Article
Medicine, Research & Experimental
Liu Wei, Hou Hongping, Li Chufang, Mingji Cuomu, Li Jintao, Cai Kaiyin, Chen Lvyi, Chen Weiwu, Ye Zuguang, Zhong Nanshan
Summary: Shiwei Longdanhua Granule (SWLDH) is a traditional Tibetan medicine used for treating respiratory diseases. It inhibits pulmonary inflammation by interfering with arachidonic acid metabolism pathways, reduces oxidative stress, decreases mucus hypersecretion, alleviates cough hypersensitivity, and prevents the development of chronic diseases. SWLDH also has antitussive effects by suppressing cough urge and airway smooth muscle contraction, and it shows potential in affecting airway remodeling.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Balint Botz, Gabor Kriszta, Kata Bolcskei, Adam Istvan Horvath, Attila Mocsai, Zsuzsanna Helyes
Summary: The study showed that capsaicin-sensitive peptidergic sensory nerves play a crucial anti-inflammatory role in the early phase of rheumatoid arthritis, characterized by reduced cellular and vascular inflammatory components through the release of anti-inflammatory neuropeptides. These fibers may serve as important gatekeepers in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Antonio Di Zazzo, Marco Coassin, Alessandra Micera, Tommaso Mori, Maria De Piano, Luca Scartozzi, Roberto Sgrulletta, Stefano Bonini
Summary: The study revealed that type I diabetic patients commonly exhibit chronic inflammation and neurogenic dysregulation of the ocular surface, with disease duration, HbA1c levels, and severity of diabetic retinopathy being critical factors.
Article
Cardiac & Cardiovascular Systems
Jacob Levy, Abul Kashem, Gengo Sunagawa, Huaqing Zhao, Kenji Minakata, Suresh Keshavamurthy, Stacey Brann, Eros Leotta, Norihisa Shigemura, Yoshiya Toyoda
Summary: This study compared the continuous and interrupted suture techniques for bronchial anastomosis. The results showed that the continuous suture technique had a higher incidence of postoperative bronchial complications, while the interrupted suture technique had a lower incidence. In terms of survival, the interrupted suture technique had better survival rates.
ANNALS OF THORACIC SURGERY
(2022)
Article
Mathematics
Anastasia Mozokhina, Anass Bouchnita, Vitaly Volpert
Summary: Spontaneous blood clotting in pulmonary circulation caused by thrombo-inflammation is a major cause of mortality during the COVID-19 disease, leading to reduced pulmonary circulation and blood oxygenation. A multiscale model considering the interaction of a local thrombus growth model with 1D hemodynamics in a vessel network has been developed to evaluate flux reduction depending on the level of lung obstruction and to investigate the interaction of blood clotting and flow in complex vessel networks.
Article
Biochemistry & Molecular Biology
Ulf Hedstrom, Lisa Oberg, Outi Vaarala, Goran Dellgren, Martin Silverborn, Leif Bjermer, Gunilla Westergren-Thorsson, Oskar Hallgren, Xiaohong Zhou
Summary: The study found that airway epithelial cells in patients with Chronic Obstructive Pulmonary Disease (COPD) are damaged, and COPD epithelial cells show differential gene expression on COPD airway scaffolds compared to normal epithelial cells, with increased proliferation and maintained basal cell phenotype.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Respiratory System
Mirjam P. Roffel, Ilse M. Boudewijn, Jos L. L. van Nijnatten, Alen Faiz, Corneel J. Vermeulen, Antoon J. van Oosterhout, Karen Affleck, Wim Timens, Ken R. Bracke, Tania Maes, Irene H. Heijink, Corry-Anke Brandsma, Maarten van den Berge
Summary: In this study, several differentially expressed miRNAs were identified and their associations with asthma were explored. miR-125b-5p, miR-223-3p, and miR-26a-5p were identified as potential regulators that could contribute to the pathogenesis of asthma.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Junwei Zhao, Tianci Jiang, Pengfei Li, Lingling Dai, Guang Shi, Xiaogang Jing, Shuhui Gao, Liuqun Jia, Shujun Wu, Yu Wang, Youmei Peng, Zhe Cheng
Summary: The study showed that TF promotes airway pathological features by enhancing the EMT of bronchial epithelial cells in asthma, while downregulation of TF reduces airway hyperresponsiveness, eosinophil inflammation, and EMT process. TF downregulation also inhibits migration and invasion, and decreases fibronectin 1 and TGF-β1 expression while increasing E-cadherin expression in stimulated 16HBE cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yingjie Zhu, Dong Sun, Han Liu, Linzi Sun, Jing Jie, Jingjing Luo, Liping Peng, Lei Song
Summary: Bixin, a natural compound isolated from Bixa Orellana seeds, has shown potential in treating asthma by suppressing allergic airway inflammation, reversing glucocorticoids resistance, and alleviating airway remodeling and hyperresponsiveness. It functions as an antagonist of PI3K/Akt signaling, offering a novel strategy for asthma treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Ivan Ramirez-Moral, Bianca L. Ferreira, Joe M. Butler, Michel van Weeghel, Natasja A. Otto, Alex F. de Vos, Xiao Yu, Menno D. de Jong, Riekelt H. Houtkooper, Tom van der Poll
Summary: This study demonstrated the impact of HIF1 alpha stabilization on the response of respiratory epithelial cells, showing increased expression of genes involved in glycolysis and inhibition of key innate immune pathways. It also revealed a downregulation of cell-cell junction organization pathway and impaired barrier function. These findings provide insights into the effects of HIF1 alpha on maintaining homeostasis in response to bacterial stimulation.
Article
Biochemistry & Molecular Biology
Eleonora Spekker, Masaru Tanaka, Agnes Szabo, Laszlo Vecsei
Summary: Migraine is a debilitating primary headache disorder characterized by long-lasting and interfering pain. Neurogenic inflammation and neuropeptides play important roles in the pathophysiology of migraine, and recent advances in preclinical research and therapeutic approaches have provided new insights for its treatment.
Review
Biochemistry & Molecular Biology
Nandita Menon, Anil Kishen
Summary: Periradicular tissues contain trigeminal nociceptors that play a role in both relaying pain signals and modulating immune responses in apical periodontitis. Studies have investigated the neuroanatomy and biomolecules profiles to understand the contributions and mechanisms of these nociceptors in inflammation and tissue regeneration. This narrative review aims to address the complex interactions between trigeminal nociceptors and macrophages in the clinical manifestations of apical periodontitis.
Review
Immunology
Alex Kayongo, Nicole M. Robertson, Trishul Siddharthan, Moses Levi Ntayi, Josephine Caren Ndawula, Obondo J. Sande, Bernard S. Bagaya, Bruce Kirenga, Harriet Mayanja-Kizza, Moses L. Joloba, Sofia K. Forslund
Summary: Chronic Obstructive Pulmonary Disease (COPD) is a major contributor to global mortality, with three million deaths reported annually. The impact is expected to increase, with approximately five million people predicted to die from COPD-related causes each year in the next 40 years. The immune mechanisms driving disease progression, as well as the relationship between airway microbiome changes and immune activation, remain unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Linchen He, Christina Norris, Xiaoxing Cui, Zhen Li, Karoline K. Barkjohn, Yanbo Teng, Lin Fang, Lili Lin, Qian Wang, Xiaojian Zhou, Jianguo Hong, Feng Li, Yinping Zhang, James J. Schauer, Marilyn Black, Michael H. Bergin, Junfeng (Jim) Zhang
Summary: Exposure to PM2.5 and O-3 may cause inflammation and oxidative damage in the oral cavity, which could contribute to the worsening of airway inflammation and asthma symptoms. The study found a positive association between PM2.5 exposure and salivary IL-6 concentration, but no clear association between O-3 exposure and salivary biomarkers. Increased salivary IL-6 was related to increased pulmonary inflammation and worsening asthma symptoms. Salivary IL-6 mediated a portion of the association between PM2.5 exposure and FeNO as well as C-ACT scores.
ENVIRONMENTAL RESEARCH
(2022)
Review
Medicine, General & Internal
Marius Nicolae Popescu, Cristina Beiu, Madalina Gabriela Iliescu, Mara Madalina Mihai, Liliana Gabriela Popa, Ana Maria Alexandra Stanescu, Mihai Berteanu
Summary: Psoriasis is an immune-mediated inflammatory disorder that has attracted significant scientific interest. The use of nerve-targeting treatments, such as BoNT-A, shows potential in managing psoriasis by interfering with its immunopathogenesis.
MEDICINA-LITHUANIA
(2022)