Article
Biotechnology & Applied Microbiology
A. Rodriguez Jimenez, E. Dechamps, A. Giaux, L. Goetghebuer, M. Bauwens, P. Willenz, S. Flahaut, M. S. Laport, I. F. George
Summary: Cultivable bacteria associated with the marine sponges Hymeniacidon perlevis and Halichondria panicea exhibit promising antibacterial activity against multi-drug-resistant Staphylococcus aureus, indicating their potential as a valuable source of antibacterial compounds with pharmaceutical interest. This study is the first to show the antibacterial potential of these bacteria against MDR bacteria, including vancomycin nonsusceptible and methicillin-resistant strains, highlighting the urgent need for new antibiotics.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
B. H. Nataraj, C. Ramesh, R. H. Mallappa
Summary: The study investigated the antimicrobial and antibiofilm potential of biosurfactants derived from different Lactobacillus strains against MRSA, demonstrating significant effects in both antibacterial action and antibiofilm activity.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
T-P Nguyen, N-A Vu Thi, X-N Nguyen Diep, T. N. Nguyen, L. M. Bui
Summary: This study investigated the antibacterial activities of diethyl ether extracts from six medicinal plants in Vietnam against Staphylococcus aureus and its variants. The findings showed a low-resistance tendency of S. aureus to antimicrobial plant extracts, with strains adapted to the extracts being collateral sensitive to antibiotics. In contrast, antibiotic-adapted strains exhibited cross-resistance to both antibiotics and extracts.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Infectious Diseases
Duangdaow Khunbutsri, Nattakarn Naimon, Khomson Satchasataporn, Natnaree Inthong, Sarawan Kaewmongkol, Samak Sutjarit, Chanokchon Setthawongsin, Nattakan Meekhanon
Summary: This study aimed to investigate the potential antibacterial activity of Solanum torvum leaf extract against multidrug-resistant Staphylococcus isolated from clinically healthy dogs. The results showed that the leaf extract displayed inhibitory effects, especially when used in combination with oxacillin.
Review
Geriatrics & Gerontology
Virgilio Hernandez-Ruiz, Emmanuel Forestier, Gaetan Gavazzi, Tristan Ferry, Nicolas Gregoire, Dominique Breilh, Marc Paccalin, Sylvain Goutelle, Claire Roubaud-Baudron
Summary: Some studies suggest that the subcutaneous route could be an alternative to intravenous administration of antibiotics, particularly for time dependent antibiotics and certain patient populations. However, clinical evidence regarding the benefits and risks of subcutaneous antibiotic administration is still scarce and of low level. Further clinical studies are needed to assess the pharmacokinetic/pharmacodynamic properties of subcutaneous antibiotic administration.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Biotechnology & Applied Microbiology
Isabella Centeleghe, Phillip Norville, Louise Hughes, Jean-Yves Maillard
Summary: This study aimed to produce a dual species dry surface biofilm (DSB) and evaluate the efficacy of commercially available wipe products in eliminating pathogens within a dual species DSB and preventing their transfer. The results showed that some wipe products were effective in eliminating pathogens, but were not effective in preventing the transfer of Staphylococcus aureus between surfaces. This study provides important insights into the behavior of dual species DSB and the suitability of wipe products for disinfection.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Chemistry, Analytical
Abhishesh Kumar Mehata, M. Nikitha Lakshmi Suseela, Patharaj Gokul, Ankit Kumar Malik, Matte Kasi Viswanadh, Chandrashekhar Singh, Joseph Selvin, Madaswamy S. Muthu
Summary: Antibiotics play a crucial role in preventing and mitigating infectious diseases, but their mass production has led to the accelerated development of antimicrobial resistance. Conventional wastewater treatment methods are inefficient in removing antibiotics, and it is essential to develop highly efficient analytical methods for quantifying antibiotic residues in the environment. This review provides an overview of sampling techniques, purification and enrichment methods for antibiotics from environmental matrices, as well as various analytical methods for the quantification of extracted antibiotics.
MICROCHEMICAL JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
W. G. Duan, X. Liu, Z. Na, L. Zhou, F. M. Huang, Q. S. Song, Q. F. Fan
Summary: Oroxylum indicum is a valuable Dai pharmaceutical used for treating acute cough and sore throat. Compounds extracted from O. indicum showed antibacterial activities, especially baicalein exhibited strong activity against MRSA strains. This study provides new evidence for the traditional use of O. indicum in Dai peoples' life.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Marynes Quintero, Lina M. Blandon, Oscar M. Vidal, Juan D. Guzman, Jorge E. Gomez-Marin, Albert D. Patino, Diego A. Molina, Gloria M. Puerto-Castro, Javier Gomez-Leon
Summary: This study evaluated the biological activity of extracts from marine bacteria cultures against Toxoplasma gondii and Mycobacterium tuberculosis. The Bacillus sp. INV FIR48 extract showed anti-T. gondii and anti-tuberculosis biological activity with low cytotoxicity, and peptide metabolites were detected in the extract. Marine bacteria are promising sources of natural products for anti-infective purposes, especially against prevalent diseases like toxoplasmosis and tuberculosis.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Juan F. Garcia, M. Jose Diez, Ana M. Sahagun, Raquel Diez, Matilde Sierra, Juan J. J. Garcia, Cristina Lopez, M. Nelida Fernandez
Summary: This study analyzed web pages where antibiotics for veterinary use can be purchased online. The findings revealed that the most offered antibiotics were those considered critically important by the OIE. Penicillins and tetracyclines were widely available in English, while fluoroquinolones and tetracyclines were predominant in Spanish. Most offers were for oral and parenteral administration and intended for cats, dogs, and bovines.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Nisha Rathor, Chandan Kumar Thakur, Bimal Kumar Das, Rama Chaudhry
Summary: This study aimed to isolate and characterize a lytic bacteriophage against drug-resistant Pseudomonas aeruginosa. The results showed that the Pseudomonas phage AIIMS-Pa-A1 is a novel member of the Autographiviridae family, truly lytic in nature for drug-resistant P. aeruginosa. It has promising potential for future therapeutic intervention to treat drug-resistant P. aeruginosa infections.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Gabriela N. Tenea, Gabriela Lizeth Gonzalez, Jose Luis Moreno
Summary: A strain of Bacillus subtilis Fa17.2 isolated from a plant inflorescence in Ecuador showed potential antimicrobial properties, inhibiting the growth of both Gram-negative and Gram-positive bacteria without antibiotic resistance.
Article
Infectious Diseases
Charlie Tran, Ian E. Cock, Xiaojing Chen, Yunjiang Feng
Summary: The use of antibiotic growth promoters in the agricultural industry has resulted in the spread of antibiotic resistance, leading to bans in several countries. This has led to an increase in pathogenic outbreaks in livestock. Research has shown that spore-forming bacteria from the Bacillus genus might offer an economically viable, non-toxic, and renewable alternative to antibiotics, but their mechanisms of action remain unexplored.
Article
Pharmacology & Pharmacy
Qianlin Meng, Fei Lin, Baodong Ling
Summary: Peptide antibiotics combined with other antimicrobials have synergistic or additive effects on extensively drug-resistant A. baumannii in planktonic and biofilm cells, and the combination of polymyxins with carbapenems or azithromycin could be an ideal therapy against extensively drug-resistant A. baumannii infections.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Infectious Diseases
Jan J. De Waele, Jerina Boelens, Dirk Van De Putte, Diana Huis In't Veld, Tom Coenye
Summary: Intra-abdominal infections are common in hospitalized patients and require antimicrobial therapy and source control. The use of abdominal drains is increasing for treating these infections, but biofilm formation in the drains makes using abdominal fluid for diagnosis unreliable.
Article
Chemistry, Medicinal
Werner J. Geldenhuys, Robert Skolik, Mary E. Konkle, Michael A. Menze, Timothy E. Long, Aaron R. Robart
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Biotechnology & Applied Microbiology
Meagan E. Valentine, Brandon D. Kirby, Thomas R. Withers, Shannon L. Johnson, Timothy E. Long, Youai Hao, Joseph S. Lam, Richard M. Niles, Hongwei D. Yu
MICROBIAL BIOTECHNOLOGY
(2020)
Article
Microbiology
Brandon D. Kirby, Roy Al Ahmar, T. Ryan Withers, Meagan E. Valentine, Monica Valentovic, Timothy E. Long, James R. Gaskins, Hongwei D. Yu
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Infectious Diseases
Jonah A. Moore, Michaela Meakin, Mikaela H. Earl, Tiffany M. Kummer, Jeremy P. McAleer, Timothy E. Long
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Article
Biotechnology & Applied Microbiology
Maria-Paz Cabal, Timothy E. Long, Edward Turos, Ana-Belen Garcia, Jessie L. Allen, Bridget G. Budny, Lindsey N. Shaw
JOURNAL OF ANTIBIOTICS
(2020)
Article
Infectious Diseases
Tyler B. Clay, Kara W. Orwig, Raice A. Stevens, Emily P. Davis, Timothy M. Jennings, Timothy E. Long, Brittany L. Riley, Michael D. Hambuchen
Summary: MRSA PCR wound swabs showed high sensitivity, specificity, and predictive values in SSTIs, demonstrating their potential as a valuable tool.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Alexandria D. Lewis, Taylor M. Riedel, Meredith B. A. Kesler, Melinda E. Varney, Timothy E. Long
Summary: Disulfide analogs of disulfiram showed antimicrobial activity against MRSA and other pathogenic organisms. Lipophilicity and bulkiness of the substituents were found to correlate with the activity, and optimal analogs contained S-octyl disulfides and N,N-dimethyl- or N-pyrrolidine dithiocarbamate substituents.
JOURNAL OF ANTIBIOTICS
(2022)
Article
Infectious Diseases
Claire N. Shanholtzer, Cameron Rice, Katherine Watson, Hannah Carreon, Timothy E. Long
Summary: This study evaluated the impact of copper on the antifungal activity of disulfiram against fluconazole-resistant Candida species. The results showed that copper addition enhanced the inhibitory effects of disulfiram on Candida cultures, but it also antagonized the fungicidal activity of disulfiram.
Article
Biochemistry & Molecular Biology
Adeoluwa A. Adeluola, Nana Bosomtwe, Timothy E. Long, A. R. M. Ruhul Amin
Summary: This study evaluated the anti-tumor efficacy and mechanism of action of ActD in aerodigestive tract cancers. Results showed that ActD strongly inhibited the growth of aerodigestive tract cancer cells and induced efficient apoptosis. Mechanistic studies revealed that ActD increased the expression of p53 and influenced its downstream targets.
Article
Microbiology
Hasitha Chavva, Yogesh Meka, Timothy E. E. Long
Summary: This study found that the combination of disulfiram (DSF) and vancomycin (VAN) can significantly enhance bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA), but antagonistic effects were observed on the post-antibiotic effect of VAN.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Ebenezer Newton, Sarah A. Starcovic, Michael Menze, Mary E. Konkle, Timothy E. Long, Lori A. Hazlehurst, Jason D. Huber, Aaron R. Robart, Werner J. Geldenhuys
Summary: MitoNEET is a protein belonging to the CDGSH Iron-Sulfur Domain (CISD)-gene family, containing a [2Fe-2S] cluster, and located on the outer membrane of mitochondria. Its specific functions in regulating mitochondrial bioenergetics in metabolic diseases are not fully understood. A protocol for high-throughput screening (HTS) assay targeting mitoNEET has been developed, which facilitates drug discovery for metabolic disorders.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Lindsay Blume, Timothy E. Long, Edward Turos
Summary: Sulfur-containing molecules have a rich history in bioactivity, particularly as antibacterial agents against infectious pathogens. Natural organosulfur compounds have been used for treating infections since ancient times. Additionally, many commercially available antibiotics also contain sulfur-based components in their structures. In this review, we provide a summary of sulfur-containing antibacterial compounds, with a focus on disulfides, thiosulfinates, and thiosulfonates, and discuss potential opportunities for future advancements in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Kathleen C. Brown, Kushal J. Modi, Reagan S. Light, Ashley J. Cox, Timothy E. Long, Rama S. Gadepalli, John M. Rimoldi, Sarah L. Miles, Gary Rankin, Monica Valentovic, Krista L. Denning, Maria T. Tirona, Paul T. Finch, Joshua A. Hess, Piyali Dasgupta
Summary: Capsaicin, the heterocyclic vanilloid compound, is responsible for the spicy flavor of chili peppers and has been shown to suppress the growth of multiple human cancers. In addition to capsaicin, natural and synthetic capsaicin-like compounds also exhibit growth suppressive activity in human cancers. This manuscript describes the isolation and synthesis of capsaicin analogs with structural modifications in region B, as well as their pharmacokinetic properties, anticancer activity, and signaling pathways underlying their growth-inhibitory effects. The discovery of novel, second-generation region B capsaicin analogs holds promise for innovative nutrition-based combination therapies in human cancers.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Werner J. Geldenhuys, Timothy E. Long, Pushkar Saralkar, Toshio Iwasaki, Raisa A. A. Nunez, Rajesh R. Nair, Mary E. Konkle, Michael A. Menze, Mark V. Pinti, John M. Hollander, Lori A. Hazlehurst, Aaron R. Robart
COMMUNICATIONS CHEMISTRY
(2019)
