Article
Pediatrics
Pilar Storch-De-Gracia, Valeria Antonanzas-Bernar, Beatriz Vergara-Munoz, Nuria Lamagrande-Casanova, Marianna Di Campli-Zaghlul, Maria Suarez-Bustamante, Juan Anon-Hidalgo, Miguel Maiques
Summary: This study compared the efficacy of amoxicillin administered twice or three times daily in children with acute otitis media, and measured and compared treatment adherence between the two groups. The results showed that twice-daily amoxicillin had similar efficacy to a three-dose daily regimen and offered advantages in terms of administration schedule for caregivers.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Oren Ziv, Dana Adelson, Reem Sadeh, Sofia Kordeluk, Sabri El-Saied, Eugene Leibovitz, Mordechai Kraus, Daniel Kaplan
Summary: This retrospective cohort study showed that immunization with pneumococcal conjugate vaccines (PCV) significantly reduced the occurrence of recurrent acute otitis media (rAOM) in infants following an early episode of acute otitis media (AOM).
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Naoko Fuji, Michael Pichichero, Ravinder Kaur
Summary: This study found that the prevalence of Haemophilus influenzae in the nasopharynx of young children is very low during health periods, but is high in middle ear fluid at the onset of acute otitis media (AOM). Nontypeable H. influenzae accounts for over 90% of all isolates, with type f being the most prevalent among encapsulated strains. Beta-lactamase production and antibiotic nonsusceptibility are common among H. influenzae strains isolated from the nasopharynx and middle ear fluid.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Eun Hye Lee, Yong-Sung Choi, Jeewon Ryu, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is caused by various factors including infections, anatomo-physiological abnormalities, allergies, and environmental influences. This study highlights the immune responses in otitis media patients, focusing on antibodies and transcription factors produced by B cells, as well as the important functions of B cells in immune defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Saskia Hullegie, Roderick P. Venekamp, Thijs M. A. van Dongen, Alastair D. Hay, Michael V. Moore, Paul Little, Anne G. M. Schilder, Roger A. M. J. Damoiseaux
Summary: In children with acute onset ear discharge, Streptococcus pneumoniae and Haemophilus influenzae are the predominant bacteria, followed by Staphylococcus aureus and Streptococcus pyogenes. Limited antimicrobial resistance data are available, and no clear shift in the prevalence of bacteria and antimicrobial resistance over time was found. Ongoing surveillance is needed to guide antibiotic selection and assess the impact of children's pneumococcal conjugate vaccine status in children with acute otitis media.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Su Young Jung, Dokyoung Kim, Dong Choon Park, Sung Soo Kim, Tong In Oh, Dae Woong Kang, Sang Hoon Kim, Seung Geun Yeo
Summary: Otitis media is mainly caused by upper respiratory tract infection and eustachian tube dysfunction. The expression of Toll-like receptors (TLRs) is closely related to the occurrence, recurrence, chronicization, and complications of otitis media, playing an important role in the early response to external antigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Medicine, General & Internal
Alexander E. Perl, Giovanni Martinelli, Jorge E. Cortes, Andreas Neubauer, Ellin Berman, Stefania Paolini, Pau Montesinos, Maria R. Baer, Richard A. Larson, Celalettin Ustun, Francesco Fabbiano, Harry P. Erba, Antonio Di Stasi, Robert Stuart, Rebecca Olin, Margaret Kasner, Fabio Ciceri, Wen-Chien Chou, Nikolai Podoltsev, Christian Recher, Hisayuki Yokoyama, Naoko Hosono, Sung-Soo Yoon, Je-Hwan Lee, Timothy Pardee, Amir T. Fathi, Chaofeng Liu, Nahla Hasabou, Xuan Liu, Erkut Bahceci, Mark J. Levis
Summary: The article contains errors in the numbers of patients receiving previous FLT3 inhibitor therapy and requires correction.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Dong Gu Hur, Arwa Kurabi, Hyun Woo Lim, Meghan Spriggs, Kwang Pak, Allen F. Ryan
Summary: The study demonstrates the critical role of macrophages in resolving otitis media, with macrophage genes being significantly regulated during OM and macrophage depletion increasing the duration of middle ear infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Saskia Hullegie, Roderick P. Venekamp, Thijs M. A. van Dongen, Sanne Mulder, Willem van Schaik, G. Ardine de Wit, Alastair D. Hay, Paul Little, Michael Moore, Elisabeth A. M. Sanders, Marc J. M. Bonten, Debby Bogaert, Anne G. M. Schilder, Roger A. M. J. Damoiseaux
Summary: Current guidance recommends oral antibiotics as first-line treatment for children with acute otitis media, but there is a lack of evidence on the effectiveness of local administration of antibiotics in children with AOMd. This study aims to address this gap by comparing the efficacy of eardrops and oral antibiotics in treating AOMd, with a focus on reducing systemic side effects and selective resistance pressure on bacteria.
Article
Infectious Diseases
Ismail Mohamed Ali, Cihan Duman, Ilkay Bozdag, Abdihakim Artan Abdi, Mohamed Nor Abdi, Suleyman Emre Karakurt, Ozgur Yigit
Summary: This study aimed to determine the microbiological profile and antibiotic susceptibility pattern of bacterial isolates obtained from patients with chronic suppurative otitis media (CSOM). Gram-negative bacteria were found to be more prevalent, with a high rate of resistance against penicillin antibiotics. Further research is needed to investigate the bacterial profile and antibiotic susceptibility pattern of CSOM patients in Mogadishu and other parts of Somalia.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Pediatrics
Elisa Barbieri, Gloria Porcu, Tianyan Hu, Tanaz Petigara, Francesca Senese, Gian Marco Prandi, Antonio Scamarcia, Luigi Cantarutti, Anna Cantarutti, Carlo Giaquinto
Summary: This study aimed to assess the incidence trends of acute otitis media (AOM) in children following the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in Italy. The results showed a significant decrease in AOM incidence rates after the introduction of PCV13, with older children benefiting the most.
Review
Pediatrics
Katerina Tsergouli, Nikolaos Karampatakis, Theodoros Karampatakis
Summary: This systematic review aimed to evaluate the efficacy of antimicrobial agents or placebo compared to amoxicillin-clavulanate in treating acute otitis media (AOM) in children aged 6 months to 12 years. Based on 12 randomized controlled trials, it was concluded that amoxicillin-clavulanate should be the preferred treatment for AOM.
TURKISH JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Wenyan Fan, Hongming Xu, Chenling Shen, Jia Fang, Xiaoyan Li
Summary: Acute and chronic otitis media (AOM and COM) are common middle ear infections that can lead to hearing loss and other complications. Recent research has shown that both macrophages and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway are involved in the immune response to and the resolution of otitis media. However, the specific effects of Nrf2 on macrophages in the transition of AOM to COM are not well understood, and a practical approach to prevent this transition by targeting Nrf2/macrophages has not been established.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Otorhinolaryngology
Nicole Favre, Vijay A. Patel, Michele M. Carr
Summary: This study evaluated the incidence and management of complications related to pediatric acute mastoiditis using data from a national database, finding that children with intracranial complications are more likely to undergo surgical procedures with wide variability in practice patterns, indicating persistent controversies in the management of otitis media complications.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, General & Internal
Kyu Hyun Park, Seung-Ah Choe, Ju-Young Shin, Young June Choe
Summary: This study describes the changing patterns of antibiotic use in children with acute otitis media in South Korea. The prescription of amoxicillin has increased while cephalosporin and macrolide use has decreased. Multifaceted approaches are needed to control antimicrobial resistance.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Integrative & Complementary Medicine
Sonja C. Luer, Jeannette Goette, Rolf Troller, Christoph Aebi
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2014)
Article
Immunology
Pierre Alex Crisinel, Klara Maria Posfay-Barbe, Christoph Aebi, Jean-Jacques Cheseaux, Christian Kahlert, Christoph Rudin, David Nadal, Claire-Anne Siegrist, Swiss Mother
CLINICAL AND VACCINE IMMUNOLOGY
(2012)
Article
Immunology
Luregn J. Schlapbach, Steffen Thiel, Christoph Aebi, Andreas Hirt, Kurt Leibundgut, Jens C. Jensenius, Roland A. Arnmann
Article
Immunology
Luregn J. Schlapbach, Andreas Woerner, Steffen Thiel, Roland A. Ammann, Christoph Aebi, Mathias Nelle, Jens C. Jensenius
Article
Oncology
Sonja Lueer, Rolf Troller, Christoph Aebi
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2012)
Article
Oncology
Fabienne Luethi, Kurt Leibundgut, Felix K. Niggli, David Nadal, Christoph Aebi, Nicole Bodmer, Roland A. Ammann
PEDIATRIC BLOOD & CANCER
(2012)
Article
Emergency Medicine
Katayun Hojat, Andrea Duppenthaler, Christoph Aebi
PEDIATRIC EMERGENCY CARE
(2013)
Article
Immunology
Sara Bernhard, Kristin Kernland Lang, Roland A. Ammann, Sonja Lueer, Kurt Leibundgut, Miriam Diepold, Christoph Aebi
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2012)
Article
Pediatrics
Luregn J. Schlapbach, Troels R. Kjaer, Steffen Thiel, Maika Mattmann, Mathias Nelle, Bendicht P. Wagner, Roland A. Ammann, Christoph Aebi, Jens C. Jensenius
PEDIATRIC RESEARCH
(2012)
Article
Multidisciplinary Sciences
Violeta Spaniol, Stefan Wyder, Christoph Aebi
Review
Medicine, General & Internal
Sara Bernhard, Violeta Spaniol, Christoph Aebi
SWISS MEDICAL WEEKLY
(2012)
Article
Immunology
Sarah Flohr, Alban Ramette, Philipp K. A. Agyeman, Andrea Duppenthaler, Cordula Scherer, Peter M. Keller, Christoph Aebi
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Immunology
Larissa Stoffel, Philipp K. A. Agyeman, Kristina Keitel, Maria Teresa Barbani, Andrea Duppenthaler, Matthias Kopp, Christoph Aebi
Summary: A study from a Swiss University Hospital in Bern, Switzerland, showed an unprecedented absence of pediatric enteroviral meningitis in 2020, possibly due to unintended consequences of public health measures for COVID-19. This finding highlights the potential of nonpharmaceutical interventions in controlling the circulation of major pediatric pathogens transmitted via the fecal-oral route.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Joyce Odeke Akello, Richard Kamgang, Maria Teresa Barbani, Franziska Suter-Riniker, Christoph Aebi, Christian Beuret, Daniel H. Paris, Stephen L. Leib, Alban Ramette
Summary: This study used whole-genome sequencing to compare circulating HAdV strains associated with severe and mild infections among pediatric patients in Bern, Switzerland, finding that HAdV species C were the main cause of severe infections. Recombination events occurred more frequently in severe cases, highlighting the importance of further research on HAdVs for public health preparedness.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Nina Schobi, Philipp Ka Agyeman, Andrea Duppenthaler, Andreas Bartenstein, Peter M. Keller, Franziska Suter-Riniker, Kristina M. Schmidt, Matthias Kopp, Christoph Aebi
Summary: Pediatric tularemia in Switzerland typically presents with early, self-limiting fever, a characteristic entry site lesion, and regional lymphadenopathy. Early identification and treatment with agents specifically targeting F. tularensis may reduce the need for surgical therapy.
OPEN FORUM INFECTIOUS DISEASES
(2022)