Article
Cell Biology
Jeong-Hwa Jin, Hyuk Sung Kwon, Seong Hye Choi, Seong-Ho Koh, Eun-Hye Lee, Jee Hyang Jeong, Jae-Won Jang, Kyung Won Park, Eun-Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Hyun-Hee Park, Jungsoon Ha, Jong Eun Park, Myung Hoon Han
Summary: This study found a relationship between sleep parameters and longitudinal shortening of leukocyte telomere length (LTL). Poor sleep quality, specifically short sleep duration, long sleep latency, and low sleep efficiency were associated with faster longitudinal shortening of LTL.
Article
Cell Biology
Xiaotong Yang, Paula A. Benny, Elorri Cervera-Marzal, Biyu Wu, Cameron B. Lassiter, Joshua Astern, Lana X. Garmire
Summary: Variations in telomere length have been linked to aging, stress, and diseases. This study investigated the association between placental telomere length and preeclampsia. The results suggest that placental telomere length is not significantly different between severe preeclampsia cases and healthy controls, but it is negatively correlated with gestational age and influenced by race.
Article
Endocrinology & Metabolism
Racha Ghoussaini, Hani Tamim, Martine Elbejjani, Maha Makki, Lara Nasreddine, Hussain Ismaeel, Mona P. P. Nasrallah, Nathalie K. K. Zgheib
Summary: This longitudinal study found that age, gender, and baseline C-peptide level were associated with telomere shortening, indicating the potential role of metabolic dysregulation in early aging. Further understanding and addressing high C-peptide levels are important for preventing premature aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Elizabeth M. Curtis, Veryan Codd, Christopher Nelson, Stefania D'Angelo, Qingning Wang, Elias Allara, Stephen Kaptoge, Paul M. Matthews, Jonathan H. Tobias, John Danesh, Cyrus Cooper, Nilesh J. Samani, Nicholas C. Harvey
Summary: This study investigated the association between telomere length and the risk of fracture and arthroplasty. The results showed that longer telomere length was associated with a decreased risk of hip arthroplasty in both men and women, and knee arthroplasty in men. However, the association with the risk of fracture was weak, especially in men.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Behavioral Sciences
Ana Paula Mendes-Silva, Erica Leandro Marciano Vieira, Gabriela Xavier, Lucelia Scarabeli Silva Barroso, Laiss Bertola, Efrem Augusto Ribeiro Martins, Elisa Macedo Brietzke, Sintia Iole Nogueira Belangero, Breno Satler Diniz
Summary: The study found that older adults with late-life depression have shorter telomeres compared to healthy controls, especially those with more severe depressive symptoms. There was a negative correlation between telomere length and the severity of depressive symptoms and medical burden, but no significant correlation with cognitive performance.
BRAIN AND BEHAVIOR
(2021)
Article
Cell Biology
Xin Zhang, Mengting Shi, Xi Zhao, Ennan Bin, Yucheng Hu, Nan Tang, Huaping Dai, Chen Wang
Summary: This study aimed to investigate the regeneration capacity of AT2 cells with short telomeres. It was found that short telomeres in AT2 cells result in reduced expression level of TPPP3, thereby limiting the differentiation and regeneration capacity of AT2 cells.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Myung-Hoon Han, Eun-Hye Lee, Hyun-Hee Park, Seong Hye Choi, Seong-Ho Koh
Summary: This study found that early subjective depressive symptoms and cognitive complaints are associated with relatively shorter telomere length in relatively healthy elderly individuals. The study also found that interleukin-6 plays an important role in the relationship between telomere shortening and early subjective depressive symptoms and cognitive complaints.
Review
Geriatrics & Gerontology
Huimin Xie, Yubo Ma, Ming Shao, Jiangping Kong, Tingting Zhou, Feier Wang, Guoqi Cai, Shenqian Xu, Faming Pan
Summary: The study systematically evaluated the relationship between telomere length (TL) and osteoarthritis (OA) by analyzing six original studies, showing that OA patients have shorter TL in peripheral blood leukocytes (PBLs) compared to healthy controls. Sex ratio and body mass index (BMI) were identified as possible sources of heterogeneity.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yi-Yun Lin, Min-Hsuan Li, Yen-Chan Chang, Peng-Yu Fu, Ryosuke L. Ohniwa, Hung-Wen Li, Jing-Jer Lin
Summary: Telomeres are crucial for chromosome maintenance, and Cdc13 is an essential telomeric DNA binding protein that caps telomeres and regulates telomerase function. Research shows that specific binding of Cdc13 on single-stranded telomeric DNA can shorten duplex DNA into distinct states, and this shortening is dynamic and independent of duplex DNA sequences or length. Moreover, the inability of Pif1 helicase to remove Cdc13 from the shortened DNA-Cdc13 complex suggests a structurally stable complex formation through shortening of bound DNA.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Pavel Cuevas Diaz, Humberto Nicolini, German Alberto Nolasco-Rosales, Isela Juarez Rojop, Carlos Alfonso Tovilla-Zarate, Ester Rodriguez Sanchez, Alma Delia Genis-Mendoza
Summary: This study aimed to investigate the role of telomere length in three different types of diabetes: latent autoimmune diabetes of adulthood (LADA), latent autoimmune diabetes in the young (LADY), and type 2 diabetes mellitus (T2DM). A total of 115 patients were included, and their telomere length was measured using real-time Polymerase Chain Reaction. The results showed that T2DM patients had higher BMI compared to LADA and LADY groups, while LADA patients had shorter telomeres compared to T2DM patients but not LADY patients. Furthermore, T2DM may have longer telomeres thanks to the protective effects of both metformin and insulin, despite the higher BMI in this group.
Article
Biochemistry & Molecular Biology
Manassanan Jitjumnong, Pornpan Chalermkitpanit, Tanyawan Suantawee, Sinsuda Dechsupa, Ladawan Vajarintarangoon, Sittisak Honsawek
Summary: This study found that patients with lumbar disc degeneration (LDD) had shorter telomeres, increased oxidative stress, and decreased antioxidant levels. The telomere length was negatively correlated with the severity of LDD, while oxidative stress markers (MDA and 8-OHdG) showed positive correlations with severity. These findings suggest that telomere length, as well as MDA and 8-OHdG levels, may be potential non-invasive biomarkers for assessing the severity of LDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Dries S. Martens, Charlotte Van der Stukken, Catherine Derom, Evert Thiery, Esm Ee M. Bijnens, Tim S. Nawrot
Summary: The study found that there is a correlation between telomere length at birth and later in life in both children and adults. The ranking of telomere length tends to be stable over time, indicating the importance of understanding the initial setting of newborn telomere length and its significance for later life. Additionally, longer maternal telomere length is associated with lower telomere attrition in the next generation.
Review
Pharmacology & Pharmacy
Xin-Xin Zhang, Shi-Hao He, Xu Liang, Wei Li, Tian-Fang Li, Dai-Feng Li
Summary: Osteoarthritis is a chronic joint disease characterized by cartilage destruction, with aging playing a key role. Current treatments are palliative, and there is a need for disease-modifying drugs. Cellular senescence, synovial inflammation, and epigenetic changes may contribute to its pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Eun-Hye Lee, Myung-Hoon Han, Jungsoon Ha, Hyun-Hee Park, Seong-Ho Koh, Seong Hye Choi, Jae-Hong Lee
Summary: The study indicated a negative association between age and telomere length, with individuals with Alzheimer's disease showing a greater rate of telomere shortening per year compared to healthy individuals and those with mild cognitive impairment. Additionally, women experienced more significant telomere shortening per year than men.
Article
Geriatrics & Gerontology
Hatice Kubra Barcin-Guzeldere, Meral Aksoy, Turan Demircan, Mervenur Yavuz, Mahmut Beler
Summary: This study evaluated the effect of anthropometric measurements and dietary habits on telomere length in older residents in rural and urban areas. The results showed that urban women had longer telomeres than rural women. Rural men had higher hip circumference, middle-upper arm circumference, and fat-free mass than urban men. Additionally, the consumption of red meat, milk-based dessert, and pastry, as well as waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio, were found to be associated with telomere length.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Genetics & Heredity
Tadeusz Bieganski, Peter Beighton, Maciej Lukaszewski, Krzysztof Bik, Lukasz Kuszel, Ewa Wasilewska, Kazimierz Kozlowski, Malwina Czarny-Ratajczak
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2017)
Article
Genetics & Heredity
Malwina Czarny-Ratajczak, Krystyna Chrzanowska, Tadeusz Bieganski, Jerzy Sulko, Dobromila Baranska, Beata Kocyla-Karczmarewicz, Lukasz Kuszel, Lucjusz Jakubowski, Kryspin Niedzielski, Kazimierz Kozlowski
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2009)
Article
Biotechnology & Applied Microbiology
Ivo Marik, Olga Hudakova, Sarka Petrasova, Lukasz Kuszel, Malwina Czarny-Ratajczak, Kazimierz Kozlowski
JOURNAL OF APPLIED GENETICS
(2012)
Article
Biotechnology & Applied Microbiology
Anna Wawrocka, Agata Sikora, Lukasz Kuszel, Maciej R. Krawczynski
JOURNAL OF APPLIED GENETICS
(2013)
Article
Parasitology
Lukasz Pielok, Szymon Nowak, Matylda Kludkowska, Krystyna Frackowiak, Lukasz Kuszel, Pawel Zmora, Jerzy Stefaniak
PARASITOLOGY RESEARCH
(2019)
Article
Genetics & Heredity
Marie Shaw, Anna Winczewska-Wiktor, Magdalena Badura-Stronka, Sunita Koirala, Alison Gardner, Lukasz Kuszel, Piotr Kowal, Barbara Steinborn, Monika Starczewska, Sarah Garry, Ingrid E. Scheffer, Samuel F. Berkovic, Jozef Gecz
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2020)
Article
Immunology
Dagny Lorent, Rafal Nowak, Carolina Roxo, Elzbieta Lenartowicz, Aleksandra Makarewicz, Bartosz Zaremba, Szymon Nowak, Lukasz Kuszel, Jerzy Stefaniak, Ryszard Kierzek, Pawel Zmora
Summary: Poland reported a relatively low number of confirmed COVID-19 cases in the early months of the pandemic compared to other European countries. A serosurvey conducted after the first wave of COVID-19 in Europe found that 1.67% of the Poznan metropolitan area's population had antibodies against SARS-CoV-2, with a decrease in seroprevalence to 0.93%. Age, occupation with constant contact, travel, non-compliance with recommendations, and direct contact with the virus were associated with positive antibody results.
Article
Genetics & Heredity
Anna Wawrocka, Joanna Walczak-Sztulpa, Magdalena Socha, Lukasz Kuszel, Anna Sowinska-Seidler, Bartlomiej Budny, Ewelina Bukowska-Olech, Magdalena Pilas-Pomykalska, Aleksander Jamsheer, Maciej R. Krawczynski
Summary: Aniridia is often caused by pathogenic variants in the PAX6 gene, but in some cases, it may result from chromosomal rearrangements. This study identified a novel homozygous deletion in the DCDC1 gene, not involving the PAX6 gene, in a patient with isolated aniridia born to consanguineous parents. This is the first reported case of such a deletion downstream of the PAX6 gene.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Clinical Neurology
Magdalena Badura-Stronka, Lukasz Kuszel, Agnieszka Wencel-Warot, Kamila Cudnoch, Katarzyna Wolynska, Karolina Rutkowska, Barbara Steinborn, Rafal Ploski
Summary: This article reports on a family affected by epilepsy, where a variant in the SV2A gene was identified. The findings further support the role of the SV2A gene in autosomal dominant epilepsy.
Article
Immunology
Dagny Lorent, Rafal Nowak, Monika Jankowska, Lukasz Kuszel, Pawel Zmora
Summary: Children are efficient carriers of respiratory viruses, including emerging variants of SARS-CoV-2. Vaccinating individuals who have close contact with children, such as teachers, is crucial. This study compared the antibody responses of teachers vaccinated with mRNA and vector vaccines and evaluated their effectiveness against COVID-19.
Review
Biotechnology & Applied Microbiology
Magdalena Frydrychowicz, Lukasz Kuszel, Grzegorz Dworacki, Joanna Budna-Tukan
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide. Late-stage diagnosis contributes to poor prognosis and high mortality. Finding new biomarkers, particularly miRNA expression, is essential for predicting outcomes and maximizing treatment effectiveness. Liquid biopsy, specifically circulating tumor nucleic acids, is a promising non-invasive method for this purpose.
JOURNAL OF APPLIED GENETICS
(2023)
Letter
Immunology
Szymon P. Nowak, Pawel Zmora, Lukasz Pielok, Lukasz Kuszel, Ryszard Kierzek, Jerzy Stefaniak, Malgorzata Paul
EMERGING INFECTIOUS DISEASES
(2019)
Article
Genetics & Heredity
Joanna Walczak-Sztulpa, Anna Wawrocka, Agata Sobierajewicz, Lukasz Kuszel, Jan Zawadzki, Ryszard Grenda, Anna Swiader-Lesniak, Beata Kocyla-Karczmarewicz, Anna Wnuk, Anna Latos-Bielenska, Krystyna H. Chrzanowska
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2017)