The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex

(2014) Cuicui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of MST2 SARAH domain provides insights into its interaction with RAPL

(2014) Guoguang Liu et al.   JOURNAL OF STRUCTURAL BIOLOGY

STRIPAK components determine mode of cancer cell migration and metastasis

(2014) Chris D. Madsen et al.   NATURE CELL BIOLOGY

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

TRAF6 Stimulates the Tumor-Promoting Effects of TGF  Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

(2014) S. K. Gudey et al.   Science Signaling

UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination

(2013) Xiaofei Zhang et al.   CELL RESEARCH

A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress

(2013) Yunhao Liu et al.   JOURNAL OF CELL BIOLOGY

Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III

(2013) Xueyong Xu et al.   STRUCTURE

Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism

(2013) Zhubing Shi et al.   STRUCTURE

Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases

(2013) Meng Zhang et al.   STRUCTURE

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

Knockdown of connective tissue growth factor by plasmid-based short hairpin RNA prevented pulmonary vascular remodeling in cigarette smoke-exposed rats

(2011) Ran Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization

(2011) Derek F. Ceccarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analysis of Core STRIPAK Proteins

(2011) Michelle J. Kean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

(2011) Daniel T. Starczynowski et al.   JOURNAL OF CLINICAL INVESTIGATION

The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

(2011) Jae-Min Yuk et al.   NATURE IMMUNOLOGY

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

(2011) Yabing Mu et al.   Nature Communications

The Role of the Wnt Family of Secreted Proteins in Rat Oval “Stem” Cell-Based Liver Regeneration

(2010) Jennifer M. Williams et al.   AMERICAN JOURNAL OF PATHOLOGY

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling

(2010) Jian Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Negative Feedback Regulation of NF- B Action by CITED2 in the Nucleus

(2010) X. Lou et al.   JOURNAL OF IMMUNOLOGY

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Ubiquitin chain cleavage: CYLD at work

(2010) Ramin Massoumi   TRENDS IN BIOCHEMICAL SCIENCES

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination

(2008) Y WU et al.   CELLULAR SIGNALLING