Article
Chemistry, Medicinal
Katarzyna Papaj, Patrycja Spychalska, Katarzyna Hopko, Patryk Kapica, Andre Fisher, Markus A. Lill, Weronika Bagrowska, Jakub Nowak, Katarzyna Szleper, Martin Smiesko, Anna Kasprzycka, Artur Gora
Summary: In this study, a small library of thionocarbamates, thiolocarbamates, sulfide, and disulfide were tested as potential lead compounds for SARS-CoV-2 Mpro drug design using the microscale thermophoresis technique. The identified binder from the thionocarbamates group showed high potential for future modifications to improve affinity and solubility. Computational studies highlighted the inadequacy of simple approaches and the necessity of more advanced methods to properly evaluate the affinity of potential SARS-CoV-2 Mpro binders.
Article
Infectious Diseases
Edriss Yassine, Balazs Rada
Summary: This article discusses the antimicrobial mechanism of action of the natural product OSCN- against Streptococcus pneumoniae and elaborates on its potential therapeutic use as a treatment for infections.
Article
Mathematics, Applied
Xiaoyan Jiang, Jianguo Sun
Summary: This article discusses the local differential geometrical properties of the lightlike Killing magnetic curve gamma(s) in S-1(3) with a magnetic field V. A new Frenet frame {gamma, T, N, B} is established, and the local structure of gamma(s) is obtained, along with the singular properties of its binormal lightlike surface. An example is used to illustrate the main results of the paper.
Article
Biochemistry & Molecular Biology
Michal Marcinkowski, Tomas Pilzys, Damian Garbicz, Jan Piwowarski, Kaja Przygonska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jaroslaw Poznanski, Elzbieta Grzesiuk
Summary: FTO is an N-6-methyladenosine demethylase which can remove methyl groups from nucleic acids, forming complexes with other proteins. Research indicates an interaction between FTO and calmodulin (CaM), influencing calcium-binding loops in CaM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Luca Cavinato, Francesco R. Luly, Valentina Pastore, Daniele Chiappetta, Gloria Sangiorgi, Eva Ferrara, Pia Baiocchi, Giuseppe Mandarello, Giuseppe Cimino, Paola Del Porto, Fiorentina Ascenzioni
Summary: Cystic fibrosis (CF) is characterized by chronic bacterial lung infection and inflammation due to mutations in CF transmembrane conductance regulator (CFTR). Monocytes and monocyte-derived macrophages in CF have been shown to have defective phagocytosis and antimicrobial activity against relevant pathogens. This study evaluated the effect of CFTR triple modulator therapy on CF monocyte activity against Pseudomonas aeruginosa. The results showed that CF monocytes exhibited improved phagocytic and microbicidal activity, reduced oxidative burst, and decreased inflammatory response after ETI therapy.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Nutrition & Dietetics
Marta Gascon-Ruiz, Diego Casas-Deza, Irene Torres-Ramon, Maria Zapata-Garcia, Natalia Alonso, Andrea Sesma, Julio Lambea, Maria Alvarez-Alejandro, Elisa Quilez, Dolores Isla, Jose M. Arbones-Mainar
Summary: The study indicates that the prevalence of malnutrition in outpatient cancer patients is higher when using the GLIM criteria rather than ESPEN criteria. GLIM criteria are more sensitive in diagnosing patients with high baseline BMI or MM compared to ESPEN criteria.
CLINICAL NUTRITION
(2021)
Article
Oncology
Ayechew A. Getu, Ming Zhou, Shi-Yuan Cheng, Ming Tan
Summary: Cancer, a complex and dynamic disease, remains a leading cause of death in humans. The Mammalian Sterile 20-Like Kinase 4 (MST4 or STK26) plays a crucial role in cell migration and polarity, and is involved in various processes such as tumor cell proliferation, migration, invasion, survival, and cancer metastasis. MST4 interacts with PDCD10 to promote tumor growth and migration, and phosphorylates ATG4B to mediate autophagy signaling and contribute to treatment resistance. Overall, MST4 functions as an oncogene and shows potential as a therapeutic target.
Article
Energy & Fuels
Ravikiran Hiremath, Tukaram Moger
Summary: This paper proposes a modified super twisting algorithm for the DFIG system under low voltage sag condition. The algorithm uses second-order sliding mode control and introduces higher-order switching functions for sliding surface control. The Lyapunov analysis is utilized to reduce chattering amplitude. The proposed algorithm reduces system uncertainties and chattering effect, and improves the settling period of system parameters.
Article
Microbiology
Gicelle T. T. Malajacan, Mae Ashley G. Nacario, Marie Christine M. Obusan, Windell L. L. Rivera
Summary: A microbial source tracking method was used to identify the sources of fecal contamination in Laguna Lake, Philippines. The markers HF183 (human), BoBac (cattle), Pig-2-Bac (swine), and DuckBac (duck) were detected in water samples from nine lake stations. HF183 was the most frequently detected marker, while Pig-2-Bac was the most abundant. The concentrations of the markers varied based on land use patterns and were higher during the wet season. The markers showed acceptable sensitivity and specificity, suggesting their potential use for continuous monitoring and intervention design.
Article
Cell Biology
Frida Sommer, Vincenzo Torraca, Yufei Xie, Aliede E. in't Veld, Joost Willemse, Annemarie H. Meijer
Summary: Chemotactic signaling influences the bactericidal properties of macrophages and affects cell localization during chemotaxis.
Article
Geosciences, Multidisciplinary
Nur'ainul Miftahul Huda, Nurfitri Imro'ah
Summary: One factor in constructing the GSTAR model is the weight matrix, which represents the relationship between different locations. The accuracy of the weight matrix significantly affects the prediction results. The study finds that the MST weight matrix should be utilized with a prediction error tolerance of 19%.
SPATIAL STATISTICS
(2023)
Article
Engineering, Environmental
Warish Ahmed, Aaron Bivins, Sudhi Payyappat, Michele Cassidy, Nathan Harrison, Colin Besley
Summary: Using human fecal marker genes (HFMGs) for quantitative microbial risk assessment (QMRA) is a useful water quality management tool. The study found that the concentrations of potential pathogenic viruses were lower than HFMGs in untreated wastewater, and the concentrations of HFMGs were stable with little variation. The correlation and ratios between HFMGs and pathogenic virus GC can contribute to improved QMRA of human health risks.
Article
Cultural Studies
Jessica Carniel
Summary: Conchita Wurst gained fame as a bearded drag queen and achieved more success than before. However, the image of Conchita became limiting for the artist's own expression and growth, leading to the introduction of a second persona, WURST. This article explores the construction and function of these personas, showing how they have allowed the artist to create a more versatile performance identity and artistic brand.
Article
Biochemistry & Molecular Biology
Tanusree Mookherjee, Sanchari Bhattacharjee, Angshuman Bagchi, Rita Ghosh
Summary: CircRNAs have become important in gene regulation and cancer prognosis. Translated peptides in circRNAs play a role in cellular processes, and the circPPP1R12A translated peptide affects the functioning of the Mst pathway, which is important for cancer regulation. In this study, we predicted the structure of the peptide, providing insight into its molecular interactions and functionality.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
P. K. Praseetha, M. Anto Godwin, Mohamad S. AlSalhi, Sandhanasamy Devanesan, S. Vijayakumar, R. Sangeetha, S. Prathipkumar, Woong Kim
Summary: Supplying safe drinking water is a high-risk challenge globally. Hybrid technologies involving nanomaterials have the potential to provide solutions, specifically by exploring natural biopolymers. Although porous chitosan with high specific surface area has promising properties, its use as a membrane in water purification is rarely reported.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
