Article
Multidisciplinary Sciences
Hugo O. Valdivia, Priyaleela Thota, Greys Braga, Leonila Ricopa, Keare Barazorda, Carola Salas, Danett K. Bishop, Christie A. Joya
Summary: Gazelle, a novel rapid malaria diagnostic device, showed comparable diagnostic accuracy to light microscopy for detecting P. vivax infections and outperformed two rapid diagnostic tests, even in cases of low parasitemia infections.
Article
Public, Environmental & Occupational Health
Wenjie Xu, Xuan Zhang, Hualiang Chen, Jiaqi Zhang, Qiaoyi Lu, Wei Ruan, Xiaoxiao Wang
Summary: This study investigated the molecular marker distributions of k13, Pfcrt, and Pfmdr1 genes in Plasmodium falciparum parasites imported from central Africa to Zhejiang Province, China between 2016 and 2021. The results showed geographical and temporal variations in the polymorphisms of these genes. This data provides updated evidence for adjusting anti-malarial drug policies in central Africa and China.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Christina Yek, Sreyngim Lay, Jennifer A. Bohl, Somnang Man, Sophana Chea, Chanthap Lon, Vida Ahyong, Cristina M. Tato, Joseph L. DeRisi, Siv Sovannaroth, Jessica E. Manning
Summary: Despite successful efforts to reduce the regional incidence of Plasmodium falciparum malaria, cases of zoo-notic malaria are increasing in Southeast Asia. Recent genetic sequencing in Cambodia identified six patients initially diagnosed with P. malariae who were actually infected with P. knowlesi. As a result, Cambodia has incorporated P. knowlesi-specific PCR diagnostics into their national malaria surveillance efforts.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Mariko S. Peterson, Chester J. Joyner, Stacey A. Lapp, Jessica A. Brady, Jennifer S. Wood, Monica Cabrera-Mora, Celia L. Saney, Luis L. Fonseca, Wayne T. Cheng, Jianlin Jiang, Stephanie R. Soderberg, Mustafa Nural, Allison Hankus, Deepa Machiah, Ebru Karpuzoglu, Jeremy D. DeBarry, Rabindra Tirouvanziam, Jessica C. Kissinger, Alberto Moreno, Sanjeev Gumber, Eberhard O. Voit, Juan B. Gutierrez, Regina Joice Cordy, Mary R. Galinski
Summary: This study provides a comprehensive analysis of P. knowlesi infections in rhesus monkeys, showing a higher parasite burden and extensive margination in the gastrointestinal tissues, which may explain the gastrointestinal symptoms frequently reported by patients with P. knowlesi malaria infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Chaturong Putaporntip, Napaporn Kuamsab, Urassaya Pattanawong, Surasuk Yanmanee, Sunee Seethamchai, Somchai Jongwutiwes
Summary: Among symptomatic malaria patients in Thailand, a study found a prevalence of Plasmodium cynomolgi co-infection with P. vivax, P. falciparum, or P. knowlesi, suggesting its widespread distribution in the country.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Antia Figueroa-Romero, Daniel Bissombolo, Martin Meremikwu, Arsene Ratsimbasoa, Charfudin Sacoor, Iwara Arikpo, Elsha Lemba, Abel Nhama, Rianasoambolanoro Rakotosaona, Mireia Llach, Clara Pons-Duran, Sergi Sanz, Laurence Ma, Cecile Doderer-Lang, Christina Maly, Elaine Roman, Franco Pagnoni, Alfredo Mayor, Didier Menard, Raquel Gonzalez, Clara Menendez
Summary: The study aimed to assess the effect of community delivery of intermittent preventive treatment of malaria in pregnancy (C-IPTp) on the development of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine. The results showed that C-IPTp did not increase the prevalence of molecular markers associated with sulfadoxine-pyrimethamine resistance after three years of implementation.
LANCET GLOBAL HEALTH
(2023)
Article
Chemistry, Medicinal
Ilaria D'Agostino, Susi Zara, Simone Carradori, Viviana De Luca, Clemente Capasso, Clemens H. M. Kocken, Anne-Marie Zeeman, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran
Summary: The hybrid compounds synthesized in this study, which combine the Artesunate core with a sulfonamide moiety, showed high inhibition potency against the protozoan PfCA, while exhibiting low cytotoxic effects on human cells, indicating a wide therapeutic window.
Article
Parasitology
Nantha Kumar Jeyaprakasam, Sandthya Pramasivan, Jonathan Wee Kent Liew, Lun Van Low, Wan-Yusoff Wan-Sulaiman, Romano Ngui, Jenarun Jelip, Indra Vythilingam
Summary: The study evaluated the potential of Mosquito Magnet as a collection tool for Anopheles mosquito vectors of simian malaria and found that while it was slightly less efficient compared to human trapping methods, it showed superior performance in catching certain Anopheles species.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Sri Riyati Sugiarto, J. Kevin Baird, Balbir Singh, Iqbal Elyazar, Timothy M. E. Davis
Summary: Kalimantan, a part of Indonesia, has low and stable transmission of malaria except for the province of East Kalimantan. Recent deforestation and potential exposure to zoonotic malaria differentiate it from other parts of Indonesia. This review examines the history and current epidemiology of malaria in Kalimantan, including control efforts, mosquito vector prevalence, anti-malarial use, and the presence of knowlesi malaria.
Review
Multidisciplinary Sciences
Manas Kotepui, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Aongart Mahittikorn, Polrat Wilairatana
Summary: This systematic review aimed to evaluate the prevalence and proportion of asymptomatic Plasmodium infection in Asia. The results showed a low prevalence of asymptomatic Plasmodium infection in different parts of Asia, but a high proportion of asymptomatic infection among all parasitised individuals. These findings are important for the elimination and control programs of asymptomatic Plasmodium infection in Asia.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Chemistry, Analytical
Nikunja Kolluri, Shwetha Kamath, Patrick Lally, Mina Zanna, James Galagan, Jesse Gitaka, Moses Kamita, Mario Cabodi, Srinivasa Raju Lolabattu, Catherine M. Klapperich
Summary: In the process of malaria elimination, persistent infections may be difficult to diagnose and treat. A novel isothermal amplification assay was designed using a computational approach, which showed analytical sensitivity comparable to PCR methods in amplifying Plasmodium DNA.
ANALYTICAL CHEMISTRY
(2021)
Article
Microbiology
Franziska Mohring, Donelly A. van Schalkwyk, Ryan C. Henrici, Benjamin Blasco, Didier Leroy, Colin J. Sutherland, Robert W. Moon
Summary: Several unrelated antimalarial compounds targeting PfATP4 have lower efficacy against other malaria parasite species infecting humans. By replacing the ATP4 genes in P. knowlesi with orthologues from different species, researchers found significant differences in susceptibility to ATP4 inhibitors among the parasites. This study highlights the importance of developing antimalarials that can effectively target all human malaria parasite species.
Article
Multidisciplinary Sciences
Aline Gaelle Bouopda Tuedom, Elangwe Milo Sarah-Matio, Carole Else Eboumbou Moukoko, Brice Lionel Feufack-Donfack, Christelle Ngou Maffo, Albert Ngano Bayibeki, Hermann Parfait Awono-Ambene, Lawrence Ayong, Antoine Berry, Luc Abate, Isabelle Morlais, Sandrine Eveline Nsango
Summary: The study evaluated the prevalence of drug resistance gene mutations in different epidemiological settings in Cameroon. The results showed significant differences in the prevalence of mutations between sites, especially for Pfcrt and Pfmdr1 genes. High levels of mutations related to sulfadoxine-pyrimethamine (SP) resistance were detected, raising concerns about the future efficacy of certain malaria control strategies in Cameroon.
Article
Immunology
Jean C. Digitale, Perri C. Callaway, Maureen Martin, George Nelson, Mathias Viard, John Rek, Emmanuel Arinaitwe, Grant Dorsey, Moses Kamya, Mary Carrington, Isabel Rodriguez-Barraquer, Margaret E. Feeney
Summary: The study found that HLA class I molecules play a role in restricting parasitemia caused by P. falciparum, but no HLA alleles were associated with protection from malaria. This suggests the essential role of the cellular immune response in P. falciparum immunity.
FRONTIERS IN IMMUNOLOGY
(2021)