Article
Biotechnology & Applied Microbiology
Ruru Zhang, Kuan Lu, Li Xiao, Xuelan Hu, Wu Cai, Linjiang Liu, Yan Liu, Weihua Li, Hui Zhou, Zhiyuan Qian, Sixia Wang, Can Chen, Jianfeng Zeng, Mingyuan Gao
Summary: This study utilized ultrasmall iron oxide nanoparticles in combination with magnetic resonance imaging (MRI) to achieve early and noninvasive diagnosis of atherosclerotic plaques. The experiment demonstrated that the nanoparticles could enhance the signal at the plaque sites, providing a means for dynamic evaluation over a specific time frame.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Mengmeng Zhang, Tianze Wu, Hui Zhang, Zhenxia Chen, Yannan Yang, Yun Ling, Yaming Zhou
Summary: Fe-Gd/CHS exhibits enhanced photothermal properties compared to symmetric Fe-Gd/CS, showing satisfactory MR/PA imaging-guided photothermal therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biophysics
Chiara Turrina, Max Schoenen, Davide Milani, Anna Klassen, Diana M. Rojas Gonzalez, Gerhard Cvirn, Petra Mela, Sonja Berensmeier, Ioana Slabu, Sebastian P. Schwaminger
Summary: Coated iron oxide nanoparticles have potential applications in nanomedicine, such as imaging, magnetic hyperthermia, and drug delivery. This study demonstrates the importance of coating material and thickness in influencing the behavior and performance of these nanoparticles in the human body, and highlights their potential in nanomedicine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Shehzahdi S. Moonshi, Karla X. Vazquez-Prada, Joyce Tang, Nicholas J. Westra J. van Holthe, Gary Cowin, Yuao Wu, Huong D. N. Tran, Ryan Mckinnon, Andrew C. Bulmer, Hang Thu Ta
Summary: In this study, a novel nanohybrid, silver-iron oxide nanoparticles (AgIONPs), was designed for effective photothermal treatment and dual imaging strategy using MRI and photoacoustic imaging (PAI) in a cancer model. The combination of the inherent anticancer activity of silver and photothermal therapy demonstrated excellent therapeutic capability of AgIONPs. The in vivo imaging studies showed preferential uptake of folate-targeted NPs in a cancer mice model, indicating their selective targeting efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Li Wu, Chunting Wang, Yu Li
Summary: This review discusses the targeting mechanisms, toxicity issues, and applications of iron oxide nanoparticles (IONPs) in tumor MRI and therapy. The authors highlight the advantages of targeting IONPs and aim to increase the possibility of converting them from biomedical applications to clinical applications.
Article
Biochemistry & Molecular Biology
Abdulkader Baki, Amani Remmo, Norbert Loewa, Frank Wiekhorst, Regina Bleul
Summary: The colloidal stability of magnetic iron oxide nanoparticles (MNP) in physiological environments is crucial for their (bio)medical application. By modifying and coating the MNP, they can be suitable contrast agents for multimodal imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Vasiliki Tsampasian, Ioannis Merinopoulos, Donnie Cameron, Pankaj Garg, Vassilios S. Vassiliou
Summary: Myocardial inflammation is proposed as a common mechanism underlying the development and progression of cardiovascular diseases. Cardiac magnetic resonance (CMR) is a non-invasive technique that allows direct visualization of the myocardium. The use of ultrasmall superparamagnetic particles of iron oxide (USPIO) in CMR is gaining research interest and can provide valuable information for identifying active inflammation in the myocardium, which is hypothesized to be the substrate for adverse remodeling and heart failure.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Lei Yang, Mohammad Javad Afshari, Jianxian Ge, Dandan Kou, Lei Chen, Dandan Zhou, Cang Li, Shuwang Wu, Leshuai Zhang, Jianfeng Zeng, Jian Zhong, Roland H. Stauber, Mingyuan Gao
Summary: Hypoxia is a common condition in malignant solid tumors, and its assessment is important for predicting tumor development and evaluating prognosis. Magnetic resonance imaging (MRI) offers unique features such as no ionizing radiation and high spatial resolution, making it a potential tool in tumor diagnosis. This study developed a fluorescent traceable and hypoxia-sensitive MRI probe by conjugating a hypoxia-sensitive metronidazole moiety and a dye with iron oxide nanoparticles. The probe showed excellent performance in terms of relaxivity, biocompatibility, and hypoxia specificity, with noticeable signal enhancement in hypoxic areas, indicating its feasibility for sensing tumor hypoxia via T1-weighted MRI.
Article
Chemistry, Multidisciplinary
Jeff W. M. Bulte, Chao Wang, Ali Shakeri-Zadeh
Summary: Superparamagnetic iron oxide (SPIO)-labeling of cells for magnetic resonance imaging (MRI) cell tracking has a long history, but studies have shown that the labeled cells may have different behaviors compared to unlabeled cells. With the emergence of magnetic particle imaging (MPI) cell tracking, there has been a renaissance in the formulation of SPIO nanoparticles optimized for MPI. Lessons learned from past experiences with SPIO-labeling for MRI could potentially facilitate the clinical translation of (combined) MRI/MPI cell tracking.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Can Chen, Jianxian Ge, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng, Mingyuan Gao
Summary: USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Physics, Applied
Gonzalo G. Rodriguez, Eustaquio M. Erro, Esteban Anoardo
Summary: Dynamic images acquired by proton fast field-cycling magnetic resonance imaging for the first time are presented, discussing image contrast mediated by superparamagnetic iron oxide nanoparticles and relaxation times. Real-time recording of exemplary physical situations evolving in a compatible time-scale is allowed within 8 seconds through fast MRI acquisition and processing. This study represents an initial step in the development of field-cycling functional MRI for biomedical and physical applications.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Pharmacology & Pharmacy
Weijie Zhang, Zhongyue Zhang, Shitong Lou, Zhiwei Chang, Baohong Wen, Tao Zhang
Summary: This paper reports the synthesis of hyaluronic acid-stabilized Fe3O4 nanoparticles, which exhibit good colloidal stability and targeting ability, and demonstrate effectiveness as contrast agents for MRI in both in vitro and in vivo models.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Engineering, Biomedical
Shengxiang Fu, Zhongyuan Cai, Hua Ai
Summary: MRI is commonly used for disease diagnosis, and the development of stimulus-responsive contrast agents provides new opportunities to overcome the limitations of traditional contrast agents. By tuning the structural features of contrast agents, optimization of the T(1) and T(2) relaxation properties can be achieved, thereby improving the sensitivity and specificity of the contrast agents.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Pedro Farinha, Joao M. P. Coelho, Catarina Pinto Reis, Maria Manuela Gaspar
Summary: Magnetic nanoparticles (MNPs) have been widely studied for diagnostic purposes in medicine, especially in Magnetic Resonance Imaging (MRI). Current research focus is on developing MNPs with better safety profiles and enhanced magnetic properties to overcome challenges in their market entry.