Article
Cardiac & Cardiovascular Systems
Andrei C. Sposito, Ikaro Breder, Joaquim Barreto, Jessica Breder, Isabella Bonilha, Marcus Lima, Alessandra Oliveira, Vaneza Wolf, Beatriz Luchiari, Helison R. do Carmo, Daniel Munhoz, Daniela Oliveira, Otavio R. Coelho-Filho, Otavio R. Coelho, Jose Roberto Matos-Souza, Filipe A. Moura, Luiz Sergio F. de Carvalho, Wilson Nadruz, Thiago Quinaglia, Sheila T. Kimura-Medorima
Summary: The addition of evolocumab to empagliflozin in individuals with T2D improves endothelial function, leading to better vascular function.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Sport Sciences
Francisco Javier Soto-Rodriguez, Eva Isidoro Cabanas, Jose Manuel Perez-Marmol
Summary: Prolonged sitting can affect endothelial function, and strategies that interrupt sitting have shown significant improvements in shear rate, flow-mediated dilation, and blood flow, thus playing a crucial role in preventing endothelial dysfunction.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Physiology
Andrea Tryfonos, Joseph Mills, Daniel J. Green, Anton J. M. Wagenmakers, Ellen A. Dawson, Matthew Cocks
Summary: This study examined the relationships between in vivo measures of vascular function and the expression of atherogenic risk-modulating proteins in endothelial cells (ECs) isolated from the radial artery of CAD patients. The results revealed a difference in the regulation of endothelium-dependent vasodilation measured in vivo between patients with CAD compared to previously reported data in subjects without a clinical diagnosis, suggesting that eNOS Ser(1177) phosphorylation may be the key to maintain vasodilation in CAD patients.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Rheumatology
Kavita Poonia, Mala Bhalla, Kanika Dogar, Anita Malhotra, Kajal Aggarwal
Summary: Flow-mediated dilatation (FMD) testing can assess macrovascular dysfunction in systemic sclerosis (SS) and correlate FMD values with disease severity. Lower FMD values were observed in SS patients compared to healthy controls. Lung manifestations in SS patients were associated with lower FMD values.
CLINICAL RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung
Summary: This study investigated the prognostic value of reactive hyperemia index (RHI), a measure of endothelial function, in patients with heart failure (HF). The findings suggest that a lower RHI value is associated with an increased risk of adverse clinical outcomes in HF, indicating that endothelial dysfunction may be an important prognostic marker in HF patients.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Christos Chatzakis, Nikolaos Koletsos, Maria Tirta, Konstantinos Dinas, Eugenia Gkaliagkousi, Alexandros Sotiriadis
Summary: This meta-analysis compared endothelial dysfunction between women with and without gestational diabetes mellitus (GDM) during pregnancy and post-partum. The results indicated that pregnant women with GDM had lower flow-mediated dilation (FMD) compared to those without GDM. Additionally, women with previous GDM showed lower FMD in the immediate post-partum period, but there was no significant difference in the late post-partum period (more than 4 years).
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Peripheral Vascular Disease
Theresa Herbrand, Hans-Veit Coester, Roberto Sansone, Annelie Fischer, Christian Heiss, Tim Heise, Malte Kelm, Hans J. DeVries
Summary: The study found that assessing FMD using the maximum dilatory peak (MDP) was more accurate and precise than the traditional 60-second method in both healthy subjects and those with type 2 diabetes mellitus (T2DM), leading to a significant reduction in necessary sample size.
Article
Endocrinology & Metabolism
Li-ying Hou, Xiao Li, Guo-qiang Zhang, Chuang Xi, Chen-tian Shen, Hong-jun Song, Wen-kun Bai, Zhong-ling Qiu, Quan-yong Luo
Summary: The purpose of this study was to assess the impact of short-term hypothyroidism on endothelial function and metabolic changes in patients with differentiated thyroid cancer during radioiodine therapy. The results showed that endothelial function was impaired during short-term hypothyroidism, but immediately returned to normal after restoring thyroid stimulating hormone suppression therapy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Sheung Yin San, Jennifer. M. F. Wan, Jimmy Chun Yu Louie
Summary: This study aimed to compare the efficacy of four formulations of plant-based functional foods on the protection against salt-induced endothelial dysfunction. The results showed that salt reduction may still be the most effective strategy to improve vascular health.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Peripheral Vascular Disease
Keishi Ichikawa, Toru Miyoshi, Yuko Ohno, Kazuhiro Osawa, Mitsutaka Nakashima, Takahiro Nishihara, Takashi Miki, Hironobu Toda, Masatoki Yoshida, Hiroshi Ito
Summary: This study found that there is an association between high PCAT attenuation and endothelial dysfunction assessed using FMD in patients with suspected coronary artery disease. These results suggest that endothelial dysfunction may be one of the pathophysiological mechanisms linking pericoronary inflammation to cardiac mortality.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Article
Cardiac & Cardiovascular Systems
Enrique Garcia-Sayan, Miryoung Lee, James R. Stone, Danielle M. Stone, Beverly Smulevitz, David D. McPherson, Susan P. Fisher-Hoch, Joseph B. McCormick, Susan T. Laing
Summary: Endothelial dysfunction assessed by impaired brachial flow-mediated dilation (FMD) predicts incident cardiovascular disease (CVD). This study aimed to assess determinants of impaired FMD response (%FMD), an earlier marker of atherosclerosis, in a population-based sample of asymptomatic Mexican Americans. The results showed age-dependent associations between cardiometabolic biomarkers and an FMD response in a sample composed of Mexican Americans without previous CVD.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Georgios Mavraganis, Maria-Angeliki Dimopoulou, Dimitrios Delialis, Dimitrios Bampatsias, Raphael Patras, Alexandros Sianis, Eleni Maneta, Kimon Stamatelopoulos, Georgios Georgiopoulos
Summary: Research suggests that endothelial dysfunction and increased arterial stiffness are associated with the severity and prognosis of COVID-19. These vascular impairments may play a crucial role in the clinical manifestations of COVID-19 and can be used for risk stratification.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Joshua I. Barzilay, Petra Buzkova, Howard A. Fink, Jane A. Cauley, Laura Carbone, Rachel Elam, John A. Robbins, Phyllis Stein, Kerry Sheets, Diana Jalal, Kenneth J. Mukamal
Summary: Endothelial dysfunction, which is associated with atherosclerotic vascular disease, was not found to have a significant association with hip fracture risk in older adults based on the examination of two markers of endothelial dysfunction.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Environmental Sciences
Szymon Mucka, Martyna Miodonska, Grzegorz K. Jakubiak, Monika Starzak, Grzegorz Cieslar, Agata Stanek
Summary: Assessment of endothelial function, particularly using the non-invasive method of flow-mediated dilation (FMD), is crucial in predicting the risk of cardiovascular diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Orthopedics
Chul Ki Goorens, Niels Debaenst, Kjell Van Royen, Steven Provyn, Jean F. Goubau
Summary: Comparing MIPO with PQ sparing and conventional PQ repair for distal radial fractures, the study found that MIPO group had better flexion-extension mobility and lower Quick Disabilities of the Arm, Shoulder and Hand scores, with significantly lower pain scores at 6 weeks but no significant differences in grip strength and patient satisfaction.
JOURNAL OF WRIST SURGERY
(2022)
Article
Physiology
Costantino Balestra, Francois Guerrero, Sigrid Theunissen, Peter Germonpre, Pierre Lafere
Summary: This study monitored technical divers during a wreck diving expedition and found a high incidence of high-grade VGE. No clinical decompression sickness was detected in the 30 recorded dives. Echographic and Doppler recordings were highly correlated.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Environmental Sciences
Sigrid Theunissen, Costantino Balestra, Sebastien Bolognesi, Guy Borgers, Dirk Vissenaeken, Georges Obeid, Peter Germonpre, Patrick M. Honore, David De Bels
Summary: Acute ascent to high altitudes resulted in decreased oxygen saturation without hypoxia symptoms. Cardiac output and oxygen delivery index increased as compensatory mechanisms. Vascular function changed but returned to normal after descent to lower altitudes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Rehabilitation
E. A. H. D. Duijn, S. van Roy, Y. H. J. M. Karel, S. Provyn, N. Pouliart
Summary: This study demonstrates a strong level of agreement and reliability among a limited group of physical therapists, a radiologist, and an orthopedic surgeon in detecting rotator cuff pathology and involvement of the rotator cable through the use of musculoskeletal ultrasound on fresh frozen cadaver shoulders.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2022)
Article
Endocrinology & Metabolism
Cassandra Parent, Elodie Lespagnol, Serge Berthoin, Semah Tagougui, Joris Heyman, Chantal Stuckens, Iva Gueorguieva, Costantino Balestra, Cajsa Tonoli, Berengere Kozon, Pierre Fontaine, Jacques Weill, Remi Rabasa-Lhoret, Elsa Heyman
Summary: This study aimed to investigate whether perceived barriers to physical activity (PA) in individuals with type 1 diabetes are based on real-life experienced glycemic effects. The results showed that in children/adolescents, the higher the risk of nocturnal hypoglycemia after PA sessions, the more they reported it as a barrier. Conversely, in adults, a higher proportion of PA sessions accompanied by a drop in blood glucose led to less hypoglycemia being a barrier.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Biochemistry & Molecular Biology
Clement Leveque, Simona Mrakic-Sposta, Pierre Lafere, Alessandra Vezzoli, Peter Germonpre, Alexandre Beer, Stephane Mievis, Fabio Virgili, Kate Lambrechts, Sigrid Theunissen, Francois Guerrero, Costantino Balestra
Summary: This study investigated the effects of normobaric oxygen intake on metabolic responses, with a focus on mild and high fractions. The results showed that oxidation markers increased from 30 min to reach a peak at 8 h post intake. Inflammation markers started to appear after 8 h, with a significantly higher level in the 100% oxygen group compared to the 30% group. This study suggests a biphasic response characterized by initial permissive oxidation followed by increased inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Michele Salvagno, Giacomo Coppalini, Fabio Silvio Taccone, Giacomo Strapazzon, Simona Mrakic-Sposta, Monica Rocco, Maher Khalife, Costantino Balestra
Summary: Hypoxia affects aerobic organisms at various levels and can be beneficial without detrimental consequences through normobaric oxygen therapy. This therapy has potential applications in surgical preconditioning, prevention of postoperative anemia, improvement of pre-surgical condition, treatment of critically ill patients, and enhancement of athletes' physical preparation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Awadhesh K. K. Arya, Costantino Balestra, Veena M. M. Bhopale, Laura J. J. Tuominen, Anne Raisanen-Sokolowski, Emmanuel Dugrenot, Erwan L'Her, Abid R. R. Bhat, Stephen R. Thom
Summary: Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers using a closed circuit rebreathing apparatus and custom-mixed gases to diminish some diving risks. The study found that specific proteins in extracellular vesicles significantly increased in deep and shallow divers, indicating that diving triggers inflammatory events that are not proportional to the depth of diving.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Clement Leveque, Simona Mrakic Sposta, Sigrid Theunissen, Peter Germonpre, Kate Lambrechts, Alessandra Vezzoli, Maristella Gussoni, Morgan Levenez, Pierre Lafere, Francois Guerrero, Costantino Balestra
Summary: This study investigated the metabolic responses to hypoxic breathing for 1 hour with inspired fractions of 10% and 15% oxygen. Blood samples were taken from 14 healthy nonsmoking volunteers before and at different time points after the hypoxic exposure. The study examined the levels of oxidative stress, antioxidant systems, and immune-inflammation markers. The findings provide insights into how acute hypoxia affects bodily functions and the protective mechanisms the body employs to maintain redox homeostasis in response to oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Clement Leveque, Simona Mrakic Sposta, Sigrid Theunissen, Peter Germonpre, Kate Lambrechts, Alessandra Vezzoli, Gerardo Bosco, Morgan Levenez, Pierre Lafere, Francois Guerrero, Costantino Balestra
Summary: Hyperbaric oxygen therapy (HBOT) is a treatment method that exposes the body to pure oxygen at increased atmospheric pressure. This study investigated the metabolic responses to hyperbaric hyperoxia exposures at 1.4 and 2.5 ATA for 1 hour. The results showed that both mild and high hyperbaric hyperoxia led to a significant increase in the production of reactive oxygen species (ROS) and antioxidant reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Simona Mrakic-Sposta, Maristella Gussoni, Mauro Marzorati, Simone Porcelli, Gerardo Bosco, Costantino Balestra, Michela Montorsi, Claudio Lafortuna, Alessandra Vezzoli
Summary: Exposure to acute normobaric hypoxia (NH) leads to reactive oxygen species (ROS) accumulation, which can cause oxidative damage. This study investigated the production kinetics of ROS and its impact on oxidative damage. Nine subjects were monitored for ROS production and oxidative damage markers in blood and urine. The results showed a peak ROS production at 4 hours, and oxidative damage markers increased at 4 hours and 1 hour after hypoxia offset. These reversible phenomena were SpO(2)-dependent. The experimental model could be useful for evaluating acclimatization level, especially in mountain rescues involving technical/medical workers with limited acclimatization time, such as helicopter flights.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Emmanuel Gouin, Costantino Balestra, Jeremy Orsat, Emmanuel Dugrenot, Erwan L'Her
Summary: This study aimed to examine the impact of CCR diving on lung function and autonomous cardiac activity. The results showed that lung aeration disorders and changes in heart rate variability occurred after diving, but returned to baseline within 24 hours.
MEDICINA-LITHUANIA
(2023)
