Article
Clinical Neurology
Ethan N. Biggs, Ryan Budde, John G. R. Jefferys, Pedro P. Irazoqui
Summary: The study aimed to test the hypothesis that death similar to sudden unexpected death in epilepsy (SUDEP) in humans can be induced in seizing rats. Results showed that sudden death can be induced in two seizure models with pathophysiology consistent with human SUDEP, providing a potential explanation for observations made in human cases.
Article
Genetics & Heredity
Hyun Yong Koh, Alireza Haghighi, Christine Keywan, Sanda Alexandrescu, Erin Plews-Ogan, Elisabeth A. Haas, Catherine A. Brownstein, Sara O. Vargas, Robin L. Haynes, Gerard T. Berry, Ingrid A. Holm, Annapurna H. Poduri, Richard D. Goldstein
Summary: This study aimed to evaluate genetic contributions to sudden unexpected death. Through exome sequencing and analysis of 352 cases, genetic variants related to sudden death were identified. The study also found an excess burden of de novo pathogenic variants and damaging gene variants in individuals with sudden unexpected death.
GENETICS IN MEDICINE
(2022)
Review
Pediatrics
Aysha Jawed, Mandeep Jassal
Summary: Sudden Unexpected Infant Death (SUID) from sleep-related causes is a major contributor to infant mortality worldwide. Despite tobacco exposure being one of the primary safe sleep recommendations, there has been a lack of comprehensive evaluation on the role of tobacco-related factors in reducing the risk of sleep-related infant deaths. This review integrates best practices, strategies, and recommendations for future research and program implementation to address tobacco exposure as a risk factor for sleep-related infant deaths.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Libny Martinez-Valdez, Vesta Richardson, Aurora Bautista-Marquez, Mauricio Hernandez-Avila
Summary: This study analyzed data on sudden unexpected infant death (SUID) in Mexico and found that sudden infant death syndrome (SIDS) is one of the leading causes of infant death in Mexico. There is underreporting of SIDS and other SUID subcategories. Health workers should be trained to improve diagnosis and data registration, and a public health campaign is needed.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Maria Godoy, Matthew Maher
Summary: This study aimed to identify risk factors associated with sleep-related deaths of infants in Manitoba, Canada. The results showed that unsafe sleep environments, particularly non-approved sleep surfaces and bedsharing, were major risk factors for sleep-related infant deaths. Families in low-income neighborhoods, Indigenous families, and families with young mothers were disproportionately affected.
Article
Pediatrics
Paul Nathan Goldwater
Summary: This paper presents a critique of mainstream SIDS research, highlighting its shortcomings in investigating the pathological findings and epidemiological risk factors of SIDS. It questions the scientific rigor of unsupported research findings and hypotheses.
FRONTIERS IN PEDIATRICS
(2022)
Article
Critical Care Medicine
Jeremy E. Orr, Indu Ayappa, Danny J. Eckert, Jack L. Feldman, Chandra L. Jackson, Shahrokh Javaheri, Rami N. Khayat, Jennifer L. Martin, Reena Mehra, Matthew T. Naughton, Winfried J. Randerath, Scott A. Sands, Virend K. Somers, M. Safwan Badr
Summary: The international multidisciplinary group identified 11 specific research priorities regarding central sleep apnea (CSA) in heart failure patients, focusing on areas such as control of breathing, variability across individuals, examination techniques, treatment impact, and implementation strategies. Advancing care for patients with CSA in the context of heart failure will require progress in translational, epidemiological, and patient-centered outcome research. Priority should be given to targeted research to improve knowledge of CSA pathogenesis and treatment, given the increasing prevalence of heart failure and its substantial burden.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Pediatrics
Kelty Allen, Tatiana M. Anderson, Urszula Chajewska, Jan-Marino Ramirez, Edwin A. Mitchell
Summary: The study found that factors associated with the age of death in SUID mainly include maternal smoking, lower socioeconomic status, as well as low birth weight, prematurity, and admission to the neonatal intensive care unit. These factors are typically linked to younger age at death.
Review
Pediatrics
Stephanie Enner, Ivan Pavkovic, Sanjeev V. Kothare
Summary: Despite many years of study, sudden unexplained death is still a diagnosis of exclusion. Failure in the complex interplay between peripheral sensors and central cardiorespiratory regulation may result in sudden death. Recent studies emphasize the importance of diagnostic testing in identifying high-risk patients and suggest common pathways in sudden unexplained death in children.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Pediatrics
Katherine O. Salada, Colleen M. Badke
Summary: Sudden unexpected infant death (SUID) is the leading cause of death in children 28 days to 1 year of age. This study found that majority of SUID infants had prior healthcare encounters, indicating the important role healthcare professionals have in providing education on safe sleep and prevention of SUID.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Catherine Ellis, Anna Pease, Joanna Garstang, Debbie Watson, Peter S. Blair, Peter J. Fleming
Summary: This study reviewed interventions aimed at reducing the risk of sudden unexpected infant deaths, finding a shift from information delivery to personalized information exchange models. While progress has been made, further evidence is needed to support the effectiveness of these interventions.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Niamh O' Brien, Cliona McGarvey, Karina Hamilton, Breda Hayes
Summary: Despite global improvements in reducing SIDS mortality, the rate in Ireland has plateaued. The study found that intentions regarding safe sleep practices in infants varied among participants, with factors such as ethnicity, age, and education level playing a role in mothers' intentions. Educational campaigns in Ireland should target younger, non-Irish mothers with lower educational attainment to address modifiable SIDS risk factors.
Article
Clinical Neurology
Michelle N. Stram, Alan C. Seifert, Etty Cortes, Alara Akyatan, Emma Woodoff-Leith, Valeriy Borukhov, Amber Tetlow, Dimath Alyemni, Michael Greenberg, Avneesh Gupta, Amanda Krausert, Lauren Mecca, Sophia Rodriguez, Jay Stahl-Herz, Miguel A. Guzman, Bradley Delman, John F. Crary, Kristen Dams-O'Connor, Rebecca D. Folkerth
Summary: This study reports postmortem SARS-CoV-2 pathology in 8 pediatric cases, including infants and older children. The pathology observed subtle lesions related to vascular compromise and the presence of underlying conditions played a significant role in fatal outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Elisa Micalizzi, Alice Ballerini, Giada Giovannini, Maria Cristina Cioclu, Simona Scolastico, Matteo Pugnaghi, Niccolo Orlandi, Marcella Malagoli, Maurilio Genovese, Alessandra Todeschini, Leandra Giunta, Flavio Villani, Stefano Meletti, Anna Elisabetta Vaudano
Summary: By using MRI and analysis, it was found that in patients with ICA, there was an increase in gray matter volume in the amygdala ipsilateral to the epileptogenic zone, specifically in the basolateral complex. These structural changes in the amygdala may serve as valuable morphological biomarkers for ICA.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Medicine, General & Internal
Carmel Therese Harrington, Naz Al Hafid, Karen Ann Waters
Summary: This study investigated the changes in butyrylcholinesterase (BChE) activity in infants and young children who died from Sudden Infant Death Syndrome (SIDS). The findings suggest a potential association between cholinergic deficit and SIDS. The measurement of BChE activity in dried blood spots taken 2-3 days after birth may serve as a potential method to identify vulnerability to SIDS.