Journal
JOURNAL OF ANTIBIOTICS
Volume 66, Issue 6, Pages 311-317Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2013.17
Keywords
chemical screening; endophytic actinomycete; hemolysis inhibitor; Polymorphospora rubra; trehangelins
Funding
- Quality Assurance Flamework of Higher Education from the Ministry of Education, Culture, Sports, Sciences and Technology (MEXT), Japan
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Three new natural products, designated trehangelins A, B and C, were isolated by solvent extraction, silica gel and octadecylsilyl silica gel column chromatographies and subsequent preparative HPLC from the cultured broth of an endophytic actinomycete strain, Polymorphospora rubra K07-0510. The trehangelins consisted of a trehalose moiety and two angelic acid moieties. Trehangelins A (IC50 value, 0.1 mg ml(-1)) and C (IC50 value, 0.4 mg ml(-1)), with symmetric structures, showed potent inhibitory activity against hemolysis of red blood cells induced by light-activated pheophorbide a. However, trehangelin B, with an asymmetric structure, displayed only a slight inhibition (IC50 value, 1.0 mg ml(-1)).
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