Review
Chemistry, Medicinal
Sonia Singh, Aman Kumar, Bhupesh C. Semwal
Summary: Indian prickly ash, also known as Zanthoxylum armatum, is a traditional medicinal plant with bioactive metabolites that have potential antimicrobial, antifungal, antibacterial, and hepatoprotective effects. This review provides comprehensive information on the organoleptic, microscopy, phytochemistry, and biological activities of Z. armatum, emphasizing the need for further research to explore its potential efficacy.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhaoyang Wang, Chunmao Yuan, Junlei Chen, Yuhuan Li, Yinghuan Wei, Huanyang Li, Juelin Qiu, Liejun Huang, Zhanxing Hu, Xiaojiang Hao, Wei Gu
Summary: Phytochemical investigation of Zanthoxylum dimorphophyllum Hemsl resulted in the discovery of a new compound, 7-(4 ' R-hydroxy-3 ',7 '-dimethyl-2 ' E,6 '-octadienyloxy) coumarin (1), along with fourteen known compounds including coumarins, alkaloids, lignans, and flavone. The structures were determined using various spectroscopic methods and compared with literature data. The chemotaxonomic significance of the isolated compounds was also discussed.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kai Wang, Xian-Hua Meng, Tian Chai, Cheng-Bo Wang, Chun-Yan Sang, Wei-Feng Wang, Xian-Yi Shang, Jun-Li Yang
Summary: The phytochemical study of Zanthoxylum bungeanum Maxim led to the isolation of sixteen compounds, including a new compound and fifteen other known compounds. Some of these compounds were isolated from this plant for the first time, and their chemotaxonomic significance was discussed in the study.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Review
Chemistry, Medicinal
Japheth O. Ombito
Summary: The genus Zanthoxylum is a rich source of bioactive compounds with diverse pharmacological activities, including anti-inflammatory, antimicrobial, cytotoxic, and antioxidant properties. Phytochemical and pharmacological studies have shown great potential in exploring the medicinal uses of Zanthoxylum species.
NATURAL PRODUCTS JOURNAL
(2021)
Article
Food Science & Technology
Lorena Gonzalez-Gomez, Sonia Morante-Zarcero, Jorge A. M. Pereira, Jose S. Camara, Isabel Sierra
Summary: This study presents an optimized methodology for the determination of tropane alkaloids, atropine, and scopolamine in leafy vegetable samples using miniaturized QuEChERS followed by HPLC-MS/MS. The method was successfully validated and applied to the analysis of TA-producing plants and commercial mixed leafy vegetables, revealing high concentrations of scopolamine and atropine.
Article
Biochemical Research Methods
Yang Yang, Yanqun Li, Victor Amoroso, Florfe Acma, Maria Melanie Guiang, Hong Wu
Summary: This study aimed to detect and identify the bioactive components of different parts and regions of Z. nitidum using various techniques. The results showed that the compounds extracted from root bark and root wood were similar in type and quantity, but the former had substantially higher alkaloid content. The samples from Guangdong had higher alkaloid content compared to those from Guangxi Province. Hierarchical cluster analysis and principal component analysis effectively identified and evaluated samples from different regions based on alkaloids and other bioactive substances. These findings have important implications for the harvesting, usage, origin identification, quality evaluation, and sensible use of Z. nitidum resources.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Fabiola Eugelio, Sara Palmieri, Federico Fanti, Luana Messuri, Alessia Pepe, Dario Compagnone, Manuel Sergi
Summary: In this study, a sensitive and reliable HPLC-MS/MS method was developed for the identification and quantification of thirteen lupin alkaloids. The method was validated according to FDA guidelines and showed good selectivity with minimized matrix interference. The method provided a sensitive and reliable determination of the target compounds, with limits of quantification below the requested maximum levels. The method was applied to evaluate the LAs profile in different batches of Lupinus albus samples.
Article
Plant Sciences
Fabian Alperth, Anna Schneebauer, Olaf Kunert, Franz Bucar
Summary: This study conducted the first investigation of the heartwood of Swiss Stone Pine, Pinus cembra L., using HPLC, UHPLC-DAD-ESI-MSn, and NMR spectroscopy. Various secondary metabolites such as stilbenes, bibenzyls, and flavonoids were detected in the heartwood extract. The study also improved and compared HPLC analysis methods for Pinus stilbenes and flavonoids.
Article
Biochemistry & Molecular Biology
Tomasz Tuzimski, Anna Petruczynik, Malgorzata Szultka-Mlynska, Mateusz Sugajski, Boguslaw Buszewski
Summary: This study optimized the conditions for cholinesterase activity determination and investigated the inhibition activity of acetylcholinesterase and butyrylcholinesterase by some isoquinoline alkaloids and extracts from Macleaya cordata. The results showed high cholinesterase activity inhibition by certain alkaloids and Macleaya cordata extracts.
Article
Plant Sciences
Guanghou Wang, Hongjin Wang, Ziwei Lin, Lijuan Hou, Jia Yue Wang, Lixin Sun
Summary: This study aimed to investigate the phytochemical profile of alkaloids in N. officinalis total alkaloids and determine their pharmacokinetic behaviors. The results showed that 55 alkaloids were identified in N. officinalis total alkaloids, with 25 alkaloids absorbed by rats after oral administration. The established LC-ESI-MS/MS method was successfully applied for the simultaneous determination of major active alkaloids in rat plasma, providing valuable insights for pre-clinical and clinical investigations.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Adeline Karolkowski, Christine Belloir, Geraldine Lucchi, Christophe Martin, Emilie Bouzidi, Loic Levavasseur, Christian Salles, Loic Briand
Summary: This study aimed to determine the bitter molecules in faba beans, especially saponins and alkaloids. It was found that the low-alkaloid cultivar and the protein fractions had higher saponin content. Soyasaponin β and alkaloids were discovered to activate 11 TAS2Rs, while vicine only activated TAS2R16. This research provides a better understanding of the bitter molecules in faba beans and suggests that selecting low-alkaloid ingredients or alkaloid removal treatments could improve their flavor.
Article
Chemistry, Multidisciplinary
Guy Kleks, Darren C. Holland, Joshua Porter, Anthony R. Carroll
Summary: DOSY NMR allows for analysis of compound mixtures by predicting molecular weight based on diffusion coefficients, multiple physicochemical properties are used to establish prediction models, dereplication and identification of new compounds is carried out by matching experimental D with predicted D in a database.
Article
Chemistry, Medicinal
Jinli Tian, Shaohua Yu, Wei Zhao, Lu Wang, Degang Kong, Fujie Cai, Xiaohui Sun, Zhenhua Tian, Liqiao Zhu, Wenru Zhang, Honglei Zhou
Summary: Two new indole compounds were isolated and identified from the seeds of Raphanus sativus L., Brassicaceae using NMR and HR-ESI-MS.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Chemistry, Analytical
Gema Casado-Hidalgo, Sonia Morante-Zarcero, Damian Perez-Quintanilla, Isabel Sierra
Summary: The aim of this study was to develop an efficient, fast, and environmentally friendly method to control the content of opium alkaloids (OAs) in food products containing poppy seeds. By optimizing the ultrasound-assisted extraction and solid phase extraction steps, the concentrations of OAs in the samples were successfully analyzed and detected.
MICROCHEMICAL JOURNAL
(2022)
Article
Food Science & Technology
Lorena Gonzalez-Gomez, Sonia Morante-Zarcero, Jorge A. M. Pereira, Jose S. Camara, Isabel Sierra
Summary: This study analyzed 33 samples of tea and herbal tea infusions purchased in Spain and Portugal and found that 64% of the samples were contaminated with atropine and scopolamine. White and green teas were more contaminated compared to black and other herbal teas. Among the 21 contaminated samples, 15 had concentrations above the maximum limit set by the EU Commission Regulation (0.2 ng/mL) for liquid herbal infusions.
Article
Biology
Sergio Fuentes Anton, David Rodriguez de la Cruz, Jose Sanchez Sanchez, Estefania Sanchez Reyes
Article
Biology
David Rodriguez-de la Cruz, Estefania Sanchez-Reyes, Alberto Martin-Baz, Jose Angel Sanchez-Agudo
Article
Public, Environmental & Occupational Health
Stefania Fraenkel, Oscar Daniel Salvioni, Antonieta Rojas de Arias, Veronica Paola Arze, Miriam Rolon, Natalia Ramirez, Celeste Vega Gomez
PATHOGENS AND GLOBAL HEALTH
(2020)
Article
Environmental Sciences
Sergio Fuentes Anton, David Rodriguez de la Cruz, Asuncion Garcia Sanchez, Ignacio Davila, Jose Sanchez Sanchez, Estefania Sanchez Reyes
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2020)
Article
Biochemistry & Molecular Biology
Mariano Walter Pertino, Alexander F. de la Torre, Guillermo Schmeda-Hirschmann, Celeste Vega, Miriam Rolon, Cathia Coronel, Antonieta Rojas de Arias, Karla Leal Lopez, Pilar Carranza-Rosales, Ezequiel Viveros Valdez
BIOORGANIC CHEMISTRY
(2020)
Article
Infectious Diseases
Adolfo Borges, Antonieta Rojas de Arias, Sabrina de Almeida Lima, Bruno Lomonte, Cecilia Diaz, Carlos Chavez-Olortegui, Matthew R. Graham, Evanguedes Kalapothakis, Cathia Coronel, Adolfo R. de Roodt
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Green & Sustainable Science & Technology
Ivan Barbero-Bermejo, Gabriela Crespo-Luengo, Ricardo Enrique Hernandez-Lambrano, David Rodriguez de la Cruz, Jose angel Sanchez-Agudo
Summary: The study focuses on the design of conservation plans for the Iberian lynx habitat, using ecoinformatic tools from the GIS environment to establish potential ecological corridors and improve connectivity between natural spaces to enhance the species's habitat.
Article
Green & Sustainable Science & Technology
Ricardo Enrique Hernandez-Lambrano, David Rodriguez de la Cruz, Jose Angel Sanchez Agudo
Summary: Biogeographical theory suggests that anthropogenic climate change may affect species' rear edges, especially those dependent on specific water conditions. This study examined the potential impact of climate change on threatened rear edge populations of five hydrophyte plants in the Iberian Peninsula, finding that these populations tend to occur in less suitable environments and are highly sensitive to thermal extremes and seasonal variations. Predictions for 2050 indicated that most populations will face environmental risks, highlighting the need to prioritize conservation efforts in vulnerable areas.
Article
Biology
S. Fuentes Anton, E. Sanchez Reyes, D. Rodriguez de la Cruz, A. Garcia Sanchez, I. Davila, J. Sanchez Sanchez
Summary: This study aims to contribute to the understanding of fungal spores in the atmosphere of Salamanca by comparing Alternaria spore levels at two different sampling points. The results showed minimal variation in spore levels between the two locations, with a significant positive correlation in the daily concentrations of spores. Additionally, temperature and sunshine were found to have a positive effect on spore levels, while humidity and rainfall had a negative effect.
Article
Multidisciplinary Sciences
Antonieta Rojas de Arias, Louisa Alexandra Messenger, Miriam Rolon, Maria Celeste Vega, Nidia Acosta, Cesia Villalba, Paula L. Marcet
Summary: Although domestic infestations by Triatoma infestans have been successfully controlled in Latin America, recurrent post-spraying house colonization in the Gran Chaco region remains a significant challenge. Our study demonstrates that sylvatic T. infestans can threaten vector control strategies as a source of reinfestation or by providing temporary refuge during insecticide spraying. Human interactions with neighboring forested areas also play a role in recolonization.
Article
Agronomy
Abel Fernandez Ruiz, David Rodriguez de la Cruz, Jose Luis Vicente Villardon, Sergio Sanchez Duran, Prudencio Garcia Jimenez, Jose Sanchez Sanchez
Summary: The methodology used in determining macrofungal diversity in Mediterranean areas varies, making it difficult to compare results. This study conducted a weekly field analysis of macrofungal diversity over a period of two years in a Mediterranean holm oak forest, revealing that weekly collection throughout the year could provide a sufficient estimate of the macrofungal biodiversity in this ecosystem.
Article
Public, Environmental & Occupational Health
Milena Beatriz Britos Molinas, Elvio Gayozo Melgarejo, Antonieta Rojas de Arias
Summary: This study aimed to investigate the association between the number of Aedes aegypti eggs and climatic conditions and environmental variables in dengue endemic areas in Paraguay. The study found morphometric variations between different populations of Aedes aegypti and significant statistical associations between the number of eggs and relative humidity, Normalized Difference Vegetation Index and Normalized Difference Water Index.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Plant Sciences
Guillermo Schmeda-Hirschmann, Alberto Burgos-Edwards, Antonieta Rojas de Arias, Camila Lopez-Torres, Charlotte Palominos, Sebastian Fuentes-Retamal, Yarela Herrera, Karen Dubois-Camacho, Felix A. Urra
Summary: This study analyzed a traditional recipe used by the Mbya culture in Paraguay to treat cancer with the native toad Rhinella schneideri. The composition of the recipe was determined and its effects on human breast cancer cells were evaluated. The results showed that the recipe contains various metabolites, including alkaloids and bufadienolide derivatives. The recipe did not have cytotoxic effects on breast cancer cells, but it increased mitochondrial bioenergetics and inhibited cell migration.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Oscar D. Salomon, Antonieta Rojas De Arias
Summary: Yellow fever epidemics in South America during the 21st century have reached an unprecedented scale and spread. The current outbreaks are primarily caused by sylvatic cycles of yellow fever, and have been mitigated by vector control, vaccination, surveillance, and case management measures. While urban outbreaks of Aedes-Human yellow fever are still possible in the Americas, the probability is low.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Review
Parasitology
Antonieta Rojas de Arias, Carlota Monroy, Felipe Guhl, Sergio Sosa-Estani, Walter Souza Santos, Fernando Abad-Franch
Summary: Chagas disease remains a heavy burden in Latin American countries, with thousands of new infections each year and millions of carriers of Trypanosoma cruzi. While transmission through blood transfusion and organ transplantation is under control, interrupting vector-borne transmission of T. cruzi seems unfeasible. Stronger surveillance systems, increased screening for pregnant women, and improved patient care are needed.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2022)
