Review
Polymer Science
Jovana Milutinov, Veljko Krstonosic, Dejan Cirin, Nebojsa Pavlovic
Summary: Novel delivery systems such as emulgels play an important role in incorporating and protecting active substances for cosmetics, drugs, and food ingredients. The selection of main constituents determines the stability and efficacy of emulgels, which are dual-controlled release systems. Emulsifiers and gelling agents are crucial in ensuring emulsion stability and improving sensory properties.
Review
Pharmacology & Pharmacy
Tomasz Osmalek, Anna Froelich, Barbara Jadach, Adam Tatarek, Piotr Gadzinski, Aleksandra Falana, Kinga Gralinska, Michal Ekert, Vinam Puri, Joanna Wrotynska-Barczynska, Bozena Michniak-Kohn
Summary: The vagina has long been considered as a potential drug administration route, with most formulations made of natural or synthetic polymers serving different functions. In addition to topical applications, the anatomical and physiological features of the vagina make it suitable for systemic drug absorption. Research shows that intravaginal products continue to attract scientific attention, with ongoing exploration of novel polymers and formulations.
Review
Chemistry, Multidisciplinary
Wenxin Liu, Alideertu Dong, Bing Wang, Han Zhang
Summary: Black phosphorus (BP), as a potential platform for constructing intelligent drug delivery systems (DDS) with outstanding photothermal therapy and photodynamic therapy properties, is considered promising for cancer treatment. Current research on BP-based DDS for cancer therapy covers topics such as construction, platform classification, stimuli-responsive controlled drug release, as well as applications in cancer therapy and studies on biocompatibility.
Article
Chemistry, Multidisciplinary
Keegan Mendez, William Whyte, Benjamin R. Freedman, Yiling Fan, Claudia E. Varela, Manisha Singh, Juan C. Cintron-Cruz, Sandra E. Rothenbucher, Jianyu Li, David J. Mooney, Ellen T. Roche
Summary: Soft robotic technologies for therapeutic biomedical applications require conformal and atraumatic tissue coupling for effective drug delivery or tissue stimulation. A new class of hybrid hydrogel actuator is introduced, which can facilitate enhanced drug delivery through tunable mechanoresponsive release. The actuator can adhere to tissue via a flexible, drug-permeable adhesive bond and achieve improved drug spatial delivery. Future integration with other soft robotic assistive technologies can enable a synergistic approach for disease treatment.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Fuyu Song, Jingwei Gong, Yehan Tao, Yi Cheng, Jie Lu, Haisong Wang
Summary: This study presents a novel interpenetrating strategy to construct a robust hydrogel with dual stimuli-responsive properties, enhancing mechanical strength and potential applications in drug delivery and intestinal inflammation treatment. The copolymerization of NIPAM and AM effectively regulates the LCST of the hybrid hydrogel, making it suitable for physiological temperature conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Abdurrahman Muhammad Fahmy, Mariam Hassan, Doaa Ahmed El-Setouhy, Saadia Ahmed Tayel, Abdulaziz Mohsen Al-mahallawi
Summary: The study successfully formulated VRC into ternary micellar systems (TMSs) for the topical treatment of ocular mycosis, which showed high solubilization efficiency and small micellar size. After various tests, it exhibited good stability and safety for ocular use, indicating that it can be a promising treatment for ocular mycosis.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ming Sun, Lidi Cheng, Zexian Xu, Liqiang Chen, Yanshan Liu, Yaoxiang Xu, Dongyang Zhou, Xiuxiu Zhang, Qihui Zhou, Jian Sun
Summary: This study aims to explore the potential feasibility of a novel temperature-sensitive hydrogel-based dual sustained-release system for the repair and treatment of infectious jaw defects. The results indicate that the system shows outstanding sustained-release ability, biocompatibility, and antibacterial properties. This study provides new insights for the treatment of infectious jaw defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Sreekanth Reddy Obireddy, Wing-Fu Lai
Summary: In this study, a new type of nanocomposites was designed as a carrier for controlled delivery of bioactive agents. The nanocomposites showed pH-responsive behavior, reactive oxygen species (ROS)-generating capacity, and cell type-dependent toxicity. This research demonstrates the high potential of the nanocomposites for use in bioactive agent delivery and their potential as pH-responsive carriers for therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Anas Ahmad, Mohammad Imran, Nisha Sharma
Summary: The assessment of human and environmental risks of nanoparticulate material is crucial and requires the development of scientific tools and techniques. Challenges exist in toxicology assessment and regulatory guidance for nanocarriers. Nanotoxicology plays a significant role in pharmaceutical drug development and commercialization potential.
Review
Biochemistry & Molecular Biology
Geun-Woo Jin, N. Sanoj Rejinold, Jin-Ho Choy
Summary: Polyphosphazenes (PPZs), with their structural flexibility and biodegradability, have attracted great interest as synthetic polymers in the field of biomedical science. The introduction of various functional groups has enabled the development of multi-functionalized PPZs, which have shown potential as biomaterials in the form of nanoparticles (NPs) and hydrogels for various applications such as drug delivery, bioimaging, phototherapy, bone regeneration, and dental liners.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Xiang Chen, Haojie Yu, Li Wang, Nan Wang, Qian Zhang, Weibin Zhou, Md Alim Uddin
Summary: This study investigates the direct loading of insulin into polymerized glucose-responsive microneedle patch, demonstrating that insulin loading procedure was related to glucose concentration. The release of insulin on the surface of microneedles was uncontrolled by microneedles, while the release of insulin within microneedles depended on glucose concentration.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ambika Somasundar, Ayusman Sen
Summary: The development of nano and micromotors for actively delivering drugs to disease sites in vivo faces challenges such as safety, biocompatibility, ability to traverse body fluids, and reach cellular targets. Furthermore, scalability and uniformity in production are critical factors.
Article
Materials Science, Multidisciplinary
Xinyi Li, Mengjie Ye, Yong-E. Gao, Shengxin Hou, Peng Jia, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: Nanoparticle-based theranostics have become a preferential technology for the diagnosis and treatment of diseases. This study introduces a drug delivery system based on natural silk fibroin (SF NPs). It has been evaluated and found to have high stability, universal drug delivery ability, and good biosafety both in vitro and in vivo.
ADVANCED FIBER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Mahsa Safari, Mahmoud Naseri, Ehsan Naderi, Elaheh Esmaeili
Summary: In this study, spinel ferrite nanocarriers with different concentrations were fabricated and their structural characteristics, physical properties, drug release behavior, and cytotoxicity were studied. The results showed variations in drug release behavior and cellular activity for different concentrations of nanocarriers.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Erfan Rahmani, Mohammad Mahdi Eshaghi, Amin Shamsabadipour, Suresh Ghotekar, Abbas Rahdar, Luiz Fernando Romanholo Ferreira
Summary: g-C3N4 has been widely employed in fields such as photocatalytic reactions, energy production, environmental remediation, and microbial disinfection. Its potential biomedical applications have drawn considerable attention due to its thermal, chemical, and electrical stability, unique surface activity, biocompatibility, and viability. This paper provides a comprehensive review of the structure, characteristics, and fabrication techniques of g-C3N4 and its composites, focusing on its application as a drug delivery element for controlled and responsive drug release behavior in cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Dilshad Qureshi, Srusti Pattanaik, Biswaranjan Mohanty, Arfat Anis, Viktoryia Kulikouskaya, Kseniya Hileuskaya, Vladimir Agabekov, Preetam Sarkar, Samarendra Maji, Kunal Pal
Summary: The study focused on the preparation and characterization of novel phase-separated composite films based on PVA and CL, showing excellent UV-shielding and drug release properties. Films with 7.5 wt% CL exhibited the highest crystallinity, higher release rate of CPH, and excellent antimicrobial efficacy against model organisms. These findings suggest the potential of the PVA/CL composite films for UV-shielding and drug delivery applications.
Article
Materials Science, Ceramics
Krishna Dixit, Senthilguru Kulanthaivel, Tarun Agarwal, Kunal Pal, Supratim Giri, T. K. Maiti, Indranil Banerjee
Summary: Bone tissue engineering is an important field in orthopaedic healthcare, and the development of biomaterials with angiogenic and osteogenic properties is crucial for successful implants. This study explores the biofunctionalization of nano-hydroxyapatite with gum tragacanth, resulting in a material with both angiogenic and osteogenic potential.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Deepti Bharti, Indranil Banerjee, Agnieszka Makowska, Maciej Jarzebski, Przemyslaw Lukasz Kowalczewski, Kunal Pal
Summary: Researchers evaluated the use of stearyl alcohol (SA)- and Span-60 (SP)-tailored sunflower wax/sunflower oil oleogels as a substitute for butter in whole wheat batter and cake. The study found that complete replacement of butter with SA-containing oleogels resulted in a more uniform distribution of gas cells in the batter, leading to a softer and more porous cake. The study suggests that emulsifier-tailored oleogels could be a potential alternative to butter in baking.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Wojciech Smulek, Maciej Jarzebski, Marek Ochowiak, Magdalena Matuszak, Jan Kaczorek, Jerzy Stangierski, Jaroslaw Pawlicz, Pawel Drobnik, Piotr T. Nowakowski, Joanna Dyrda-Muskus, Grzegorz Fiutak, Mieczyslaw Gorzelak, Sirsendu S. Ray, Kunal Pal
Summary: Nowadays, the search for new ways to fight pathogens, which are becoming more resistant to drugs, antibiotics, and antiviral medicaments, is intensively studied. Natural products, particularly essential oils, are being investigated as alternatives to synthesized compositions due to their known antimicrobial properties. In this study, the droplet size distribution and other properties of a particular essential oil composition called five thieves' oil (5TO) were evaluated. The study found that 5TO solutions or emulsion systems could potentially be used for active antimicrobial applications, such as surface spraying.
Article
Nutrition & Dietetics
Agata Zaremba, Anna Gramza-Michalowska, Kunal Pal, Krystyna Szymandera-Buszka
Summary: The aim of this research was to estimate the effect of a vegan diet on iodine intake in Polish people. The study found that vegans had lower iodine intake compared to omnivores (p < 0.05); 90% of vegans had iodine intake below 150 μg/day. Vegans relied on iodized salt as their primary source of iodine, but the supply was limited, especially among female subjects.
Article
Food Science & Technology
Somali Dhal, Arfat Anis, Hamid M. Shaikh, Abdullah Alhamidi, Kunal Pal
Summary: This study investigated the effect of mixing time on the physical and structural properties of whole wheat flour-based cookie dough. The study found that dough mixed for 3 minutes had better organized components compared to other times. Longer mixing times resulted in water agglomeration and harder cookies. The study concluded that a mixing time of 5 minutes resulted in good quality cookies.
Article
Polymer Science
Somali Dhal, Anupam Pal, Anna Gramza-Michalowska, Doman Kim, Biswaranjan Mohanty, Sai S. Sagiri, Kunal Pal
Summary: The development of consumer-friendly nutraceutical dosage forms is crucial. In this study, emulgel-based candies were prepared as bi-modal carriers for delivering hydrophilic and hydrophobic nutraceutical agents. The physico-chemical properties of the formulations were thoroughly analyzed, revealing the interference of olive oil with the polymer networks of pectin and the crystallization properties of sugar in candies. In vitro disintegration studies showed no significant difference in the behavior of candies with varying olive oil concentrations. The developed jelly candy formulations were capable of delivering both hydrophilic and hydrophobic nutraceutical agents. This study opens new directions for designing and developing oral nutraceutical dosage forms.
Article
Food Science & Technology
Aditi Pradhan, Arfat Anis, Mohammad Asif Alam, Saeed M. Al-Zahrani, Maciej Jarzebski, Kunal Pal
Summary: This study investigated the replacement of butter with SW/RBO oleogel in cookie dough and the resulting cookies. The findings suggest that replacing butter with oleogel by up to 50% does not significantly compromise the physicochemical properties of cookie dough and cookies.
Article
Materials Science, Biomaterials
Luong Ngoc Diem, Selorm Torgbo, Indranil Banerjee, Kunal Pal, Udomlak Sukatta, Prapassorn Rugthaworn, Prakit Sukyai
Summary: In this study, nanocomposite film was fabricated using cellulose nanocrystals (CNCs) as nanofiller in a polymer matrix of polyvinyl alcohol (PVA) and gum tragacanth (GT). The films showed improved characteristics such as prolonged stability and increased mechanical properties. The addition of betel leaf extract to the PVA/GT/CNC film resulted in excellent antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa.
INTERNATIONAL JOURNAL OF BIOMATERIALS
(2023)
Review
Computer Science, Artificial Intelligence
Suraj Kumar Nayak, Bikash Pradhan, Biswaranjan Mohanty, Jayaraman Sivaraman, Sirsendu Sekhar Ray, Jolanta Wawrzyniak, Maciej Jarzebski, Kunal Pal
Summary: Heart rate variability (HRV) is a non-invasive tool for understanding cardiac autonomic function. This article provides a comprehensive overview of signal decomposition techniques and time-series modeling methods used in HRV analyses. It also discusses the clinical applications of HRV, such as in detecting diabetes and sleep apnea. The article emphasizes the importance of these HRV analysis methods for future research.
Article
Engineering, Chemical
Diksha Chaturvedi, Deepti Bharti, Somali Dhal, Deblu Sahu, Haladhar Behera, Minaketan Sahoo, Doman Kim, Maciej Jarzebski, Arfat Anis, Biswaranjan Mohanty, Sai S. Sagiri, Kunal Pal
Summary: This study investigates the effects of incorporating stearic acid in candelilla wax and groundnut oil oleogel. The results show that stearic acid modifies the crystal structure of the oleogel and increases ordering within the crystallite network. Interestingly, the firmness of the oleogel remains unaffected, but the spreadability decreases with the addition of stearic acid. The addition of stearic acid also affects the color and crystallization rate of the oleogel.
Article
Polymer Science
Somali Dhal, Abdullah Alhamidi, Saeed M. Al-Zahrani, Arfat Anis, Kunal Pal
Summary: This research investigated the effects of stearic acid, sunflower lecithin, and sorbitan monooleate on SYW/RBO-based oleogels. The samples were analyzed using various techniques, including colorimetry, microscopy, FTIR, mechanical testing, crystallization kinetics, X-ray diffraction, and drug release investigation. The results showed that emulsifiers did not affect the appearance or oil binding capacity of the oleogels. Emulsifiers smoothed the surface and influenced the crystallization kinetics of the oleogels. The drug release study indicated that emulsifiers had a significant impact on the release of curcumin from the oleogels.
Article
Polymer Science
Deepti Bharti, Doman Kim, Indranil Banerjee, Derick Rousseau, Kunal Pal
Summary: This study investigated the effect of solid emulsifiers on the physicochemical parameters of oleogels. The results showed that the emulsifiers co-crystallized with wax molecules, increasing the crystal growth rate and density, and could modulate the nutrient release from the oleogels without affecting their mechanical properties.
Correction
Polymer Science
Dipak K. Shah, Sai S. Sagiri, B. Behera, Kunal Pal, Krishna Pramanik
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Correction
Polymer Science
B. Behera, V. Patil, S. S. Sagiri, K. Pal, S. S. Ray
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
