Article
Cardiac & Cardiovascular Systems
Satyam Sarma, James P. MacNamara, Bryce N. Balmain, Christopher M. Hearon, Denis J. Wakeham, Andrew R. Tomlinson, Linda S. Hynan, Tony G. Babb, Benjamin D. Levine
Summary: Exercise intolerance is a common symptom in patients with heart failure with preserved ejection fraction (HFpEF), which is believed to be caused by a marked rise in pulmonary capillary wedge pressure (PCWP). This study investigated the effect of nitroglycerin on PCWP and exercise capacity in patients with HFpEF. The results showed that nitroglycerin successfully reduced PCWP during exercise, but did not improve peak oxygen uptake. These findings suggest that reducing PCWP alone is not sufficient to enhance exercise capacity in patients with HFpEF.
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Medicine, General & Internal
Teruhiko Imamura, Toshihide Izumida, Nikhil Narang, Hiroshi Onoda, Masaki Nakagaito, Shuhei Tanaka, Makiko Nakamura, Ryuichi Ushijima, Hayato Fujioka, Kota Kakeshita, Koichiro Kinugawa
Summary: Pulmonary congestion is measured by the ReDS system, while systemic congestion is estimated by calculated plasma volume. The association between these two parameters and the type of patient profile remains uncertain. This study aims to assess the relationship between ReDS values and plasma volume status.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Teruhiko Imamura, Nikhil Narang, Koichiro Kinugawa
Summary: New therapeutics have significantly reduced clinical risk for patients with chronic heart failure. Adaptive servo-ventilation is a novel treatment option for patients refractory to conventional therapies. Patients who do not respond to oral medical therapy alone may benefit from these new treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Herman A. Carneiro, Rebecca J. Song, Joowon Lee, Brian Schwartz, Ramachandran S. Vasan, Vanessa Xanthakis
Summary: This study found that individuals with elevated diastolic blood pressure during exercise and slower recovery of systolic blood pressure and heart rate after exercise are at higher risk for heart failure with reduced ejection fraction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Teruhiko Imamura, Masakazu Hori, Yohei Ueno, Nikhil Narang, Hiroshi Onoda, Shuhei Tanaka, Makiko Nakamura, Naoya Kataoka, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa
Summary: This study investigated the association between remote dielectric sensing (ReDS) values and pulmonary capillary wedge pressure in patients with chronic heart failure. The results showed a moderate collinearity between ReDS values and pulmonary capillary wedge pressure, even among patients with small stature. The study suggests that ReDS, based on electromagnetic technology, could be a potential tool to estimate cardiac pressure in patients with heart failure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Benedicte Heegaard, Tania Deis, Kasper Rossing, Mads Ersboll, Caroline Kistorp, Finn Gustafsson
Summary: This study aims to investigate the impact of diabetes on hemodynamics in heart failure patients. It found that heart failure patients with diabetes have higher filling pressures, including pulmonary capillary wedge pressure, central venous pressure, cardiac index, and mean arterial pressure. Additionally, poor glycemic control in diabetic patients is associated with higher filling pressures. Therefore, diabetic cardiomyopathy may contribute to the increased mortality in heart failure patients with diabetes, but other unknown mechanisms beyond hemodynamic factors are also likely involved.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Peripheral Vascular Disease
Gary F. Mitchell
Summary: Aortic stiffness increases significantly with age and is linked to various adverse clinical outcomes. While evidence of its negative effects is overwhelming, incorporating measures of aortic stiffness into routine clinical practice has been slow.
Article
Cardiac & Cardiovascular Systems
Essa Hariri, Nikolaos Kakouros, David A. Bunsick, Stuart D. Russell, James O. Mudd, Katherine Laws, Mikhailia W. Lake, Jeffrey J. Rade
Summary: Nonplatelet thromboxane generation is associated with the severity and prognosis of heart failure. Measuring urine thromboxane metabolites can serve as a surrogate marker for cardiovascular hemodynamics and performance, providing prognostic information and guiding personalized therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
C. Charles Jain, Dawn Pedrotty, Philip A. Araoz, Alan Sugrue, Vaibhav R. Vaidya, Deepak Padmanabhan, Shivaram P. Arunachalam, Lilach O. Lerman, Samuel J. Asirvatham, Barry A. Borlaug
Summary: In a study using a pig model of heart failure with preserved ejection fraction, minimally invasive pericardiotomy was found to mitigate the increase in left ventricular end-diastolic pressure with volume loading. This effect was sustained for at least 4 weeks without excessive chamber remodeling or other significant complications. These findings support further trials evaluating minimally invasive pericardiotomy as a novel treatment for heart failure with preserved ejection fraction in humans.
CIRCULATION-HEART FAILURE
(2021)
Article
Hematology
Bastien Poitier, Richard Chocron, Christophe Peronino, Aurelien Philippe, Yuri Pya, Nadia Rivet, Ulysse Richez, Mahabbat Bekbossynova, Nicolas Gendron, Marc Grimme, Marie Cecile Bories, Julie Brichet, Antoine Capel, Jeanne Rancic, Benoit Vedie, Jean Christian Roussel, Anne-Sophie Jannot, Piet Jansen, Alain Carpentier, Peter Ivak, Christian Latremouille, Ivan Netuka, David M. Smadja
Summary: This study evaluates the potential hemolysis and acquired von Willebrand syndrome (AVWS) after A-TAH implantation. The results demonstrate that A-TAH support does not cause hemolysis or modify the multimers profile of VWF. Fluid structure interaction models and computational fluid dynamics simulations show an increase in blood damage with increasing cardiac output.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Yohei Ueno, Teruhiko Imamura, Akira Oshima, Hiroshi Onoda, Ryuichi Ushijima, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa
Summary: In this study, respiratory stability time (RST) significantly improved following TAVR, while a lower RST was associated with an increased risk of heart failure readmission.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Teruhiko Imamura, Wataru Gonoi, Masakazu Hori, Yohei Ueno, Nikhil Narang, Hiroshi Onoda, Shuhei Tanaka, Makiko Nakamura, Naoya Kataoka, Ryuichi Ushijima, Mitsuo Sobajima, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa
Summary: The remote dielectric sensing (ReDS) system may be a promising noninvasive tool to quantify lung fluid levels. ReDS values were moderately correlated with the percentage of high attenuation area on computed tomography, and independently predicted the percentage of high attenuation area.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Cardiac & Cardiovascular Systems
Timothy W. Churchill, Shawn X. Li, Lisa Curreri, Emily K. Zern, Emily S. Lau, Elizabeth E. Liu, Robyn Farrell, Mark W. Shoenike, John Sbarbaro, Rajeev Malhotra, Matthew Nayor, Carsten Tschoepe, Rudolf A. de Boer, Gregory D. Lewis, Jennifer E. Ho
Summary: The article includes additional digital content.
Article
Cardiac & Cardiovascular Systems
J. C. Weavil, T. S. Thurston, T. J. Hureau, J. R. Gifford, P. A. Kithas, R. M. Broxterman, A. D. Bledsoe, J. N. Nativi, R. S. Richardson, M. Amann
Summary: HFpEF patients show similar central and peripheral fatigue development as healthy controls during exercise not limited by cardiac output at the same relative intensity. However, HFpEF patients exhibit a greater susceptibility to neuromuscular fatigue during exercise at a given absolute intensity, which impairs functional capacity. The compromised leg blood flow response likely contributes to the attenuated fatigue resistance in HFpEF patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)