Article
Biochemistry & Molecular Biology
Noha M. Abd El-Fadeal, Mohamed S. Nafie, Mohammed K. El-kherbetawy, Amr El-mistekawy, Hala M. F. Mohammad, Alaaeldeen M. Elbahaie, Abdullah A. Hashish, Suliman Y. Alomar, Sheka Yagub Aloyouni, Mohamed El-dosoky, Khaled M. Morsy, Sawsan A. Zaitone
Summary: This study demonstrates that nitazoxanide can induce cytotoxicity and promote apoptosis in colon cancer cells by inhibiting the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Jiawei He, Anhui Yang, Xuyu Zhao, Yang Liu, Shuyan Liu, Di Wang
Summary: Gloeostereum incarnatum polysaccharides (GIPS) exhibit anti-colon cancer effects by regulating cytokines and the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory and tumor growth inhibition properties.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Oncology
Rahui Park, Seungmin Lee, Hyunjung Chin, Anh Thai-Quynh Nguyen, Daekee Lee
Summary: In this study, the researchers found that GNA14 promotes the progression of colorectal cancer (CRC) through the ERK and beta-catenin pathways. Knockdown of GNA14 inhibits the proliferation of CRC cells and suppresses malignant tumor progression in the intestine. These findings suggest that GNA14 may be a potential therapeutic target for CRC.
Article
Gastroenterology & Hepatology
Romain Sanson, Silvia Luna Lazzara, David Cune, Caterina Luana Pitasi, Coralie Trentesaux, Marie Fraudeau, Franck Letourneur, Benjamin Gaintpierre, Morgane Le Gall, Pascale Bossard, Benoit Terris, Pascal Finetti, Francois Bertucci, Emilie Mamessier, Beatrice Romagnolo, Christine Perret
Summary: Axin1 is a negative regulator of the Wnt/beta-catenin signaling pathway with tumor-suppressor function. It has redundant function with Axin2 for down-regulation of the pathway in normal intestine. Axin1 deficiency increases susceptibility to chemically induced colon carcinogenesis, but reduces dextran sulfate sodium-induced colitis by attenuating the induction of a proinflammatory program. Axin1 controls an interferon gamma/Th1 immune program that enhances the inflammatory response and prevents tumor growth. The Axin1-dependent gene expression signature identifies a group of patients with potential vulnerability to immune checkpoint blockade therapies in colorectal cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Markus A. Brown, Thomas Ried
Summary: The major signaling pathways in colon cancer are WNT, RAS, and TGF-beta. Mutations in these pathways reflect the behavior of intestinal stem cells and play a role in the progression of colon cancer. Understanding the intersection and interaction between these pathways can provide insights into the regulation of cell proliferation and the development of colon cancer.
Article
Agriculture, Multidisciplinary
Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu
Summary: Overwhelming evidence supports the role of the Wnt/beta-catenin signaling pathway in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and plants, has shown potent anticancer activity against CRC, although its mechanism of action is not fully understood. This study aimed to investigate the effects of UA on CRC and its impact on the Wnt/beta-catenin signaling pathway. The study demonstrated that UA significantly inhibited proliferation, migration, and clonality, induced apoptosis, and arrested the cell cycle in CRC cells. Moreover, UA suppressed tumor growth, improved pathological features, induced apoptosis, and arrested the cell cycle in CRC tissue, by diminishing the Wnt/beta-catenin signaling pathway. These findings suggest that UA has the potential to inhibit the malignant phenotype of CRC by attenuating the Wnt/beta-catenin signaling axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Oncology
Jiong Ning, Qi Sun, Zijie Su, Lifeng Tan, Yun Tang, Sapna Sayed, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Desheng Lu
Summary: CK1 delta/epsilon enhance beta-catenin-mediated transcription by regulating beta-catenin acetylation. CK1 delta/epsilon interact with Tip60 and facilitate its recruitment to the beta-catenin complex, leading to increased beta-catenin acetylation at K49. Furthermore, this study discovers that a complex consisting of CK1 delta/CK1 epsilon/beta-catenin/Tip60 is present in colon cancer cells, and this complex plays an important role in beta-catenin acetylation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Young-Eun Cho, Jeong-Hee Kim, Young-Hyun Che, Yong-Jun Kim, Ji-Youn Sung, Yoon-Wha Kim, Bong-Geun Choe, Sun Lee, Jae-Hoon Park
Summary: ZKSCAN3 acts as an oncogenic transcription factor in human malignant tumors, and it has been identified as a downstream effector of the Wnt/β-catenin signaling pathway. It upregulates chromosomal instability in colon cancer cells by suppressing MAD2L2 expression. Moreover, the upregulation of ZKSCAN3 is an early event in the adenoma-carcinoma sequence during colon cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zongyuan Wang, Xin Qiang, Yijie Peng, Yanni Wang, Quanyi Zhao, Dian He
Summary: Bile acid derivatives have anticancer and anti-inflammatory activities against colon cancer, and they can target colon tissues through improved drug delivery and transport.
RSC MEDICINAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Qihong Nie, Wei Wei Peng, Yuli Wang, Liting Zhong, Xuebing Zhang, Ling Zeng
Summary: This study revealed that berberine can inhibit the proliferation of colon cancer cells by regulating the β-catenin signaling pathway. The expression level of CTNNB1, the active component of berberine, was found to be higher in colon cancer patients compared to normal controls. This suggests that CTNNB1 may have potential clinical diagnostic and therapeutic value in colon cancer.
Article
Immunology
Jia Liu, Xiufeng Chen, Xianrong Zhou, Ruokun Yi, Zhennai Yang, Xin Zhao
Summary: The study showed that L. fermentum ZS09 could inhibit the EMT and angiogenesis pathways by suppressing the Wnt/beta-catenin signalling pathway, thus inhibiting tumor metastasis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Qing Wu, Xingxing Du, Jianing Cheng, Xiuying Qi, Huan Liu, Xiaohong Lv, Xieyang Gong, Changxin Shao, Muhong Wang, Luxiao Yue, Xin Yang, Shiyu Li, Yafang Zhang, Xuemei Li, Huike Yang
Summary: Diabetes mellitus enhances the occurrence and progression of colon cancer through the internalization of platelet-endothelial cell adhesion molecule 1 (PECAM-1) and subsequent activation of beta-catenin-mediated endothelial-mesenchymal transition (EndMT).
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Pharmacology & Pharmacy
Young Yun Jung, Jae-Young Um, Arunachalam Chinnathambi, Chandramohan Govindasamy, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of Withaferin A (WFA) on apoptosis and autophagy in human colorectal cancer cells. The results showed that WFA could induce cell cycle arrest, increase apoptotic cell death, and activate autophagy. The WFA-induced effects on apoptosis and autophagy were mediated through the modulation of the beta-catenin pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Munmun Panda, Bijesh K. Biswal
Summary: The natural dietary alkaloid Evodiamine (EVO) extracted from Evodia rutaecarpa has been found to play an important role in inhibiting cell proliferation, migration, and invasion in lung cancer cells. EVO inhibits cell growth by inducing apoptosis and ROS production, and interferes with cell invasion by altering the expression of related proteins. Additionally, EVO suppresses tumorigenicity and the expression of cancer stem cell markers.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Blas A. Guigni, Jos van der Velden, C. Matthew Kinsey, James A. Carson, Michael J. Toth
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Sport Sciences
Brittany R. Counts, Justin P. Hardee, Dennis K. Fix, Brandon N. Vanderveen, Ryan N. Montalvo, James A. Carson
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2020)
Article
Physiology
Justin P. Hardee, Dennis K. Fix, Ho-Jin Koh, Xuewen Wang, Edie C. Goldsmith, James A. Carson
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Sport Sciences
B. R. A. N. D. O. N. N. VANDERVEEN, D. E. N. N. I. S. K. FIX, B. R. I. T. A. N. N. Y. R. COUNTS, J. A. M. E. S. A. CARSON
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Physiology
Brandon N. VanderVeen, Alexander T. Sougiannis, Kandy T. Velazquez, James A. Carson, Daping Fan, E. Angela Murphy
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Sport Sciences
Brittany R. Counts, Jessica L. Halle, James A. Carson
Summary: This study found that cancer-induced skeletal muscle mass loss is a critical characteristic of cachexia. It also found that early-onset physical inactivity and altered systemic lipid oxidation in LLC tumor-bearing mice were associated with the eventual development of cachexia.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Cell Biology
Jessica L. Halle, Brittany R. Counts-Franch, Rose M. Prince, James A. Carson
Summary: This study showed that mechanical signaling induced growth stimulus and preserved MyHC-Fast protein expression in myotubes pre-incubated with conditioned media, independent of changes in mRNA expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physiology
Dennis K. Fix, Brittany R. Counts, Ashley J. Smuder, Mark A. Sarzynski, Ho-Jin Koh, James A. Carson
Summary: Disruptions to muscle protein turnover and metabolic regulation contribute to muscle wasting during the progression of cancer cachexia. Initiation of cachexia is also associated with decreased physical activity, and exercise can help improve skeletal muscle AMPK signaling in pre-cachectic mice.
PHYSIOLOGICAL REPORTS
(2021)
Article
Critical Care Medicine
Geremy Clair, Lisa M. Bramer, Ravi Misra, Matthew D. McGraw, Soumyaroop Bhattacharya, Joseph A. Kitzmiller, Song Feng, Vincent G. Danna, Gautam Bandyopadhyay, Harsh Bhotika, Heidie L. Huyck, Gail H. Deutsch, Thomas J. Mariani, James P. Carson, Jeffrey A. Whitsett, Gloria S. Pryhuber, Joshua N. Adkins, Charles Ansong
Summary: This study provides a comprehensive analysis of the human lung proteome during development, revealing distinct molecular substages of alveolar development and evidence of post-transcriptional control in early postnatal development. The study also supports the extensive remodeling of the lung proteome during development and the concept of immune system maturation as an inherent part of normal lung development.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Mehdi Chaib, Laura M. M. Sipe, Johnathan R. R. Yarbro, Margaret S. S. Bohm, Brittany R. R. Counts, Ubaid Tanveer, Ajeeth K. K. Pingili, Deidre Daria, Tony N. N. Marion, James A. A. Carson, Paul G. G. Thomas, Liza Makowski
Summary: This study investigates the effect of PKC agonists on MDSC expansion, differentiation, and recruitment to the tumor microenvironment. The results demonstrate that PKC agonists decrease MDSC expansion and induce their differentiation to an APC-like phenotype. Additionally, PKC agonists enhance MDSC cross-priming capacity and reduce their suppressive activity. Furthermore, the combination of PKC agonists with CD40 agonist leads to reduced tumor growth and increased activated CD8(+) T cells in a breast cancer mouse model.
Review
Cell Biology
Justin P. Hardee, James A. Carson
Summary: Skeletal muscle atrophy and dysfunction are significant factors contributing to increased morbidity and mortality in cancer patients. The complex pathophysiology of cachexia involves disruptions to the systemic cancer environment and interactions with various tissues. This article provides an overview of the current understanding of how resistance-type exercise impacts mechanisms involved in cancer-induced muscle wasting, particularly focusing on the role of IL-6 and gp130 receptors. The authors also discuss the gaps in knowledge and future research directions to improve preclinical studies and translate findings to human patients with cancer.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jessica L. Halle, Brittany R. Counts, Quan Zhang, James A. Carson
Summary: FOLFOX chemotherapy induces persistent deficits in physical function, but short-duration aerobic exercise can partially reverse this.
Article
Biology
Laura M. Sipe, Mehdi Chaib, Emily B. Korba, Heejoon Jo, Mary Camille Lovely, Brittany R. Counts, Ubaid Tanveer, Jeremiah R. Holt, Jared C. Clements, Neena A. John, Deidre Daria, Tony N. Marion, Margaret S. Bohm, Radhika Sekhri, Ajeeth K. Pingili, Bin Teng, James A. Carson, D. Neil Hayes, Matthew J. Davis, Katherine L. Cook, Joseph F. Pierre, Liza Makowski
Summary: Bariatric surgery can protect against obesity-exacerbated breast cancer progression, but it is less effective than dietary intervention in reducing tumor burden. After surgery, tumors display increased inflammation and expression of immune checkpoint ligands, while dietary intervention shows resistance to immune checkpoint blockade therapy. Additionally, there are conserved molecular changes between bariatric surgery and breast cancer progression.
Article
Biochemistry & Molecular Biology
Jessica K. K. Lukowski, Heather Olson, Marija Velickovic, Juan Wang, Jennifer E. E. Kyle, Young-Mo Kim, Sarah M. M. Williams, Ying Zhu, Heidi L. L. Huyck, Matthew D. D. McGraw, Cory Poole, Lisa Rogers, Ravi Misra, Theodore Alexandrov, Charles Ansong, Gloria S. S. Pryhuber, Geremy Clair, Joshua N. N. Adkins, James P. P. Carson, Christopher R. R. Anderton
Summary: Human disease states are complex and understanding the characteristics of diseases at different levels, cell types, and microanatomical tissue compartments is crucial for a comprehensive understanding of diseases. To accurately observe the molecular landscape in human lungs, it is necessary to use special methods to maintain tissue integrity and molecular stability. By optimizing mass spectrometry imaging methods, unique lipid distributions in different airway regions of the lungs can be observed, and high-resolution proteomic analysis reveals the specific localization of certain proteins in these airway regions. The inflation method shows better results compared to other preservation methods. Through various experiments, we can begin to uncover the spatial connections between the metabolome, lipidome, and proteome in human lungs and across different disease states.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Gastroenterology & Hepatology
Kandy T. Velazquez, Reilly T. Enos, Jackie E. Bader, Alexander T. Sougiannis, Meredith S. Carson, Ioulia Chatzistamou, James A. Carson, Prakash S. Nagarkatti, Mitzi Nagarkatti, E. Angela Murphy
WORLD JOURNAL OF HEPATOLOGY
(2019)