Article
Cell Biology
Jia Shi, Yi Yang, Ya-Nan Wang, Qing Li, Xue Xing, An-Ying Cheng, Xiao-Na Zhan, Jie Li, Gang Xu, Fan He
Summary: This study reveals the association between metabolism and the progression of vascular calcification in chronic kidney disease (CKD). High phosphate and uremic serum enhance mitochondrial respiration capacity in vascular smooth muscle cells (VSMCs), while glycolysis level remains unchanged. Suppression of cytochrome c oxidase (COX) activity attenuates vascular calcification.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Guoliang Zhu, Hui Zeng, Shuangbo Zhang, Jana Juli, Linhua Tai, Danyang Zhang, Xiaoyun Pang, Yan Zhang, Sin Man Lam, Yun Zhu, Guohong Peng, Hartmut Michel, Fei Sun
Summary: The study elucidated the structure of a hyperthermophilic bacterium cytochrome c oxidase, revealing a unique dimeric structure essential for naphthoquinol binding. This suggests an evolutionary adaptation of the oxidase to its hyperthermophilic environment, shedding light on the structural variation of cytochrome c oxidases in different species.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M. Pentimalli, Rene Juettner, Petar Glazar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie-Therese Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, Tobias Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, Michela Di Virgilio, Johannes A. Mayr, Saskia B. Wortmann, Josef Priller, Michael Gotthardt, Dean P. Jones, Ertan Mayatepek, Werner Stenzel, Sebastian Diecke, Ralf Kuehn, Erich E. Wanker, Nikolaus Rajewsky, Markus Schuelke, Alessandro Prigione
Summary: Leigh syndrome (LS) is a severe neurometabolic disorder lacking effective models. This study found that LS carrying mutations in SURF1 gene exhibit impaired neuronal morphogenesis due to metabolic deficiencies.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Hongjiao Gao, Qiao Xiang, Jindie Li, Meng Yu, Yalin Lan, Junqiang Ba, Yan Liu, Haoming Tian
Summary: Patients with Sheehan's syndrome are prone to elevated serum muscle enzymes, which may be associated with hypothyroidism and hyponatremia. Routine monitoring of serum muscle enzymes is important for patient management.
Article
Multidisciplinary Sciences
Michael B. Powner, Glen Jeffery
Summary: Systemic glucose levels can be modulated through specific solar wavelengths that affect mitochondrial metabolism. Different wavelengths of light have opposing effects on mitochondrial respiration, with longer wavelengths increasing ATP production and shorter wavelengths suppressing metabolism. This study in a bumblebee model found that manipulating mitochondrial activity with specific wavelengths of light significantly altered circulating glucose concentration. This research contributes to our understanding of how light can affect systemic metabolism.
Article
Cell Biology
Sue Ellen Brand, Martha Scharlau, Lois Geren, Marissa Hendrix, Clayre Parson, Tyler Elmendorf, Earl Neel, Kaila Pianalto, Jennifer Silva-Nash, Bill Durham, Francis Millett
Summary: Cytochrome c (Cc) has undergone accelerated evolution from anthropoid primates to humans, with several amino acid changes occurring near the binding site of the Cc:CcO complex. These changes affect the dissociation constant and the role of phosphorylation in regulating mitochondrial electron transport and membrane potential.
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xu Sun, Qiong Liu, Dan Li, Erkang Wang, Jin Wang
Summary: Most nanozyme research focuses on oxidase and peroxidase capabilities, but this study explores N, P, or S doped carbon nanotubes (CNTs) as enzyme mimics of NADH oxidase and Cyt c reductase. Doping N significantly enhances the NADH oxidase-like activity of CNTs, increasing the maximum initial velocity by 4.28 times. NAD(+) is produced as a biologically active product during NADH oxidation, while oxygen is selectively reduced to water or hydrogen peroxide, similar to natural NADH oxidase. Additionally, carbon nanotubes can promote electron transfer from NADH to Cyt c, mimicking the properties of Cyt c reductase.
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xu Sun, Qiong Liu, Dan Li, Erkang Wang, Jin Wang
Summary: In this study, N, P, or S doped carbon nanotubes (CNTs) were used as enzyme mimics of nicotinamide adenine dinucleotide (NADH) oxidase and cytochrome c (Cyt c) reductase. Through N doping, the NADH oxidase-like activity of CNTs was significantly enhanced, with a 4.28-fold increase in the maximum initial velocity for N-doped CNTs (N-CNTs) compared to the unmodified ones. Biologically active NAD* was produced during NADH oxidation, and oxygen was selectively reduced to water or hydrogen peroxide, consistent with natural NADH oxidase. Additionally, it was discovered for the first time that carbon nanotubes can facilitate the electron transfer from NADH to Cyt c, mimicking the properties of Cyt c reductase.
Review
Chemistry, Medicinal
Mohammad Beba, Hamed Mohammadi, Cain C. T. Clark, Kurosh Djafarian
Summary: The study aimed to assess the effects of curcumin supplementation on exercise-induced muscle damage, muscle soreness, inflammation, muscle strength, and joint flexibility. The meta-analysis showed that curcumin supplementation significantly reduced creatine kinase activity, muscle soreness, and TNF-alpha concentration, and improved muscle strength and range of motion. However, no significant changes were found in IL-6 and IL-8 levels. Further high-quality studies are needed to evaluate the long-term effects and safety of curcumin supplementation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Longlong Gong, Zhengzhi Zou, Lei Liu, Shuang Guo, Da Xing
Summary: The study showed that PBMT improved glucose metabolism in diabetic mouse models by increasing ATP and ROS production through elevating CcO activity in skeletal muscle, leading to accelerated glucose uptake and glycogen synthesis.
Article
Multidisciplinary Sciences
Agnes Moe, Justin Di Trani, John L. Rubinstein, Peter Brzezinski
Summary: Energy conversion in aerobic organisms involves electron transfer from low-potential donors to dioxygen through the membrane-bound respiratory chain. The formation of supercomplex CIII2CIV1/2 facilitates electron transfer by two-dimensional diffusion of cyt. c, increasing QH(2):O-2 oxidoreductase activity and suggesting a regulatory role for supercomplex formation in the respiratory chain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Mariyah Hidayat, Khalid Pervez Lone
Summary: The intake of melatonin during pregnancy and lactation has been found to protect the brains of offspring from apoptosis caused by maternal hypothyroidism.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Cell Biology
Nathaniel J. Pope, Michael L. Denton
Summary: Photobiomodulation refers to using low-power red to near-infrared light to stimulate positive biological effects. The molecular mechanisms of these effects are poorly understood, although it is postulated that light absorption by cytochrome c oxidase initiates a signaling cascade, resulting in improved cellular function. This study found that near-infrared light exposure enhanced the activity of complex IV, while depressing the activity of complex III and showed no effect on complex II. The effect on complex IV did not exhibit irradiance reciprocity, suggesting a non-photochemical basis for the enhancement.
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xiuna Jia, Dan Li, Jin Wang, Erkang Wang
Summary: Recently, there has been increased attention on the study of mimic enzymes. However, research on the oxidoreductase activity of electron mediators in the biological respiratory chain is still limited. In this study, we found that cadmium sulfide (CdS) nanorods can catalyze the formation of superoxide anions and exhibit NADH oxidase-like activity and Cyt c reductase-like activity. This provides a new perspective for the in-depth study of new nanozymes.
Article
Chemistry, Multidisciplinary
Wenshu Cong, Li Meng, Yuanjie Pan, Han Wang, Jiahui Zhu, Yuanyu Huang, Qingli Huang
Summary: Population aging is a global issue, and this study presents a novel approach using Pd-based single-atom nanozymes to improve mitochondrial function and attenuate aging. The nanozyme mimics enzyme activities in the mitochondrial respiratory chain and enhances mitochondrial activities and abundance. Additionally, it demonstrates excellent anti-aging and neuroprotective effects through the activation of the mitochondrial unfolded protein response (UPRmt) pathway.