Journal
NATURE MEDICINE
Volume 21, Issue 10, Pages 1123-1125Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3971
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During viral infections, antigen-presenting cells (APC) have traditionally been thought to recruit and activate CD4(+) T cells by presenting fragments of viral proteins captured from the extracellular environment. A new study indicates that the material the APCs need to present is much closer: in fact, APCs need to make it themselves.
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