Article
Nutrition & Dietetics
Gianluca Gortan Cappellari, Aneta Aleksova, Matteo Dal Ferro, Antonio Cannata, Annamaria Semolic, Alberto Guarnaccia, Michela Zanetti, Mauro Giacca, Gianfranco Sinagra, Rocco Barazzoni
Summary: Skeletal muscle derangements in chronic heart failure (CHF), such as mitochondrial dysfunction and high reactive oxygen species (ROS) generation, lead to muscle wasting and reduced exercise capacity. 8-week n-3-PUFA dietary replacement normalizes mitochondrial dynamics, reduces oxidative stress, and preserves skeletal muscle mass in CHF.
Review
Nutrition & Dietetics
Antia Fernandez-Pombo, Gemma Rodriguez-Carnero, Ana I. Castro, Ana Canton-Blanco, Luisa M. Seoane, Felipe F. Casanueva, Ana B. Crujeiras, Miguel A. Martinez-Olmos
Summary: Chronic heart failure often leads to involuntary weight loss and muscle wasting, necessitating careful nutritional evaluation and treatment to prevent or improve cardiac cachexia and sarcopenia, as well as improve the course of the disease.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Evelien Van Roie, Charlotte Hiroux, Mathias Vanmunster, Walter Coudyzer, Frank Suhr, Stijn Bogaerts, Ruud Van Thienen, Katrien Koppo
Summary: The study found that while Ω-3 fatty acids contribute to increased muscle strength in older adults, they do not improve beneficial catabolic or inflammatory adaptations induced by resistance exercise. Changes in muscle quality, rather than muscle volume, might explain the gains in strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ana Cristina Simoes e Silva, Eduardo A. A. Oliveira, Wai W. W. Cheung, Robert R. H. Mak
Summary: Redox signaling alterations contribute to CKD-associated cachexia. This review summarizes studies on the redox pathophysiology in CKD-associated cachexia and muscle wasting, and discusses potential therapeutic approaches using antioxidant and anti-inflammatory molecules to restore redox homeostasis. Antioxidant molecules have been studied in experimental models and patients with CKD, and oxidative stress is increased in CKD due to factors such as uremic toxins, inflammation, and metabolic and hormone alterations. Rehabilitation and anti-inflammatory molecules have shown beneficial effects for CKD-associated cachexia, and experimental studies have shown the importance of oxidative stress through the use of antioxidant therapies. Further studies are needed for potential therapies involving antioxidant therapy.
Review
Cardiac & Cardiovascular Systems
Ethan R. Holder, Faisal J. Alibhai, Samantha L. Caudle, John C. McDermott, Stephanie W. Tobin
Summary: This review explores the potential for sex-specific differences in cardiac cachexia, summarizing the advantages and disadvantages of clinical methods used to measure muscle mass and function and providing alternative measurements that should be considered in preclinical studies. It also summarizes the sex-dependent effects on muscle wasting in preclinical models of heart failure, disuse, and cancer. Additionally, it discusses the endocrine function of the heart and outlines unanswered questions that could impact patient care directly.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Sport Sciences
Camila S. Padilha, Paola S. Cella, Patricia Chimin, Fabricio A. Voltarelli, Poliana C. Marinello, Mayra Tardelli de Jesus Testa, Philippe B. Guirro, Jose A. R. Duarte, Rubens Cecchini, Flavia A. Guarnier, Rafael Deminice
Summary: The study found that resistance training (RT) can prevent myofiber atrophy and reduce muscle strength in tumor-bearing rats, and this effect is associated with the activation of mTORC1. However, the preventive effect of RT on myofiber atrophy in tumor-bearing rats does not depend on the activation of mTORC1 and p70S6K.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Multidisciplinary Sciences
T. W. Jones, L. Eddens, J. Kupusarevic, D. C. M. Simoes, M. J. W. Furber, K. A. van Someren, G. Howatson
Summary: The study did not find support for a molecular interference effect in cyclists under controlled conditions. There was no intensity-dependent regulation of AMPK, nor differential activation of anabolism with the manipulation of endurance exercise intensity.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Paloma Pandhi, Koen W. Streng, Stefan D. Anker, John G. Cleland, Kevin Damman, Kenneth Dickstein, Pierpaolo Pellicori, Chim C. Lang, Leong Ng, Nilesh J. Samani, Faiez Zannad, Marco Metra, Patrick Rossignol, Gerasimos Filippatos, Dirk J. van Veldhuisen, Adriaan A. Voors, Jozine M. ter Maaten
Summary: Lower spot urinary creatinine is associated with smaller body dimensions, renal dysfunction, and more severe HF in patients with new-onset/WHF. Additionally, lower spot urinary creatinine is associated with an increased risk of weight loss and a poorer exercise capacity/quality of life, indicating it could be a novel marker for assessing muscle wasting in HF patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Geriatrics & Gerontology
Rebecca E. Schmitt, Aneesha Dasgupta, Paige C. Arneson-Wissink, Srijani Datta, Alexandra M. Ducharme, Jason D. Doles
Summary: Up to half of sepsis survivors suffer from chronic critical illness (CCI), which includes multiple physical and mental disabilities that hinder their return to regular activities. A study has shown that muscle stem cells (MuSCs) and muscle regeneration play crucial roles in post-sepsis muscle recovery and that sepsis triggers morphological, functional, and transcriptional changes in MuSCs.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Immunology
Anna Klimiuk, Anna Zalewska, Malgorzata Knapp, Anna Skutnik-Radziszewska, Mateusz Maciejczyk
Summary: Heart failure (HF) not only affects cardiovascular function but also leads to various oral and salivary gland pathologies. This study evaluated the correlation between salivary inflammatory and anti-inflammatory factors and hyposalivation in HF patients, as well as the use of salivary biomarkers in HF diagnostics. The results showed significantly higher levels of pro-inflammatory cytokines, anti-inflammatory cytokines, Th1, Th2, Th17, chemokines, and growth factors in the saliva of HF patients. However, there was no dominance of either branch of the immune response. The concentration of selected biomarkers was significantly higher in HF patients with salivary gland dysfunction compared to patients with normal saliva secretion and healthy subjects. Multivariate regression analysis showed that salivary cytokines, chemokines, and growth factors were closely related to salivary gland function. Using receiver operating characteristic (ROC) analysis, salivary TNF-alpha, INF-gamma, IL-12, and EOTAXIN/CCL11 were identified as the most effective markers for differentiating HF patients with hyposalivation from those with normal saliva secretion and controls. Interestingly, some pro- and anti-inflammatory mediators were found to have higher concentrations in saliva than in plasma. However, the diagnostic utility of salivary cytokines and chemokines in the differential diagnosis of HF patients was not confirmed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Yan Zhang, Jia Zhang, Wenqing Ni, Xueli Yuan, Hongmin Zhang, Ping Li, Jian Xu, Zhiguang Zhao
Summary: Sarcopenia is prevalent among patients with heart failure, with a pooled prevalence of 34%. The prevalence is higher in hospitalized patients compared to ambulatory patients. Early detection and intervention are important to improve patient outcomes.
Article
Cell Biology
Traci L. L. Parry, Louisa Tichy, Jason T. T. Brantley
Summary: Cancer cachexia is a common metabolic wasting syndrome in cancer patients, and there is currently no clear diagnostic criteria for it. Aerobic exercise has been shown to slow down its development and attenuate muscle loss. However, the optimal timing, duration, and intensity of exercise as a protective measure against cancer cachexia are still debated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Naoyuki Kawao, Miku Kawaguchi, Takashi Ohira, Hiroki Ehara, Yuya Mizukami, Yoshimasa Takafuji, Hiroshi Kaji
Summary: Chronic renal failure reduces muscle mass, grip strength, and cortical BMD in mice, while also decreasing the expression of the myokine irisin in the gastrocnemius muscles. Irisin may play a role in cortical bone loss induced by renal failure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Medicine, General & Internal
Jenjiratchaya Thanapholsart, Ehsan Khan, Tevfik F. Ismail, Geraldine A. Lee
Summary: Cardiac cachexia is a complex muscle wasting process associated with chronic heart failure, resulting in weight loss, decreased physical activity, and reduced quality of life. This review discusses the pathophysiology of cardiac cachexia, including hormonal changes, mechanisms of muscle wasting, and gastrointestinal abnormalities. These pleiotropic mechanisms highlight the intricate interplay between affected systems, contributing to the clinical challenge of managing cardiac cachexia. The review provides a summary of the current understanding of cardiac cachexia and identifies gaps for further research in this field.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Henning T. Langer, Agata A. Mossakowski, Suraj Pathak, Mark Mascal, Keith Baar
Summary: CBD has shown to decrease pro-inflammatory signaling in the tibialis anterior muscle of rats without affecting the anabolic response to exercise. However, higher levels of p62 were observed in the CBD group and one animal experienced serious side effects. Further research is needed to determine if these effects extend to improved recovery without altering adaptation in humans.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2021)
Article
Endocrinology & Metabolism
John O. Ogunbileje, Craig Porter, David N. Herndon, Tony Chao, Doaa R. Abdelrahman, Anastasia Papadimitriou, Maria Chondronikola, Teresa A. Zimmers, Paul T. Reidy, Blake B. Rasmussen, Labros S. Sidossis
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Cell Biology
Craig Porter, David N. Herndon, Maria Chondronikola, Tony Chao, Palam Annamalai, Nisha Bhattarai, Manish K. Saraf, Karel D. Capek, Paul T. Reidy, Alexes C. Daquinag, Mikhail G. Kolonin, Blake B. Rasmussen, Elisabet Borsheim, Tracy Toliver-Kinsky, Labros S. Sidossis
Review
Nutrition & Dietetics
Paul T. Reidy, Blake B. Rasmussen
JOURNAL OF NUTRITION
(2016)
Article
Neurosciences
Christopher S. Fry, Craig Porter, Labros S. Sidossis, Christopher Nieten, Paul T. Reidy, Gabriel Hundeshagen, Ronald Mlcak, Blake B. Rasmussen, Jong O. Lee, Oscar E. Suman, David N. Herndon, Celeste C. Finnerty
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Review
Endocrinology & Metabolism
Tatiana Moro, Scott M. Ebert, Christopher M. Adams, Blake B. Rasmussen
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Physiology
Paul T. Reidy, Michael S. Borack, Melissa M. Markofski, Jared M. Dickinson, Christopher S. Fry, Rachel R. Deer, Elena Volpi, Blake B. Rasmussen
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Geriatrics & Gerontology
Ted G. Graber, Brandy L. Rawls, Bing Tian, William J. Durham, Camille R. Brightwell, Allan R. Brasier, Blake B. Rasmussen, Christopher S. Fry
EXPERIMENTAL GERONTOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Ted G. Graber, Christopher S. Fry, Camille R. Brightwell, Tatiana Moro, Rosario Maroto, Nisha Bhattarai, Craig Porter, Maki Wakamiya, Blake B. Rasmussen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Physiology
Kaleen M. Lavin, Brandon M. Roberts, Christopher S. Fry, Tatiana Moro, Blake B. Rasmussen, Marcas M. Bamman
Article
Physiology
Tatiana Moro, Camille R. Brightwell, Elena Volpi, Blake B. Rasmussen, Christopher S. Fry
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Editorial Material
Nutrition & Dietetics
Blake B. Rasmussen, Christopher M. Adams
JOURNAL OF NUTRITION
(2020)
Article
Geriatrics & Gerontology
Ted G. Graber, Rosario Maroto, Christopher S. Fry, Camille R. Brightwell, Blake B. Rasmussen
Summary: The study aimed to develop a Comprehensive Functional Assessment Battery (CFAB) using a small animal model to assess physical function and exercise capacity in mice of different age groups. Results showed an overall age-related decline in physical function in mice, with some individual mice retaining functionality similar to younger mice.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Michael S. Borack, Jared M. Dickinson, Christopher S. Fry, Paul T. Reidy, Melissa M. Markofski, Rachel R. Deer, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen
Summary: The study investigated the conservation of the amino acid sensing mechanism in human skeletal muscle by treating subjects with chloroquine and found that chloroquine did not inhibit amino acid-induced activation of mTORC1 signaling and skeletal MPS in humans as it does in C2C12 muscle cells. Different in vivo experimental approaches are needed to confirm the precise role of the lysosome and amino acid sensing in human skeletal muscle.
NUTRITION & METABOLISM
(2021)
Article
Sport Sciences
Camille R. Brightwell, Melissa M. Markofski, Tatiana Moro, Christopher S. Fry, Craig Porter, Elena Volpi, Blake B. Rasmussen
TRANSLATIONAL SPORTS MEDICINE
(2019)
Article
Physiology
Paul T. Reidy, Christopher S. Fry, Jared M. Dickinson, Micah J. Drummond, Blake B. Rasmussen
PHYSIOLOGICAL REPORTS
(2017)
