Article
Medicine, General & Internal
Huilin Zhao, Xinyi Wang, Bingjie Wang, Yanlei Xu, Lulin Rao, Baoshan Wan, Yinjuan Guo, Xiaocui Wu, Jingyi Yu, Liang Chen, Meilan Li, Fangyou Yu
Summary: The prevalence of fusidic acid (FA) resistance among MRSA isolates in China was relatively high with geographic differences. High-level FA resistance was mostly associated with fusA mutations, especially the L461K mutation, while fusB usually conferred low-level resistance to FA. The spread of the ST5-MRSA-II-t2460 clone with high-level resistance to FA contributed greatly to the increase of FA-resistant MRSA isolates, especially in Hubei.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Ben Chung-Lap Chan, Nilakshi Barua, Clara Bik-San Lau, Ping-Chung Leung, Kwok-Pui Fung, Margaret Ip
Summary: This study found that the combination of kuraridin from Sophora flavescens and epicatechin gallate (ECG) from green tea inhibits the growth of MRSA strains and enhances the antibacterial activities of multiple antibiotics. Kuraridin and ECG also have anti-inflammatory effects and reduce MRSA colonization in a mouse pneumonia model.
Article
Infectious Diseases
Stefan Monecke, Amira K. Bedewy, Elke Mueller, Sascha D. Braun, Celia Diezel, Amel Elsheredy, Ola Kader, Martin Reinicke, Abeer Ghazal, Shahinda Rezk, Ralf Ehricht
Summary: The study characterised MRSA isolates from a tertiary care centre in Alexandria, Egypt. The isolates belonged to 11 different clonal complexes and 14 strains, with CC15-MRSA-[V+fus] and CC1-MRSA-[V+fus+tir+ccrA/B-1] (PVL+) being the most common strains. Most isolates carried variant SCCmec elements and the fusidic acid resistance gene fusC. PVL genes were also prevalent. The study revealed an increase in fusC and PVL carriage and a decrease in the prevalence of the CC239 strain when compared to data from a previous study.
Article
Multidisciplinary Sciences
Rasoul Mirzaei, Rasoul Yousefimashouf, Mohammad Reza Arabestani, Iraj Sedighi, Mohammad Yousef Alikhani
Summary: The study found that subinhibitory concentrations of cloxacillin, cefazolin, and clindamycin can induce biofilm production in methicillin-resistant Staphylococcus epidermidis (MRSE) strains, while subinhibitory concentrations of vancomycin do not increase biofilm formation. Sub-MIC of antibiotics also up-regulated the expression of biofilm-associated genes.
Review
Veterinary Sciences
Chahrazed Belhout, Rachid Elgroud, Patrick Butaye
Summary: Staphylococci, including methicillin-resistant strains, are recognized as important opportunistic pathogens that pose a significant risk to human and animal health. This study aims to provide an overview of the prevalence and distribution of methicillin-resistant staphylococci (MRS) in Arab countries, where there is currently a lack of information on this topic. The increasing observation of MRS in different animal species raises concerns about their impact on animal health and the potential for zoonotic transmission. The availability of comprehensive data on MRS in animals and food products worldwide is crucial for understanding their relevance in the One Health domain.
VETERINARY SCIENCES
(2022)
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biology
Usasom Khongsri, Peerawit Chongrattanameteekul, Sineenart Chantarachart, Kornravee Photichai, Nittaya Chanayat, Thanya Varinrak, Raktham Mektrirat, Nuttawan Srifawattana
Summary: The prevalence of MRSP causing pyoderma is changing gradually, with annual variations. Research on cotrimazole susceptibility to MRSP is limited, but the empirical use of cotrimazole remains interesting. This study aimed to evaluate the susceptibility of cotrimazole to canine pyoderma MRSP isolates.
Article
Pharmacology & Pharmacy
Kushal Vanamala, Ketki Bhise, Hiram Sanchez, Razieh Kebriaei, Duy Luong, Samaresh Sau, Hosam Abdelhady, Michael J. Rybak, David Andes, Arun K. Iyer
Summary: This study aims to improve the efficacy of VAN treatment by identifying the folate receptor for MRSA infected tissues and developing folate decorated lipid nanoparticles containing VAN (LVAN). In comparison to conventional VAN, LVAN showed a higher bactericidal effect and a superior ability to inhibit biofilm in MRSA with an enhanced accumulation in MRSA infected thigh tissues and a reduced accumulation in kidney. The results suggested that LVAN is a promising candidate to overcome the current limitations of bacterial resistance and adverse side effects in kidneys found in VAN.
Article
Agriculture, Dairy & Animal Science
A. Schnitt, T. Lienen, H. Wichmann-Schauer, B-A Tenhagen
Summary: This study found the occurrence of MR-NAS on dairy farms in Germany, with varying positive rates among different types of samples and in the environment. Nine species of MR-NAS were identified. Similar mobile genetic elements were detected in MR-NAS and MRSA on some farms, suggesting potential transfer of resistance genes between NAS and Staph. aureus on these farms.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Infectious Diseases
Benjamin Baetz, Abdelhakim Boudrioua, Axel Hartke, Caroline Giraud
Summary: Gram positive pathogens are a significant cause of healthcare-associated infections, with Staphylococci and Enterococci being the most prevalent ones. Although vancomycin is a last resort glycopeptide used to fight these bacteria, the emergence of resistance against this drug leaves patients with limited therapeutic options. New generations of antibiotics have been developed to counter vancomycin-resistant pathogens, but resistance has already been reported. Strategies include traditional antimicrobials and non-traditional antimicrobials, with hopes that combination therapies could provide treatment options for vancomycin-resistant Gram-positive pathogens.
Article
Infectious Diseases
Duangdaow Khunbutsri, Nattakarn Naimon, Khomson Satchasataporn, Natnaree Inthong, Sarawan Kaewmongkol, Samak Sutjarit, Chanokchon Setthawongsin, Nattakan Meekhanon
Summary: This study aimed to investigate the potential antibacterial activity of Solanum torvum leaf extract against multidrug-resistant Staphylococcus isolated from clinically healthy dogs. The results showed that the leaf extract displayed inhibitory effects, especially when used in combination with oxacillin.
Article
Microbiology
Charles Omollo, Vinayak Singh, Elizabeth Kigondu, Antonina Wasuna, Pooja Agarwal, Atica Moosa, Thomas R. Ioerger, Valerie Mizrahi, Kelly Chibale, Digby F. Warner
Summary: The study aimed to identify synergistic anti-TB drug combinations capable of restoring therapeutic efficacy against drug-resistant mutants of Mycobacterium tuberculosis. The results showed that certain drug combinations exhibited potentiating effects against M. tuberculosis, and some combinations could partially restore sensitivity against resistant mutants.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Alexandre Bourles, Anne Tristan, Francois Vandenesch, Michele Bes, Frederic Laurent, Anne-Gaelle Ranc, Malia Kainiu, Ann-Claire Gourinat, Antoine Biron, Cecile Cazarola, Cyrille Goarant, Julien Colot
Summary: This study investigated the epidemiology of MRSA in New Caledonia and identified a low diversity with the dominance of a clonal complex not reported previously. The recommendation to stop the topical use of fusidic acid was made to control the emergence of this severe MRSA clone.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad, Mona Johannessen, Kristin Hegstad, Victor Nizet, Fatemeh Askarian
Summary: This study revealed that MRSA-derived MVs are capable of reducing the pathogen's susceptibility to VAN, thereby increasing its resistance to treatment, particularly in interactions with human neutrophils. Additionally, the elevated expression of proteins associated with antibiotic resistance in MVs may further impact MRSA's resistance.
Article
Multidisciplinary Sciences
Natkamon Saenhom, Rada Kansan, Peechanika Chopjitt, Parichart Boueroy, Rujirat Hatrongjit, Anusak Kerdsin
Summary: Methicillin-resistant staphylococci (MRS), including MRSA and MRCoNS, have a significant impact on public health, causing morbidity, mortality, and economic costs. Accurate detection of MRS is crucial for effective treatment and control measures. A newly developed screening broth showed good validity for MRSA/MSSA detection, but poor validity for MRCoNS/MSCoNS.
Article
Clinical Neurology
Ioannis D. Gelalis, Nikolaos K. Paschos, Emilios E. Pakos, Angelos N. Politis, Christina M. Arnaoutoglou, Athanasios C. Karageorgos, Avraam Ploumis, Theodoros A. Xenakis
EUROPEAN SPINE JOURNAL
(2012)
Review
Critical Care Medicine
Ioannis D. Gelalis, Angelos N. Politis, Christina M. Arnaoutoglou, Anastasios V. Korompilias, Emilios E. Pakos, Marios D. Vekris, Athanasios Karageorgos, Theodoros A. Xenakis
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2012)
Article
Orthopedics
G. Dimitrios, K. Athanasios, K. Ageliki, S. Spiridon
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2010)
Letter
Medicine, Research & Experimental
Charalampos Matzaroglou, Christos S. Georgiou, Hans Joachim Wilke, Konstantinos Assimakopoulos, Athanasios Karageorgos, Dimitris Konstantinou, Dimitris Velissaris, Elias Panagiotopoulos, Konstantinos Kafchitsas
MEDICAL HYPOTHESES
(2013)
Article
Orthopedics
Zafiria G. Papathanassiou, Panagiotis Megas, Theodore Petsas, Dionisios J. Papachristou, John Nilas, Dimitrios Siablis
Review
Clinical Neurology
Ioannis D. Gelalis, Athanasios Karageorgos, Christina Arnaoutoglou, Dimitrios Gartzonikas, Aggelos Politis, Nikolaos Georgakopoulos, Adamandios P. Petsanas, Charalambos Matzaroglou, Theodoros Xenakis
Article
Radiology, Nuclear Medicine & Medical Imaging
Charalampos Matzaroglou, Christos S. Georgiou, Kostantinos Assimakopoulos, Costas Giannakenas, Athanasios Karageorgos, Alkis Saridis, Konstantinos Kafchitsas, Hans J. Wilke
HELLENIC JOURNAL OF NUCLEAR MEDICINE
(2011)
Article
Orthopedics
Zouboulis E. Panagiotis, Karageorgos Athanasios, Dimakopoulos Panagiotis, Tyllianakis Minos, Matzaroglou Charis, Lambiris Elias
Article
Orthopedics
E Panagiotopoulos, T Maraziotis, A Karageorgos, P Dimopoulos, D Koumoundourou
Article
Orthopedics
E Lambiris, AX Papadopoulos, A Karabasi, A Karageorgos
ACTA ORTHOPAEDICA SCANDINAVICA
(2004)
Article
Orthopedics
AX Papadopoulos, A Panagopoulos, A Karageorgos, M Tyllianakis
JOURNAL OF ORTHOPAEDIC TRAUMA
(2004)
Article
Orthopedics
P Megas, P Zouboulis, AX Papadopoulos, A Karageorgos, E Lambiris
INTERNATIONAL ORTHOPAEDICS
(2003)
