Editorial Material
Biochemistry & Molecular Biology
Birgit Sawitzki
Summary: In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to post-acute sequelae of COVID-19 (PASC). In this study, Cheong et al. demonstrate that severe infections via IL-6 induce persistent epigenetic signatures in hemopoietic stem cells and their myeloid progenitors associated with increased inflammatory potential.
Review
Biochemistry & Molecular Biology
Xuanshuo Wei, Jin Tang, Chuwen Lin, Xuan Jiang
Summary: Besides its role in miRNA biogenesis, Drosha also has various functions including promoting DNA damage repair, transcriptional regulation, mRNA stability control, etc. This review provides an overview of the diverse functions of Drosha in novel biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Jizhou Zhang, Qingqing Wu, Courtney B. Johnson, Giang Pham, Jeremy M. Kinder, Andre Olsson, Anastasiya Slaughter, Margot May, Benjamin Weinhaus, Angelo D'Alessandro, James Douglas Engel, Jean X. Jiang, J. Matthew Kofron, L. Frank Huang, V. B. Surya Prasath, Sing Sing Way, Nathan Salomonis, H. Leighton Grimes, Daniel Lucas
Summary: This study develops imaging approaches for myelopoiesis in mice and generates atlases showing the differentiation of granulocytes, monocytes, and dendritic cells in the bone marrow. It reveals that local cues from distinct blood vessels are responsible for the spatial organization of definitive blood cell differentiation.
Article
Engineering, Aerospace
John M. Knapman, Peter A. Swan
Summary: The space elevator allows for fast interplanetary travel with minimal fuel and reaction mass needed. It can reach high velocities, enabling travel to Mars and outer planets in a short amount of time.
Article
Biotechnology & Applied Microbiology
Sara Ciceri, Rafaela Montalvao-de-Azevedo, Amir Tajbakhsh, Alessia Bertolotti, Rosalin Dolores Spagnuolo, Luna Boschetti, Maria Capasso, Paolo D'Angelo, Annalisa Serra, Francesca Diomedi-Camassei, Mariaclaudia Meli, Marilina Nantron, Paola Quarello, Anna Maria Buccoliero, Angela Tamburini, Chiara Maura Ciniselli, Paolo Verderio, Paola Collini, Paolo Radice, Filippo Spreafico, Daniela Perotti
Summary: Mutations in SIX1 and miRNAPGs may play crucial roles in the recurrence of Wilms tumor (WT), providing an advantage and acting as oncogenic drivers in the progression of the disease. These findings suggest a potential association between miRNAPGs mutations and the occurrence of relapse, highlighting the importance of understanding the underlying genetic factors in WT development.
CANCER GENE THERAPY
(2021)
Article
Gastroenterology & Hepatology
Tanya M. Monaghan, Anna M. Seekatz, Nicholas O. Markham, Tung On Yau, Maria Hatziapostolou, Tahseen Jilani, Niki Christodoulou, Brandi Roach, Eleni Birli, Odette Pomenya, Thomas Louie, D. Borden Lacy, Peter Kim, Christine Lee, Dina Kao, Christos Polytarchou
Summary: The study found that FMT for rCDI can lead to changes in miRs, which affect inflammatory genes and cellular protective effects, revealing potential therapeutic targets.
Article
Chemistry, Multidisciplinary
Junsheng Zhang, Siu Hong Dexter Wong, Xin Wu, Hai Lei, Meng Qin, Peng Shi, Wei Wang, Liming Bian, Yi Cao
Summary: It has been shown that bioactive ligands can be made mechanically invisible by increasing their tether lengths to the substrate, allowing for the regulation of mechanotransduction. Light switchable tethers have been designed to modulate their lengths reversibly by switching a light-responsive protein, providing control over stem cell adhesion, spreading, and differentiation. This study demonstrates the spatiotemporal regulation of differential cell fates on the same substrate, which may be a crucial step towards constructing complex organoids or mini tissues by defining the mechanical cues of the cellular microenvironment with light.
ADVANCED MATERIALS
(2021)
Editorial Material
Cell Biology
Hanaa Hariri, W. Mike Henne
Summary: This article discusses the important roles of SNX-RGS proteins in multiple interorganelle contact sites, as well as their emerging roles in cellular metabolism, human disease, and lipid trafficking.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Akankshi Munjal, Edouard Hannezo, Tony Y-C Tsai, Timothy J. Mitchison, Sean G. Megason
Summary: The formation of zebra fish semicircular canals is primarily driven by hyaluronan secretion instead of conventional actomyosin-driven behaviors. Hyaluronan generates isotropic extracellular pressure to deform the epithelium into buds, while actomyosin and E-cadherin-rich membrane tethers help shape buds into tubes. This study challenges the traditional view that actomyosin contractility is the main driving force in tissue morphogenesis, suggesting that hyaluronate pressure shaped by anisotropic tissue stiffness may be a widespread mechanism for morphological change in organogenesis and tissue engineering.
Article
Cell Biology
Ana Cardoso, Ana Catarina Martins, Ana Raquel Maceiras, Wei Liu, Isabel Castro, Antonio G. Castro, Antonio Bandeira, James P. Di Santo, Ana Cumano, Yan Li, Paulo Vieira, Margarida Saraiva
Summary: The study reveals that IL-10 triggers emergency myelopoiesis (EM) by expanding the myeloid progenitor compartment and production of myeloid cells. Unexpectedly, IL-10 also reprograms CD4 and CD8 T cells to produce IFN-gamma, suggesting new perspectives for IL-10-based immunotherapies.
Article
Cell Biology
Soomin Son, Baekgyu Kim, Jihye Yang, V. Narry Kim
Summary: In this study, the researchers explore the role of the N-terminal proline-rich disordered domain (PRD) of DROSHA in miRNA processing. They find that the PRD specifically promotes the maturation of intronic miRNAs, independent of splicing reactions. They also discover that PRD is more important for rapidly evolving miRNAs, suggesting a role in miRNA evolution.
GENES & DEVELOPMENT
(2023)
Review
Biochemistry & Molecular Biology
Anna A. Kiseleva, Andrey Poleshko
Summary: The nuclear envelope is crucial for organizing the genome in the nucleus. The inner nuclear membrane is coated with lamin proteins, which facilitate various cellular processes. Certain lamin-bound proteins, like PRR14, function as anchors to retain silent heterochromatin at the nuclear periphery, exhibiting a unique role among chromatin tethers. This review summarizes the current knowledge of the structure and function of PRR14 in organizing heterochromatin at the nuclear periphery.
Article
Biochemistry & Molecular Biology
Liping Yang, Yixuan Hou, Yan-e Du, Qiao Li, Fanlin Zhou, Yu Li, Huan Zeng, Ting Jin, Xueying Wan, Shengdong Guan, Rui Wang, Manran Liu
Summary: The nonclassical miRNA miR-4646-5p plays a pivotal role in gastric cancer metastasis by targeting PHD3 to stabilize HIF1A, and up-regulating RhoA expression to promote cancer cell invasion. ABHD16A mediated abnormal lipid metabolism may serve as a new target for clinical treatment of gastric cancer.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biology
Andrea Cugno, Alex Marki, Klaus Ley
Summary: Leukocytes, propelled by blood flow, can roll on inflamed endothelium by transient bonds between selectins and integrins; tether formation can be observed and extracted using various methods; studying the biomechanical properties of leukocyte tethers helps understand the advantages and disadvantages of different approaches.
Article
Cell Biology
Oscar A. Pena, Alexandra Lubin, Jasmine Rowell, Yvette Hoade, Noreen Khokhar, Hanna Lemmik, Christopher Mahony, Phoebe Dace, Chianna Umamahesan, Elspeth M. Payne
Summary: Germline loss or mutation of one copy of the transcription factor GATA2 in humans results in clinical phenotypes affecting hematopoietic, lymphatic, and vascular systems. In this research, zebrafish with two copies of the Gata2 gene were used to investigate the effects of these genes on hematopoiesis during development, revealing unique roles at different stages and a potential redundancy between the two genes. The study also showed defects in the myeloid compartment in adult zebrafish with combined heterozygosity loss, similar to GATA2 loss in humans, adding to our understanding of GATA2 deficiency and its developmental effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pierre V. Maillard, Annemarthe G. van der Veen, Enzo Z. Poirier, Caetano Reis e Sousa
Review
Biochemistry & Molecular Biology
Sanne L. Landman, Maaike E. Ressing, Annemarthe G. van der Veen
CYTOKINE & GROWTH FACTOR REVIEWS
(2020)
Review
Immunology
Jorn E. Stok, M. Eloisa Vega Quiroz, Annemarthe G. van der Veen
JOURNAL OF IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Enzo Z. Poirier, Michael D. Buck, Probir Chakravarty, Joana Carvalho, Bruno Frederico, Ana Cardoso, Lyn Healy, Rachel Ulferts, Rupert Beale, Caetano Reis e Sousa
Summary: The discovery of a Dicer isoform called antiviral Dicer provides protection for tissue stem cells against RNA viruses, shedding light on the molecular regulation of antiviral RNAi in mammalian innate immunity. Different cell-intrinsic antiviral pathways can be tailored to the differentiation status of cells.
Article
Biochemistry & Molecular Biology
Jorn E. Stok, Timo Oosenbrug, Laurens R. ter Haar, Dennis Gravekamp, Christian P. Bromley, Santiago Zelenay, Caetano Reis e Sousa, Annemarthe G. van der Veen
Summary: This study reveals the crucial role of LGP2 in inducing a type I interferon response in ADAR1-deficient cells. In addition, the sensitivity of tumor cells to ADAR1 loss is dependent on LGP2 expression.
Editorial Material
Immunology
Raul Y. Sanchez-David, Pierre V. Maillard
Summary: The study highlights the significance of RNA interference in antiviral immunity in mammals and demonstrates the potential of designer peptides as a promising approach for antiviral therapy.
Review
Biochemistry & Molecular Biology
Eleanor Childs, Conor M. Henry, Johnathan Canton, Caetano Reis e Sousa
Summary: Cells have mechanisms to protect the integrity of endocytic organelle membranes and to repair damaged membranes when necessary. In some cases, cells may deliberately induce damage to these organelles. Understanding these mechanisms could lead to improvements in vaccination and intracellular drug delivery.
Editorial Material
Biochemistry & Molecular Biology
Kristina L. Schierhorn, Raul Y. Sanchez-David, Pierre Maillard
Summary: Recent work has demonstrated the role of RNA interference (RNAi) in mammalian cell-autonomous antiviral defence. This defence mechanism relies on the accumulation of virus-derived small interfering RNAs (vsiRNAs) to degrade viral RNAs. A new study reveals that vsiRNAs can enter the bloodstream via extracellular vesicles (EVs) and confer sequence-specific antiviral activity to recipient cells in infected mice, suggesting the involvement of both cell-autonomous and non-cell-autonomous mechanisms in mammalian antiviral RNAi.
Article
Oncology
Kok Haw Jonathan Lim, Evangelos Giampazolias, Oliver Schulz, Neil C. Rogers, Anna Wilkins, Erik Sahai, Jessica Strid, Caetano Reis E. Sousa
Summary: Loss of sGSN enhances the responsiveness of cDC1 and DNGR-1 to chemotherapy, targeted therapy, and radiotherapy, leading to improved tumor control.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Conor M. Henry, Carlos A. Castellanos, Caetano Reis E. Sousa
Summary: In this review, the role of dendritic cell natural killer group receptor-1 (DNGR-1) in cDC1 and its functions in anti-viral and anti-tumor immunity are discussed. The study found that DNGR-1 can promote inducible rupture of phagocytic or endocytic compartments containing dead cell debris, making dead cell-associated antigens accessible to cDC1. Additionally, DNGR-1 can recognize dead cells and participate in immune response. Therefore, the study of DNGR-1 has opened new perspectives into cross-presentation, which may have applications in immunotherapy of cancer and vaccination against viral diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Hale Tunbak, Rocio Enriquez-Gasca, Christopher H. C. Tie, Poppy A. Gould, Petra Mlcochova, Ravindra K. Gupta, Liane Fernandes, James Holt, Annemarthe G. van der Veen, Evangelos Giampazolias, Kathleen H. Burns, Pierre V. Maillard, Helen M. Rowe
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Mar Cabeza-Cabrerizo, Janneke van Blijswijk, Stephan Wienert, Daniel Heim, Robert P. Jenkins, Probir Chakravarty, Neil Rogers, Bruno Frederico, Sophie Acton, Evelyne Beerling, Jacco van Rheenen, Hans Clevers, Barbara U. Schraml, Marc Bajenoff, Michael Gerner, Ronald N. Germain, Erik Sahai, Frederick Klauschen, Caetano Reis e Sousa
SCIENCE IMMUNOLOGY
(2019)
