Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria

Only for substrate antibiotics are a functional AcrAB-TolC efflux pump and RamA required to select multidrug-resistant Salmonella Typhimurium

(2009) V. Ricci et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways

(2009) V. Ricci et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Global Consequence of Disruption of the AcrAB-TolC Efflux Pump in Salmonella enterica Includes Reduced Expression of SPI-1 and Other Attributes Required To Infect the Host

(2009) M. A. Webber et al.   JOURNAL OF BACTERIOLOGY

RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine

(2008) A. M. Bailey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quantitative structure–activity relationship (QSAR) of aryl alkenyl amides/imines for bacterial efflux pump inhibitors

(2008) A. Nargotra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synergy between gemifloxacin and trimethoprim/sulfamethoxazole against community-associated methicillin-resistant Staphylococcus aureus

(2008) S. N. Leonard et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Triclosan resistance in Salmonella enterica serovar Typhimurium

(2008) M. A. Webber et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB

(2008) J. A. Bohnert et al.   JOURNAL OF BACTERIOLOGY

The Bacteria Fight Back

(2008) G. Taubes   SCIENCE