, make it a useful and widespread test for PJI diagnosis in clinical practice.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Infectious Diseases
Uta S. Koepf, Sebastian Scheidt, Gunnar T. R. Hischebeth, Christian P. Strassburg, Dieter C. Wirtz, Thomas M. Randau, Philipp Lutz
Summary: This study showed that periprosthetic joint infections in cirrhotic patients are often caused by enteric bacteria, and the resistance to rifampicin increases significantly in patients taking rifaximin. Therefore, careful consideration should be given to the use of rifampicin in the treatment of PJI.
BMC INFECTIOUS DISEASES
(2022)
Article
Orthopedics
Timothy C. Keating, Jonathan Guntin, William E. Harkin, Matthew T. Weintraub, Vasili Karas, Richard A. Berger
Summary: This study evaluated the incidence of iatrogenic periprosthetic joint infection (PJI) following diagnostic knee aspiration within 6 months of primary total knee arthroplasty (TKA). The results showed that the rate of iatrogenic PJI was extremely low (0%).
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Tyler J. Humphrey, Mehdi S. Salimy, Christopher M. Melnic, Hany S. Bedair
Summary: Debridement, antibiotics, and implant retention (DAIR) is a common treatment option for hip periprosthetic joint infection (PJI). This study aimed to evaluate risk factors for hip dislocation post-DAIR for both primary and revision total hip arthroplasty (THA).
JOURNAL OF ARTHROPLASTY
(2023)
Article
Medicine, General & Internal
Wen-Chi Su, Yu-Chin Lai, Cheng-Hung Lee, Cheng-Min Shih, Chao-Ping Chen, Li-Ling Hung, Shun-Ping Wang
Summary: This study aimed to investigate the effectiveness of preoperative bathing with chlorhexidine gluconate in reducing postoperative periprosthetic joint infection (PJI) rates after total hip arthroplasty (THA). The study included 933 primary THA patients, with no statistically significant differences in age, sex, or operated side between the group that underwent chlorhexidine bathing and the control group. While PJI cases were more common in the control group, the difference was not statistically significant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Akhil Katakam, Austin K. Collins, Nicholas Sauder, David Shin, Charles R. Bragdon, Antonia F. Chen, Christopher M. Melnic, Hany S. Bedair
Summary: Increasing BMI is a significant risk factor for failure to achieve the 1-year PROMIS PF-10a MCID following TJA, with obese patients at higher risk of this adverse outcome. Surgeons should consider advising patients with elevated BMIs accordingly.
JOURNAL OF ARTHROPLASTY
(2021)
Review
Orthopedics
Jacopo Albanese, Pietro Feltri, Angelo Boffa, Brian C. Werner, Francesco Traina, Giuseppe Filardo
Summary: The aim of this study was to evaluate the risk of periprosthetic joint infection (PJI) or other complications after joint arthroplasty in patients who received preoperative corticosteroids injections. The study found a significant association between corticosteroids injections and PJI in total hip arthroplasty (THA) patients, but no association in knee arthroplasty patients. Furthermore, the timing of the injections is important, and corticosteroids should not be administered within 3 months before hip arthroplasty.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Jonathan M. Frank, Erdan Kayupov, Mario Moric, John Segreti, Erik Hansen, Curtis Hartman, Kamil Okroj, Katherine Belden, Brian Roslund, Randi Silibovsky, Javad Parvizi, Craig J. Della Valle
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2017)
Article
Orthopedics
Bryan D. Haughom, Darren R. Plummer, Mario Moric, Craig J. Della Valle
JOURNAL OF ARTHROPLASTY
(2016)
Article
Orthopedics
Yale A. Fillingham, Erdan Kayupov, Darren R. Plummer, Mario Moric, Tad L. Gerlinger, Craig J. Della Valle
JOURNAL OF ARTHROPLASTY
(2016)
Article
Orthopedics
Roshan P. Shah, Darren R. Plummer, Mario Moric, Scott M. Sporer, Brett R. Levine, Craig J. Della Valle
JOURNAL OF ARTHROPLASTY
(2016)
Article
Anesthesiology
Asokumar Buvanendran, Jeffrey S. Kroin, Craig J. Della Valle, Mario Moric, Kenneth J. Tuman
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2016)
Article
Anesthesiology
Asokumar Buvanendran, Jeffrey S. Kroin, Jinyuan Li, Mario Moric, Kenneth J. Tuman
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2016)
Article
Orthopedics
Darren R. Plummer, Paul H. Yi, Joshua J. Jacobs, Robert M. Urban, Mario M. Moric, Craig J. Della Valle
JOURNAL OF ARTHROPLASTY
(2017)
Article
Orthopedics
Erdan Kayupov, Yale A. Fillingham, Kamil Okroj, Darren R. Plummer, Mario Moric, Tad L. Gerlinger, Craig J. Della Valle
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2017)
Article
Anesthesiology
Asokumar Buvanendran, Jeffrey S. Kroin, Arvind Rajagopal, Sherry J. Robison, Mario Moric, Kenneth J. Tuman
Article
Anesthesiology
Vaskar Das, Jeffrey S. Kroin, Mario Moric, Asokumar Buvanendran
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2017)
Article
Orthopedics
Rachel M. Frank, Peter N. Chalmers, Mario Moric, Timothy Leroux, Matthew T. Provencher, Anthony A. Romeo
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2018)
Article
Orthopedics
Erdan Kayupov, Kamil Okroj, Adam C. Young, Mario Moric, Timothy J. Luchetti, Gilat Zisman, Asokumar Buvanendran, Tad L. Gerlinger, Craig J. Della Valle
JOURNAL OF ARTHROPLASTY
(2018)
Letter
Orthopedics
Erdan Kayupov, Mario Moric, Craig J. Della Valle
JOURNAL OF ARTHROPLASTY
(2018)
Article
Anesthesiology
Jeffrey S. Kroin, Jinyuan Li, Sasha Shafikhani, Kajal H. Gupta, Mario Moric, Asokumar Buvanendran
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2018)
Article
Anesthesiology
Asokumar Buvanendran, Craig J. Della Valle, Jeffrey S. Kroin, Mahendra Shah, Mario Moric, Kenneth J. Tuman, Robert J. McCarthy
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2019)