Article
Chemistry, Multidisciplinary
Vinicius C. Rocha, Rayssa A. Cajas, Allan I. Andrade-de-Siqueira, Roberto B. P. Almeida, Julia Godoy-Silva, Marina M. Goncalves, Joao Henrique G. Lago, Josue de Moraes
Summary: This study identifies dehydrodieugenol B from the Brazilian Nectandra leucantha plant as a potential treatment for schistosomiasis, showing superior efficacy compared to praziquantel in early stage infections.
Article
Immunology
Nidhi Dheman, Nicole Mahoney, Edward M. Cox, John J. Farley, Thushi Amini, Michael L. Lanthier
Summary: The longitudinal analysis of investigational new drug applications for new, systemic antibacterial drugs from 1980 to 2019 showed fluctuations in the number of applications, success rates, and development times over the past three decades. The majority of active new drug programs in development as of 2019 come from established drug classes, with most being sponsored by small pharmaceutical companies.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Computer Science, Information Systems
Wenli Wang, Zhuliang Jia, Mengfan Xu, Shundong Li
Summary: This paper proposes a strong privacy-preserving CSD query scheme called SPCS, which enables accurate double-CSD queries without disclosing any private information.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Review
Agriculture, Dairy & Animal Science
Elena Baralla, Maria P. Demontis, Filomena Dessi, Maria V. Varoni
Summary: This review discusses the increasing use of antibiotics globally and their accumulation in the environment as contaminants of emerging concern. Bivalves are proposed as biomonitoring organisms for antibiotic residues due to their global presence and filtration capacity. Studies have shown antibiotics presence in bivalves across European, American, and Asian coasts, with notable detection of macrolides, sulfonamides, and quinolones. Further investigations are needed to prevent antimicrobial resistance and reduce the risk of seafood consumption.
Article
Immunology
Antonia Thassya Lucas dos Santos, Jose Bezerra de Araujo-Neto, Maria Milene Costa da Silva, Maria Elenilda Paulino da Silva, Joara Nalyda Pereira Carneiro, Victor Juno Alencar Fonseca, Henrique Douglas Melo Coutinho, Paulo Nogueira Bandeira, Helcio Silva dos Santos, Francisco Rogenio da Silva Mendes, Debora Lima Sales, Maria Flaviana Bezerra Morais-Braga
Summary: The study aimed to evaluate the antimicrobial and potentiating activity of synthetic chalcones against strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Candida tropicalis. Chalcones were synthesized by Claisen-Schimidt aldol condensation and characterized using Nuclear Magnetic Resonance (NMR) and Gas Chromatography Coupled to Mass Spectrometry (GC/MS). The chalcone DB-Acetone showed inhibitory activity against P. aeruginosa, while DB-CNM and DB-Anisal inhibited the growth of S. aureus. The chalcones also showed potentiating activity with fluconazole against fungal strains.
MICROBIAL PATHOGENESIS
(2023)
Article
Chemistry, Organic
Jingjing Geng, Deli Sun, Yanhong Song, Weiqi Tong, Fan Wu
Summary: This study presents a nickel-catalyzed enantioconvergent reductive cross-coupling reaction between alpha-chlorosulfones and vinyl bromides, enabling the enantioselective construction of chiral allylic sulfones. The mild reaction conditions demonstrate excellent functional group compatibility, as evidenced by a broad substrate scope and tolerance of complex bioactive molecules.
Review
Medicine, General & Internal
Rasha Alhiary, Aaron S. Kesselheim, Sarah Gabriele, Reed F. Beall, S. Sean Tu, William B. Feldman
Summary: This study analyzed how manufacturers of brand-name GLP-1 receptor agonists have used patents and regulatory systems to extend market exclusivity. The findings suggest that manufacturers have submitted numerous patents and regulatory exclusivities to prolong the protection period of their products, preventing generic entry into the market. Therefore, patent and regulatory reforms are needed to ensure timely generic entry of GLP-1 receptor agonists.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Lotte A. Minnema, Thijs J. Giezen, Jarno Hoekman, Toine C. G. Egberts, Hubert G. M. Leufkens, Helga Gardarsdottir
Summary: This study assessed the overlap of adverse drug reactions (ADRs) in the summary of product characteristics (SmPCs) of TNF-alpha inhibitors, finding significant variations in the number and type of ADRs described among different drugs. Serious ADRs and those classified as important risks were more frequently described in subsequent versions of the SmPC.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Medicine, General & Internal
Rasha Alhiary, Aaron S. Kesselheim, Sarah Gabriele, Reed F. Beall, S. Sean Tu, William B. Feldman
Summary: This study analyzes how manufacturers of brand-name GLP-1 receptor agonists have utilized the patent and regulatory systems to prolong market exclusivity. The findings reveal that drug manufacturers list a median of 19.5 patents per product, with 54% of patents focused on delivery devices rather than active ingredients. The study suggests the need for patent and regulatory reform to ensure timely entry of generic GLP-1 receptor agonists to the market.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Infectious Diseases
Davorka Repac Antic, Marijo Parcina, Ivana Gobin, Mirna Petkovic Didovic
Summary: In the era of escalating antimicrobial resistance, finding antibacterial drugs with novel or improved modes of action is a crucial health concern. This review article provides insight into the modes of action of antibacterial agents through the perspective of chelation, demonstrating the important role of chelation in antibacterial mechanisms.
Review
Nanoscience & Nanotechnology
Jin Qi, Ran Zhang, Xiaoming Liu, Yingyu Liu, Qingmei Zhang, Huaiyi Cheng, Ran Li, Lu Wang, Xiuping Wu, Bing Li
Summary: Carbon dots (CDs) have great potential in drug delivery, especially in the treatment of inflammatory, bacterial, and cancer diseases. CDs improve cellular uptake and absorption and have controlled release properties, enhancing the therapeutic effects. They also offer advantages such as high drug-loading, increased targeting, and reduced systemic side effects. However, the safety and toxicity of CDs need to be carefully evaluated before their clinical application.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Irina Le-Deygen, Anastasia Safronova, Polina Mamaeva, Yana Khristidis, Ilya Kolmogorov, Anna Skuredina, Peter Timashev, Elena Kudryashova
Summary: The severe course of COVID-19 can lead to long-term pulmonary diseases, and developing new effective drug formulations, including inhalation administration, is crucial. This study proposes a method for creating lipid-polymer delivery systems using liposomes decorated with mucoadhesive mannosylated chitosan for fluoroquinolones and pirfenidone. The interactions between drugs and liposomes of different compositions are studied, and the role of the polymer shell in stabilizing vesicles and delaying the drug release is demonstrated. Results show prolonged accumulation of moxifloxacin in lung tissues after a single endotracheal administration in mice.
Article
Behavioral Sciences
Alice Servonnet, Hiroyuki Uchida, Anne-Noel Samaha
Summary: Continuous exposure to antipsychotic drugs may increase the risk of long-term adverse effects, while regular but extended dosing has been proved to be safer and more effective for patients, reducing overall drug exposure. Studies in laboratory animals show that compared to continuous exposure, regular but extended dosing has superior antipsychotic-like efficacy and substantially reduces the likelihood of motor side effects and dopamine receptor supersensitivity.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Entomology
Yasuhiko Matsumoto, Yuki Tateyama, Takashi Sugita
Summary: Cutibacterium acnes is a common bacterium on human skin, causing inflammatory skin diseases and systemic infections. Establishment of a new systemic infection model using silkworms can help evaluate the efficacy of antibacterial drugs for C. acnes treatment.
Article
Biotechnology & Applied Microbiology
Bunyamin Ozgeris
Summary: A series of thioureas were synthesized from various amines and nicotinic acid, exhibiting antimicrobial and antioxidant properties. These compounds showed moderate activity against bacteria causing nosocomial infections with acquired resistance to antibiotics, along with strong antioxidant properties. Thus, they have the potential to be developed as agents for treating bacterial infections and health issues related to aging such as cancer and neurodegenerative diseases.
JOURNAL OF ANTIBIOTICS
(2021)
