Review
Infectious Diseases
Biagio Pinchera, Antonio Riccardo Buonomo, Nicola Schiano Moriello, Riccardo Scotto, Riccardo Villari, Ivan Gentile
Summary: Surgical site infections are a growing concern in nosocomial infections. Antibiotic resistance, increasing surgical interventions, and patients' complex comorbidities contribute to this problem. It is important to consider all risk factors, preventive measures, and possible therapeutic interventions in managing surgical site infections.
Article
Multidisciplinary Sciences
Elizabeth E. Mmari, Eunice S. Pallangyo, Athar Ali, Dereck A. Kaale, Isaac H. Mawalla, Muzdalifat S. Abeid
Summary: This study investigated the perceptions of surgeons on surgical antibiotic prophylaxis use at an urban tertiary hospital, finding that surgeons perceived inadequate data to support practice and emphasized the importance of choosing antibiotics based on local resistance patterns. However, they expressed a lack of knowledge regarding hospital guidelines and data for surgical site infection rates. Surgeons also reported prolonged antibiotic use due to fear of unknown factors and anticipation of complications, highlighting the need for guidelines incorporating local resistance data and enhanced antibiotic stewardship programs to address implementation challenges.
Article
Infectious Diseases
Fatima Khan, Bhanu Chaudhary, Asfia Sultan, Manzoor Ahmad, Yasir Alvi, Mohammad Salman Shah, Haris M. Khan
Summary: The knowledge and attitudes of surgeons towards appropriate SAP prescribing are crucial for the implementation of guidelines. Including them in policy-making decisions can facilitate strong guideline adherence.
SURGICAL INFECTIONS
(2021)
Article
Public, Environmental & Occupational Health
Chloe Vo, Aurelie Vintze Geoffrion, Zahra Abow Mohamed, Jean-Noel Morin, Sarah Lagac-Nadon, Annie Routhier, Sandra Chapados, Pierre-Louis Desaulniers, Pierre-Marie David, Anita Ang
Summary: This study evaluated the impact of periodically sending individualized feedback letters to surgeons and anesthesiologists on their compliance rate to surgical antibiotic prophylaxis (SAP) guidelines. The findings showed that sending individualized feedback letters did not significantly improve the overall compliance to local SAP guidelines.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Infectious Diseases
Daniel J. G. Thirion, Jean-Alexandre Caissy, Florence Poulin, Camille S. H. Lanfranchi, Albin Deda, Armen Aprikian, Charles Frenette, Sero Andonian
Summary: The study compared the impact of augmented prophylaxis (ciprofloxacin with an aminoglycoside) and empirical prophylaxis (ciprofloxacin alone) on post-prostate biopsy infectious complication rates. A total of 2835 patients were evaluated in a retrospective cohort study, and the results showed that augmented prophylaxis was associated with significantly lower rates of infectious complications compared to empirical prophylaxis. Risk factors such as recent fluoroquinolone use and previous urinary tract infection also had a significant impact on infection rates.
Article
Infectious Diseases
Maryam Sherkat Masoum, Sarah Oorschot, Brittany Roles, Claire Italiano
Summary: This study investigated the indications and usage of surgical antimicrobial prophylaxis (SAP) in Australian hospitals and identified barriers to optimal prophylaxis, such as poor understanding of guidelines, lack of timely identification of MRSA carriers, and limitations of operating room management software. These findings can inform targeted antimicrobial stewardship strategies to improve compliance with guidelines, optimize prophylaxis, and reduce surgical site infections.
SURGICAL INFECTIONS
(2023)
Article
Surgery
Kathrin Rothe, Nathalie Muenster, Alexander Hapfelmeier, Angela Ihbe-Heffinger, Stefan Paepke, Markus Niemeyer, Susanne Feihl, Dirk H. Busch, Marion Kiechle, Christine E. Brambs
Summary: This study evaluated the association between perioperative antibiotic prophylaxis duration and the incidence of postoperative surgical-site infections in immediate implant-based breast reconstruction in breast cancer patients. The study found no association between short-course perioperative antibiotic prophylaxis (<= 24 hours) and an increased rate of postoperative surgical-site infection.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Immunology
Rachel M. Reeves, Maarten van Wijhe, Toni Lehtonen, Luca Stona, Anne C. Teirlinck, Liliana Vazquez Fernandez, You Li, Richard Osei-Yeboah, Thea K. Fischer, Terho Heikkinen, Michiel van Boven, Hakon Boas, Daniele Dona, Elisa Barbieri, Harry Campbell
Summary: This systematic review aimed to identify clinical practice guidelines (CPGs) for the prevention of respiratory syncytial virus (RSV) infection across Europe. The study found discrepancies in recommendations for palivizumab prophylaxis for premature infants and children with various diseases. The study recommends that agencies adopt the RIGHT reporting requirements to improve the presentation of evidence-based decisions.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Surgery
Carlos Cordova-Cassia, Daniel Wong, Mary B. Cotter, Thomas E. Cataldo, Vitaliy Y. Poylin
Summary: The global use of extended enoxaparin prophylaxis for colorectal surgery patients is safe but does not reduce VTE rates compared to selective use. Patient non-adherence may play a significant role in this outcome.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Public, Environmental & Occupational Health
Sobhi Khoury, Shiran Kaplan, Ronit Zaidenstein, Erica Cohen, Dinni Tischler-Aurkin, Rivka Sheffer, Lewis Mathew, Zohar Mor
Summary: The study revealed that 85% of Israeli travelers did not adhere to the antimalarial chemoprophylaxis, mainly due to a perception of low risk of contracting malaria. It is crucial for counselors at pre-travel clinics to emphasize the importance of taking antimalarial chemoprophylaxis in highly endemic countries and consider alternative treatment strategies.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Immunology
Aditya Shah, Priya Sampathkumar, Ryan W. Stevens, John K. Bohman, Brian D. Lahr, Prabij Dhungana, Kirtivardhan Vashistha, John C. O'Horo
Summary: This study analyzed the use of prophylactic antimicrobials in ECMO patients over seven years, and found a significant reduction in broad-spectrum antimicrobial use without an increase in infection rates after revision and streamlining of the protocol.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Ching-Yun Lin, Ko Chang, Chai-Jan Chang
Summary: This study aimed to investigate travelers' compliance and side effects of malaria prophylaxis to prevent a malaria outbreak in Taiwan. The results showed that 36.0% of the travelers reported side effects, with insomnia, somnolence, irritability, nausea, and anorexia associated with poor compliance. Factors such as younger age, visiting friends and relatives, visiting the travel clinic more than 1 week before the trip, and wanting to use the same antimalarial regimen on the next trip influenced chemoprophylaxis compliance.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Matti Aapro, Zoe Caprariu, Petio Chilingirov, Marika Chrapava, Razvan-Ovidiu Curca, Laurentia Gales, Alexandru C. Grigorescu, Joanna Huszno, Bara Karlinova, Renata Kellnerova, Miroslava Malejcikova, Mihai Marinca, Edgar Petru, Adam Pluzanski, Petra Pokorna, Zuzana Pribulova, Maryna Rubach, Gunther G. Steger, Petra Tesarova, Lubica Valekova, Nicolay Yordanov, Anna Walaszkowska-Czyz
Summary: This study evaluated the application of evidence-based antiemetic guidelines in the prevention of chemotherapy-induced nausea and vomiting. The study found inconsistencies between clinical practice and guideline-recommended treatment. Patients receiving guideline-consistent prophylaxis had significantly higher complete response rates and less impact on daily living compared to patients receiving guideline-inconsistent treatment.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Veterinary Sciences
Simon P. Hagley, Anne Kruppert, Rodolfo Oliveira Leal, Jose Carlos Pizarro del Valle, Claudia Iannucci, Imke Hennink, Ludivine Boiron, Sabrina N. Hoehne
Summary: This study assessed the compliance of small animal veterinarians in Western Europe with the 2012 RECOVER CPR guidelines. The results showed wide variation in awareness and compliance across regions, with overall low compliance scores. Further research is needed to identify factors contributing to poor guideline awareness and compliance in order to improve veterinary CPR in Europe.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Infectious Diseases
Petros Ioannou, Stamatis Karakonstantis, Jeroen Schouten, Tomislav Kostyanev, Esmita Charani, Vera Vlahovic-Palcevski, Diamantis P. Kofteridis
Summary: This study explores the targets for antimicrobial stewardship (AMS) interventions for medical antibiotic prophylaxis (AP) in adult patients. Potential targets include addressing underutilization of antibiotic-sparing strategies, reducing unnecessary AP beyond recommended indications, reducing the use of broad-spectrum AP, controlling the duration of AP, evaluating the role of antibiotic cycling, and addressing research gaps regarding appropriate indications and regimens for medical prophylaxis.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Nutrition & Dietetics
Andrea Maugeri, Martina Barchitta, Giuliana Favara, Claudia La Mastra, Maria Clara La Rosa, Roberta Magnano San Lio, Antonella Agodi
Summary: In recent decades, researchers have used different multivariate techniques to analyze multidimensional dietary datasets and identify meaningful patterns of dietary habits. Principal component analysis (PCA) and cluster analysis are the two most commonly used techniques, either separately or in parallel. In this study, a workflow combining PCA, hierarchical clustering, and a K-means algorithm is proposed for deriving dietary patterns. However, subjective decisions in the workflow may influence the final clustering solution, so alternative approaches are provided. The proposed approach, referred to as clustering on principal components, disentangles dietary data better than simple clustering algorithms and can be valuable for leveraging the strengths of each method.
Review
Dentistry, Oral Surgery & Medicine
O. Di Fede, F. Canepa, L. Maniscalco, P. Tozzo, D. Matranga, G. Giuliana
Summary: Oral mucositis (OM) is a significant side effect of cancer therapy, but there is no gold standard for its prevention or treatment. Sodium bicarbonate (SB) rinses are commonly used for OM management, but this review found no evidence supporting their effectiveness. Indiscriminate use of SB may be counterproductive.
Article
Neurosciences
Rosario Maugeri, Lara Brunasso, Andrea Sciortino, Alba Scerrati, Felice Buscemi, Luigi Basile, Giuseppe Roberto Giammalva, Roberta Costanzo, Francesco Bencivinni, Eleonora Bruno, Domenica Matranga, Laura Maniscalco, Francesco Gioia, Silvana Tumbiolo, Domenico Gerardo Iacopino
Summary: The restoration of posterior disc height through cage insertion seems to be effective in increasing foraminal height in symptomatic patients with cervical foraminal stenosis.
Article
Geriatrics & Gerontology
Nicola Veronese, Laura Maniscalco, Domenica Matranga, Guido Lacca, Ligia J. Dominguez, Mario Barbagallo
Summary: This study aimed to investigate the potential association between air and noise pollution and frailty and prefrailty in older adults. The cross-sectional study of UK Biobank participants aged 60 and older found that increased exposure to nitrogen oxides (NOx) and particulate matter (PM2.5, PM2.5-10, PM10) was associated with a higher probability of being in the prefrail and frail category. These findings suggest that air pollution may contribute to frailty and highlight the importance of considering the impact of air pollutants in frailty prevention and intervention strategies.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Andrea Maugeri, Martina Barchitta, Federico Puglisi, Antonella Agodi
Summary: This ecological analysis examines the relationship between demographic, economic, governance, health, and freedom characteristics of 30 European countries and antibiotic consumption and antimicrobial resistance (AMR). The study finds that the governance index has a significant impact on both antibiotic consumption and AMR proportion. However, reducing antibiotic use alone is unlikely to solve the AMR problem, and more interventions are needed to improve governance efficiency.
GLOBALIZATION AND HEALTH
(2023)
Article
Nutrition & Dietetics
Martina Barchitta, Roberta Magnano San Lio, Maria Clara La Rosa, Claudia La Mastra, Giuliana Favara, Giuliana Ferrante, Fabiola Galvani, Elisa Pappalardo, Carla Ettore, Giuseppe Ettore, Antonella Agodi, Andrea Maugeri
Summary: Limited evidence exists on the effects of maternal dietary patterns on birth weight, and most studies conducted so far did not adjust their findings for gestational age and sex, leading to potentially biased conclusions. In this study, a novel method was applied to derive dietary patterns among pregnant women and evaluate the associations with birth weight for gestational age. The findings suggest that adherence to an unhealthy dietary pattern is associated with an increased likelihood of having a large for gestational age newborn.
Article
Infectious Diseases
Andrea Maugeri, Martina Barchitta, Roberta Magnano San Lio, Antonella Agodi
Summary: A positive linear association was found between temperature change and antimicrobial resistance rates, but this association disappeared when adjusting for economic and governance factors. Instead, antibiotic consumption, population density, and governance efficiency were identified as the main predictors of antimicrobial resistance. Ensuring appropriate antibiotic use and improving governance efficiency are effective strategies to counteract antimicrobial resistance.
Article
Biology
Salvatore Pezzino, Maria Sofia, Chiara Mazzone, Sergio Castorina, Stefano Puleo, Martina Barchitta, Antonella Agodi, Luisa Gallo, Gaetano La Greca, Saverio Latteri
Summary: There is increasing evidence linking dysbiosis of the gut microbiome to the etiopathogenesis of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH) and cirrhosis. Probiotics, prebiotics, and synbiotics have shown promise in restoring dysbiosis and improving clinical indicators of disease. Additionally, postbiotics and parabiotics have gained attention as potential therapeutic options. This bibliometric analysis aims to evaluate recent publishing trends on the role of the gut microbiome in NAFLD, NASH, and cirrhosis, and its connection with various biotics.
Article
Chemistry, Multidisciplinary
Patrizia Toia, Ludovico La Grutta, Salvatore Vitabile, Bruna Punzo, Carlo Cavaliere, Carmelo Militello, Leonardo Rundo, Domenica Matranga, Clarissa Filorizzo, Erica Maffei, Massimo Galia, Massimo Midiri, Roberto Lagalla, Luca Saba, Eduardo Bossone, Filippo Cademartiri
Summary: This study proposes an advanced computer-assisted approach to analyze epicardial adipose tissue (EAT) in patients undergoing Cardiac CT (CCT) during statin administration, and examines its relation to body mass index (BMI). The study finds that statins can lead to significant quantitative and qualitative changes in EAT detected by CCT, and BMI influences the composition of EAT.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Giuseppe Pizzo, Domenica Matranga, Laura Maniscalco, Fortunato Buttacavoli, Guglielmo Campus, Giovanna Giuliana
Summary: There are very few epidemiologic studies on caries disease in 6-7 year old children living in Sicily. This study aims to estimate the prevalence of caries in this population and the prevalence of affected first permanent molars (FPMs). The study found that socio-economic factors, unhealthy behaviors, and social deprivation are associated with an increased risk of moderate and extensive caries in 6-7 year old schoolchildren.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Antonella Agodi, Arturo Montineri, Rosa Manuele, Paola Noto, Giuseppe Carpinteri, Giacomo Castiglione, Patrizia Grassi, Antonio Lazzara, Anna Rita Mattaliano, Giuseppa Granvillano, Claudia La Mastra, Maria Clara La Rosa, Andrea Maugeri, Martina Barchitta
Summary: Due to the COVID-19 pandemic, traditional programs aimed at preventing healthcare-associated infections and combating antimicrobial resistance have been neglected. This study characterized the colonization or infection with Acinetobacter baumannii in COVID-19 patients, identifying clonality between different isolates. The majority of isolates exhibited resistance to multiple antibiotics.
Review
Environmental Sciences
Roberta Magnano San Lio, Martina Barchitta, Andrea Maugeri, Serafino Quartarone, Guido Basile, Antonella Agodi
Summary: Laparoscopic cholecystectomy is a standard treatment for gallstone patients, but there are multiple risk factors that can lead to conversion to open surgery. This systematic review examines the main factors associated with conversion and finds that male gender, age over 60, acute cholecystitis, diabetes, hypertension, heart diseases, obesity, and previous upper abdominal surgery increase the likelihood of conversion. Understanding these preoperative factors can help improve surgical planning and post-operative recovery.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)