Article
Cardiac & Cardiovascular Systems
Deborah Peana, Luis Polo-Parada, Timothy L. Domeier
Summary: TRPV4 contributes to pro-arrhythmic cardiomyocyte Ca2+ signalling, electrophysiological abnormalities, and ventricular arrhythmia in the aged mouse heart.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biology
Xueyong Wang, Murad Nawaz, Chris DuPont, Jessica H. Myers, Steve Ra Burke, Roger A. Bannister, Brent D. Foy, Andrew A. Voss, Mark M. Rich
Summary: Excitation-contraction coupling is the process of converting electrical excitation of muscle into force generation. Depolarization of skeletal muscle can lead to failure of ECC, specifically the failure to generate calcium transients. Different AP properties, such as AP peak and AP integral, play important roles in different steps of ECC, including AP conduction and calcium release.
Review
Physiology
Walter C. Thompson, Paul H. Goldspink
Summary: This review focuses on the crucial role of 14-3-3 proteins in regulating excitation-contraction coupling in muscle, highlighting the need for further investigation into their mechanistic actions in force generation.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Di Lang, Roman Y. Medvedev, Lucas Ratajczyk, Jingjing Zheng, Xiaoyu Yuan, Evi Lim, Owen Y. Han, Hector H. Valdivia, Alexey Glukhov
Summary: This study provides a detailed characterization of the region-specific distribution of the transversal-axial tubule system (TATS) in mouse and human atrial myocardium, highlighting its structural foundation for anatomical heterogeneity of Ca2+ dynamics and contractility in the atria.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Toxicology
Joshua A. Keefe, Oliver M. Moore, Kevin S. Ho, Xander H. T. Wehrens
Summary: This review provides a comprehensive overview of the roles of Ca2+-handling proteins in healthy cardiac function and the mechanisms by which mutations in these proteins contribute to inherited arrhythmias. The major Ca2+ channels and Ca2+-sensitive regulatory proteins involved in cardiac excitation-contraction coupling are discussed, with special emphasis on the function of the RyR2 macromolecular complex. Inherited arrhythmia disorders caused by mutations in Ca2+-handling proteins are also discussed.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Physiology
Young Keul Jeon, Jae Won Kwon, Jihyun Jang, Seong Woo Choi, Joohan Woo, Su Han Cho, Byeong Il Yu, Yang Sook Chun, Jae Boum Youm, Yin Hua Zhang, Sung Joon Kim
Summary: Right ventricular cardiomyocytes have shorter action potential and smaller shortening compared to left cardiomyocytes. The lower expression of Ca2+-binding troponin in right ventricular cardiomyocytes may explain the interventricular differences in excitation-contraction coupling.
JOURNAL OF GENERAL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lei Yang, Rong-Chang Li, Bin Xiang, Yi-Chen Li, Li-Peng Wang, Yun-Bo Guo, Jing-Hui Liang, Xiao-Ting Wang, Tingting Hou, Xin Xing, Zeng-Quan Zhou, Haihong Ye, Ren-Qing Feng, Edward G. Lakatta, Zhen Chai, Shi-Qiang Wang
Summary: The contraction of heart cells is regulated by the signaling interaction between LCCs and RyRs, which is influenced by the nanodistance between JPH2 in the SR and CAV3 in the TT. Our study revealed that SRF and myocardin concurrently regulate the expression of JPH2 and CAV3, leading to enhanced efficiency of LCC-RyR signaling and compensation for LCC down-regulation during hibernation, maintaining heart power and avoiding calcium overload.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Daiki Watanabe, Ryo Ikegami, Yutaka Kano
Summary: This study investigated the mechanisms underlying faster force recovery from eccentric contractions in female mice compared to male mice. Superior mitochondrial responses and the contribution of estrogen were found to play a significant role in the faster recovery of force in females. These findings highlight the importance of mitochondrial function and estrogen in sex differences in force recovery.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Zheng Fang Yang, Pankaj Panwar, Ciaran R. McFarlane, Wietske E. Tuinte, Marta Campiglio, Filip Van Petegem
Summary: Junctophilins (JPH) are proteins that connect the plasma membrane and the endoplasmic or sarcoplasmic reticulum, facilitating communication between proteins in different membranes. This study presents crystal structures of two JPH isoforms, revealing their importance in muscle excitation-contraction coupling. Various mutations in JPH2 and the L-type calcium channel affect their interaction and have been linked to cardiomyopathy and cardiac arrhythmia, respectively.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Xin Jin, Matthew Amoni, Guillaume Gilbert, Eef Dries, Rosa Donate Puertas, Ashutosh Tomar, Chandan K. Nagaraju, Ankit Pradhan, David I. Yule, Tobie Martens, Roxane Menten, Pieter Vanden Berghe, Filip Rega, Karin Sipido, H. Llewelyn Roderick
Summary: The interaction between InsP(3)R and RyR in heart failure plays a central role in inducing arrhythmias, providing potential therapeutic targets.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhilin Qu, Dasen Yan, Zhen Song
Summary: This article reviews the progress and challenges in modeling intracellular calcium cycling in the cardiac system. The calcium release channels in cardiac myocytes form a network that gives rise to various dynamic processes. Modeling the intracellular calcium cycling dynamics in the cardiac system is challenging due to its complexity.
Review
Medicine, General & Internal
Qing He, Yixia Lin, Ye Zhu, Lang Gao, Mengmeng Ji, Li Zhang, Mingxing Xie, Yuman Li
Summary: Right ventricular-pulmonary artery coupling refers to the relationship between RV contractility and RV afterload. RV-PA uncoupling leads to RV dysfunction and right heart failure. Accurate evaluation of RV-PA coupling is important for patient assessment, clinical decision making, risk stratification, and prognosis judgment in cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Jaime Balderas-Villalobos, J. M. L. Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Rafael J. Ramirez, Alex Y. Tan, Karoly Kaszala, Montserrat Samso, Jose F. Huizar, Jose M. Eltit
Summary: Premature ventricular contractions (PVCs) are common ventricular arrhythmias that can enhance contractility acutely but lead to cardiomyopathy over time. Altered Ca2+ reuptake, as observed in PVC-CM, may contribute to contractile dysfunction. Study findings suggest delayed Ca2+ reuptake, reduced SERCA2 activity, and altered expression and phosphorylation of SERCA2 and PLB in PVC-CM. These alterations moderately contribute to functional adaptations in PVC-CM.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Sport Sciences
Jeppe F. Vigh-Larsen, Niels Ortenblad, Joachim Nielsen, Ole Emil Andersen, Kristian Overgaard, Magni Mohr
Summary: The study investigated the relationship between muscle glycogen content and localization and high-intensity exercise performance. The results showed that changes in muscle glycogen levels can affect high-intensity exercise performance, especially at the single-fiber and subcellular levels. Additionally, carbohydrate intake also influences ratings of perceived exertion and repeated sprint ability.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Cardiac & Cardiovascular Systems
David Bode, Natale P. L. Rolim, Tim Guthof, Niklas Hegemann, Paulina Wakula, Uwe Primessnig, Anne Marie Ormbostad Berre, Volker Adams, Ulrik Wisloff, Burkert M. Pieske, Frank R. Heinzel, Felix Hohendanner
Summary: In a metabolic rat model of HFpEF, impaired Ca2+ release was observed under baseline conditions. HIIT and MICT had different effects on Ca2+ homeostasis, with MICT showing positive effects on stroke volume, end-diastolic volume, and cellular arrhythmogenicity.
Article
Neurosciences
Raphael Teixeira Rocha Melo, Laila Cristina Moreira Damazio, Maira de Castro Lima, Pablo Herthel de Carvalho, Vanessa Guedes Pereira, Barbara Silva Okano, Betania Souza Monteiro, Antonio Jose Natali, Ricardo Junqueira Del Carlo, Izabel Regina dos Santos Costa Maldonado
Summary: This study analyzed the impact of treadmill training on muscle fiber atrophy and motor performance in rats after cerebral ischemia induction. The results showed that low-intensity exercise can reduce muscle fiber atrophy and improve motor performance.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Aline Rosignoli da Conceicao, Kelly A. Dias, Stephanie Michelin Santana Pereira, Luis Claudio Saraiva, Livya Alves Oliveira, Eliana Carla Gomes de Souza, Reggiani Vilela Goncalves, Sergio Luis Pinto da Matta, Antonio J. Natali, Hercia Stampini D. Martino, Ceres Mattos Della Lucia
Summary: The study showed that the combination of whey protein concentrate and curcumin can reduce blood glucose levels, oxidative damage, and inflammatory responses, which helps mitigate the effects of exhaustive physical exercise in swimming.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Sport Sciences
Victor Neiva Lavorato, Denise Coutinho de Miranda, Filipe Rios Drummond, Leonardo Matheus Teixeira Rezende, Maria do Carmo Gouveia Peluzio, Marcelo Eustaquio Silva, Antonio Jose Natali
Summary: The study found that acai consumption reduced serum total cholesterol levels, while AET increased exercise capacity and decreased body fat. Both AET and acai consumption reduced the concentrations of aspartate aminotransferase and TBARS, and also decreased the degree of macrovesicular steatosis. However, the combination of acai consumption and AET did not have additional effects on the development of NAFLD induced by a high-fat diet in rats.
SPORT SCIENCES FOR HEALTH
(2022)
Article
Medicine, Research & Experimental
Pedro Z. Suarez, Antonio J. Natali, Jose G. Mill, Leonardo M. T. de Rezende, Leoncio L. Soares, Filipe R. Drummond, Lucas C. C. Cardoso, Emily C. C. Reis, Victor N. Lavorato, Miguel A. Carneiro-Junior
Summary: This study aimed to investigate the effects of moderate-intensity continuous (MICT) and high-intensity interval (HIIT) aerobic training on cardiac morphology and function and the mechanical properties of single cardiomyocytes in spontaneously hypertensive rats (SHR). The results showed that both training programs led to beneficial adaptations to cardiac morphology, function, and mechanical properties in SHR.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Victor Hugo Antonio Joaquim, Noemy Pinto Pereira, Tiago Fernandes, Edilamar Menezes Oliveira
Summary: Circular RNAs (circRNAs) are endogenous noncoding RNAs (ncRNAs) that play various roles, mainly involving microRNAs (miRNAs) and RNA-binding proteins. With cardiovascular diseases (CVDs) being the leading cause of global death, it is crucial to develop new therapies and strategies, such as gene therapies or nonpharmacological interventions like physical exercise, for the alleviation of these diseases. Increasing evidence suggests that ncRNAs, including circRNAs, could serve as promising targets for the diagnosis and treatment of CVDs. However, little is known about the role of circRNAs in CVDs compared to miRNAs and lncRNAs. In this mini review, we focus on the mechanisms of circRNAs and their involvement in CVDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Natan D. D. da Silva Jr, Aluisio Andrade-Lima, Marcel R. R. Chehuen, Anthony S. S. Leicht, Patricia C. C. Brum, Edilamar M. M. Oliveira, Nelson Wolosker, Bruno R. A. Pelozin, Tiago Fernandes, Claudia L. M. Forjaz
Summary: Peripheral artery disease (PAD) patients have reduced muscle capillary density. Walking training (WT) promotes angiogenesis in PAD-affected muscle by increasing the gastrocnemius capillary-fiber ratio and the expression of miRNA-126 and vascular endothelium growth factor (VEGF) while decreasing the expression of PI3KR2. These findings suggest that miRNA-126 may play a role in this adaptation by inhibiting PI3KR2 and enabling the progression of the VEGF signaling pathway.
Article
Engineering, Biomedical
Ana Paula de Souza, Quenaz B. Soares, Eduardo M. A. M. Mendes, Leonardo B. Felix
Summary: This study investigates Auditory Selective Attention (ASA) using stimuli with AM modulation and spatial coherence to identify optimal combinations of electrodes and evaluate repetition rates and intervals in an inter-individual approach. The best result achieved an average hit rate of 75% and an information transfer rate (ITR) of 2.217 bits/min using AM stimuli and a combination of frontal and prefrontal electrodes with a 5-second interval between repetitions. These findings suggest the potential for a vision-free BCI that caters to individual differences and allows for communication through selective auditory attention without prior training.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Materials Science, Multidisciplinary
Luiz Otavio Guimaraes-Ervilha, Leoncio Lopes Soares, Isabela da Silva Pereira Bento, Renner Philipe Rodrigues Carvalho, Thaina Iasbik Lima, Fernanda Carolina Ribeiro Dias, Daniel Silva Sena Bastos, Jamile Fernanda Silva Cossolin, Ana Claudia Ferreira Souza, Emily Correna Carlo Reis, Jose Eduardo Serrao, Antonio Jose Natali, Mariana Machado-Neves
Summary: Pulmonary arterial hypertension (PAH) is characterized by elevated arterial pressure and vascular resistance. PAH may cause alterations in the microcirculation of several organs, including the kidney, liver, brain, and testes. This study investigated the impact of PAH on testicular morphology and function and found that PAH has deleterious effects on these parameters. However, resistance exercise training (RT) was shown to attenuate the negative effects of PAH on testicular parameters and improve testosterone levels.
MICROSCOPY AND MICROANALYSIS
(2023)
Review
Physiology
Filipe Rios Drummond, Luciano Bernardes Leite, Denise Coutinho de Miranda, Lucas Rios Drummond, Victor Neiva Lavorato, Leoncio Lopes Soares, Clovis Andrade Neves, Antonio Jose Natali
Summary: Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Filipe Rios Drummond, Leoncio Lopes Soares, Tiago Ferreira Leal, Luciano Bernardes Leite, Leonardo Mateus Teixeira Rezende, Meilene Ribeiro Fidelis, Victor Neiva Lavorato, Denise Coutinho Miranda, Miguel Araujo Carneiro Jr, Mariana Machado Neves, Luciane Carla Alberici, Emily Correna Carlo Reis, Clovis Andrade Neves, Antonio Jose Natali
Summary: The effects of voluntary running on skeletal muscle in rats with pulmonary arterial hypertension (PAH) were examined. Rats were induced with PAH using a single injection of monocrotaline (MCT). Sedentary hypertensive rats showed reduced physical exertion tolerance throughout the experiment, while those in the sedentary control, exercise control, exercise hypertension, and median exercise groups maintained or increased their tolerance. Muscle citrate synthase activity did not differ between groups. The EH group showed a higher survival time compared to the SH group. The EM and EH groups had a higher proportion of muscle fiber and lower extracellular matrix compared to the SH group. Gene expression analysis revealed lower PGC1-a expression and higher VEGF expression in the SH and EM groups compared to the SC group, with elevated PGC1-a expression in the EH group. The carbonylated protein levels did not differ between groups, but the TNF-a/IL-10 ratio was increased in the EH group. In conclusion, voluntary running improves the survival and physical tolerance in rats with MCT-induced PAH by increasing the proportion of muscle fiber and affecting gene expression of inflammatory and mitochondrial biogenesis markers.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Filipe Rios Drummond, Lucas Rios Drummond, Helton Oliveira Campos, Joao Guilhermo Rios Pimenta Fernandes, Mateus da Costa Monteiro, Henrique Fernandes Gerspacher Lara, Tito Cardoso de Almeida Mafra, Victor Neiva Lavorato, Andre Bahia Pereira, Laura Hora Rios Leite, Maristela de Oliveira Poletini, Candido Celso Coimbra
Summary: This study systematically analyzed the effects of melatonin supplementation on physical performance and recovery, as well as the impact of exercise on melatonin secretion. The results showed that melatonin supplementation did not improve aerobic or strength performance, but it did enhance post-exercise recovery. Furthermore, exercise did not immediately affect melatonin secretion.
Article
Biology
J. M. C. R. J. Bertoldi, R. Kindlovits, H. N. M. Rocha, C. Fernandes-Santos, J. L. P. Gomes, E. M. Oliveira, I. C. Muniz, M. M. Santos, J. F. Pereira, N. G. Rocha, A. C. L. da Nobrega, R. F. Medeiros
Summary: L-arginine and chronic exercise reduce oxidative stress. The aim of this research was to explore the effects of L-arginine supplementation and aerobic training on systemic oxidative stress and their consequences on cardiomyocytes during cardiometabolic disease caused by excessive fructose. The findings showed that moderate aerobic exercise reduced lipid peroxidation, and both training and L-arginine prevented metabolic changes caused by excess fructose. Myocardial vascularization was impaired by fructose, and cardiomyocyte hypertrophy appeared to be influenced by pro-inflammatory and oxidative environments.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Ian Alves Prado, Luciano Bernardes Leite, Davi Correia da Silva, Daniela Gomes Rosado, Victor Neiva Lavorato
Summary: In football, the effect of relative age plays a role in the success of players, especially those born in the first months of the year. A study conducted during the 2019 FIFA U-17 Men's World Cup revealed that the effect of relative age was present among the athletes, with variations observed between players in different positions.
REVISTA BRASILEIRA DE FUTSAL E FUTEBOL
(2022)
