Article
Biochemistry & Molecular Biology
Deng-Sen Xiong, Ya-Bin Yang, Bin-Yuan Hu, Cui-Ping Miao, Yong-Liang Wang, Jin-Mei Zou, Lei Li, Yi-Qing Li, Xiao-Dong Luo, Li-Xing Zhao
Summary: Through the study of six new compounds produced by Myrothecium sp. BS-31, an endophyte isolated from Panax notoginseng, two of these compounds showed weak antifungal activity against pathogenic fungi causing root-rot disease, providing potential for further research on their use as antifungal agents.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Applied
Li Zhen-Hua, Yang Hui-Yuan, Zhu Wen-Ting, Jing Dong-Dong, Li Shi-Neng, Yan Peng-Ke
Summary: A new alkylresorcinol, myrothecol A (1), and two known compounds were isolated from a fungal strain Myrothecium sp. GY170016. The structures were determined by spectroscopic analysis, and the absolute configuration of 1 was confirmed by electronic circular dichroism experiment. These compounds showed cytotoxic activities against human cancer cell line MCF-7.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Ke-Tao Zhang, Zhi-Pu Huang, Xiao-Rong Xu, Si-Heng Li, Yu-Xiao Xu, Qing Zhao, Xiao-Mei Zhang
Summary: Two new diketopiperazines, samsoniellain A (1) and samsoniellain B (2), were obtained from the Cordyceps fungus Samsoniella sp. XY4. Their structures were determined by various spectroscopic techniques. The antimicrobial activity results showed that one of the compounds exhibited weak bacteriostatic activities against certain strains.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Chemistry, Applied
Huiling Wen, Yi Zang, Qianheng Zhu, Sheng Ouyang, Juanjuan Luo, Nianhua Luo, Hucheng Zhu, Yonghui Zhang
Summary: This article reports the isolation and structural elucidation of two new compounds from a marine-derived fungus, as well as the evaluation of their biological activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Meng Bai, Cheng-Hai Gao, Kai Liu, Long-Yan Zhao, Zhen-Zhou Tang, Yong-Hong Liu
Summary: A new benzophenone derivative and a new benzophenone natural product, along with two known compounds, were isolated from the endophytic fungus Penicillium sp. collected in the South China Sea. The new compounds exhibited moderate antibacterial activities against methicillin-resistant Staphylococcus aureus.
JOURNAL OF ANTIBIOTICS
(2021)
Article
Biochemistry & Molecular Biology
Gaoran Liu, Ruiyun Huo, Shubin Niu, Fuhang Song, Ling Liu
Summary: Two new decalin derivatives, fusarielins O and P, were isolated from the crude extract of Talaromyces sp., along with seven known compounds. The structures of the new compounds were determined through comprehensive spectroscopic analyses. The compounds were evaluated for their cytotoxic and radical scavenging activities.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Applied
Zhao-Long Xu, Ben-Chao Li, Li-Li Huang, Liu-Xia Lv, Yan Luo, Wei-Feng Xu, Rui-Yun Yang
Summary: Two new open-chain cytochalasins and six known analogues were isolated from a Chinese medicinal plant Sophora tonkinensis. One of the new compounds showed moderate antibacterial activities against Bacillus subtilis and Escherichia coli.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Ting Shi, Yan-Yan Yu, Jia-Jia Dai, Yi-Ting Zhang, Wen-Peng Hu, Li Zheng, Da-Yong Shi
Summary: Pseudogymnoascus is a psychrophilic pathogenic fungus widely distributed in Antarctica, and studies on its secondary metabolites are rare. Through systematic research guided by molecular networking, a novel polyketide, pseudophenone A, along with six known analogs, was isolated from the fungus Pseudogymnoascus sp. HSX2#-11. The structure of the new compound was elucidated through extensive spectroscopic investigation and single-crystal X-ray diffraction. Pseudophenone A exhibited antibacterial activities against a panel of strains, marking the first use of molecular networking to study the metabolic profiles of Antarctica fungi.
Article
Chemistry, Medicinal
Pei Wang, Huifang Wang, Juchun Yang, Li Yang, Caihong Cai, Jingzhe Yuan, Fei Wu, Cuijuan Gai, Wenli Mei, Haofu Dai
Summary: Five new isocoumarins, phaeosphaerins A-E (1-5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated using NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1-7 displayed weak neuroprotective effects against H2O2-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
Article
Biochemistry & Molecular Biology
Huawei Lv, Jinkun Zhang, Yaxin Xue, Songwei Li, Xiaoyu Sun, Jia Jia, Hongkai Bi, Shoubao Wang, Haibo Su, Mengdi Zhu, Hong Wang, Kui Hong, Xingnuo Li
Summary: Two new austocystin analogs, austocystin P (1) and austocystin Q (2), were isolated from the fermentation extract of Aspergillus sp. WHUF05236, along with fourteen known compounds. Compounds 3, 11, and 12 exhibited antimicrobial activities against Helicobacter pylori, while compounds 3, 6, and 7 showed cytotoxicities against human colon cancer cell lines Hct-116.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Medicinal
Yuxiu Ye, Jiaqi Liang, Jianglian She, Xiuping Lin, Junfeng Wang, Yonghong Liu, Dehua Yang, Yanhui Tan, Xiaowei Luo, Xuefeng Zhou
Summary: Marine sponge-derived fungi have been found to produce bioactive natural products, including two new alkaloids (polonimides E and D) and a new butenolide derivative (eutypoid F). In addition, thirteen known compounds were also isolated from the fungus Penicillium sp. SCSIO 41413. The inhibitory effects of the butenolide derivatives on the enzyme PI3K were investigated, and two compounds showed significant binding to the PI3K protein. Furthermore, two compounds exhibited inhibitory activity against LPS-induced NF-kappa B activation in cells.
Article
Chemistry, Applied
De-Wen Bi, Jian- Feng, Wen-Hui Pang, Peng-Yun Yang, Yao-Jun Xu, Muhammad Aurang Zeb, Meng-Ru Wang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Guang Wang, Wei-Lie Xiao
Summary: Three new lanostane triterpenoids (1-3) and two new amide fatty compounds (4-5) were isolated from the ethyl acetate extract of the endophytic fungus Alternaria sp. gx-2. The structures of these compounds were identified through NMR and HRESIMS analysis. Compound 1 showed moderate anti-inflammatory activity on the activation of NLRP3 inflammasome with a lactate dehydrogenase (LDH) inhibition rate of 54.45% at a concentration of 10 μM.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Weixi Gao, Fengli Li, Shuang Lin, Beiye Yang, Jianping Wang, Jie Cao, Zhengxi Hu, Yonghui Zhang
Summary: This study reported the chemical investigation of the endophytic fungus Periconia sp. TJ403-rc01 isolated from the leaves of Rosa chinensis Jacq. Two new lanostane-type triterpenoids were discovered and their structures were determined. Notably, these compounds were found for the first time in species of Periconia. Compounds 1 and 2 exhibited moderate anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Bei-Qian Deng, Ming-Qi Chen, Hong-Xiao Wang, Xiao-Xia Wang, Huan Zhao, Chuan-Hui Li, Sheng-Ying Qin, Dan Hu, Guo-Dong Chen, Hao Gao
Summary: Two new alkaloids, 19-Hydroxybrevianamide M (1) and 6 R-methoxybrevianamide V (2), were isolated from the extract of the endophytic fungus Aspergillus sp. JNU18HC0517J, along with six known analogues (3-8). Their structures were determined using extensive spectroscopic analyses, NMR calculations, and ECD calculations. 6 R-methoxybrevianamide V (2) is the first L-proline indole DKP alkaloid with substitution at C-6 on the proline ring. The cytotoxicities and antimicrobial activities of these compounds were also evaluated, with compound 8 showing moderate antibacterial activity against Staphylococcus aureus 209 P with a minimal inhibitory concentration (MIC) value of 16 μg/ml.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Medicinal
Xiuli Xu, Jiangpeng Li, Kai Zhang, Shangzhu Wei, Rui Lin, Steven W. Polyak, Na Yang, Fuhang Song
Summary: Nine new secondary metabolites, including six isocoumarin analogues and three compounds with a rare skeleton of isocoumarin coupled with phenylethylamine, were isolated and identified from the marine-derived fungus Paraphoma sp. CUGBMF180003. The chemical structures were determined using spectroscopic data, and two compounds showed strong antibacterial activity against Staphylococcus aureus.
