Journal
JOURNAL OF APPLIED CRYSTALLOGRAPHY
Volume 46, Issue -, Pages 1501-1507Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S002188981301786X
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Funding
- Molecular Biophysics Training grant [T32GM008267]
- National Science Foundation (NSF)
- National Institutes of Health (NIH)/National Institute of General Medical Sciences under NSF [DMR0936384]
- NIH [GM103485]
- Air Force Office of Scientific Research (AFOSR) through the Graphene MURI
- NSF through the Cornell Center for Materials Research (CCMR) [NSF DMR0520404, IMR0417392]
- NSF
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The overall signal-to-noise ratio per unit dose for X-ray diffraction data from protein crystals can be improved by reducing the mass and density of all material surrounding the crystals. This article demonstrates a path towards the practical ultimate in background reduction by use of atomically thin graphene sheets as a crystal mounting platform for protein crystals. The results show the potential for graphene in protein crystallography and other cases where X-ray scatter from the mounting material must be reduced and specimen dehydration prevented, such as in coherent X-ray diffraction imaging of microscopic objects. (C) 2013 International Union of Crystallography Printed in Singapore - all rights reserved
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