Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

(2015) Renee Bouley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PBP2a Mutations Causing High-Level Ceftaroline Resistance in Clinical Methicillin-Resistant Staphylococcus aureus Isolates

(2014) S. Wesley Long et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA)

(2014) Blas Blázquez et al.   BIOCHEMISTRY

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

(2014) Jennifer Fishovitz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Population Model Evaluating the Consequences of the Evolution of Double-Resistance and Tradeoffs on the Benefits of Two-Drug Antibiotic Treatments

(2014) Ellsworth M. Campbell et al.   PLoS One

Prediction of resistance development against drug combinations by collateral responses to component drugs

(2014) C. Munck et al.   Science Translational Medicine

Redefining the Role of the β-Lactamase Locus in Methicillin-Resistant Staphylococcus aureus: β-Lactamase Regulators Disrupt the MecI-Mediated Strong Repression onmecAand Optimize the Phenotypic Expression of Resistance in Strains with ConstitutivemecAExpression

(2013) Pedro Arêde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial evolution of antibiotic hypersensitivity

(2013) V. Lazar et al.   Molecular Systems Biology

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

(2013) L. H. Otero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

(2013) L. Imamovic et al.   Science Translational Medicine

The Pharmaco –, Population and Evolutionary Dynamics of Multi-drug Therapy: Experiments with S. aureus and E. coli and Computer Simulations

(2013) Peter Ankomah et al.   PLoS Pathogens

The emerging problem of linezolid-resistant Staphylococcus

(2012) B. Gu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics

(2011) Sang Ho Lee et al.   CHEMISTRY & BIOLOGY

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

Emergence of daptomycin resistance following vancomycin-unresponsive Staphylococcus aureus bacteraemia in a daptomycin-naïve patient—a review of the literature

(2010) S. J. van Hal et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns

(2010) Audrey Tupin et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Waves of resistance: Staphylococcus aureus in the antibiotic era

(2009) Henry F. Chambers et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa

(2008) T. Koga et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Co-opting the Cell Wall in Fighting Methicillin-ResistantStaphylococcus aureus: Potent Inhibition of PBP 2a by Two Anti-MRSA β-Lactam Antibiotics

(2008) Adriel Villegas-Estrada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accelerated evolution of resistance in multidrug environments

(2008) M. Hegreness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA