Foamy macrophage responses in the rat lung following exposure to inhaled pharmaceuticals: a simple, pragmatic approach for inhaled drug development

Surfactant phospholipid metabolism

(2012) Marianna Agassandian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulatory toxicology considerations for the development of inhaled pharmaceuticals

(2012) Keith Owen   DRUG AND CHEMICAL TOXICOLOGY

Tiotropium Bromide Inhalation Powder

(2012) Gillian M. Keating   DRUGS

A novel subpopulation of monocyte-like cells in the human lung after lipopolysaccharide inhalation

(2012) Mairi Brittan et al.   EUROPEAN RESPIRATORY JOURNAL

Activation of Sterol-response Element-binding Proteins (SREBP) in Alveolar Type II Cells Enhances Lipogenesis Causing Pulmonary Lipotoxicity

(2012) Laurent Plantier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrastructural Analysis in Preclinical Safety Evaluation

(2012) Jane A. Fagerland et al.   TOXICOLOGIC PATHOLOGY

Predicting the mechanism of phospholipidosis

(2012) Robert Lowe et al.   Journal of Cheminformatics

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

(2011) Adam D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expression of muscarinic receptors by human macrophages

(2011) A. Koarai et al.   EUROPEAN RESPIRATORY JOURNAL

Drug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review

(2011) Mario Pellegatti et al.   Expert Opinion on Drug Metabolism & Toxicology

Can β2-adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD?

(2011) Wen-Hui Zhang et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

The paradox of respiratory R&D, and why ‘inhaled-by-design’ heralds a new dawn in asthma and chronic obstructive pulmonary disease treatments

(2011) Mike Yeadon   Future Medicinal Chemistry

Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response

(2011) Y. He et al.   Science Signaling

Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity

(2011) Rhys M. Jones et al.   XENOBIOTICA

Challenges in inhaled product development and opportunities for open innovation

(2010) Ben Forbes et al.   ADVANCED DRUG DELIVERY REVIEWS

The preclinical toxicology of salmeterol hydroxynaphthoate

(2010) K. Owen et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist

(2010) François Baur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lung environment determines unique phenotype of alveolar macrophages

(2009) Amanda M. Guth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Closer we Look the more we See? Quantitative Microscopic Analysis of the Pulmonary Surfactant System

(2009) Matthias Ochs   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Emerging inhaled bronchodilators: an update

(2009) M. Cazzola et al.   EUROPEAN RESPIRATORY JOURNAL

SIGNAL TRANSDUCTION PATHWAYS LINKING THE ACTIVATION OF ALVEOLAR MACROPHAGES WITH THE RECRUITMENT OF NEUTROPHILS TO LUNGS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

(2009) Vidyasaral Murugan et al.   EXPERIMENTAL LUNG RESEARCH

Muscarinic antagonist-β-adrenergic agonist dual pharmacology molecules as bronchodilators: a patent review

(2009) Nicholas C Ray et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Dose tolerability of chronically inhaled voriconazole solution in rodents

(2009) Justin A. Tolman et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chronic Inhalation Exposure of Rats for up to 104 Weeks to a Non–Carbon-Based Magnetite Photocopying Toner

(2009) Ronald S. Slesinski et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs

(2009) P. Casarosa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role of Lung Surfactant in Respiratory Disease: Current Knowledge in Large Animal Medicine

(2009) U. Christmann et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

A Strategy for Risk Management of Drug-Induced Phospholipidosis

(2009) Linda A. Chatman et al.   TOXICOLOGIC PATHOLOGY

Current perspectives in pulmonary surfactant — Inhibition, enhancement and evaluation

(2008) Yi Y. Zuo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Alveolar Epithelial β2-Adrenergic Receptors

(2007) Gökhan M. Mutlu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY