Article
Chemistry, Multidisciplinary
Xikuang Yao, Chao Qi, Changrui Sun, Fengwei Huo, Xiqun Jiang
Summary: Poly(ethylene glycol) (PEG) has been widely used in conjugation with diagnostic and therapeutic agents or surface decoration on nanoplatforms, known as PEGylation, to enhance diagnostic and therapeutic effects. However, studies have shown that PEG abuse can lead to severe side effects and compromise therapeutic efficacy. This review presents alternatives to PEG, including poly(N-vi-nylpyrrolidone), polyacrylamides, polybetaines, poly(2-oxazoline)s, polyesters, and polysarcosine, with their synthesis, characterization, and biomedical applications in agent conjugates, nanocarriers, hydrogels, and antifouling surface coating. The potential of these PEG alternatives in constructing efficient nanoplatforms for precise nanomedicine is highlighted.
Review
Polymer Science
Vipin Chandra Kalia, Sanjay K. S. Patel, Jung-Kul Lee
Summary: PHA is a biodegradable plastic that can be produced by bacteria in environmental stress conditions. It has similar physicochemical properties to fossil-fuel-based plastics and unique features that make it suitable for medical devices. PHAs can replace traditional plastic materials used in the biomedical sector and has a wide range of applications.
Review
Biochemistry & Molecular Biology
Iwona Cicha, Ronny Priefer, Patricia Severino, Eliana B. Souto, Sona Jain
Summary: Biosensor-integrated drug delivery systems are innovative devices that enable continuous monitoring and drug administration, particularly for chronic diseases such as diabetes, cancer, and cardiovascular diseases. The advantages of this technology include high sensitivity and fast drug release.
Article
Polymer Science
Mengting Li, Changgui Li, You Zhou, Hua Tian, Qiaoyuan Deng, Haifang Liu, Li Zhu, Xueqiong Yin
Summary: The study investigated different microcapsule wall systems to improve the stability of cinnamaldehyde (CAL) and found that the MC/CMC/SA wall formulation is more suitable for CAL microencapsulation. A novel quantitative method was proposed to verify the most stable wall material microencapsulation, with the results showing the highest activation energy for the MC/CMC/SA-encapsulated CAL microcapsule. This study will be helpful in designing an ideal capsule for CAL microencapsulation.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Boojhana Elango, C. P. Shirley, Gunadhor Singh Okram, Thiyagarajan Ramesh, Kamala-Kannan Seralathan, Maghimaa Mathanmohun
Summary: Recent efforts have been made to expand the use of sustainable and commercial primal matters, which is important for understanding their hazards and noxiousness to humans and the environment. Polysaccharide materials, such as cellulose, starch, chitosan, and chitin, are widely utilized in various fields due to their degradability, nontoxicity, and biocompatibility. This review discusses the synthesis and novel applications of these carbohydrate polymers in industrial, environmental, and biomedical sciences.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Zina Jawadi, Christine Yang, Ziyad S. S. Haidar, Peter L. Santa L. Maria, Solange Massa
Summary: Muco-adhesive drug delivery systems are extensively studied for controlled pharmacokinetics and pharmacodynamics. These systems utilize muco-adhesive polymers to prolong drug residency time at the application site and improve drug delivery. Compared to traditional drug delivery systems, muco-adhesive carriers have the potential to enhance therapeutic performance and efficacy. However, achieving successful muco-adhesion involves considering various physico-chemico-mechanical parameters.
Review
Pharmacology & Pharmacy
Murtaza Haider Syed, Mior Ahmad Khushairi Mohd Zahari, Md Maksudur Rahman Khan, Mohammad Dalour Hossen Beg, Norhayati Abdullah
Summary: Polymers, especially biopolymers, are increasingly being used as a more environmentally friendly alternative to petroleum-based polymers due to their low carbon footprint and easy degradation. Drug delivery systems, especially nanofibers, hold great promise in the field of medicine and are the focus of researchers for improved therapies and tailor-made treatments. This review discusses the importance of naturally abundant biopolymers in recent medical applications, particularly their role in drug delivery systems, and provides a crucial comparison of the advantages and disadvantages of major drug delivery systems.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Katiuscia Vieira Jardim, Abraham F. Palomec-Garfias, Marcus Vinicius Araujo, Cesar Marquez-Beltran, Andris Figueiroa Bakuzis, Sergio Enrique Moya, Alexandre Luis Parize, Marcelo Henrique Sousa
Summary: Curcumin, a natural drug with promising potential in cancer therapy, has limited applicability due to its low solubility, short half-life, and low bioavailability. In this study, curcumin was encapsulated in stimuli-responsive magneto-polymeric nanoplatforms to improve its bioavailability and delivery efficiency. The results showed that magnetic hyperthermia can provide a means for the controlled release of curcumin, leading to enhanced therapeutic action.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Polymer Science
Elif Yuce-Erarslan, Abraham (Avi) J. Domb, Haytam Kasem, Vladimir N. Uversky, Orkid Coskuner-Weber
Summary: In biology and medicine, intrinsically disordered synthetic polymers, which mimic the characteristics of disordered proteins, are highly flexible and self-organizing, making them useful in various biomedical applications, such as drug delivery and organ design. The development of new synthesis and characterization methods is important for providing these polymers for medical use. This study presents strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on mimicking intrinsically disordered proteins.
Review
Chemistry, Physical
Radhakrishnan Sreena, Arputharaj Joseph Nathanael
Summary: Biopolymers, obtained from renewable or non-renewable sources, are ideal for creating tailor-made nanoparticles due to their biocompatibility, biodegradability, low toxicity, and low immunogenicity. Biopolymeric nanoparticles can be classified as natural (based on polysaccharides and proteins) or synthetic. They have gained significant interest for biomedical applications such as tissue engineering, drug delivery, imaging, and cancer therapy. Various fabrication strategies can be used to synthesize biopolymeric nanoparticles, including emulsification, ionic gelation, nanoprecipitation, and electrospray drying. This review aims to explore the use of biodegradable biopolymeric nanoparticles in biomedical applications, which has been overlooked in previous reviews. It highlights the use of protein-based (albumin, gelatin, collagen, silk fibroin), polysaccharide-based (chitosan, starch, alginate, dextran), and synthetic (poly lactic acid, poly vinyl alcohol, poly caprolactone) biopolymeric nanoparticles, as well as the fabrication strategies employed. Future perspectives and challenges in utilizing biopolymeric nanoparticles are also discussed.
Review
Engineering, Environmental
Manik Chandra Biswas, Bodiuzzaman Jony, Pranab Kumar Nandy, Reaz Ahmed Chowdhury, Sudipta Halder, Deepak Kumar, Seeram Ramakrishna, Masud Hassan, Md Ariful Ahsan, Md Enamul Hoque, Muhammad Ali Imam
Summary: Biopolymers have unique tunable characteristics such as biodegradability, biocompatibility, renewability, which are critically important for designing materials for biomedical applications. By changing the polymer components, smart biopolymers can be prepared for more targeted applications, showing a wide range of uses in drug delivery and wound healing, among others.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Review
Pharmacology & Pharmacy
Carla Serri, Iriczalli Cruz-Maya, Irene Bonadies, Giovanna Rassu, Paolo Giunchedi, Elisabetta Gavini, Vincenzo Guarino
Summary: Significant advances in nanotechnologies have enabled the design of innovative devices suitable for biomedical applications, through increasing knowledge and refining of technical practices in green chemistry and bioengineering. New bio-sustainable methodologies are developing to fabricate drug delivery systems that combine properties of materials and bioactive molecules efficiently, meeting the demands of the health market. This work provides an overview of recent developments in bio-fabrication methods for designing green platforms, emphasizing their impact on biomedical and pharmaceutical applications.
Review
Chemistry, Medicinal
Konstantina Iliou, Stefanos Kikionis, Efstathia Ioannou, Vassilios Roussis
Summary: Marine biopolymer-based electrospun nanofibrous scaffolds show great potential for applications in biomedical fields, such as tissue engineering, drug delivery, and wound healing, due to their multifunctional characteristics and tunable mechanical properties.
Article
Chemistry, Applied
Ameya Sharma, Ishnoor Kaur, Divya Dheer, Manju Nagpal, Pradeep Kumar, D. Nagasamy Venkatesh, Vivek Puri, Inderbir Singh
Summary: Numerous compounds in the oceans have extensive applications in biomedical and biotechnological fields, which make them a prime renewable source of natural substances and promote the development of novel medical systems and devices. Polysaccharides, abundantly present in the marine ecosystem, have advantages such as low extraction costs, solubility in extraction media, interactions with biological compounds, and the ability to be modified for various shapes and sizes. These properties have led to their use as raw materials for drug delivery carrier systems.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Murtaza Haider Syed, Md Maksudur Rahman Khan, Mior Ahmad Khushairi Mohd Zahari, Mohammad Dalour Hossen Beg, Norhayati Abdullah
Summary: Electrospinning is an advanced method to produce nanofibers using polymers, and its application has shifted toward biopolymers. This review focuses on the ignored parameters and new innovative methods in current research, aiming to improve the properties of nanofiber biocomposites. The findings highlight the significance of electrospinning for biomedical applications compared to conventional methods.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Composites
Ayse B. Bas, Oktay Yilmaz, Anil Ibis, Mustafa Dogu, Kadir Kirkkopru, Fatma S. Guner
JOURNAL OF COMPOSITE MATERIALS
(2017)
Article
Polymer Science
Selin Sofi Kurkcuoglu, Ozge Kurkcuoglu, F. Seniha Guner
JOURNAL OF APPLIED POLYMER SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Dilek Dalgakiran, Tugce Inan, Fatma Seniha Guner
TURKISH JOURNAL OF CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Ayhan Unlu, Mehdi Meran, Bircan Dinc, Nilgun Karatepe, Muhammet Bektas, F. Seniha Guner
MOLECULAR BIOLOGY REPORTS
(2018)
Article
Chemistry, Multidisciplinary
Mehdi Meran, Pelin Deniz Akkus, Ozge Kurkcuoglu, Elif Baysak, Gurkan Hizal, Ebru Haciosmanoglu, Ayhan Unlu, Nilgun Karatepe, F. Seniha Guner
Article
Chemistry, Multidisciplinary
Ece Gizem Cakmak, Dilek Dalgakiran, Fatma Seniha Guner
TURKISH JOURNAL OF CHEMISTRY
(2018)
Article
Polymer Science
Buesra Eroglu, Dilek Dalgakiran, Tugce Inan, Ozge Kurkcuoglu, F. Seniha Guner
JOURNAL OF POLYMER RESEARCH
(2018)
Article
Polymer Science
Banu Kocaaga, Ozge Kurkcuoglu, Melkon Tatlier, Saime Batirel, F. Seniha Guner
JOURNAL OF APPLIED POLYMER SCIENCE
(2019)
Article
Polymer Science
Ebru Sarioglu, Banu Arabacioglu Kocaaga, Deniz Turan, Saime Batirel, F. Seniha Guner
JOURNAL OF APPLIED POLYMER SCIENCE
(2019)
Article
Materials Science, Biomaterials
O. Z. Guner, B. Kocaaga, S. Batirel, O. Kurkcuoglu, F. S. Guner
Summary: Thiolated polymers are commonly used in biomedical applications for their good permeation properties, although the thiolation process is time-consuming. This study demonstrates a simple method of thiol group integration using 2-thiobarbituric acid (TBA) with pectin hydrogels, showing improved flexibility and delayed disintegration. The addition of TBA also allows for successful controlled release of theophylline in the hydrogels.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Article
Polymer Science
Seniz Rodoplu, Bengi Ezgi Celik, Banu Kocaaga, Cenk Ozturk, Saime Batirel, Deniz Turan, F. Seniha Guner
Summary: This study developed procaine-loaded pectin hydrogels for local anesthetic delivery and wound healing, with investigations showing that the hydrogels did not affect cell migration. The study also emphasized the crucial effects of initial drug concentration, pH of initial drug solution, and drying temperature of hydrogels on the procaine release behavior of pectin-based hydrogels.
Article
Materials Science, Textiles
Gulcin Baysal, Gizem Keles, Berdan Kalav, F. Seniha Guner, Burcak Karaguzel Kayaoglu
Summary: The study aimed to synthesize UV-curable water-borne polyurethane acrylate (WPUA) binders for pigment printing on synthetic leather using different types of polyols, DMPA, and isophorone diisocyanate. The synthesized binders showed good adhesion properties and lower crock fastness and abrasion resistance compared to commercial WPUA binder. This study proposed a new environmentally friendly printing method using the synthesized binders.
INTERNATIONAL JOURNAL OF CLOTHING SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Burcu Girginer Ozunlu, Fatma Seniha Guner
Summary: In this study, graphene nanoplatelets were used as a process aid to regulate cell formation in foamed copolymer polypropylene. By adjusting the amount of graphene nanoplatelets, part performance can be tuned. The nanocomposite with 2 wt % graphene nanoplatelets showed smaller cell size.
Article
Physics, Multidisciplinary
I. Gokgoz Erkoc, T. Guven, F. Yildirim, M. Sozer, F. Guner
ACTA PHYSICA POLONICA A
(2018)