Article
Microbiology
Yury Y. Borshchev, Inessa Y. Burovenko, Alena B. Karaseva, Sarkis M. Minasian, Egor S. Protsak, Victor Y. Borshchev, Natalia Y. Semenova, Olga V. Borshcheva, Alexander N. Suvorov, Michael M. Galagudza
Summary: This study investigated the effects of different probiotics on myocardial infarct size in rats with diet-induced obesity and chemically-induced colitis. It also studied the potential associations between probiotic effects, gut microbiome patterns, and serum levels of pro- and anti-inflammatory cytokines, lipopolysaccharide, and short chain fatty acids. The administration of certain probiotics resulted in a reduction in myocardial infarct size and changes in cytokine concentrations. Additionally, the use of specific probiotics led to a reduction in lipopolysaccharide levels, suggesting improved intestinal barrier permeability.
Article
Dentistry, Oral Surgery & Medicine
Yara Loyanne de Almeida Silva Levi, Marcella Costa Ribeiro, Pedro Henrique Felix Silva, Giselle Aparecida Silva, Sergio Luiz de Souza Salvador, Sergio Luis Scombatti de Souza, Renato Casarin, Arthur Belem Novaes Junior, Mario Taba Junior, Daniela Bazan Palioto, Heitor Marques Honorio, Michel Reis Messora, Flavia Aparecida Chaves Furlaneto
Summary: This study evaluated the adjuvant effects of Bifidobacterium lactis HN019 on the treatment of plaque-induced generalized gingivitis. The results showed that the use of B. lactis HN019 can reduce bleeding, lower gingival index, and decrease the proportion of patients with gingivitis. This study demonstrates that Bifidobacterium can have positive effects in the treatment of plaque-induced generalized gingivitis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biology
Louiza Kadja, Amira Leila Dib, Nedjoua Lakhdara, Assia Bouaziz, Elena Espigares, Mohammed Gagaoua
Summary: The study demonstrated that probiotics have an impact on the biochemical and hematological parameters of rabbits, and the three strains of probiotics had a positive effect on the weight gain of the rabbits. Supplementing the rabbits' feed with the three probiotic strains showed positive effects on most of the biochemical and hematological parameters investigated during a 60-day period, with a significant improvement in the rabbits' body weight at the end of the experiment.
Article
Oncology
Xiang Liu, Ge Jin, Qiang Tang, Shumin Huang, Yujie Zhang, Yue Sun, Tianyu Liu, Zixuan Guo, Cheng Yang, Bangmao Wang, Kui Jiang, Weilong Zhong, Hailong Cao
Summary: Early life colonisation with Lactobacillus rhamnosus GG (LGG) can inhibit intestinal tumour formation in offspring by influencing gut microbiota composition and regulating signaling pathways.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones
Summary: The study shows that oral administration of Lactobacillus rhamnosus GG can enhance colonic CD8 T-cell responses in mice and reduce tumor burden. This suggests the potential use of LGG to augment antitumor immune responses in colorectal cancer patients and increase the efficacy of immunotherapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alla Splichalova, Sharon M. Donovan, Helena Tlaskalova-Hogenova, Zbynek Stranak, Zdislava Splichalova, Igor Splichal
Summary: Monoassociation of preterm germ-free piglets with probiotic BB12 did not fully prevent LT2 infection, but could reduce LT2 colonization in the intestine and liver, and alleviate LT2-induced damage to the luminal structure of the ileum. LT2 infection led to increased levels of inflammatory cytokines, which were mildly downregulated by BB12.
Article
Endocrinology & Metabolism
M. E. Baldassarre, A. Di Mauro, F. Cresi, S. Salvatore, S. Aragona, G. Ciprandi
Summary: This real-life study demonstrated that BB-12 supplementation significantly reduced functional regurgitation symptoms in formula-fed infants.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Endocrinology & Metabolism
M. E. Baldassarre, A. Di Mauro, F. Cresi, S. Salvatore, S. Aragona, G. Ciprandi
Summary: Cow's milk allergy is common in infancy, but there is no simple diagnostic tool. This study found that a two-month supplementation of the probiotic strain BB-12 significantly reduced symptom severity in artificially fed infants.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Nutrition & Dietetics
Kemin Mao, Jie Gao, Xianghong Wang, Xiyu Li, Shuo Geng, Tuo Zhang, Faizan Ahmed Sadiq, Yaxin Sang
Summary: This study confirms the effects of BB-12 on gut microbiota disorders caused by a high-fat diet. BB-12 was found to improve the composition of gut microbiota and prevent obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Taiyu Zhai, Wenbo Ren, Pingping Wang, Lei Zheng
Summary: Gut microbiota plays an important role in atherosclerosis, and probiotic Lactobacillus rhamnosus GG can effectively inhibit the generation of AS plaques. It participates in the antiatherosclerotic mechanism by altering the composition of gut microbiota and metabolites.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Oktay Yerlikaya, Derya Saygili, Asli Akpinar
Summary: The study demonstrated that the texture, viscosity, and sensory attributes of probiotic yoghurt-like products containing Bifidobacterium lactis subsp. lactis BB12(R) and Enterococcus were affected by the starter culture type. The combination of Streptococcus thermophilus, Bifidobacterium animalis subsp. lactis BB-12(R), and Enterococcus yielded better results in textural parameters and apparent viscosity in the probiotic yoghurt-like product.
Article
Microbiology
Hongchang Cui, Qian Wang, Congrui Feng, Chaoqun Guo, Jingyan Zhang, Xinping Bu, Zhi Duan
Summary: This study investigated the effects of Bifidobacterium animalis subsp. lactis VHProbi (R) YB11 on sucralfate-induced constipation. The results showed that YB11 increased fecal water content and intestinal peristalsis, indicating its positive impact on gastrointestinal mobility.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Aaron N. Colamarino, Thomas M. Johnson, Daniel M. Boudreaux, Joseph M. Dutner, Brian W. Stancoven, Adam R. Lincicum, Joshua A. Akers
Summary: This study evaluated the influence of probiotic bacteria supplementation, along with prebiotic inulin, on biofilm composition using an ex vivo model. The results showed that inulin supplementation increased the relative abundances of Lactobacillus and Bifidobacterium species, while decreasing the abundances of Streptococcus, Veillonella, Fusobacterium, Parvimonas, and Prevotella species. Inoculation with L. reuteri or B. animalis subsp. lactis only increased the relative abundance of the supplemented probiotic genera. Additionally, inulin supplementation led to decreased biofilm diversity.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Nutrition & Dietetics
Jing Cheng, Arja Laitila, Arthur C. Ouwehand
Summary: This review investigates the roles of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019 (TM)) in gut health and its mechanisms of action. Research supports the hypothesis that B. lactis HN019 (TM) has a beneficial role in maintaining intestinal barrier function and normal physiological function in immunosenescent elderly, as well as reducing intestinal transit time and increasing bowel movement frequency in functional constipation.
FRONTIERS IN NUTRITION
(2021)
Article
Microbiology
Carlotta Vizioli, Rosario Jaime-Lara, Scott G. Daniel, Alexis Franks, Ana F. Diallo, Kyle Bittinger, Tina P. Tan, Daniel J. Merenstein, Brianna Brooks, Paule V. Joseph, Katherine A. Maki
Summary: This study aimed to investigate the effects of probiotic consumption on the gut microbiome and metabolome of children. The results showed no significant changes in the global metagenomic or metabolomic profiles between the two intervention groups. However, there was a measurable impact on the relative abundance of the probiotics of interest in the gut microbiome. Future research should explore longer probiotic interventions and focus on children at risk for gastrointestinal disorders to further understand the potential protective effects of functional metabolite changes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Alicja M. Nogacka, Silvia Arboleya, Naghmeh Nikpoor, Jeremie Auger, Nuria Salazar, Isabel Cuesta, Laura Mantecon, Gonzalo Solis, Miguel Gueimonde, Thomas A. Tompkins, Clara G. de los Reyes-Gavilan
Summary: The study highlights the impact of HMOs, particularly 2'FL, on the establishment of intestinal microbiota, with the rate of 2'FL degradation being a crucial factor influencing microbiota evolution. Further research is needed to fully understand how early intervention with HMOs may affect the microbiota based on its ability to utilize 2'FL.
Article
Microbiology
Silvia Saturio, Marta Suarez, Leonardo Mancabelli, Nuria Fernandez, Laura Mantecon, Clara G. de los Reyes-Gavilan, Marco Ventura, Miguel Gueimonde, Silvia Arboleya, Gonzalo Solis
Summary: The use of intrapartum antibiotics prophylaxis negatively affects the establishment of bifidobacterial populations, impacting both diversity and compositional levels. Developing gut microbiota-based products should focus on promoting proper bifidobacterial microbiota development when intrapartum antibiotics prophylaxis is required.
Article
Geriatrics & Gerontology
Estefania Diaz-Del Cerro, Manuel Lambea, Judith Felix, Nuria Salazar, Miguel Gueimonde, Monica De la Fuente
Summary: The ingestion of a new probiotic AKK for a month improved behavior, immune functions, and oxidative stress in old mice, suggesting it as a promising nutritional strategy for healthy longevity.
Article
Microbiology
Alicja M. Nogacka, Silvia Arboleya, Naghmeh Nikpoor, Jeremie Auger, Nuria Salazar, Isabel Cuesta, Jorge R. Alvarez-Buylla, Laura Mantecon, Gonzalo Solis, Miguel Gueimonde, Thomas A. Tompkins, Clara G. de los Reyes-Gavilan
Summary: 2'-Fucosyllactose (2'-FL) is a highly abundant oligosaccharide in human milk that benefits neonatal health. This study evaluated the impact of different probiotic strains or a probiotic formulation on the microbiota and degradation of 2'-FL. Results showed that certain probiotic strains promoted the degradation of 2'-FL in slow-degrading microbiota. Additionally, significant changes in microbiota composition and metabolic activity were observed with specific probiotic strains or the probiotic formulation in slow degraders. Further research is needed to understand the role of host intestinal microbiota in the efficacy of these strains.
Article
Microbiology
Silvia Saturio, Alicja M. Nogacka, Guadalupe M. Alvarado-Jasso, Nuria Salazar, Clara G. de los Reyes-Gavilan, Miguel Gueimonde, Silvia Arboleya
Summary: Bifidobacteria are crucial microorganisms during infancy, playing a dominant role in the healthy development of breastfed infants. The different species and quantities of Bifidobacteria have been shown to be important for infant health, with reduced levels potentially linked to infant diseases. Bifidobacterium strains are extensively studied for their probiotic properties, with research on their use as probiotics in neonates.
Article
Biochemistry & Molecular Biology
Ismael Martinez-Guardado, Silvia Arboleya, Francisco Javier Grijota, Aleksandra Kaliszewska, Miguel Gueimonde, Natalia Arias
Summary: Oxidative stress is a contributing factor in aging and neurological disorders. Physical exercise and probiotics intake can improve brain's stress response and provide neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Marta Selma-Royo, Sonia Gonzalez, Miguel Gueimonde, Melinda Chang, Annalee Furst, Cecilia Martinez-Costa, Lars Bode, Maria Carmen Collado
Summary: This study examines the association between maternal diet and human milk oligosaccharide (HMO) profiles. The results show that diet has a more significant effect on HMO profiles in secretor mothers. (Poly)phenols, fibers, and certain insoluble polysaccharides are associated with secretor HMO profiles. Further research is needed to understand the relationship between maternal diet and bioactive compounds, including HMOs, in human milk.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Maria Gomez-Martin, David Herrero-Morin, Silvia Arboleya, Miguel Gueimonde, Sonia Gonzalez
Summary: The first years of life are crucial for establishing proper dietary patterns and maintaining them. A study on Spanish children aged 2 to 36 months found that breastfeeding rates were low, animal food intake exceeded recommendations, while fruits, vegetables, and vitamin D intake were insufficient. Moreover, there were associations between energy intake and Mediterranean Diet Score, indicating a need for guidelines promoting breastfeeding and healthy early-life food habits.
Article
Microbiology
Janneke P. Ouwerkerk, Hanne L. P. Tytgat, Janneke Elzinga, Jasper Koehorst, Pieter Van den Abbeele, Bernard Henrissat, Miguel Gueimonde, Patrice D. Cani, Tom Van de Wiele, Clara Belzer, Willem M. de Vos
Summary: This study isolated six novel strains of Akkermansia muciniphila from healthy human donors and compared their genomic, proteomic, and physiological characteristics to the type strains. The isolates clustered into two distinct subspecies, with one subspecies yet to be well characterized. All strains showed unique characteristics, and it was found that single healthy individuals can carry multiple strains of A. muciniphila. The strains exhibited strong conservation in mucin degradation pathways and showed potential as beneficial microbes without significant antibiotic resistance risks.
Review
Gastroenterology & Hepatology
Anna Samarra, Maria Esteban-Torres, Raul Cabrera-Rubio, Manuel Bernabeu, Silvia Arboleya, Miguel Gueimonde, Maria Carmen Collado
Summary: Resistance to antibiotics is a global threat, especially for newborns whose immune systems are still developing. The moment of birth exposes infants to antibiotic-resistant microorganisms that can colonize their gut and other body sites. Understanding the vertical transmission of antibiotic resistance from mothers to their offspring is crucial for developing strategies to reduce antibiotic resistance in early life.
Editorial Material
Microbiology
Gonzalo Solis, Miguel Gueimonde
Article
Nutrition & Dietetics
Aida Zapico, Silvia Arboleya, Nuria Salazar, Carmen Perillan, Sergio Ruiz-Saavedra, Clara G. de los Reyes-Gavilan, Miguel Gueimonde, Sonia Gonzalez
Summary: Non-communicable diseases are prevalent among low-income individuals due to the consumption of processed foods, fat, and sugars. This study evaluated the effects of a nutrition education intervention on sensory perception, health-related parameters, and gut microbiota of low socio-economic individuals. The intervention led to positive changes in dietary intake, reduced consumption of potentially carcinogenic compounds, and improved discrimination and depressive symptoms.
Review
Microbiology
Silvia Saturio, Alejandra Rey, Anna Samarra, Maria Carmen Collado, Marta Suarez, Laura Mantecon, Gonzalo Solis, Miguel Gueimonde, Silvia Arboleya
Summary: The development of the neonate's intestinal microbiome begins at birth when the mother provides the initial microbial inoculum. This microbiome contains antibiotic resistance genes, which are affected by different perinatal factors. Antibiotics, commonly used in pediatrics, can disrupt the early microbiota and increase the levels of antibiotic resistance genes. Understanding the factors influencing the development of the resistome in early life is crucial due to the emergence of antibiotic-resistant microorganisms.
Article
Microbiology
Alicja M. Nogacka, Isabel Cuesta, Miguel Gueimonde, Clara G. de los Reyes-Gavilan
Summary: Breastfeeding is crucial for infant nutrition, and 2-fucosyllactose (2'FL) is an important bioactive component in breastmilk. This study found a synergistic effect between Bifidobacterium bifidum IPLA20048 and Lactobacillus gasseri IPLA20136, where L. gasseri can utilize galactose released from the hydrolysis of 2'FL by B. bifidum. This phenomenon may be common among lactobacilli and bifidobacteria in the infant gut.
Article
Biochemistry & Molecular Biology
Sergio Ruiz-Saavedra, Carmen Gonzalez del Rey, Adolfo Suarez, Ylenia Diaz, Aida Zapico, Silvia Arboleya, Nuria Salazar, Miguel Gueimonde, Clara G. de los Reyes-Gavilan, Sonia Gonzalez
Summary: Diet is an important factor that affects the gut microbiota, which in turn plays a role in colorectal cancer development. This study aimed to explore the associations between dietary factors and gut microbiota in different clinical diagnosis groups. The results showed that the intake of red meat and polycyclic aromatic hydrocarbons (PAHs) was associated with changes in the abundance of certain microbial groups. The intake of heterocyclic amines, nitroso compounds, and ethanol was also associated with changes in the abundance of other microbial groups.
