Article
Immunology
Jin Luo, Feng Wu, Wenge Liu, Qiaoyun Ren, Peiwen Diao, Guiquan Guan, Jianxun Luo, Hong Yin, Guangyuan Liu
Summary: In this study, a new miRNA (nov-miR-17) was identified and found to play an important role in the blood-sucking and spawning processes of ticks, along with its target gene TAB2.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Julia Schwarz, Kilian Schumacher, Sophie Brameyer, Kirsten Jung
Summary: This review discusses how acid-resistant Gram-negative bacteria, such as Escherichia, Salmonella, Helicobacter, and Brucella, adapt to acidic environments and the defense mechanisms they employ, including proton consumption, ammonia production, cellular remodeling, and chemotaxis. It also explores how these bacteria sense environmental acidity and provides a detailed examination of the powerful proton-consuming decarboxylase systems.
FEMS MICROBIOLOGY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Weichen Duan, Miao Yu, Jiajia Chen
Summary: The BET family proteins, including BRD2, BRD3 and BRD4, are epigenetic readers that play multiple roles in the tumorigenesis and growth of various human malignancies. This review focuses on summarizing the roles and mechanisms of BRD4 in the initiation and development of glioblastoma, and evaluates the use of various BRD4 inhibitors and degraders as novel treatment strategies against glioblastoma.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Neurosciences
Luis M. A. Oliveira, Thomas Gasser, Robert Edwards, Markus Zweckstetter, Ronald Melki, Leonidas Stefanis, Hilal A. Lashuel, David Sulzer, Kostas Vekrellis, Glenda M. Halliday, Julianna J. Tomlinson, Michael Schlossmacher, Poul Henning Jensen, Julia Schulze-Hentrich, Olaf Riess, Warren D. Hirst, Omar El-Agnaf, Brit Mollenhauer, Peter Lansbury, Tiago F. Outeiro
Summary: The authors aim to summarize critical features of alpha-synuclein and identify knowledge gaps in PD research to propose future research directions. Their goal is to develop therapies that can slow or stop the progression of PD.
NPJ PARKINSONS DISEASE
(2021)
Review
Pharmacology & Pharmacy
Bingqing Yang, Dan Fang, Qingyan Lv, Zhiqiang Wang, Yuan Liu
Summary: The emergence and rapid spread of antibiotic resistance pose a global public health threat. Innovations in targeted therapy strategies are urgently needed to combat this crisis, with abuse of broad-spectrum antibiotics exacerbating resistance and burdening intestinal microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Plant Sciences
Ping Wang, Brendan Mormile, Ping He
Summary: Glutamate receptor-like (GLR) proteins are ligand-gated ion channels that play important roles in plant immunity by regulating calcium channels and mediating long-distance defense against herbivores. A recent study identified a cotton GLR as a noncanonical resistance protein to Fusarium wilt, expanding the paradigm of GLR functions in plant immunity.
TRENDS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Wanda Maczka, Anna Duda-Madej, Malgorzata Grabarczyk, Katarzyna Winska
Summary: The purpose of this article is to present recent studies on the antimicrobial properties of linalool, the mechanism of action on cells, and detoxification processes. Linalool, commonly found in many herbs and black tea, has been shown to have a broad spectrum of biological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, and antimicrobial effects. It is particularly effective against Gram-negative bacteria, and further research is being conducted to understand its mechanism of action and biotransformation processes.
Review
Fisheries
Melbourne Rio Talactac, Emmanuel Pacia Hernandez, Takeshi Hatta, Kentaro Yoshii, Kodai Kusakisako, Naotoshi Tsuji, Tetsuya Tanaka
Summary: Ticks, as obligate hematophagous arthropods, are exposed to various blood-borne pathogens, including arboviruses, and their feeding behavior can transmit economically important viral pathogens to humans and animals. The replication and transmission of tick-borne viruses must be carefully regulated by their tick vectors to avoid negative effects on tick development. However, research on the tick-virus interface lags behind that of mosquitoes, due to the complexity of tick feeding behavior, limiting the understanding of tick immunity against tick-borne viruses.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Silvia Mara Baez Rodriguez, Georgiana-Adeline Staicu, Ani-Simona Sevastre, Carina Baloi, Vasile Ciubotaru, Anica Dricu, Ligia Gabriela Tataranu
Summary: Glioblastoma stem cells (GSCs) are self-renewing cells that can initiate tumors and are linked to tumor heterogeneity. Standard treatments fail to eradicate GSCs, leading to disease recurrence. Understanding the biology and survival mechanisms of GSCs is crucial for targeting them effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhirui Yang, Feng Qin
Summary: With global climate change, water scarcity-induced drought stress poses a significant threat to agricultural productivity. Plants adapt to drought stress through physiological and morphological changes, such as stomatal closure and altered root architecture. Recent studies have identified drought-related genetic resources in various crop species, and the molecular analysis of these genes has enhanced our understanding of drought responses in crops and provided targets for improving drought resistance. This review summarizes recent advances in cloning and functional analysis of drought resistance genes, as well as the development of technologies to mitigate the impacts of drought on crop production.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Claudia Rebeca Rivera-Yanez, Porfirio Alonso Ruiz-Hurtado, Maria Isabel Mendoza-Ramos, Julia Reyes-Reali, Gina Stella Garcia-Romo, Glustein Pozo-Molina, Aldo Arturo Resendiz-Albor, Oscar Nieto-Yanez, Adolfo Rene Mendez-Cruz, Claudia Fabiola Mendez-Catala, Nelly Rivera-Yanez
Summary: Skin is the main external organ that needs protection from various harmful agents. There are skin disorders that lack effective and accessible treatment. Flavonoids from propolis have beneficial effects on skin diseases, with antioxidant and anti-inflammatory properties that help control and regulate cellular and biochemical changes caused by these diseases.
Article
Microbiology
Minghua Li
Summary: Interferons and interferon-stimulated genes play a crucial role in the host's innate immunity against viral infection. A recent study identified phospholipid scramblase 1 as a novel interferon-stimulated gene that restricts SARS-CoV-2 infection by blocking virus-cell fusion.
CELL HOST & MICROBE
(2023)
Review
Chemistry, Medicinal
Junlan Tan, Jian Yi, Xianya Cao, Feiying Wang, Silin Xie, Aiguo Dai
Summary: Respiratory diseases pose a global risk and effective treatments are essential to reduce the burden. Astragaloside IV (AS-IV), a compound derived from Chinese medicine, has gained popularity for its potential anti-inflammatory, antioxidant, and anticancer properties. Accumulated evidence suggests that AS-IV has a protective effect against respiratory diseases. This article reviews the roles and mechanisms of AS-IV in combating respiratory diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Chemistry, Medicinal
Mousumi Shyam, Deepak Shilkar, Harshita Verma, Abhimanyu Dev, Barij Nayan Sinha, Federico Brucoli, Sanjib Bhakta, Venkatesan Jayaprakash
Summary: The article discusses the current progress in discovering novel endogenous targets for tuberculosis treatment and the use of Trojan horse approach to disrupt iron metabolism in mycobacteria.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Soon Sang Park, Yong Won Choi, Jang-Hee Kim, Hong Seok Kim, Tae Jun Park
Summary: Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, not only increase the malignant potency of cancer cells through the SASP, but also protect nonsenescent tumor cells from immune attack. Despite the potential role of therapy-induced senescent tumor cells in promoting tumor progression and recurrence, the complex causative factors and heterogeneity in different cancers make it challenging to establish their physiological role. Therapeutic strategies targeting senescent tumor cells or modulating their secretory phenotype are currently being explored to maximize the positive effects while minimizing the negative impacts.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)