Article
Biochemistry & Molecular Biology
Vidyani Suryadevara, Connor J. Krehbial, Danielle Halsey, Monte S. Willis
Summary: The ubiquitin proteasome system plays a role in bone loss by regulating bone turnover and metabolism. This study focused on the muscle-specific ubiquitin ligases, MuRF1, MuRF2, MuRF3, and Atrogin, and their impact on bone homeostasis. The depletion of each of these proteins was found to alter bone structure and mechanical properties in a sex-dependent manner.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Daniela Aravena-Canales, Jorge E. Aedo, Alfredo Molina, Juan Antonio Valdes
Summary: This study revealed that cortisol plays a complex regulatory role in the expression of atrogenes in rainbow trout skeletal muscle, with both early downregulation and later upregulation observed. Membrane-initiated cortisol action was found to regulate murf1 gene expression in rainbow trout myotubes, while having no significant effect on atrogin-1.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Young In Kim, Hyunjung Lee, Farida S. Nirmala, Hyo-Deok Seo, Tae Youl Ha, Chang Hwa Jung, Jiyun Ahn
Summary: Valeriana fauriei may ameliorate muscle atrophy and act as a reactive oxygen species scavenger.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Siegfried Labeit, Stephanie Hirner, Julijus Bogomolovas, Andre Cruz, Moldir Myrzabekova, Anselmo Moriscot, Thomas Scott Bowen, Volker Adams
Summary: The muscle-specific ubiquitin ligase MuRF1 is involved in regulating muscle catabolism during chronic wasting states, with potential implications for glucose and fat metabolism regulation. Knockout mice for MuRF1 and MuRF2 show elevated serum glucose, triglycerides, and perturbed signaling pathways related to glucose and fat metabolism. Adenoviral re-expression of MuRF1 in KO mice helps normalize metabolic parameters, while the inhibitors MyoMed-205 and MyoMed-946 show potential in attenuating muscle weakness in a mouse model for T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Tian Li, Yue Yin, Nan Mu, Yishi Wang, Manling Liu, Mai Chen, Wenhua Jiang, Lu Yu, Yan Li, Heng Ma
Summary: The study revealed that accumulation of CHMP2B inhibits autophagic flux, leading to decreased myocardial ischemic tolerance. Metformin can degrade CHMP2B through the AMPK-atrogin-1-dependent pathway to maintain the homeostasis of autophagic flux, enhancing cardioprotection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
N. P. Syamprasad, Siddhi Jain, Bishal Rajdev, Samir Ranjan Panda, Jagadeesh Kumar Gangasani, Veerabhadra Swamy Challa, Jayathirtha Rao Vaidya, Gopal C. Kundu, V. G. M. Naidu
Summary: The cardioprotective effect of AKR1B1 inhibitor NARI-29 was evaluated in this study. The results showed that NARI-29 increased the sensitivity of breast cancer cells to Dox, while reducing its toxicity to cardiomyocytes and decreasing the secretion of inflammatory cytokines. Animal experiments also confirmed the protective effect of NARI-29 on Dox-induced cardiac injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Young Mi Seok, Jae-Myung Yoo, Yoonju Nam, Jungeun Kim, Jin Soo Kim, Jun-Ho Son, Hyo Jung Kim
Summary: The study showed that mountain ginseng inhibits dexamethasone-induced muscle atrophy by decreasing MuRF1 and atrogin1, and has positive effects on L6 myotubes.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xi'e Wang, Junyu Xiao, Chih-chen Wang, Lei Wang
Summary: This study reveals a unique mechanism for the secretion and activation of Fam20C, showing that only mature Fam20C processed by S1P functions in osteoblast differentiation and mineralization, providing a molecular link between biomineralization and lipid metabolism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Claudia Sepulveda, Michael A. Guzman, Qingtian Li, Jose Antonio Villaecija-Aguilar, Stephanie E. Martinez, Muhammad Kamran, Aashima Khosla, Wei Liu, Joshua M. Gendron, Caroline Gutjahr, Mark T. Waters, David C. Nelson
Summary: Karrikin molecules, found in smoke, can stimulate seed germination after fire. The KAI2 pathway in Arabidopsis thaliana plays a crucial role in responding to Karrikin. In addition to sensing Karrikin, KAI2 is also capable of recognizing an endogenous signal called KL. The KUF1 gene specifically affects the ability of KAI2 to detect certain signals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Sun-Ok Kim, Kyoung Sang Cho, Bo Yeon Kim, Kyung Ho Lee
Summary: Primary cilia are important cell structures regulated by various cellular signals, abnormal regulation of which is related to human diseases. This study identified a novel regulatory factor CUL1, which induces Dvl2 degradation through ubiquitination to promote ciliogenesis, providing a new therapeutic target for cilia-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Kyohei Furukawa, Marika Kousaka, Huijuan Jia, Hisanori Kato
Summary: The study found that turmeric extract has a suppressive effect on muscle atrophy induced by dexamethasone treatment, by suppressing the expression of Fbxo32 and Murf1.
Article
Clinical Neurology
Deokcheol Lee, Tomofumi Kuroki, Takuya Nagai, Keisuke Kawano, Kiyoshi Higa, Syuji Kurogi, Hideaki Hamanaka, Etsuo Chosa
Summary: This study retrospectively analyzed a group of patients who underwent lumbar surgery to examine the prevalence of sarcopenia and the association between spine-pelvic deformity and skeletal muscle volume loss and ectopic fat infiltration. The findings suggest that muscle quality deterioration and volume loss in lumbar paravertebral muscles, as well as ectopic fat infiltration, may cause lumbo-pelvic deformity.
Article
Plant Sciences
Bruno E. Rojas, Matias D. Hartman, Carlos M. Figueroa, Alberto A. Iglesias
Summary: The study analyzed the proteolysis of PEPCK1 in germinating Arabidopsis thaliana seedlings, and found that shorter versions of the protein may be generated by metacaspase-9. Truncated mutants Delta 19 and Delta 101 of AthPEPCK1 exhibited similar kinetic parameters, but activation by malate and inhibition by glucose 6-phosphate were abolished in the .101 mutant. This proteolysis is proposed to adapt the sensitivity to allosteric regulation during the transition from sink to source in germinating seedlings.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Agriculture, Multidisciplinary
Chaoyu Zhai, Steven M. Lonergan, Elisabeth J. Huff-Lonergan, Logan G. Johnson, Kitty Brown, Jessica E. Prenni, Mahesh Nair
Summary: The objective of this study was to evaluate the effects of lipid peroxidation products, specifically malondialdehyde (MDA), hexenal, and 4-hydroxynonenal (HNE), on the activity of calpain-1. It was found that calpain-1 activity increased slightly after incubation with 100 mu M MDA, but not with higher concentrations of MDA. On the other hand, calpain-1 activity was lowered by hexenal and HNE at all tested concentrations. Adducts of MDA and HNE were detected on specific amino acid residues in calpain-1. These findings suggest that lipid peroxidation products can have a concentration-dependent impact on calpain-1 activity and potentially affect meat tenderness postmortem.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Hyun Lee, Lucas Ibrahimi, Dimitri T. Azar, Kyu-Yeon Han
Summary: MT1-MMP is a protease enzyme that regulates cellular activities, especially cell migration. It interacts with various molecules and can not only change the extracellular environment but also regulate cell signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Natany G. Reis, Ana P. Assis, Natalia Lautherbach, Dawit A. Goncalves, Wilian A. Silveira, Henrique J. N. Morgan, Rafael R. Valentim, Lucas F. Almeida, Lilian C. Heck, Neusa M. Zanon, Tatiana E. Koike, Audrei R. Santos, Elen H. Miyabara, Isis C. Kettelhut, Luiz C. Navegantes
Summary: This study found that maternal vitamin D deficiency selectively affects the development of type-II muscle fibers in male offspring rats, leading to muscle atrophy. However, compensatory increase in vitamin D content in adult age may increase fiber size and fatigue resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Immunology
Enio Setsuo Arakaki Pacini, Naiara Ayako Satori, Edwin Kerry Jackson, Rosely Oliveira Godinho
Summary: Adenosine modulates inflammation and immune responses via activation of G protein-coupled receptors. In addition to extracellular adenosine generated from the metabolism of extracellular ATP released from damaged cells, there is evidence for the existence of the cAMP-adenosine pathway. The cAMP-adenosine pathway plays a significant role in the efficacy of beta(2)-adrenoceptor agonists in the airways and has potential implications in chronic respiratory inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Natalia Lautherbach, Dawit A. P. Goncalves, Wilian A. Silveira, Silvia Paula-Gomes, Rafael Rossi Valentim, Neusa M. Zanon, Marcelo G. Pereira, Elen H. Miyabara, Luiz C. C. Navegantes, Isis C. Kettelhut
Summary: Ucn2 activates cAMP signaling and promotes muscle hypertrophy, protein synthesis, and signaling pathways, while decreasing atrogin-1 mRNA levels and protein degradation through lysosomal proteolytic activity inhibition. Ucn2 also induces a fiber type shift and improves fatigue muscle resistance. These findings suggest that Ucn2 triggers an anabolic and anti-catabolic response in skeletal muscle, potentially through the activation of cAMP cascade and participation of Akt and ERK1/2 signaling.
MOLECULAR METABOLISM
(2022)
Article
Rehabilitation
Isadora Grade, Henrique Andrade, Renato Guerreiro, Eduardo Stieler, Flavia R. da Silva, Hesojy G. V. da Silva, Roberto Vital, Renan A. Resende, Dawit A. P. Goncalves, Andre G. Andrade, Marco T. de Mello, Andressa Silva
Summary: A systematic review found that Paralympic athletes have poor sleep quality and quantity, with high rates of daytime sleepiness. Subjective questionnaires are commonly used to assess their sleep.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Psychology, Biological
Maicon Rodrigues Albuquerque, Beatriz Hooper, Iasmin Oliveira de Sousa Viana, Paulo H. C. Mesquita, Tony Meireles Santos, Tercio Apolinario-Souza, Leonardo de Sousa Fortes, Dawit Albieiro Pinheiro Goncalves
Summary: This study evaluated the effects of different exercise intensities on executive functions (EFs), gaze behavior, and pupil diameter. The results showed that psychophysiological measures varied between conditions. Exercise above the lactate threshold (LT) resulted in worse EFs performance compared to rest and exercise below LT. Response time was faster at LT and above LT than at rest, and faster above LT than below LT. Gaze behavior measures indicated that exercise, regardless of intensity, improved the number of fixations with shorter durations. There were no significant differences in average and peak pupil diameter between conditions.
Article
Microbiology
Michele M. Moraes, Thiago T. Mendes, Leandro Borges, Alice L. Marques, Cristian Nunez-Espinosa, Dawit A. P. Goncalves, Carolina B. Simoes, Tales S. Vieira, Roberto V. P. Ladeira, Talita G. B. Lourenco, Danielle V. Ribeiro, Elaine Hatanaka, Debora Heller, Rosa M. E. Arantes
Summary: Antarctic camps, with their isolated, confined, and extreme (ICE) conditions, can affect the microbiome and inflammatory responses. A 7-week expedition to Nelson Island resulted in fluctuations in the microbiome, a reduction in disease-associated microbes, and changes in inflammation markers. These findings suggest that Antarctic environments and behaviors play a role in modulating oral microbiome and inflammation.
Editorial Material
Peripheral Vascular Disease
Leandro Bueno Bergantin
CURRENT HYPERTENSION REVIEWS
(2023)
Article
Physiology
Marcelo T. Andrade, Matheus M. S. Nunes-Leite, Rubio S. Bruzzi, Carlos H. Souza, Joao P. Uendeles-Pinto, Luciano S. Prado, Danusa D. Soares, Dawit A. P. Goncalves, Candido C. Coimbra, Samuel P. Wanner
Summary: The aim of this study was to identify the factors predicting the body core temperature of athletes at the end of a 10 km self-paced run in a hot environment. The main finding was that hyperthermia in athletes subjected to self-paced running depends on several factors, such as heart rate, sweat rate, wet-bulb globe temperature, running speed and maximal oxygen consumption. These factors are practical for use outside the laboratory environment and important in minimizing heat-induced impairment of endurance performance and reducing the occurrence of exertional heatstroke.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Naiara Ayako Satori, Enio Setsuo Arakaki Pacini, Rosely Oliveira Godinho
Summary: 132-adrenoceptor agonists and phosphodiesterase (PDE) inhibitors are effective bronchodilators by increasing intracellular cAMP levels, but cAMP efflux and the cAMP-adenosine pathway only affect the relaxation induced by 132-adrenoceptor agonists, not PDE inhibitors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Marcio Vinicius Damico, Cristiane Damas Gil, Rosely Oliveira Godinho, Enio Setsuo Arakaki Pacini, Consuelo Latorre Fortes -Dias, Vanessa Moreira
Summary: The inhibition of 5-LOX and 12-LOX pathways can promote the regeneration of skeletal muscle fibers. Oral treatment with 5-LOX inhibitor MK886 or 12-LOX inhibitor baicalein can reduce inflammation and facilitate the healing process of muscle injury. Inhibition of the 5-LOX pathway enhances muscle resistance, while inhibition of the 12-LOX pathway promotes early recovery of muscle fiber activity and function.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Rehabilitation
Eduardo Stieler, Marco T. de Mello, Ingrid L. B. Lobo, Dawit A. Goncalves, Renan Resende, Andre G. Andrade, Thiago F. Lourenco, Anselmo A. C. Silva, Henrique A. Andrade, Renato Guerreiro, Andressa Silva
Summary: This review examines the methods used to assess external load in Paralympic sports, aiming to provide scientific evidence for multidisciplinary teams to prescribe and monitor athlete's development, enhance performance, and reduce injury/illness risks. The study identified 8 methods to quantify external load in 8 different Paralympic sports and highlights the need for further research to validate the effectiveness and reliability of these methods.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Sport Sciences
Daiane do Carmo Correa, Igor Moreira, Renan Resende, Andre Gustavo Andrade, Andressa Silva, Marco Tulio de Mello, Rafael Longhi, Dawit Albieiro Goncalves
Summary: The lack of studies on the effects of restrictive diets in paralympic athletes with Spinal Cord Injury justifies the need for this review. Spinal Cord Injury causes metabolic alterations, changes in digestive functions, and imbalance in body composition. Low carb diets and intermittent fasting can reduce body mass but may not be suitable for athletes during high-intensity training due to potential negative effects on performance and health.
RBNE-REVISTA BRASILEIRA DE NUTRICAO ESPORTIVA
(2022)
Article
Multidisciplinary Sciences
Ygor A. T. Martins, Renata L. F. Passos, Alice L. Marques, Dawit A. P. Goncalves, Thiago T. Mendes, Cristian Nunez-Espinosa, Luiz O. C. Rodrigues, Samuel P. Wanner, Michele M. Moraes, Rosa M. E. Arantes, Danusa D. Soares
Summary: This study evaluated the influence of camping in Antarctica on physical performance and exercise-induced thermoregulatory responses. The results showed that camping in Antarctica improved participants' performance and elicited heat-related adaptations. Despite the acclimatization, participants did not report differences in thermal sensation and comfort.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)