Article
Orthopedics
Jesus M. Villa, Tejbir S. Pannu, Ibrahim Theeb, Martin A. Buttaro, Jose Onativia, Lisandro Carbo, Daniel H. Rienzi, Jose Fregeiro, Nikolai N. Kornilov, Svetlana A. Bozhkova, Nemandra A. Sandiford, Nicolas S. Piuzzi, Carlos A. Higuera, Daniel O. Kendoff
Summary: The most common pathogens for periprosthetic joint infections were Staphylococcus aureus and Staphylococcus epidermidis. The US and the UK had the lowest rates of resistant organisms, while Germany and Russia had the highest. The UK and Uruguay had the lowest rates of polymicrobial infections.
JOURNAL OF ARTHROPLASTY
(2021)
Review
Medicine, General & Internal
Christos Koutserimpas, Symeon Naoum, Vasileios Giovanoulis, Konstantinos Raptis, Kalliopi Alpantaki, Konstantinos Dretakis, Georgia Vrioni, George Samonis
Summary: Fungal hip prosthetic joint infections (PJIs) are rare but severe infections. This review analyzed all published cases of fungal hip PJIs to provide comprehensive information on demographics, causative fungi, treatment options, and infection outcomes.
Article
Orthopedics
Robert A. McCulloch, Antony J. Palmer, James Donaldson, Benjamin J. Kendrick, Jonathan Miles, Adrian Taylor
Summary: This study retrospectively analyzed patients with fungal periprosthetic joint infection (PJI) who underwent revision surgery at two high-volume arthroplasty centers. The study found that less than half of the patients achieved eradication of fungal PJI, and the outcomes were comparable for total knee arthroplasty (TKA) and total hip arthroplasty (THA). Most patients with fungal PJI presented with open wounds or a history of sinus disease.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Bernhard J. H. Frank, Alexander Aichmair, Sebastian Simon, Gilbert M. Schwarz, Martin Dominkus, Jochen G. Hofstaetter
Summary: This study found that a positive microbiological result at reimplantation may lead to a failed 2-stage revision arthroplasty, with changes in microbiological spectrum and resistance pattern between culture positive first and second stage procedures. This needs to be considered in the antimicrobial treatment of periprosthetic joint infections.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Amit S. Piple, Jennifer C. Wang, Kareem J. Kebaish, Emily S. Mills, Daniel A. Oakes, Jay R. Lieberman, Alexander B. Christ, Nathanael D. Heckmann
Summary: This study aimed to assess the relationship between prednisone dosage and rates of periprosthetic joint infection (PJI) following total joint arthroplasty (TJA). The study found that patients receiving prednisone therapy were at increased risk of PJI and sepsis, but no dose-dependent relationship between prednisone and infectious complications was identified.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Medicine, General & Internal
Alberto Delgado-Gonzalez, Juan Jose Morales-Viaji, Guillermo Criado-Albillos, Adoracion del Pilar Martin-Rodriguez, Josefa Gonzalez-Santos, Remedios Lopez-Liria, Carla Collazo-Riobo, Raul Soto-Camara, Jeronimo J. Gonzalez-Bernal
Summary: Retrospective study found that patients with patellar replacement, surgeries performed by experienced surgeons, male patients, and those with longer surgery or hospital stays were at a higher risk of infection after TKA. Patellar replacement may be a factor of infection but should be confirmed with randomized clinical trials. Close monitoring of patients with longer surgeries or hospital stays is suggested for early detection and proper treatment of infections.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Janna van den Kieboom, Venkatsaiakhil Tirumala, Liang Xiong, Christian Klemt, Young-Min Kwon
Summary: The diagnostic performance of serum and synovial markers for detecting PJI in patients with periprosthetic fractures was lower compared to those with PJI alone. Using higher thresholds and combining all markers may improve the accuracy of diagnosis.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Ajay Premkumar, David A. Kolin, Kevin X. Farley, Jacob M. Wilson, Alexander S. McLawhorn, Michael B. Cross, Peter K. Sculco
Summary: Based on the latest data, the annual hospital costs related to PJI of the hip and knee are estimated to reach $1.85 billion by 2030. The growth in costs is mainly due to increases in volume, while the incidence of PJI and cost per case remained relatively constant from 2002 to 2017. Efforts to develop effective preventive strategies are urgently needed to reduce rates of PJI after total hip and knee arthroplasty.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Infectious Diseases
Hui-Ming Peng, Zong-Ke Zhou, Fei Wang, Shi-Gui Yan, Peng Xu, Xi-Fu Shang, Jia Zheng, Qing-Sheng Zhu, Li Cao, Xi-Sheng Weng
Summary: This study analyzed the demographic and microbiological profiles of PJI patients in China, revealing differences in causative pathogens between knee and hip PJIs. It highlights the importance of paying attention to atypical organisms and resistant pathogens in PJI cases, emphasizing the need for empiric antibiotic treatment.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Cell & Tissue Engineering
A. Aichmair, B. J. H. Frank, S. Simon, G. Singer, E. Skolek, M. Dominkus, J. G. Hofstaetter
Summary: The aim of this study was to assess IL-6 measured on postoperative day 3 as a predictor of early onset PJI. The results showed that serum IL-6 values on postoperative day 3 could not predict early onset PJIs following total hip or knee arthroplasty.
EUROPEAN CELLS & MATERIALS
(2022)
Article
Orthopedics
Noam Shohat, Graham S. Goh, Samantha L. Harrer, Scot Brown
Summary: This study compared the risk of periprosthetic joint infection (PJI) in total joint arthroplasty (TJA) patients with and without dilute povidone-iodine irrigation. The findings showed that dilute povidone-iodine irrigation was associated with a lower rate of PJI, and it remained significant even after controlling for other factors. The routine use of dilute povidone-iodine was supported as a safe and cost-effective measure to reduce PJI.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Nicholas M. Hernandez, Michael W. Buchanan, Thorsten M. Seyler, Samuel S. Wellman, Jessica Seidelman, William A. Jiranek
Summary: 1.5-stage exchange arthroplasty may be a reasonable method to treat TKA PJI. At a mean follow-up of 2.7 years, there was an acceptable rate of infection recurrence and implant durability.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Jonathan J. Lee, Kingsley Oladeji, Brian F. Sweeney, Tatenda L. Chakoma, Prerna Arora, Andrea K. Finlay, Derek F. Amanatullah
Summary: This study assessed the prevalence of recurrent, synchronous, and metachronous periprosthetic joint infection (PJI) in patients who had multiple arthroplasties and identified risk factors for a subsequent PJI. The results showed that over 20% of patients with multiple arthroplasties and a single PJI will develop a subsequent PJI, with 12% recurring in the initial arthroplasty and nearly 10% occurring in another arthroplasty. Tobacco use, bacteremia, and Staphylococcus aureus isolation at the time of the initial PJI were identified as particular risk factors.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Cheng Li, Hao Li, Xue Yang, Fang-Zheng Zhu, Chi Xu, Andrej Trampuz
Summary: This study aimed to assess the diagnostic performance of synovial fluid polymerase chain reaction (PCR) in periprosthetic hip and knee infection and determine its diagnostic significance compared to conventional methods. The results showed that synovial fluid PCR has a high sensitivity and specificity in the rapid diagnosis of periprosthetic joint infection and early-stage culture-negative bacterial infections.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, General & Internal
Frank Sebastian Froeschen, Sophia Schell, Matthias Dominik Wimmer, Gunnar Thorben Rembert Hischebeth, Hendrik Kohlhof, Sascha Gravius, Thomas Martin Randau
Summary: The study evaluated the diagnostic value of synovial complement factors in patients with low-grade periprosthetic joint infection (PJI) for the first time. Results showed significantly elevated levels of complement factors C1q, C3b/C3i, C4b, C5, C5a, MBL, and properdin in the PJI group, with a combined model demonstrating the best sensitivity and specificity, indicating activation of all three pathways of the complement system in PJI.