Article
Multidisciplinary Sciences
Mercy Jelagat Karoney, Mathew Kirtptonui Koech, Evangeline Wawira Njiru, Willis Dixon Owino Ong'or
Summary: TDF is a widely used anti-retroviral therapy drug, but it can cause proximal tubular renal dysfunction. This study found a higher prevalence of proximal tubular renal dysfunction in patients on TDF treatment, but no significant difference in overall renal function.
Review
Pharmacology & Pharmacy
Ke Zhang, Yang Zhang, Jing Zhou, Lulu Xu, Chi Zhou, Guanzhi Chen, Xiaojie Huang
Summary: This study compares the efficacy and safety of DOR + TDF+3TC/FTC with traditional triple therapies in treatment-naive HIV-1-positive adults. The results showed that at 48 weeks, DOR + TDF+3TC/FTC exhibited superior virological suppression compared to some other regimens, while being similar in terms of adverse events. The regimen also performed better in terms of severe adverse events and drug-related adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Zhenyan Wang, Min Zhang, Jiangrong Wang, Li Liu, Jun Chen, Renfang Zhang, Yang Tang, Yinzhong Shen, Tangkai Qi, Wei Song, Jianjun Sun, Shuibao Xu, Junyang Yang, Hongzhou Lu
Summary: This study evaluates the prevalence of HIV-1 mutation V179D/E and its impact on the virological response to the first-line efavirenz-based regimen in ART-naive patients in Shanghai, China. The study finds a high prevalence of V179D/E and suggests that the efavirenz-based regimen may not be suitable for patients with this mutation, especially those with a high baseline viral load.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Ksenia Glumakova, Georgy Ivanov, Valeria Vedernikova, Lena Shyrokova, Timofey Lebedev, Andrei Stomakhin, Anastasia Zenchenko, Vladimir Oslovsky, Mikhail Drenichev, Vladimir Prassolov, Pavel Spirin
Summary: This study identified 2',3'-isopropylidene-5-iodouridine as a novel compound with anti-HIV-1 activity and no toxic effects on T-cells. It was found to be significantly more effective than Azidothymidine (AZT) at high non-toxic concentrations and showed synergistic inhibition of HIV-1 when combined with the CDK4/6 inhibitor Palbociclib at low non-toxic concentration. AZT did not show any synergistic antiviral activity when combined with Palbociclib.
Review
Immunology
Laura Waters, Viraj Mehta, Jaideep Gogtay, Marta Boffito
Summary: This article evaluates the evidence supporting the use of TDF and 3TC combination in triple drug antiretroviral regimen, discussing the relative efficacy, safety, and resistance profile of 3TC and FTC. It also presents the clinical use of 3TC and FTC with TDF and TAF, summarizing recommendations from international guidelines for triple and emerging dual regimens. The data suggest therapeutic equivalence of 3TC and FTC, especially when combined with TDF.
JOURNAL OF VIRUS ERADICATION
(2021)
Article
Neurosciences
Emeka G. Anyanwu, Chioma L. Onuchukwu
Summary: This study revealed a significant reduction in plantar fat thickness, velocity of travel, and stride frequency among HIV-positive individuals, impacting dynamic balance. The findings suggest that HIV infection may increase the risk of falls, fractures, and mobility impairment due to changes in gait caused by plantar lipoatrophy.
Review
Medicine, General & Internal
Daniel Bradshaw, Graham Philip Taylor
Summary: This article discusses the epidemiological context of HIV-PrEP and HTLV-1 transmission, presents current knowledge of antiretrovirals in preventing HTLV-1 transmission, and identifies knowledge gaps that urgently require data to inform global public health measures to protect HIV-PrEP users from HTLV-1 acquisition.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Jeordy D. Engone-Ondo, Augustin Mouinga-Ondeme, Sonia E. Lekana-Douki, Abdoulaye Diane, Antony Mamimandjiami, Octavie Banga, Guy-Roger Ndong-Atome, Avelin F. Aghokeng
Summary: The study reveals a low rate of viral load suppression in a semi-rural context in Africa and a high burden of HIV drug resistance, impacting both current and newly recommended ART strategies.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Yiping Li, Qinjian Wang, Shu Liang, Chuanteng Feng, Hong Yang, Hang Yu, Dan Yuan, Shujuan Yang
Summary: This study found that a PI-based ART regimen is beneficial for reducing mortality in people living with HIV and HIV-1 drug resistance. Efforts should be made to detect HIV-1 drug resistance earlier and ensure timely adjustment to PI-based ART, maximizing the benefits of early switch treatment for these patients.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Infectious Diseases
Boris Revollo, Laura Vinuela, Lorena de la Mora, Federico Garcia, Marc Noguera-Julian, Mariona Parera, Roger Paredes, Josep M. Llibre
Summary: This article reports a case of integrase resistance in a patient treated with co-formulated dolutegravir/lamivudine. It highlights the importance of carefully considering and monitoring drug-drug interactions, even when they are regarded as having a low potential.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ankit Kumar Singh, Adarsh Kumar, Sahil Arora, Raj Kumar, Amita Verma, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid Emwas, Pradeep Kumar
Summary: This review examines the structure, replication cycle, reverse transcription, and drug targets of HIV-1. It focuses on nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), including their mechanisms of action, FDA-approved drugs, drugs in clinical trials, resistance and adverse effects, molecular docking studies, and highly active antiretroviral therapy (HAART).
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Infectious Diseases
Pascale Perfezou, Nolwenn Hall, Jean-Charles Duthe, Basma Abdi, Sophie Seang, Cedric Arvieux, Isabelle Lamaury, Amelie Menard, Anne-Genevieve Marcelin, Christine Katlama, Romain Palich
Summary: This study reports the experience of using doravirine/lamivudine as maintenance therapy in HIV patients. The results showed that this treatment regimen can effectively suppress viral replication and improve CD4+ T cell count.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Huseyin Tunc, Murat Sari, Seyfullah Kotil
Summary: This article proposes a mathematical modeling framework to study the impact of existing mutations, timing of initiation, and adherence levels of nucleotide reverse transcriptase inhibitors (NRTIs) on the evolutionary dynamics of HIV strains. The results are crucial for optimizing treatment protocols for HIV patients.
Article
Immunology
You Ge, Ying Zhou, Yahong Liu, Jing Lu, Tao Qiu, Ling-En Shi, Zhi Zhang, Haiyang Hu, Pingmin Wei, Gengfeng Fu
Summary: This study analyzed longitudinal samples from 1557 male patients receiving cART and found that both heterosexual and MSM patients showed an increasing trend in CD4(+) T cell counts after treatment. However, heterosexual patients had a lower CD4(+) T cell recovery rate compared to MSM patients. Heterosexuality was identified as an independent risk factor for immunological non-responders and was associated with lower probability of achieving conventional and optimal immune recovery.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Medicine, General & Internal
Hendrik Streeck, Alvino Maestri, Daniel Habermann, Trevor A. Crowell, Allahna L. Esber, Gowoon Son, Leigh Anne Eller, Michael A. Eller, Ajay P. Parikh, Peter A. Horn, Lucas Maganga, Emmanuel Bahemana, Yakubu Adamu, Francis Kiweewa, Jonah Maswai, John Owuoth, Merlin L. Robb, Nelson L. Michael, Christina S. Polyak, Daniel Hoffmann, Julie A. Ake
Summary: Chronic immune activation in HIV-1 infection is influenced by factors such as HIV viral load, sex, age, region, and ART use. Predictors and associations among biomarkers and co-infections affect biomarkers associated with noncommunicable diseases.
Article
Public, Environmental & Occupational Health
Rishma Amarsy, Sandra Fournier, David Trystram, Catherine Monteil, Xavier Raynaud, Vincent Jarlier, Jerome Robert
Summary: The impact of COVID-19 pandemic on bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals in Paris. The incidence rates of BSIs, which had been stable in 2018 and 2019, decreased for the two pathogens during the two lockdown periods in 2020. Containment policies such as social distancing, masking, and hand hygiene strengthening in community and hospital settings are likely to reduce BSIs caused by these pathogens.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Infectious Diseases
Romain Palich, Sonia Burrel, Gentiane Monsel, Agathe Nouchi, Alexandre Bleibtreu, Sophie Seang, Vincent Berot, Cecile Brin, Ariane Gavaud, Yara Wakim, Nagisa Godefroy, Antoine Faycal, Yanis Tamzali, Thomas Grunemwald, Michel Ohayon, Eve Todesco, Valentin Leducq, Stephane Marot, Vincent Calvez, Anne-Genevieve Marcelin, Valerie Pourcher
Summary: This study describes the distribution of Monkeypox virus (MPXV) in the human body, and the results show that the virus is more frequently detected and has higher viral loads in the skin, anus, and throat. These findings suggest that transmission most likely occurs through direct body contact.
LANCET INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Sophie Grabar, Valerie Potard, Lionel Piroth, Sophie Abgrall, Louis Bernard, Clotilde Allavena, Fabienne Caby, Pierre de Truchis, Claudine Duvivier, Patricia Enel, Christine Katlama, Marie-Aude Khuong, Odile Launay, Sophie Matheron, Giovanna Melica, Hugues Melliez, Jean-Luc Meynard, Juliette Pavie, Laurence Slama, Sylvie Bregigeon, Pierre Tattevin, Jacqueline Capeau, Dominique Costagliola
Summary: Many studies have found that starting an integrase strand-transfer inhibitor-based regimen for HIV-positive individuals who have not previously received antiretroviral therapy can lead to weight gain. This study examined the impact of early or advanced HIV disease progression and the specific drugs used in combination antiretroviral therapy (cART) on weight changes. The results showed that individuals with advanced disease progression experienced greater weight gain compared to those with early disease progression. The choice of antiretroviral drugs should take into account the risk of weight gain, particularly for patients with advanced disease or obesity.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Transplantation
Rianne Boenink, Anneke Kramer, Raymond C. Vanholder, Beatriz Mahillo, Ziad A. Massy, Mirela Busic, Alberto Ortiz, Vianda S. Stel, Kitty J. Jager, Survey Collaborators
Summary: A survey was conducted among kidney transplantation experts from 39 European countries to investigate the factors influencing kidney transplantation rates. The study found that low-rate countries took more measures regarding staff, equipment, and facilities, while high-rate countries took more measures specific to deceased donor transplantation. Furthermore, low-rate countries reported more potential barriers, such as lack of knowledge and distrust in the healthcare system.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Claire Tinel, Baptiste Lamarthee, Stephane Gazut, Elisabet Van Loon, Florent Von Tokarski, Aurelien Benon, Virginia Sauvaget, Victor Garcia-Paredes, Mickael Menager, Lise Morin, Laila Aouni, Nicolas Cagnard, Marion Rabant, Christophe Legendre, Fabiola Terzi, Marie Essig, Wilfried Gwinner, Maarten Naesens, Pierre Marquet, Dany Anglicheau
Summary: Increasing evidence suggests that microRNAs are involved in the pathophysiology of renal diseases, including kidney transplantation. In this study, the researchers investigated the changes in circulating microRNA expression and their involvement in antibody-mediated rejection. They found that certain microRNAs were significantly decreased in samples with rejection, and these microRNAs were associated with myeloid-related pathways and CD14+ monocytes.
Review
Biochemistry & Molecular Biology
Adelie Gothland, Aude Jary, Philippe Grange, Valentin Leducq, Laurianne Beauvais-Remigereau, Nicolas Dupin, Anne-Genevieve Marcelin, Vincent Calvez
Summary: Reprogrammed metabolism, redox equilibrium, and ROS production play important roles in cancer development and are particularly influential in HHV-8 related diseases such as Kaposi sarcoma and primary effusion lymphoma. Primaquine diphosphate has been found to induce apoptosis in HHV-8 infected PEL cell lines through ROS production, indicating that targeting the redox balance could be a potential approach for treating HHV-8 related diseases. This review focuses on the role of ROS in cancer development and provides evidence for the importance of redox pathways in HHV-8 pathologies.
Review
Microbiology
Theophile Cocherie, Karen Zafilaza, Valentin Leducq, Stephane Marot, Vincent Calvez, Anne-Genevieve Marcelin, Eve Todesco
Summary: SARS-CoV-2 variants of concern have evolved through the accumulation of mutations in the Spike protein, which is responsible for viral binding and contains immunodominant epitopes. Different variants have emerged, each with unique characteristics in terms of transmissibility, virulence, and immune escape. The appearance of successive variants has led to the progressive improvement of SARS-CoV-2's transmissibility and its ability to evade the immune system. This review provides a comprehensive summary of the impacts of Spike mutations and the variants of concern.
Review
Urology & Nephrology
Marlies Noordzij, Bjorn Meijers, Ron T. Gansevoort, Adrian Covic, Raphael Duivenvoorden, Luuk B. Hilbrands, Marc H. Hemmelder, Kitty J. Jager, Geir Mjoen, Ionut Nistor, Ekaterina Parshina, Giuseppina Pessolano, Serhan Tuglular, Priya Vart, Luca Zanoli, Casper F. M. Franssen, ERACODA collaborators
Summary: This study analyzed the infection prevention and control strategies implemented by dialysis centers in Europe during the first wave of the COVID-19 pandemic. The results showed that most centers implemented measures such as fever screening, hand disinfection, and mask-wearing to prevent the spread of the virus. There were variations between centers and national guidelines in terms of recommended distances between dialysis chairs and isolation practices.
CLINICAL KIDNEY JOURNAL
(2023)
Letter
Infectious Diseases
Aude Jary, Sokleaph Cheng, Stephane Marot, Gervillien Arnold Malonga, Theophile Cocherie, Steve Wignall, Vincent Calvez, Sophat Phal, Kem Vichet, Anne-Genevieve Marcelin, Gauthier Delvallez
JOURNAL OF INFECTION
(2023)
Article
Virology
Djeneba B. Fofana, Houdou Diarra, Ibrahima Guindo, Mahamadou K. Savadogo, Marceline d'Almeida, Fatoumata I. Diallo, Aliou Balde, Cathia Soulie, Amadou Kone, Anne-Genevieve Marcelin, Almoustapha I. Maiga, Sidonie Lambert-Niclot, Mamoudou Maiga, Sally McFall, Claudia A. Hawkins, Robert L. Murphy, Mariam Sylla, Christine Katlama, Jane L. Holl, Vincent Calvez, Laurence Morand-Joubert
Summary: Limited data exist on INI resistance in children living with HIV/AIDS in West Africa. A study was conducted on HIV-1-infected children in Benin and Mali, and it was found that no major INI resistance mutations were detected in INI-naive patients.
Editorial Material
Medicine, General & Internal
Antoine Vanier, Judith Fernandez, Sophie Kelley, Lise Alter, Patrick Semenzato, Corinne Alberti, Sylvie Chevret, Dominique Costagliola, Michel Cucherat, Bruno Falissard, Francois Gueyffier, Jerome Lambert, Etienne Lengline, Clara Locher, Florian Naudet, Raphael Porcher, Rodolphe Thiebaut, Muriel Vray, Sarah Zohar, Pierre Cochat, Dominique Le Guludec
BMJ EVIDENCE-BASED MEDICINE
(2023)
Letter
Infectious Diseases
Elisa Teyssou, Stephane Marot, Adelie Gothland, Isabelle Malet, Karen Zafilaza, Valentin Leducq, Theophile Cocherie, Eve Todesco, Cathia Soulie, Anne-Genevieve Marcelin, Vincent Calvez
JOURNAL OF INFECTION
(2023)
Article
Infectious Diseases
Elisa Teyssou, Stephane Marot, Theophile Cocherie, Antoine Fauchois, Basma Abdi, Eve Todesco, Sepideh Akhavan, Valerie Pourcher, Vincent Calvez, Anne-Genevieve Marcelin, Cathia Soulie
Summary: This study aimed to characterize and compare the viral loads (VL) of the Omicron BA.1 and BA.2 lineages and the Delta variant in newly diagnosed COVID-19 patients. The results showed no significant difference in the median CT value between the Delta variant and the two Omicron lineages during the first diagnostic test. However, the kinetics of CT decreases for the BA.1 and BA.2 lineages were significantly longer than the kinetics for the Delta variant. The BA.2 lineage had a lower median CT value (inversely proportional to the VL) compared to the BA.1 lineage. In conclusion, the BA.2 Omicron lineage presented higher VL at diagnostic and both BA.1 and BA.2 lineages had more prolonged replication compared to the Delta variant.
INFECTIOUS DISEASES NOW
(2023)