Article
Biotechnology & Applied Microbiology
Sushil Kandel, Steven Su, Richard M. Hall, Joanne L. Tipper
Summary: Polymer wear debris is a major concern in total joint replacements due to potential biological reactions. This study proposes an automatic particle segmentation algorithm using adaptive thresholding and Convolution Neural Network (CNN) classification. The use of computer algorithms and CNN allows for more efficient analysis of wear debris with complex characteristics, resulting in robust size and volume distribution graphs for estimation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Orthopedics
Byung-Ho Yoon, Jung -Wee Park, Young-Kyun Lee, Kyung-Hoi Koo, Chong Bum Chang
Summary: This systematic meta-analysis compares the long-term efficacy of highly cross-linked polyethylene (HXLPE) and conventional polyethylene (CPE) in preventing radiological osteolysis and revision surgery. The results demonstrate that HXLPE dramatically reduces the rate of osteolysis and wear-related revision surgery.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Andre Lunz, Moritz Von Falkenhayn, Sebastian Jaeger, Tobias Reiner, Christian Merle, Marcus R. Streit, Tobias Renkawitz, Moritz M. Innmann
Summary: This study aimed to determine the minimum 20-year survival rates of a cementless press-fit cup in young patients. The results showed that the 22-year survival rate for aseptic cup or inlay revision was 94%, and the survival rate for aseptic cup loosening was 99%.
Review
Biotechnology & Applied Microbiology
John Patrick Connors, John W. W. Stelzer, Patrick M. M. Garvin, Ian J. J. Wellington, Olga Solovyova
Summary: Periprosthetic osteolysis is a common complication of joint replacement surgery, caused by wear-induced particulate debris. Advances in understanding the mechanism of osteolysis and developing strategies for prevention and treatment are being made. Therapeutic agents targeting proinflammatory mediators have shown promise, but the delay in diagnosis and treatment remains challenging.
BIOENGINEERING-BASEL
(2022)
Article
Orthopedics
Ramakanth R. Yakkanti, Justin L. Ocksrider, Anand A. Patel, Matthew P. Kolevar, Rebecca D. Moore, Clare M. Rimnac, Matthew J. Kraay, Timothy M. Wright, Elexis C. Baral, Raymond P. Robinson
Summary: This study identified excessive wear and a potential risk of osteolysis associated with a uniquely designed moderately cross-linked polyethylene liner used in total hip arthroplasty.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Engineering, Biomedical
Toshiyuki Tateiwa, Saverio Affatato, Yasuhito Takahashi, Takaaki Shishido, Giuseppe Pezzotti, Kengo Yamamoto
Summary: This study evaluated the tribological acceptability of reducing the acetabular liner thickness in metal-on-vitamin-E diffused highly crosslinked ultra-high molecular weight polyethylene (Vit-E XLPE) bearings for total hip arthroplasty. The results showed that reducing the thickness by 2-4 mm did not significantly affect the wear rate of the Vit-E XLPE liner, but reducing it by 6 mm significantly increased the wear and roughness.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Polymer Science
Zirui Wang, Quan Li, Xianchun Chen, Qin Zhang, Ke Wang
Summary: The wear resistance of UHMWPE can be improved by adjusting the thermal history and utilizing γ-ray irradiation. The crystallinity of UHMWPE significantly affects the wear resistance, and high crystallinity crosslinking is more effective. These findings have important implications for developing high-performance artificial joint prosthesis materials.
Article
Orthopedics
David G. Campbell, Stuart A. Callary
Summary: This study aims to investigate the wear amount and rate in patients with second-generation XLPE bearing in THAs surgery during the first 10 years, and explore whether the wear rate changes after 5 years in situ. The results showed that femoral head penetration in second-generation XLPE liner remained very low at 10 years and accelerated wear did not occur after 5 years in situ. These findings provide encouraging evidence for the future clinical performance of this material.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Article
Engineering, Biomedical
Gen Matsumae, Hiroaki Kida, Daisuke Takahashi, Tomohiro Shimizu, Taku Ebata, Shunichi Yokota, Hend Alhasan, Mahmoud Khamis Aly, Tomoyo Yutani, Keita Uetsuki, Mohamad Alaa Terkawi, Norimasa Iwasaki
Summary: The use of vitamin E-blended ultra-high molecular weight polyethylene (VE-UHMWPE) in prosthetic components of hip implants improves mechanical properties and reduces adverse cellular responses. Through in vitro and in vivo experiments, we found that a 0.3% concentration of vitamin E is the most suitable for prosthetic components, as it reduces adverse cellular responses and extends the lifespan of the implant.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Review
Surgery
Jiangyuan Shi, Weicong Zhu, Shaohua Liang, Hongling Li, Siming Li
Summary: The study showed that HXLPE significantly outperformed CPE in preventing revision surgery and radiological osteolysis in total hip arthroplasty. It also demonstrated lower polyethylene wear rates and head penetration rates in the HXLPE group compared to the CPE group. However, no significant differences were observed in functional outcomes between the two groups.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Engineering, Biomedical
Susann Wolf, Anne Christine Johannessen, Peter Ellison, Ove Furnes, Geir Hallan, Katharina Rogg, Kathrine Skarstein, Paul Johan Hol
Summary: The combination of cemented Spectron EF stem and cemented non-crosslinked Reflection All-Poly cup has a high rate of mid-term aseptic loosening. The study assessed tissue reactions, wear particles, and blood metal ion levels in patients with failed implants. The results showed a significant presence of inflammatory cells and wear particles, with severe stem abrasion. These factors contribute to osteolysis and implant loosening.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Summary: Particle-induced osteolysis is a major cause of prosthetic loosening. In this study, the influence of fetuin-A on particle-induced osteolysis was investigated using fetuin-A-deficient mice. The results showed that fetuin-A deficiency led to increased bone resorption, eroded surface areas, and osteoclast numbers. Fetuin-A deficiency also caused changes in bone metabolism parameters. These findings suggest that fetuin-A deficiency may be a risk factor for particle-induced osteolysis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Orthopedics
Alessandro Bistolfi, Fortunato Giustra, Francesco Bosco, Carlotta Faccenda, Marianna Viotto, Luigi Sabatini, Paola Berchialla, Veronica Sciannameo, Eugenio Graziano, Alessandro Masse
Summary: The aim of this study was to compare the efficacy of highly crosslinked polyethylene (HXLPE) and conventional polyethylene (CPE) in total knee arthroplasty (TKA). The results showed no statistically significant differences between HXLPE and CPE in terms of clinical, radiological, and functional outcomes. Therefore, HXLPE can be safely used for TKA.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Engineering, Mechanical
Junhui Li, Song Wang, Songqing Fu, Yeping Peng
Summary: This study systematically investigated the wear debris characteristics of different UHMWPE materials under various motion modes. It was found that the material type and motion mode had an impact on the quantity, size, morphology, and distribution characteristics of UHMWPE debris.
Article
Biochemical Research Methods
Shenli Zhao, Chen Ge, Yao Li, Leilei Chang, Zhou Dan, Yihui Tu, Lianfu Deng, Hui Kang, Changwei Li
Summary: This study reveals the significant role of caspase-1-dependent pyroptosis in osteocytes in facilitating osteoclastic osteolysis induced by UHMWPE particles. Furthermore, it is found that DFO alleviates UHMWPE particle-induced osteoclastic osteolysis partly by inhibiting pyroptosis in osteocytes.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
