Article
Hematology
Rajeev Malhotra, Christopher J. Nicholson, Dongyu Wang, Vijeta Bhambhani, Samantha Paniagua, Charles Slocum, Haakon H. Sigurslid, Christian L. Lino Cardenas, Rebecca Li, Sophie L. Boerboom, Yin-Ching Chen, Shih-Jen Hwang, Chen Yao, Fumito Ichinose, Donald B. Bloch, Mark E. Lindsay, Gregory D. Lewis, Jayashri R. Aragam, Udo Hoffmann, Gary F. Mitchell, Naomi M. Hamburg, Ramchandran S. Vasan, Emelia J. Benjamin, Martin G. Larson, Warren M. Zapol, Susan Cheng, Jason D. Roh, Christopher J. O'Donnell, Christopher Nguyen, Daniel Levy, Jennifer E. Ho
Summary: This study finds an association between ucMGP levels and arterial stiffness, as well as future HFpEF. Experimental studies using mice also support the link between Mgp heterozygosity and arterial stiffness. These findings suggest a potential role of therapeutic targeting MGP in HFpEF.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Carla Serra, Alessandro Sestu, Veronica Murru, Giulia Greco, Matteo Vacca, Angelo Scuteri
Summary: According to this study, alterations in heart rate variability (HRV) are associated with arterial aging. Lower sympathetic and parasympathetic activity in women are significantly associated with arterial stiffening, while there is no significant association in men.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lajos Fehervari, Attila Frigy, Lorand Kocsis, Istvan Adorjan Szabo, Timea Magdolna Szabo, Melinda Urkon, Zita Jako, Elod Erno Nagy
Summary: The study aimed to evaluate the clinical and biomarker correlates of arterial stiffness (AS) in patients with heart failure with reduced ejection fraction (HFrEF). The results showed that OPG and cIMT were significantly associated with PWV, indicating that elevated AS in HFrEF may be related to these factors.
Article
Multidisciplinary Sciences
Kasper Kyhl, Sebastian von Huth, Annemie Bojer, Carsten Thomsen, Thomas Engstrom, Niels Vejlstrup, Per Lav Madsen
Summary: The study found that age-related aortic stiffening may impact LV diastolic function, highlighting the existence of atrio-ventriculo-arterial coupling.
SCIENTIFIC REPORTS
(2021)
Article
Sport Sciences
Yuto Hashimoto, Takanobu Okamoto
Summary: The study investigated the relationship between arterial stiffness and left ventricular diastolic function in endurance-trained athletes. It found that lower arterial stiffness was associated with higher left ventricular diastolic function in these athletes.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Minkwan Kim, Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Summary: This study used a large sample size to confirm the association between arterial stiffness and left ventricular diastolic function, and identified certain related parameters.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Cardiac & Cardiovascular Systems
Danish Ali, Patrick Tran, Stuart Ennis, Richard Powell, Scott McGuire, Gordon McGregor, Peter K. Kimani, Martin O. Weickert, Michelle A. Miller, Francesco P. Cappuccio, Prithwish Banerjee
Summary: This study finds that arterial stiffness increases as cardiovascular comorbidities accumulate in patients with heart failure, leading to an increased risk of heart failure. Arterial stiffness is associated with exercise capacity and cardiac function in heart failure patients.
Article
Hematology
Hongwei Zheng, Shouling Wu, Xiaokun Liu, Guoyu Qiu, Shuohua Chen, Yuntao Wu, Junjuan Li, Chunhui Yin, Qi Zhang
Summary: Arterial stiffness is independently associated with an increased risk of new-onset heart failure, regardless of age and blood pressure. This study provides important scientific evidence by investigating a large community population.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Zheng-Wei Chen, Chien-Ting Pan, Che-Wei Liao, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Shuo-Meng Wang, Ching-Chu Lu, Jeff S. Chueh, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin
Summary: This study compared the reversal of arterial stiffness in surgically and medically treated PA patients and identified predictors of effective medical treatment. The findings showed that adrenalectomy and medically treated PA patients with unsuppressed plasma renin activity (PRA) had an improvement in arterial stiffness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Lijuan Yang, Xiuqin Sun, Hong Tao, Yi Zhao
Summary: This study investigated the relationship between arterial stiffness, left ventricular diastolic dysfunction, and cardiovascular risk factors in patients with euthyroidism. The results showed a correlation between thyroid function, arterial stiffness, and left ventricular diastolic dysfunction. Further research is needed to confirm these associations.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, Mauro Feola
Summary: This study aimed to evaluate the prognostic role of arterial stiffness in heart failure patients. The results showed that arterial stiffness was inversely correlated with patient survival and could serve as a prognostic predictor. This study is important for understanding the pathogenesis and clinical outcome of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Rosaria Del Giorno, Ania Maddalena, Stefano Bassetti, Luca Gabutti
Summary: This systematic literature review examines the association between alcohol use and arterial stiffness. The results suggest a J-shaped relationship, where light-to-moderate alcohol consumption is associated with lower arterial stiffness values, while high doses of alcohol accelerate arterial aging. Gender and age may also influence this association.
Article
Cardiac & Cardiovascular Systems
Qian Wang, Xinxin Xu, Xue Geng, Haijuan Hu, Wei Cui
Summary: This study found an association between heart rate and brachial-ankle pulse wave velocity, with an increase in heart rate leading to higher pulse wave velocity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Vincenzo Russo, Erika Parente, Antonella Groppelli, Giulia Rivasi, Marco Tomaino, Alessio Gargaro, Daniele Giacopelli, Andrea Ungar, Gianfranco Parati, Artur Fedorowski, Richard Sutton, J. Gert van Dijk, Michele Brignole
Summary: This review discusses the timing of tilt-induced asystole and loss of consciousness (LOC) in tilt-testing methodology. The commonly used Italian protocol is not always followed strictly, allowing for reassessment of the incidence of asystole during early tilt-down compared to late, established LOC. Asystole is less common in early tilt down and decreases with increasing age, but more common if LOC is established as the test-end point, and it is age-independent. The review also highlights the usefulness of asystole occurrence as a guide for pacemaker therapy in highly symptomatic older vasovagal syncope patients.
Editorial Material
Cardiac & Cardiovascular Systems
Oliver O'Sullivan, Rienk Rienks, David Holdsworth, Constantinos H. Davos, Martin Halle, Alexander Bennett, Gianfranco Parati, Norbert Guettler, Edward Nicol
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gianfranco Parati, Alexandra Goncalves, David Soergel, Rosa Maria Bruno, Enrico Gianluca Caiani, Eva Gerdts, Felix Mahfoud, Lorenzo Mantovani, Richard J. McManus, Paola Santalucia, Thomas Kahan
Summary: Hypertension is a common and preventable risk factor for cardiovascular disease, but a large number of patients are undiagnosed or inadequately treated. A comprehensive approach is needed to improve hypertension management.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Daniela Lucini, Eleonora Pagani, Francesco Capria, Michele Galiano, Marcello Marchese, Stefano Cribellati, Gianfranco Parati
Summary: Workplace health promotion programs and services provided by insurers are important in fostering health and preventing chronic diseases. These programs should be tailored to meet the specific needs and characteristics of companies and employees. Age is an important factor to consider, as younger workers have different lifestyle patterns and stress levels compared to older workers.
Editorial Material
Cardiac & Cardiovascular Systems
Geza Halasz, Gianfranco Parati, Massimo F. Piepoli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Paola Faverio, Umberto Zanini, Anna Monzani, Gianfranco Parati, Fabrizio Luppi, Carolina Lombardi, Elisa Perger
Summary: The prevalence and impact of sleep-disordered breathing (SDB) in chronic respiratory infections, such as cystic fibrosis (CF), bronchiectasis, and mycobacterial infections, are reported in this narrative review. The common pathophysiological mechanisms underlying SDB onset in these infections include inflammation, nocturnal cough and pain, mucous plugs, ventilatory impairment, upper airway involvement, and comorbidities. SDB may affect approximately 50% of bronchiectasis patients and significantly impact the quality of life in both children and adults with CF. Routine assessment of SDB should be incorporated into the clinical evaluation of patients with CF from the early stages of the disease to avoid late diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Bashaaer Sharad, Giulia Rivasi, Viktor Hamrefors, Madeleine Johansson, Andrea Ungar, Richard Sutton, Michele Brignole, Gianfranco Parati, Artur Fedorowski
Summary: This study compared ambulatory blood pressure monitoring data between patients with reflex syncope and a control group. The findings showed that patients with reflex syncope had lower 24-hour systolic blood pressure, higher 24-hour diastolic blood pressure, and more frequent daytime drops in systolic blood pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Paolo Salvi, Andrea Grillo, Fausto Brunacci, Francesca Severi, Luca Montaguti, Sylvie Gautier, Lucia Salvi, Enzo Pretolani, Gianfranco Parati, Athanase Benetos
Summary: The study aimed to evaluate the microcirculatory adaptive mechanisms at different altitudes and found that high altitude causes important and significant microcirculatory adaptations, which should be considered when planning training and physical activity at altitude.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Pedicino, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Rocco Vergallo, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Peripheral Vascular Disease
Gianfranco Parati, Juan Eugenio Ochoa, Daniel T. Lackland
Article
Cardiac & Cardiovascular Systems
Damiano Magri, Giovanna Gallo, Massimo Piepoli, Elisabetta Salvioni, Massimo Mapelli, Carlo Vignati, Emiliano Fiori, Melwyn Luis Muthukkattil, Ugo Corra, Marco Metra, Stefania Paolillo, Antonello Maruotti, Pierfrancesco Alaimo Di Loro, Michele Senni, Rocco Lagioia, Domenico Scrutinio, Michele Emdin, Claudio Passino, Gianfranco Parati, Gianfranco Sinagra, Michele Correale, Roberto Badagliacca, Susanna Sciomer, Andrea Di Lenarda, Piergiuseppe Agostoni, Pasquale Perrone Filardi
Summary: This study found an association between chronotropic incompetence, exercise capacity, and cardiovascular death risk in patients with HFmrEF. Larger prospective studies are needed to determine the potential use of chronotropic incompetence in HFmrEF management.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carlo Vignati, Mauro Contini, Elisabetta Salvioni, Carolina Lombardi, Sergio Caravita, Grzegorz Bilo, Erik R. Swenson, Gianfranco Parati, Piergiuseppe Agostoni
Summary: Patients with chronic heart failure may safely spend time at altitudes <3500 m, but may experience decreased exercise capacity proportional to the severity of heart failure and altitude. Specialized 'hypoxic-tailored treatment' is necessary to avoid pharmacological interference with altitude adaptation mechanisms.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Simonetta Genovesi, Elena Tassistro, Giulia Lieti, Ilenia Patti, Marco Giussani, Laura Antolini, Antonina Orlando, Paolo Salvi, Gianfranco Parati
Summary: This study investigated the mechanical properties of different arteries and their influencing factors in children and adolescents at increased cardiovascular risk. The results showed that diastolic blood pressure and heart rate are associated with the distensibility of the upper limb vascular district, while systolic and diastolic blood pressure values and central obesity are associated with aortic stiffness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Correction
Cardiac & Cardiovascular Systems
Stephane Doutreleau, Mathilde Ulliel-Roche, Ivan Hancco, Sebastien Bailly, Laura Oberholzer, Paul Robach, Julien Brugniaux, Aurelien Pichon, Emeric Stauffer, Elisa Perger, Gianfranco Parati
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)