Spontaneous and induced mutations to rifampicin, streptomycin and spectinomycin resistances in actinomycetes: mutagenic mechanisms and applications for strain improvement

Activation and Products of the Cryptic Secondary Metabolite Biosynthetic Gene Clusters by Rifampin Resistance (rpoB) Mutations in Actinomycetes

(2013) Y. Tanaka et al.   JOURNAL OF BACTERIOLOGY

Triggers and cues that activate antibiotic production by actinomycetes

(2013) Hua Zhu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

(2013) Brian O. Bachmann et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements

(2013) Kozo Ochi et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Development of the ability to produce secondary metabolites in Streptomyces through the acquisition of erythromycin resistance

(2012) Yu Imai et al.   JOURNAL OF ANTIBIOTICS

Strain improvement in actinomycetes in the postgenomic era

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Development of a Genetic System for Combinatorial Biosynthesis of Lipopeptides in Streptomyces fradiae and Heterologous Expression of the A54145 Biosynthesis Gene Cluster

(2010) D. C. Alexander et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes

(2009) Y. Tanaka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Comparison of two commercial assays for the characterization of rpoB mutations in Mycobacterium tuberculosis and description of new mutations conferring weak resistance to rifampicin

(2009) Y. Hauck et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY