Article
Green & Sustainable Science & Technology
Sorath Abbasi, Joonho Ko, Jihan Kim
Summary: By analyzing rental transaction data, the study found that the supply level of public transit service has a positive impact on the selection of carsharing stations and demand, while population density has a negative impact. A weak association between the location of carsharing stations and demand from users aged 40 and older was discovered, indicating that operators mainly target young users when selecting station locations.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Microbiology
Yi-Chieh Lee, Hsueh-Yu Li, Wan-Ni Lin
Summary: Diagnosing HIV is challenging due to non-specific symptoms. Two newly diagnosed HIV patients with sore throat were reported in this study. Biopsy revealed acute and chronic inflammation, and further laboratory analysis confirmed HIV infection. Antiviral treatment improved laryngeal symptoms.
Article
Mathematical & Computational Biology
Johanna Munoz, Orestis Efthimiou, Vincent Audigier, Valentijn M. T. de Jong, Thomas P. A. Debray
Summary: Missing data is a common problem in medical research, and traditional imputation methods may not be suitable for non-random missing data. A novel multilevel imputation method based on Heckman selection models and two-stage meta-analysis is proposed to handle missing data in clustered datasets.
STATISTICS IN MEDICINE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Nicholas Dopkins, Douglas F. Nixon
Summary: A new study by Yoh et al. revealed that the host factor PQBP1 enhances immune recognition of retroviral DNA by recruiting the cytosolic DNA scavenger cGAS to the HIV-1 capsid, leading to the production of interferons. These findings highlight the significance of innate immune sensing in HIV-1 infection.
TRENDS IN MICROBIOLOGY
(2023)
Article
Engineering, Environmental
Yuan Li, Ling Yang, Wenbo Yu, Xuezhi Yu, Kai Wen, Bing Shao, Jiefang Sun, Jianzhong Shen, Zhanhui Wang
Summary: The study introduced a new mAb discovery platform named TCSM for producing antibodies specific to small molecule haptens. Compared to traditional methods, TCSM is able to efficiently select hapten-specific hybridoma cells faster, resulting in antibodies with superior performance.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Agriculture, Dairy & Animal Science
Yutaka Masuda, Shogo Tsuruta, Matias Bermann, Heather L. Bradford, Ignacy Misztal
Summary: In this study, genetic trends were compared among models with UPG and MF H-inverses, showing that EUPG and MF H-inverses are preferred for their lack of genetic trend biases.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Jiaying Wang, Yulin Bai, Xiaoqing Zou, Chengyu Li, Junyi Yang, QiaoZhen Ke, Ji Zhao, Tao Zhou, Peng Xu
Summary: The performance of single-step genomic best linear unbiased prediction (SSGBLUP) in large yellow croakers was investigated, and the effects of the number of phenotypic records and genotyping per family on SSGBLUP's predictive ability were evaluated. The results showed that the SSGBLUP model has great potential and advantages in genomic breeding of large yellow croakers. It is recommended to provide 100 phenotypic individuals per family, of which 40 individuals should have genotyping data for SSGBLUP model prediction and family resistance evaluation.
MARINE BIOTECHNOLOGY
(2023)
Article
Immunology
Reut Levi, Yoram Louzoun
Summary: This study reveals that beta chain rearrangement in T cells is a two-step process, where D-beta and J(beta) bind first and then V-beta is joined to the complex. The frequency of V(beta)J(beta) combinations in human and mouse deviates from the expected values based on gene usage frequency. This bias is mainly observed in functional rearrangements but also slightly in non-functional rearrangements. Preferred V(beta)J(beta) combinations in functional clones are shared between donors and samples, suggesting a common structural mechanism for these biases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Statistics & Probability
Stephane Guerrier, Roberto Molinari, Maria-Pia Victoria-Feser, Haotian Xu
Summary: This paper proposes a general framework for robust two-step estimation based on a bounded influence M-estimator of the wavelet variance to address challenges in latent time series models. The study develops asymptotic properties of two-step robust estimators using the framework of the generalized method of wavelet moments and demonstrates the good performance of the robust estimator in simulation studies and applied examples.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2022)
Article
Optics
Tatsuki Tahara, Yuichi Kozawa, Ayumi Ishii, Koki Wakunami, Yasuyuki Ichihashi, Ryutaro Oi
Summary: A new phase-shifting interferometry technique is proposed in this study, using only two in-line phase-shifted self-interference holograms without the need for additional recording or estimation. The effectiveness of the technique is demonstrated through experiments on incoherent digital holographic microscopy and color-multiplexed fluorescence digital holography. The study also achieves two-color-multiplexed four-step phase-shifting incoherent digital holography for the first time.
Article
Materials Science, Multidisciplinary
Younes Saadat, Kyungtae Kim, Reza Foudazi
Summary: In this study, a two-step thermoresponsive ultrafiltration membrane was fabricated using a polymerized liquid crystal material. The membrane exhibited reversible thermoresponsive behavior at specific temperatures, enhancing cleaning efficiency and extending product lifespan.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Younes Saadat, Kyungtae Kim, Reza Foudazi
Summary: In this study, a two-step thermoresponsive ultrafiltration (UF) membrane is fabricated using polymerization of a lyotropic liquid crystal (LLC) and its reversible thermoresponsive behavior is demonstrated. The membrane shows potential for enhancing cleaning efficiency and extending product lifetime.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Mathematics
Jianling Wang, Yihui Luan, Jiming Jiang
Summary: The main goal of this paper is to propose a two-step method for the estimation of parameters in non-linear mixed-effects models. It is shown that the proposed method is consistent and asymptotically normal, with improved performance compared to previous methods. The paper also presents a method for estimating the variance and evaluates its empirical performance. Three real-data examples are considered for validation.
Article
Polymer Science
Quan Li, Peng Dong, Huixuan Liu, Li Zhang, Qin Zhang, Ke Wang
Summary: This study proposed a unique continuous two-step two-roll mill processing method to prepare high-performance self-reinforced polyethylene materials by improving the dispersion and structural regularity of UHMWPE in the HDPE matrix. The effective UHMWPE content of 0.08% showed significantly improved tensile strength and oxygen permeability, suggesting an efficient, eco-friendly strategy for extending the application fields of polyethylene.
Article
Medicine, General & Internal
Jingjing Lang, Xin Xin, Panpan Chen, Zhen Ning, Shaotan Xiao
Summary: This study aimed to identify potential change patterns and predictors of fasting plasma glucose (FPG) and lipid levels after initiating highly active antiretroviral therapy (HAART). The study found that the change patterns of plasma glucose and lipid in patients tested positive for HIV were heterogeneous, and tailored interventions should be considered in specific subgroups.
FRONTIERS IN MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
P. Roux, M. Jauffret-Roustide, C. Donadille, L. Briand Madrid, C. Denis, I Celerier, C. Chauvin, N. Hamelin, G. Maradan, M. P. Carrieri, C. Protopopescu, L. Lalanne, M. Auriacombe
Summary: This study using data from the French COSINUS cohort found that drug consumption rooms (DCRs) have a positive impact on the health of people who inject drugs (PWID). DCR-exposed participants were less likely to report overdoses, abscesses, and emergency department visits. These findings support the expansion of DCR implementation to improve the injection environment and health of PWID.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Immunology
Romain Palich, Rachid Agher, Dimoke J. Wetshikoy, Lise Cuzin, Sophie Seang, Cathia Soulie, Roland Tubiana, Marc-Antoine Valantin, Luminita Schneider, Valerie Pourcher, Anne-Genevieve Marcelin, Lambert Assoumou, Christine Katlama
Summary: This study aims to explore the differences in antiretroviral therapy (ART) prescriptions between naive and virally suppressed HIV patients born in France and Sub-Saharan Africa. The findings suggest that the differences in ART prescriptions between these two groups cannot solely be explained by different clinical and virologic situations.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Chemistry, Medicinal
Peter J. Slavish, Maxime G. Cuypers, Mary Ashley Rimmer, Alireza Abdolvahabi, Trushar Jeevan, Gyanendra Kumar, Jamie A. Jarusiewicz, Sivaraja Vaithiyalingam, Jeremy C. Jones, John J. Bowling, Jeanine E. Price, Rebecca M. DuBois, Jaeki Min, Richard J. Webby, Zoran Rankovic, Stephen W. White
Summary: Influenza is a major cause of disease-related deaths globally. Strategies to inhibit influenza virus replication have resulted in the emergence of resistant strains. Baloxavir marboxil, a recently approved compound, is significantly less effective due to a mutation in the active site of the target enzyme. Raltegravir, an HIV inhibitor, shows moderate activity against the enzyme. In this study, researchers used structure-guided approaches to design molecules that effectively target the enzyme's active site and successfully developed potent inhibitors for both wild-type and baloxavir-resistant forms.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Sophie Grabar, Valerie Potard, Lionel Piroth, Sophie Abgrall, Louis Bernard, Clotilde Allavena, Fabienne Caby, Pierre de Truchis, Claudine Duvivier, Patricia Enel, Christine Katlama, Marie-Aude Khuong, Odile Launay, Sophie Matheron, Giovanna Melica, Hugues Melliez, Jean-Luc Meynard, Juliette Pavie, Laurence Slama, Sylvie Bregigeon, Pierre Tattevin, Jacqueline Capeau, Dominique Costagliola
Summary: Many studies have found that starting an integrase strand-transfer inhibitor-based regimen for HIV-positive individuals who have not previously received antiretroviral therapy can lead to weight gain. This study examined the impact of early or advanced HIV disease progression and the specific drugs used in combination antiretroviral therapy (cART) on weight changes. The results showed that individuals with advanced disease progression experienced greater weight gain compared to those with early disease progression. The choice of antiretroviral drugs should take into account the risk of weight gain, particularly for patients with advanced disease or obesity.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Antoine Bachelard, Valentina Isernia, Charlotte Charpentier, Aida Benalycherif, Marion Mora, Cecile Donadille, Claudine Duvivier, Karine Lacombe, Mayssam El Mouhebb, Bruno Spire, Roland Landman, Diane Descamps, Gilles Peytavin, Lambert Assoumou, Jade Ghosn, FAST sty grp
Summary: Initiating same-day ART for newly HIV-diagnosed individuals reduces transmission risk and improves treatment adherence. The BIC/FTC/TAF regimen has been shown to be safe, effective, and well accepted for same-day initiation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Christian Laurent, Issifou Yaya, Benjamin Cuer, Luis Sagaon-Teyssier, Ephrem Mensah, Ter Tiero Elias Dah, Alou Coulibaly, Malan Jean-Baptiste Kouame, Gilles Peytavin, Laetitia Serrano, August Eubanks, Issa Traore, Fodie Diallo, Lucas Riegel, Daniela Rojas Castro, Claver A. Dagnra, Camille Anoma, Bea Vuylsteke, Bintou Dembele Keita, Bruno Spire
Summary: This study aimed to investigate HIV seroconversion, PrEP adherence, plasma drug concentrations, and HIV drug resistance among men who have sex with men (MSM) using event-driven or daily PrEP in West Africa. The results showed that participants who chose event-driven PrEP had higher HIV incidence and lower adherence. Improving adherence to event-driven PrEP is a major research and public health priority in this context.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
C. Protiere, L. Sagaon-Teyssier, C. Donadille, A. Sow, G. Gaubert, G. Girard, M. Mora, L. Assoumou, L. Beniguel, D. Michels, J. Ghosn, D. Costagliola, D. Rojas Castro, J. -M. Molina, B. Spire
Summary: Since the introduction of HIV pre-exposure prophylaxis (PrEP), stigma has been a significant barrier to its acceptance and adherence. This study aimed to determine the proportion of PrEP users who believe that taking PrEP can negatively affect their image and identify the factors associated with this perception.
Article
Infectious Diseases
Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich, Claudine Duvivier, Agathe Becker, Helene Laroche, Pascal Pugliese, Andre Cabie, Dat'AIDS Study Grp
Summary: This study analyzed the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years and its relationship with previous episodes of low-level viral load (LLVL). The results showed that LLVL was associated with VF, and even in the absence of subsequent failure, LLV episodes have a cost. Therefore, any viral load value above 50 copies/mL should lead to enhanced adherence counseling.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Virology
Djeneba B. Fofana, Houdou Diarra, Ibrahima Guindo, Mahamadou K. Savadogo, Marceline d'Almeida, Fatoumata I. Diallo, Aliou Balde, Cathia Soulie, Amadou Kone, Anne-Genevieve Marcelin, Almoustapha I. Maiga, Sidonie Lambert-Niclot, Mamoudou Maiga, Sally McFall, Claudia A. Hawkins, Robert L. Murphy, Mariam Sylla, Christine Katlama, Jane L. Holl, Vincent Calvez, Laurence Morand-Joubert
Summary: Limited data exist on INI resistance in children living with HIV/AIDS in West Africa. A study was conducted on HIV-1-infected children in Benin and Mali, and it was found that no major INI resistance mutations were detected in INI-naive patients.
Article
Medicine, General & Internal
Elisa Ruiz-Burga, Shema Tariq, Giota Touloumi, John Gill, Emily Jay Nicholls, Caroline Sabin, Cristina Mussini, Laurence Meyer, Alain Volny Anne, Christina Carlander, Sophie Grabar, Inma Jarrin, Marc Van der Valk, Linda Wittkop, Bruno Spire, Nikos Pantazis, Fiona M. Burns, Kholoud Porter
Summary: This study aims to understand the current drivers of the HIV epidemic in Europe, factors associated with access to, and uptake of prevention methods and ART initiation, and the experiences, needs, and outcomes of people with recently acquired HIV.
Review
Immunology
Emily Jay Nicholls, Nicoletta Policek, Alain Volny-Anne, Bruno Spire, Fiona Burns, Elisa Ruiz-Burga, Shema Tariq, C. A. S. C. A. D. E. Collaboration CASCADE Collaboration
Summary: This systematic review and narrative synthesis of qualitative literature on recently acquired HIV provides insights into the contextual factors underlying HIV acquisition. The study finds that further research is needed to explore the emotional impact of indeterminate test results and negotiate risk reduction, as well as to investigate sexual risk, pre-exposure prophylaxis, and treatment as prevention in the context of recently acquired HIV.
Article
Public, Environmental & Occupational Health
Thijs Reyniers, Marion Fiorentino, Stephane Alain Yoro Babo, Mamadou Ouedraogo, Ibrahima Kanta, Laurette Ekon Agbegnigan, Daniela Rojas, Camille Anoma, Ter Tiero Elias Dah, Ephrem Mensah, Bintou Dembele Keita, Bruno Spire, Bea Vuylsteke, Christian Laurent, CohMSM PrEP Study Grp
Summary: This study explored the perceived added value of bimonthly long-acting injectable pre-exposure prophylaxis (LAI-PrEP) as an HIV prevention tool among MSM in Burkina Faso, Cote d'Ivoire, Mali, and Togo. The results showed that LAI-PrEP was perceived to provide better protection against HIV and be more convenient compared to condoms and oral PrEP. However, concerns about needle fear, doubts about efficacy, potential side effects, and difficulties in ensuring timely injections were also identified. Increasing awareness about HIV and addressing discrimination based on sexual orientation remain crucial for HIV prevention.
AIDS PATIENT CARE AND STDS
(2023)
Review
Public, Environmental & Occupational Health
Victoire Sawras, Sylvie Deuffic-Burban, Marie Preau, Bruno Spire, Yazdan Yazdanpanah, Karen Champenois
Summary: This review explores the effectiveness of partner notification interventions for STIs and HIV, and identifies the need for more comprehensive outcomes and data to better understand the impact of these interventions.
Article
Immunology
Liem Binh Luong Nguyen, Jeanne Goupil de Bouille, Lola Menant, Marion Noret, Audrey Dumas, Maud Salmona, Jerome Le Goff, Constance Delaugerre, Pascal Crepey, Jeremy Zeggagh, ITOC Study Grp
Summary: In the context of low circulation of the Delta variant, there was no evidence of SARS-CoV-2 transmission among fully vaccinated participants in an indoor clubbing event. However, there was an increased risk of other respiratory virus infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Gastroenterology & Hepatology
Tangui Barre, David Zucman, Fabienne Marcellin, Clemence Ramier, Camelia Protopopescu, Raphaelle Tardieu, Karine Ory, Dominique Salmon-Ceron, Patrizia Carrieri
JOURNAL OF VIRAL HEPATITIS
(2023)