Article
Biochemistry & Molecular Biology
Ahlem Meziadi, Navid Zuberi, Hendrick W. de Haan, Marc A. Gauthier
Summary: This study reveals that the inefficiency of bioconjugation reactions, such as protein PEGylation, is caused by the excluded volume effect (EVE) between methoxy poly(ethylene glycol) (mPEG) and proteins. The researchers found that this EVE leads to the self-assembly of proteins and reactive mPEG into separate protein-rich and mPEG-rich domains. By adding unreactive low-molecular weight mPEG as a co-solvent, the association between the larger protein and reactive mPEG can be promoted, resulting in improved reaction efficiency.
Article
Chemistry, Physical
Raimundo Miguel da Silva Junior, Deuzuita dos Santos Freitas Viana, Durcilene Alves da Silva, Ana Larisse Nunes dos Santos, Igor Frederico da Silveira Ramos, Gustavo Fernandes de Sousa, Janiel Costa da Silva, Vicente Galber Freitas Viana
Summary: The advancement of biomaterials technology has facilitated the development of materials for repairing body parts and improving treatments, with a study characterizing PVA thin films added with PEG, NBx, and HA. The results indicate that these films may be a promising option for bone tissue restoration and reconstruction, as they exhibit smooth and homogeneous surfaces and desirable band displacements and peak intensities.
COLLOID AND POLYMER SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Mohammad Jafarpour, Araz Sheibani Aghdam, Ali Kosar, Fevzi Cakmak Cebeci, Morteza Ghorbani
Summary: Electrospinning is a promising method for creating nano-composite fibers with improved wettability and performance by adjusting process parameters and adding different components, showing potential for filtration and bioengineering applications.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Polymer Science
Ssu-Meng Huang, Shih-Ming Liu, Hua-Yi Tseng, Wen-Cheng Chen
Summary: In this study, electrospun polyvinyl alcohol (PVA) fiber membranes were crosslinked with citric acid (CA) at different concentrations. The effects of CA on the chemical structure, mechanical strength, swelling resistance, and cytotoxicity of the crosslinked PVA membranes were investigated. The results showed that CA crosslinking improved the modulus and strength of the membranes, increased swelling resistance, and had no cytotoxic effects at low concentrations of PVA.
Article
Chemistry, Multidisciplinary
Morgan D. McSweeney, Limei Shen, Alexander C. DeWalle, Jordan B. Joiner, Elizabeth C. Ciociola, Dharmendra Raghuwanshi, Matthew S. Macauley, Samuel K. Lai
Summary: This study explored the effectiveness of prophylaxis with free PEG or tolerogenic PEGylated liposomes as a strategy to reduce the amount of APA induced by subsequently administered PEGylated liposomes. The results showed that a single administration of free PEG alone was capable of markedly reducing the APA response to PEG-liposomes for up to 2 months, which was comparable to, and often exceeded, interventions with different tolerogenic PEG-liposomes. These findings support further research on free PEG prophylaxis as a potential strategy to mitigate the APA response to sensitizing PEGylated therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Multidisciplinary
Weichang Ke, Xiang Li, Mengyu Miao, Bing Liu, Xiaoyu Zhang, Tong Liu
Summary: In this study, polyethylene glycol (PEG) was introduced to enhance the cooling performance of polyactic acid (PLA) film for heat-not-burn (HNB) tobacco. The PEG/PLA film showed good wetting and adsorption properties, and the film with 35 wt.% PLA content exhibited the highest elasticity modulus and tensile strength.
Article
Energy & Fuels
Wanting Zhu, Yuqi Wang, Shaokun Song, Hong Ai, Feng Qiu, Denian Li, Lijie Dong
Summary: A novel PEG/PVA composite PCF was prepared without using organic solvent, showing high latent heat and long-term reliability. This eco-friendly and cost-effective CPCF paves a new way for large-scale production of phase change fiber for thermal energy storage application.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2021)
Article
Biochemistry & Molecular Biology
Asim Mushtaq, Li Li, A. Anitha, Lisbeth Grondahl
Summary: This study synthesized methoxy polyethyleneglycol grafted chitosan (mPEG-CHI) using carbodiimide-mediated coupling and evaluated the effect of reaction conditions on the degree of substitution and PEGylation yield. The optimized conditions resulted in a high DS and PEGylation yield, making the product suitable for medical applications. The cytotoxicity of mPEG-CHI was also assessed and found to be non-toxic against breast cancer cell lines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Energy & Fuels
Lan Zhou, Feng Shi, Guojin Liu, JingPeng Ye, PengShuai Han, Guoqing Zhang
Summary: The in situ cross-linked PVA/PCM composite nanofibers prepared by an emulsion-electrospinning process show good thermal energy storage property and thermal stability, as well as improved tensile strength and water resistance, which greatly expand the potential application field of PCM nanofibers.
Article
Chemistry, Multidisciplinary
Taro Shimizu, Mizuki Awata, Amr S. Abu Lila, Chihiro Yoshioka, Yoshino Kawaguchi, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Summary: In this study, we developed a delivery system using hydroxy PEG-modified liposomes (HO-PEG-Lip) that efficiently activated the complement system, facilitated the association with MZ-B cells, and significantly enhanced antigen delivery in vivo. The manipulation of HO-PEG density at 2 mol% in total lipids led to a successful induction of OVA-specific IgG response after a single intravenous injection. This new delivery technique may provide a simple and effective way to deliver antigens to MZ-B cells, inducing a significant humoral immune response.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Textiles
Yuanduo Wang, Yongfang Qian, Zhen Zhang, Lihua Lyu, Ying Wang
Summary: Ethanol and glutaraldehyde were used as crosslinking protecting agents in this study to crosslink gelatin/pullulan composite nanofibrous membranes at room temperature. The crosslinked membranes showed improved thermal and mechanical properties, higher crystallinity, and increased water stability and hydrophilicity. These crosslinked membranes are considered to be a good candidate for tissue engineering scaffolds.
JOURNAL OF THE TEXTILE INSTITUTE
(2022)
Article
Materials Science, Biomaterials
Kai Sugiura, Toshiki Sawada, Yuuki Hata, Hiroshi Tanaka, Takeshi Serizawa
Summary: This study demonstrates a simple method for distinguishing anti-PEG antibodies using antibiofouling cello-oligosaccharide assemblies tethering specific one-terminal methoxy oligo(ethylene glycol) ligands. The method allows for quantitative detection of the antibodies, even in the presence of serum.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Jinlong Cao, Xiaowen Zhao, Lin Ye
Summary: In this work, a self-healing PVA-based hydrogel was fabricated by grafting benzaldehyde groups onto a PVA molecular chain and forming reversible imine bonds with amine groups on a quaternized chitosan chain. The hydrogel showed high healing efficiency, rapid recovery, and dynamic features. It has great potential application in biomedical fields such as smart infill biomaterials and tissue engineering scaffolds.
Article
Materials Science, Multidisciplinary
Tao Liu, Hailin Lu, Qianyang Wei, Chengzhi Li, Lu Chen, Ziqin Feng, Nan Tu
Summary: Currently, the lubricating properties of polymers such as polyethylene glycol (PEG) and chitosan (CS) are widely studied. In this study, different mass ratios of powder combinations are obtained by changing the mass of CS, and polymer films are obtained by hot pressing on the surface of the aluminum disk after microarc oxidation (MAO). The tribological properties of the composite film are evaluated and the results show that the composite film with a mass ratio of 5:5:1.5 of polyvinyl alcohol (PVA), PEG, and CS has excellent lubrication performance.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Dilruba Baykara, Esra Pilavci, Sumeyye Cesur, Elif Ilhan, Songul Ulag, Mustafa Sengor, Ewa Kijenska-Gawronska, Oguzhan Gunduz
Summary: In this study, 13PVA/0.5GEL/GEN nanofibers were fabricated using polyvinyl alcohol (PVA), gelatin (GEL), and gentamicin (GEN) through electrospinning. The nanofibers were chemically crosslinked with glutaraldehyde (GA) at different time intervals to investigate the effect of crosslinking on their properties. Morphological analysis showed that increasing crosslinking time resulted in larger nanofiber diameters. Thermal characterization revealed noticeable shifts in the thermal points with different crosslinking times. Tensile testing demonstrated that crosslinking improved the mechanical strength of the nanofibers, while the release of GEN was not significantly affected by the crosslinking time.
