Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 10, Pages 1162-1165Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1041139
Keywords
isofuranodiene; galactosamine; lipopolysaccharide; hepatoprotective; rats
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Funding
- Science and Technology Development Fund of Macau Special Administrative Region [021/2012/A1]
- Research Fund of University of Macau [MYRG118(Y1-L4)-ICMS13-CXP]
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Isofuranodiene is a natural sesquiterpene rich occurring in Smyrnium olusatrum, a forgotten culinary herb which was marginalised after the domestication of the improved form of celery. Our recent data showed that isofuranodiene inhibited the proliferation and induced apoptosis in cancer cells. In this study, we investigated its protective effect on d-galactosamine/lipopolysacchride (GalN/LPS)-induced liver injury in SD rats. Oral administration of isofuranodiene (20 and 50mg/kg) dramatically inhibited GalN/LPS-induced serum elevation of aspartate aminotransferase, alanine aminotransferase and malondialdehyde levels, and significantly ameliorated liver injury as evidenced by the histological improvement in H&E staining. Furthermore, isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1, IL-6 and inducible nitric oxide synthase in liver tissues. The results from this study showed that isofuranodiene protects GalN/LPS-induced liver injury in SD rats and suggested that it may be a potential functional food ingredient for the prevention and treatment of liver diseases.
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