Article
Multidisciplinary Sciences
Abdubadie Kutubi, Luke O'Brien, Ben Murphy, Patricia Fitzpatrick, Conor Hurson, Deepa Rajendran, Eoin Feeney, Patrick Mallon, Sarmad Waqas
Summary: This study assessed the clinical outcomes, readmission rates, and financial impact of prosthetic joint infections (PJI) treated with outpatient parenteral antimicrobial therapy (OPAT). The results showed that OPAT was a safe and effective treatment option for PJI, reducing readmission rates and saving healthcare costs.
Article
Infectious Diseases
Hester H. Stoorvogel, Marlies E. J. L. Hulscher, Heiman F. L. Wertheim, Ed P. F. Yzerman, Maarten Scholing, Jeroen A. Schouten, Jaap ten Oever
Summary: This study assessed the organization of outpatient parenteral antimicrobial therapy (OPAT) in Dutch acute care hospitals and identified barriers and potential improvements. The presence of an OPAT program was associated with well-organized OPAT care. Implementing a team-based OPAT program could contribute to improvements. The observed variations provide leads for further research, guidelines, and practical implementation programs.
Article
Medicine, General & Internal
Fatma Kilinc, Matthias Setzer, Bedjan Behmanesh, Daniel Jussen, Florian Gessler, Simon Bayerl, Volkhard A. J. Kempf, Johanna Kessel, Marcus Czabanka, Vincent Prinz
Summary: OPAT is a well-established and cost-effective method for treating cranial infections, with the average hospital stay for patients after surgical treatment being 45 days. Most patients were discharged with a PICC line for OPAT, and there were no serious adverse events or complications observed post-treatment.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Lorena Rodriguez-Martinez, Ana Castro-Balado, Gonzalo Hermelo-Vidal, Enrique Bandin-Vilar, Iria Varela-Rey, Francisco Jose Toja-Camba, Teresa Rodriguez-Jato, Ignacio Novo-Veleiro, Pablo Manuel Varela-Garcia, Irene Zarra-Ferro, Miguel Gonzalez-Barcia, Cristina Mondelo-Garcia, Jesus Mateos, Anxo Fernandez-Ferreiro
Summary: Outpatient parenteral antimicrobial therapy (OPAT) with continuous infusion pumps is a promising solution for complicated infections. However, stability studies of drugs in elastomeric devices are limited. This study evaluated the stability of ampicillin in an elastomeric infusion pump and found that the 15 mg/mL concentration is suitable for use in OPAT, while the 50 mg/mL concentration is not.
Review
Infectious Diseases
Ralf Stemkens, Jeroen A. Schouten, Sophie A. M. van Kessel, Reinier P. Akkermans, Denise S. C. Telgt, Hanneke W. H. A. Fleuren, Mark A. A. Claassen, Marlies E. J. L. Hulscher, Jaap ten Oever
Summary: This study provides practical guidance on using quality indicators (QIs) to measure the quality of antibiotic use, helping AMS teams identify targets for improvement.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Oyewole Chris Durojaiye, Robin Morgan, Naziha Chelaghma, Evangelos Kritsotakis
Summary: The study identified risk factors for treatment failure and poor outcomes in patients with infective endocarditis (IE) treated through outpatient parenteral antimicrobial therapy (OPAT). Results showed that pre-existing renal failure and Charlson comorbidity score were associated with increased risk of failure, while previous endocarditis and cardiac complications were risk factors for major adverse cardiac events (MACE). Being selected for cardiac surgery during initial hospitalization for IE was shown to be a protective factor.
JOURNAL OF INFECTION
(2021)
Article
Infectious Diseases
Teeranuch Thomnoi, Virunya Komenkul, Abhisit Prawang, Wichai Santimaleeworagun
Summary: This study aimed to evaluate the clinical impact of pharmacist-led parenteral anti-infective therapy and determine the role of pharmacists in medication management. The results showed that the pharmacist-led implementation of a clinical practice guideline significantly improved patient outcomes and clinical management, suggesting the importance of pharmacist-led implementation in healthcare settings.
Article
Oncology
Alison Robins, Emma Dishner, Patrick McDaneld, Meagan Rowan, Jalen Bartek, Ying Jiang, Javier Adachi, Natalie J. M. Dailey Garnes
Summary: Efforts to improve laboratory test result monitoring for solid tumor patients receiving outpatient parenteral antimicrobial therapy (OPAT) through multiple quality improvement interventions have shown some improvement in completeness of documentation and completion of tests, although further sustained efforts are needed to fully optimize outcomes for this population.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Infectious Diseases
Mutsumi Akahane, Yuki Enoki, Reika Saiki, Yukitaka Hayashi, Kana Hiraoka, Kyoka Honma, Marina Itagaki, Mai Gotoda, Kozue Shinoda, Satomi Hanyu, Yuna Hamamura, Taichi Miyajima, Chihiro Ito, Kazuaki Taguchi, Shunsuke Uno, Yoshifumi Uwamino, Osamu Iketani, Naoki Hasegawa, Kazuaki Matsumoto
Summary: This study evaluated the stability of antimicrobial agents dissolved in infusion solutions, showing that certain antibiotics remained stable in specific conditions while others did not. Overall, cefazolin, cefmetazole, piperacillin, and tazobactam demonstrated good stability, making them suitable for outpatient parenteral antimicrobial therapy with continuous infusion pumps.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
L. Kalatharan, M. Ferman, S. Kumar, S. Rajendra, S. Pripanapong, Y. Wu, H. Richards, B. A. Rogers
Summary: This study analyzed the use and cost of benzylpenicillin and ceftriaxone in an outpatient parenteral antimicrobial therapy program. The findings showed that benzylpenicillin was often chosen over ceftriaxone due to lower cost. This cost difference should be considered when applying other antimicrobial substitution strategies.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
George D. Rodriguez, Yuexiu Wu, Krupa Karnik, Samantha Ruddy, Anna Kula, Nathan Warren, Roman Yashayev, Fizza Sajid, Nishant Prasad, James Yoon, Glenn Turett, Lok Yung, Carl Urban, Chan-Ho Lee, Jessie Abraham, Joseph T. Cooke, Manish Sharma, Amir Jaffer, Sorana Segal-Maurer
Summary: This study assessed the processes and clinical outcomes of a joint collaboration between Antimicrobial Stewardship Program (ASP) and outpatient parenteral antimicrobial therapy (OPAT) for the delivery of monoclonal antibody therapy for mild-to-moderate COVID-19. The results showed that this collaboration is an efficient and safe approach that significantly improves symptoms in patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Nerea Castillo-Fernandez, Pedro Maria Martinez Perez-Crespo, Elena Salamanca-Rivera, Laura Herrera-Hidalgo, Aristides de Alarcon, Maria Dolores Navarro-Amuedo, Teresa Marrodan Ciordia, Maria Teresa Perez-Rodriguez, Juan Sevilla-Blanco, Alfredo Jover-Saenz, Jonathan Fernandez-Suarez, Carlos Arminanzas-Castillo, Jose Maria Reguera-Iglesias, Clara Natera Kindelan, Lucia Boix-Palop, Eva Leon Jimenez, Fatima Galan-Sanchez, Alfonso del Arco Jimenez, Alberto Bahamonde-Carrasco, David Vinuesa Garcia, Alejandro Smithson Amat, Jordi Cuquet Pedragosa, Isabel Maria Reche Molina, Ines Perez Camacho, Esperanza Merino de Lucas, Belen Gutierrez-Gutierrez, Jesus Rodriguez Bano, Luis Eduardo Lopez Cortes
Summary: A post-hoc analysis of two Spanish cohorts showed that sequential OPAT is as safe and effective as conventional hospitalization for treating patients with S. aureus bacteremia.
Article
Medicine, General & Internal
Andrew Barnes, Marina Nunez
Summary: The study evaluated unplanned readmissions of patients undergoing Outpatient Parenteral Antimicrobial Therapy (OPAT) and identified diabetic foot infection, selected comorbidities, and discharge on opioids as independent risk factors for readmission. Focus on these high-risk groups is a priority to reduce readmissions among OPAT patients.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Review
Infectious Diseases
Oyewole Christopher Durojaiye, Joby Cole, Evangelos I. Kritsotakis
Summary: This systematic review investigated the risk of venous thromboembolism (VTE) in outpatient parenteral antimicrobial therapy (OPAT) and found that the incidence of non-catheter-related VTE was 0.2% and catheter-related thromboembolism (CRT) was 1.1%. The study indicates that universal thromboprophylaxis is not necessary in the OPAT setting, but a high index of suspicion should be maintained.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Pharmacology & Pharmacy
Sabrine Douiyeb, Jara R. de la Court, Bram Tuinte, Ferdi Sombogaard, Rogier P. Schade, Marianne Kuijvenhoven, Tanca Minderhoud, Kim C. E. Sigaloff
Summary: Home treatment with intravenous antimicrobial therapy in the Netherlands is a relatively new concept, and patients receiving this treatment are still at risk of readmission. Receiving aminoglycosides or vancomycin treatment and having a prosthetic infection are independent risk factors associated with readmission.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)