Article
Environmental Sciences
Mingquan Huang, Xingjie Li, Shengjun Jia, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Summary: The study reveals that BPAF can induce apoptosis of KGN cells in a concentration- and time-dependent manner by increasing the expression of pro-apoptotic proteins and decreasing the expression of anti-apoptotic proteins. Additionally, BPAF exposure leads to a significant increase in intracellular ROS levels, which mediates KGN cell apoptosis through the ROS-ASK1-JNK axis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Silvia Karim, Ruixin Hao, Caroline Pinto, Jan-Ake Gustafsson, Marina Grimaldi, Patrick Balaguer, Maria Bondesson
Summary: This study investigates the estrogenic activity of bisphenol A (BPA) and its analogues using zebrafish-based assays. The results suggest that these compounds have hormone-like effects on the heart and liver of zebrafish, and their activation of estrogen receptors varies. The study also identifies a gene that can serve as a biomarker for estrogenicity in larval fish.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Environmental Sciences
Mingquan Huang, Meizhou Huang, Xingjie Li, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Summary: The study found that BPA exposure induces apoptosis of KGN cells through the activation of GPER-dependent signaling pathways, leading to increased expression of apoptotic proteins, decreased mitochondrial membrane potential, and elevated generation of ROS and Ca2+. Inhibiting ROS and Ca2+ as well as the corresponding signaling pathways can effectively inhibit BPA-induced cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Jeremy Gingrich, Yong Pu, Brad L. Upham, Madeline Hulse, Sarah Pearl, Denny Martin, Anita Avery, Almudena Veiga-Lopez
Summary: Gap junction intercellular communication (GJIC) is crucial for ovarian function and can be modulated by chemicals like bisphenol S, which may enhance GJIC in ovine and human theca cells through signal pathway regulation. Upregulation of GJIC could lead to the hyperplasia of the theca cell layer or hinder ovulation by maintaining the oocyte in meiotic arrest.
Article
Reproductive Biology
Zhiyong Zou, Lynda K. Harris, Karen Forbes, Alexander E. P. Heazell
Summary: This study demonstrates that BPA affects the ESRRG signaling pathway in a sex-specific manner in human placentas, providing a possible biological mechanism to explain the differential effects of BPA exposure on male and female fetuses observed in epidemiological studies.
BIOLOGY OF REPRODUCTION
(2022)
Article
Environmental Sciences
Xue Wen, Man Zhu, Zehua Li, Tao Li, Xuewen Xu
Summary: This study explores the effects of BPA on wound repair and finds that dietary intake of BPA delays wound healing, while wound application of BPA accelerates skin regeneration. This is because BPA up-regulates the expression of ERβ in the wound area, and enhances the function of fibroblasts to promote wound repair. For diabetic patients, application of BPA on wounds significantly speeds up wound healing without significant adverse effects on ovarian hormone levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Genetics & Heredity
Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo
Summary: This study confirmed the important role of PGRN in regulating the estrogen signal, maintaining bone homeostasis. Our findings may provide a new strategy for the treatment of osteoporosis and maintaining bone homeostasis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Environmental Sciences
Shunli Jiang, Guanlin Yang, Shuang Zhou, Xu Zhang, Cheng Peng, Qing Lu
Summary: The study revealed a positive association between bisphenol A (BPA) exposure and hypertension risk, with specific genotypes in ESR1/2, CAT, and eNOS potentially increasing susceptibility to the hypertensive effects of BPA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Pharmacology & Pharmacy
Oly Banerjee, Siddhartha Singh, Ishita Saha, Swagata Pal, Maitrayee Banerjee, Sudipta Kundu, Alak Kumar Syamal, Bithin Kumar Maji, Sandip Mukherjee
Summary: Bisphenol A (BPA) is an endocrine disrupting chemical that is widely present in industrial production and has potential harmful effects on human health. This review focuses on the different cellular and molecular pathways through which BPA affects pancreatic islets, considering both low and high dose effects. Understanding the mechanisms of BPA action on pancreatic islets provides meaningful insights into the risks associated with exposure to BPA at different doses.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Zuping Wu, Chenchen Zhou, Quan Yuan, Demao Zhang, Jing Xie, Shujuan Zou
Summary: CTGF promotes intercellular communication in chondrocytes through upregulating Cx43 expression and activating the PI3K/Akt signaling pathway.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Laura Barberio, Luana Paulesu, Laura Canesi, Elena Grasselli, Maurizio Mandala
Summary: Maternal exposure to BPA can lead to compromised function of uterine arteries and altered fetal growth, as evidenced by reduced placental weight and increased fetal weight in BPA-treated rats. This study provides insights into the specific effects of BPA on pregnancy outcomes and the underlying molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang
Summary: This study demonstrated that schisandrol A has estrogen-like effects by inducing the expression of ER alpha through the PI3K/AKT and ERK signaling pathways, promoting the proliferation of MCF-7 cells. The effects of schisandrol A were more significant compared to E2 and could be mitigated by the ER antagonist ICI.
Article
Environmental Sciences
Chen Sang, Yu Song, Tong-wang Jin, Shuo Zhang, Linyan Fu, Yi Zhao, Xinxin Zou, Zhe Wang, Hui Gao, Sijin Liu
Summary: The study found that BPA can stimulate proliferation and metastasis of ovarian cancer cells by upregulating various proteins through the ER alpha signaling pathway. These results provide new insights into the carcinogenic effects of BPA on ovarian cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Huaixing Wang, Julie S. Haas
Summary: This study demonstrates that GABA(B) receptor activation in the thalamic reticular nucleus can influence electrical synapse plasticity, obstructing LTD induction. The findings suggest that afferent GABAergic input from the basal ganglia to the midbrain thalamus can modulate thalamocortical transmission and might act as a mediator of inhibitory effects within the thalamic reticular nucleus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Laura Marroqui, Juan Martinez-Pinna, Manuel Castellano-Munoz, Reinaldo S. dos Santos, Regla M. Medina-Gali, Sergi Soriano, Ivan Quesada, Jan-Ake Gustafsson, Jose A. Encinar, Angel Nadal
Summary: The study investigated the effects of BPS and BPF on insulin secretion and ion channel activity in pancreatic beta-cells using WT and BERKO mice. Results showed that both compounds enhance insulin release by affecting ion channel activity, with the involvement of the ER beta pathway. Molecular dynamics simulations indicated differences in ER beta ligand-binding domain among different bisphenols and PaPE-1.