Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 110, Issue 6, Pages 1572-1581Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00117.2011
Keywords
maturation; background strain; transgenic mice; respiratory rhythmogenesis; respiratory regulations
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Funding
- Centre National de la Recherche Scientifique, University Aix-Marseille II III [UMR 6231]
- Agence Nationale de la Recherche Prageder
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Mouse readiness for gene manipulation allowed the production of mutants with breathing defects reminiscent of breathing syndromes. As C57BL/6J and FVB/N inbred strains were often used as background strains for producing mutants, we compared their breathing pattern from birth onwards. At birth, in vivo and in vitro approaches revealed robust respiratory rhythm in FVB/N, but not C57BL/6J, neonates. With aging, rhythm robustness difference persisted, and interstrain differences in tidal volume, minute ventilation, breathing regulations, and blood-gas parameters were observed. As serotonin affected maturation and function of the medullary respiratory network, we examined the serotoninergic metabolism in the medulla of C57BL/6J and FVB/N neonates and aged mice. Interstrain differences in serotoninergic metabolism were observed at both ages. We conclude that differences in serotoninergic metabolism possibly contribute to differences in breathing phenotype of FVB/N and C57BL/6J mice.
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